calcium-calmodulin-dependent protein kinase

カルシウム・カルモジュリン依存性プロテインキナーゼ、カルシウムカルモジュリン依存性キナーゼ

関

calmodulin kinase、calmodulin-dependent protein kinase

WordNet

1. relying on or requiring a person or thing for support, supply, or what is needed; "dependent children"; "dependent on moisture"
2. addicted to a drug (同)dependant, drug-addicted, hooked, strung-out
3. contingent on something else (同)dependant, qualified
4. (of a clause) unable to stand alone syntactically as a complete sentence; "a subordinate (or dependent) clause functions as a noun or adjective or adverb within a sentence" (同)subordinate
5. any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
6. a white metallic element that burns with a brilliant light; the fifth most abundant element in the earths crust; an important component of most plants and animals (同)Ca, atomic number 20
7. an enzyme that catalyzes the conversion of a proenzyme to an active enzyme
8. the basic unit of money in Papua New Guinea

PrepTutorEJDIC

1. 『頼っている』,依存している,従属している / 扶養される人(家族)
2. 蛋白(たんばく)質
3. 『カルシウム』(金属元素;化学記号は『Ca』)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/10 10:03:01」(JST)

wiki en

[Wiki en表示]

CAMK is an abbreviation for the Ca²⁺/calmodulin-dependent protein kinase class of enzymes. CAMKs are activated by increases in the concentration of intracellular calcium ions (Ca²⁺) and transfers phosphates from ATP to defined serine or threonine residues in other proteins. Activated CAMK is involved in the phosphorylation of transcription factors and therefore, in the regulation of expression of responding genes. Members of this enzyme class include:

• CAMKI
  • CAMKIα
  • CAMKIβ
  • CAMKIδ
  • CAMKIγ
• CAMKII
  • CAMKIIα
  • CAMKIIβ
  • CAMKIIδ
  • CAMKIIγ
• CAMKIII
• CAMKIV

UpToDate Contents

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• 1. 黒色腫（メラノーマ）に対する遺伝的感受性 inherited susceptibility to melanoma
• 2. 肥大型心筋症の遺伝学 genetics of hypertrophic cardiomyopathy
• 3. 成人におけるカルシウム結石の危険因子 risk factors for calcium stones in adults
• 4. 複合免疫不全 combined immunodeficiencies
• 5. 虚血プレコンディショニングの定義および病因 definition and pathogenesis of ischemic preconditioning

English Journal

• Altered expression of neuroplasticity-related genes in the brain of depressed suicides.

• Fuchsova B1, Alvarez Juliá A2, Rizavi HS3, Frasch AC2, Pandey GN3.
• Neuroscience.Neuroscience.2015 Jul 23;299:1-17. doi: 10.1016/j.neuroscience.2015.04.057. Epub 2015 Apr 28.
• BACKGROUND: Expression of the neuronal membrane glycoprotein M6a (GPM6A), the proteolipid protein (PLP/DM20) family member, is downregulated in the hippocampus of chronically stressed animals. Its neuroplastic function involves a role in neurite formation, filopodium outgrowth and synaptogenesis thr
• PMID 25934039

• Alterations in left ventricular function during intermittent hypoxia: Possible involvement of O-GlcNAc protein and MAPK signaling.

• Guo X1, Shang J1, Deng Y1, Yuan X1, Zhu D1, Liu H1.
• International journal of molecular medicine.Int J Mol Med.2015 Jul;36(1):150-8. doi: 10.3892/ijmm.2015.2198. Epub 2015 Apr 24.
• Obstructive sleep apnea, characterized by recurrent episodes of hypoxia [intermittent hypoxia (IH)], has been identified as a risk factor for cardiovascular diseases. The O-linked β-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) of proteins has important regulatory implications on t
• PMID 25936416

• PDZ Domain in the Engineering and Production of a Saporin Chimeric Toxin as a Tool for targeting Cancer Cells.

• Giansanti F1, Sabatini D1, Pennacchio MR1, Scotti S1, Angelucci F1, Dhez AC1, Antonosante A1, Cimini A1,2, Giordano A3,2, Ippoliti R1.
• Journal of cellular biochemistry.J Cell Biochem.2015 Jul;116(7):1256-66. doi: 10.1002/jcb.25080.
• In this paper we have studied a PDZ protein domain as a possible tool for cellular targeting of the ribosome inactivating protein Saporin, exploiting the ability of PDZ domains to recognize and bind short peptide sequences located at the C-terminus of a cognate protein. We have focused our attention
• PMID 25581839

Japanese Journal

• Can intermediate-frequency magnetic fields affect memory function-related gene expressions in hippocampus of C57BL/6J mice?

