WordNet

have or establish a relationship to; "She relates well to her peers"
be in a relationship with; "How are these two observations related?" (同)interrelate
give an account of; "The witness related the events"
connected by kinship, common origin, or marriage
being connected either logically or causally or by shared characteristics ; "painting and the related arts"; "school-related activities"; "related to micelle formation is the...ability of detergent actives to congregate at oil-water interfaces" (同)related to
(genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors" (同)cistron, factor
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
thyroid hormone that tends to lower the level of calcium in the blood plasma and inhibit resorption of bone (同)thyrocalcitonin

PrepTutorEJDIC

(…に)〈事件・事情など〉‘を'『物語る』《+『名』+『to』+『名』》 / (…と)…‘を'『関係させる』,結びつける《+『名』+『to(with)』+『名』》 / 〈物・事が〉(…に)関係がある,かかわる《+『to(with)』+『名(wh・節・句)』》 / (…に)〈人が〉なじむ,順応する《+『to』+『名』》
関係のある
遺伝子
=sense organ / 受信装置

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/09/23 10:07:45」(JST)

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Calcitonin receptor-like (CALCRL), also known as the calcitonin receptor-like receptor (CRLR), is a human protein.^[2]

Function

The protein encoded by the CALCRL gene is a G protein-coupled receptor related to the calcitonin receptor. CALCRL is linked to one of three single transmembrane domain receptor activity-modifying proteins (RAMPs) that are essential for functional activity.

The association of CALCRL with different RAMP proteins produces different receptors:^[3]^[4]

with RAMP1: produces a CGRP receptor
with RAMP2: produces an adrenomedullin (AM) receptor, designated AM₁^[5]
with RAMP3: produces a dual CGRP/AM receptor designated AM₂

These receptors are linked to the G protein G_s,^[6] which activates adenylate cyclase and activation results in the generation of intracellular cyclic adenosine monophosphate (cAMP).

Structure

CALCRL associated with RAMP 1 produces the CGRP receptor which is a trans-membrane protein receptor that is made up of four chains. Two of the four chains contain unique sequences. It is a heterodimer protein composed of two polypeptide chains differing in composition of their amino acid residues. The sequence reveals multiple hydrophobic and hydrophilic regions throughout the four chains in the protein. These G-protein coupled receptor (GPCRs) proteins play an important role in pharmaceutical targets. Many drugs used today alter the GPCR signaling pathways.^[1]

References

^ ^a ^b PDB 3N7S; ter Haar E, Koth CM, Abdul-Manan N, Swenson L, Coll JT, Lippke JA, Lepre CA, Garcia-Guzman M, Moore JM (2010). "Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism". Structure 18 (9): 1083–93. doi:10.1016/j.str.2010.05.014. PMID 20826335.
^ Aiyar N, Rand K, Elshourbagy NA, Zeng Z, Adamou JE, Bergsma DJ, Li Y (May 1996). "A cDNA encoding the calcitonin gene-related peptide type 1 receptor". J. Biol. Chem. 271 (19): 11325–9. doi:10.1074/jbc.271.19.11325. PMID 8626685.
^ McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM (May 1998). "RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor". Nature 393 (6683): 333–9. doi:10.1038/30666. PMID 9620797.
^ Foord SM, Marshall FH (May 1999). "RAMPs: accessory proteins for seven transmembrane domain receptors". Trends Pharmacol. Sci. 20 (5): 184–7. doi:10.1016/S0165-6147(99)01347-4. PMID 10354609.
^ Kamitani S, Asakawa M, Shimekake Y, Kuwasako K, Nakahara K, Sakata T (April 1999). "The RAMP2/CRLR complex is a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells". FEBS Lett. 448 (1): 111–4. doi:10.1016/S0014-5793(99)00358-0. PMID 10217420.
^ "Receptor properties". SenseLab Project: Membrane properties resource. Yale University. Retrieved 2008-09-28.

External links

"Calcitonin receptors: CALCRL". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
calcitonin receptor-like receptor at the US National Library of Medicine Medical Subject Headings (MeSH)
CALCRL human gene location in the UCSC Genome Browser.
CALCRL human gene details in the UCSC Genome Browser.

This article on a gene on chromosome 2 is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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English Journal

H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO-TRPA1-CGRP signalling pathway.

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Nature communications.Nat Commun.2014 Jul 15;5:4381. doi: 10.1038/ncomms5381.
Nitroxyl (HNO) is a redox sibling of nitric oxide (NO) that targets distinct signalling pathways with pharmacological endpoints of high significance in the treatment of heart failure. Beneficial HNO effects depend, in part, on its ability to release calcitonin gene-related peptide (CGRP) through an
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α2A-Adrenergic Receptors Filter Parabrachial Inputs to the Bed Nucleus of the Stria Terminalis.

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Japanese Journal

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Related Pictures

★リンクテーブル★

リンク元	「CGRP receptor」「カルシトニン遺伝子関連ペプチド受容体」「カルシトニン遺伝子関連ペプチドレセプター」
関連記事	「relate」「peptide receptor」

「CGRP receptor」

Calcitonin receptor-like
	; Crystallographic structure of the ectodomain complex of the CGRP type 1 receptor and RAMP1.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	3AQF, 3N7P, 3N7R, 3N7S
Identifiers
Symbols	CALCRL ; CGRPR; CRLR
External IDs	OMIM: 114190 MGI: 1926944 HomoloGene: 21179 IUPHAR: calcitonin receptor-like ChEMBL: 3798 GeneCards: CALCRL Gene
Gene ontology
Molecular function	• adrenomedullin receptor activity; • calcitonin gene-related polypeptide receptor activity; • G-protein coupled receptor activity; • calcitonin receptor activity; • protein binding; • protein transporter activity;
Cellular component	• lysosome; • endosome; • endoplasmic reticulum; • plasma membrane; • integral component of plasma membrane;
Biological process	• angiogenesis; • cAMP biosynthetic process; • calcium ion transport; • regulation of muscle contraction; • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; • adenylate cyclase-activating G-protein coupled receptor signaling pathway; • heart development; • protein transport; • positive regulation of cAMP biosynthetic process; • receptor internalization; • positive regulation of smooth muscle cell proliferation; • negative regulation of inflammatory response; • cellular response to sucrose stimulus;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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