• Win-Shwe Tin-Tin,Ohtani Shin,Ushiyama Akira,Fujimaki Hidekazu,Kunugita Naoki
• The Journal of Toxicological Sciences 38(2), 169-176, 2013
• … The relative mRNA expression levels of the N-methyl-D aspartate (NMDA) receptor subunits NR1, NR2A, and NR2B as well as transcription factors (calcium/calmodulin-dependent protein kinase (CaMK) -IV, cyclic AMP responsive element binding protein (CREB) -1) and neurotrophins (nerve growth factor (NGF), and brain-derived neurotrophic factors (BDNF)) were not significantly altered in the IF-MF-exposed mice. …
• NAID 130004447032

• CREB activation is a key player for ischemic tolerance in the brain

• 北川 一夫,佐々木 勉,寺崎 泰和,八木田 佳樹,望月 秀樹
• 臨床神経学 52(11), 904-907, 2012
• … Then, influx of calcium ions into intracellular space activates calcium-calmodulin dependent protein kinase (CaMK). … CaMK I/IV phosphorylates Ser 133 of CREB, and Thr 484 of salt-inducible kinase (SIK). …
• NAID 130004505204

• P1-018  ループス腎炎のメサンギウム細胞におけるCalcium/calmodulin-dependent protein kinase type IVの役割

• 一瀬 邦弘,川上 純,George C. Tsokos
• 日本臨床免疫学会会誌 35(4), 335b-335b, 2012
• …   〈目的〉全身性エリテマトーデス（SLE）に合併した腎病変は未だに死因の主要因となっている．SLEのT細胞ではCalcium/calmodulin-dependent protein Kinase Type IV (CaMKIV）の発現が増加しており，T細胞機能の異常を引き起こすことが報告されている．そこで我々はSLEのモデルマウスであるMRL/lprマウスを用いて，CaMKIVの腎臓メサンギウム細胞の機能制御 …
• NAID 130003364055

Related Links

• Ca++/ Calmodulin-dependent Protein Kinase Activation

The calcium/calmodulin-dependent kinases (CaMKs) are involved in a large number of cellular responses induced by hormones, neurotransmitters and other signalling. Elevation of calcium functions as a major second messenger ...

• Calcium/Calmodulin-Dependent Protein Kinase II: An ...

... kinase that had switch-like properties (Miller and Kennedy, 1986) was met with great enthusiasm, and the role of calcium/calmodulin-dependent protein kinase II (CaMKII) in learning and memory has been Previous Section ...

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★リンクテーブル★

リンク元	「calmodulin-dependent protein kinase」「カルシウム・カルモジュリン依存性プロテインキナーゼ」「calmodulin kinase」「カルシウムカルモジュリン依存性キナーゼ」
拡張検索	「calcium-calmodulin-dependent protein kinase type 2」「calcium-calmodulin-dependent protein kinase type 1」「calcium-calmodulin-dependent protein kinase type 4」「calcium-calmodulin-dependent protein kinase kinase」
関連記事	「dependent」「kinase」「protein kinase」「calcium」「calmodulin」

「calmodulin-dependent protein kinase」

　　[★]

カルモジュリン依存性プロテインキナーゼ、カルモジュリン依存性キナーゼ

関

calcium-calmodulin-dependent protein kinase、calmodulin kinase、CaM kinase、CaMK

「カルシウム・カルモジュリン依存性プロテインキナーゼ」

　　[★]

英

calcium-calmodulin-dependent protein kinase

関

カルモジュリンキナーゼ、カルモジュリン依存性キナーゼ、カルシウムカルモジュリン依存性キナーゼ

「calmodulin kinase」

　　[★]

カルモジュリンキナーゼ

関

calcium-calmodulin-dependent protein kinase、calmodulin-dependent protein kinase、CaM kinase、CaMK

「カルシウムカルモジュリン依存性キナーゼ」

　　[★]

英

calcium-calmodulin-dependent protein kinase

関

カルシウム・カルモジュリン依存性プロテインキナーゼ

「calcium-calmodulin-dependent protein kinase type 2」

　　[★]

• カルシウム・カルモジュリン依存性プロテインキナーゼ2型

関

calmodulin-dependent protein kinase II、CaM KII、CaM kinase II、CaMKII

「calcium-calmodulin-dependent protein kinase type 1」

　　[★]

• カルシウム・カルモジュリン依存性プロテインキナーゼ1型

関

calmodulin-dependent protein kinase I、CaM kinase I

「calcium-calmodulin-dependent protein kinase type 4」

　　[★]

• カルシウム・カルモジュリン依存性プロテインキナーゼ4型

関

calmodulin-dependent protein kinase IV

「calcium-calmodulin-dependent protein kinase kinase」

　　[★]

カルシウム・カルモジュリン依存性プロテインキナーゼキナーゼ

「dependent」

　　[★]

• adj.

• 依存性の、依存的な、依存型の、依存の

関

depend、dependence、dependency、dependently

　 　 　 　 　

「kinase」

　　[★] キナーゼ カイネース リン酸化酵素 phosphoenzyme phosphotransferase 　

「protein kinase」

　　[★] プロテインキナーゼ

同

protein kinases

「calcium」

　　[★]

• カルシウム Ca2+

　 　

「calmodulin」

　　[★] カルモジュリン CaM