- 関
- CGRP receptor
WordNet
- have or establish a relationship to; "She relates well to her peers"
- be in a relationship with; "How are these two observations related?" (同)interrelate
- give an account of; "The witness related the events"
- connected by kinship, common origin, or marriage
- being connected either logically or causally or by shared characteristics ; "painting and the related arts"; "school-related activities"; "related to micelle formation is the...ability of detergent actives to congregate at oil-water interfaces" (同)related to
- (genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors" (同)cistron, factor
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
- thyroid hormone that tends to lower the level of calcium in the blood plasma and inhibit resorption of bone (同)thyrocalcitonin
PrepTutorEJDIC
- (…に)〈事件・事情など〉‘を'『物語る』《+『名』+『to』+『名』》 / (…と)…‘を'『関係させる』,結びつける《+『名』+『to(with)』+『名』》 / 〈物・事が〉(…に)関係がある,かかわる《+『to(with)』+『名(wh・節・句)』》 / (…に)〈人が〉なじむ,順応する《+『to』+『名』》
- 関係のある
- 遺伝子
- =sense organ / 受信装置
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/09/23 10:07:45」(JST)
[Wiki en表示]
Calcitonin receptor-like |
Crystallographic structure of the ectodomain complex of the CGRP type 1 receptor and RAMP1.[1] |
Available structures |
PDB |
Ortholog search: PDBe, RCSB |
List of PDB id codes |
3AQF, 3N7P, 3N7R, 3N7S
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Identifiers |
Symbols |
CALCRL ; CGRPR; CRLR |
External IDs |
OMIM: 114190 MGI: 1926944 HomoloGene: 21179 IUPHAR: calcitonin receptor-like ChEMBL: 3798 GeneCards: CALCRL Gene |
Gene ontology |
Molecular function |
• adrenomedullin receptor activity
• calcitonin gene-related polypeptide receptor activity
• G-protein coupled receptor activity
• calcitonin receptor activity
• protein binding
• protein transporter activity
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Cellular component |
• lysosome
• endosome
• endoplasmic reticulum
• plasma membrane
• integral component of plasma membrane
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Biological process |
• angiogenesis
• cAMP biosynthetic process
• calcium ion transport
• regulation of muscle contraction
• G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
• adenylate cyclase-activating G-protein coupled receptor signaling pathway
• heart development
• protein transport
• positive regulation of cAMP biosynthetic process
• receptor internalization
• positive regulation of smooth muscle cell proliferation
• negative regulation of inflammatory response
• cellular response to sucrose stimulus
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Sources: Amigo / QuickGO |
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RNA expression pattern |
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More reference expression data |
Orthologs |
Species |
Human |
Mouse |
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Entrez |
10203 |
54598 |
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Ensembl |
ENSG00000064989 |
ENSMUSG00000059588 |
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UniProt |
Q16602 |
Q9R1W5 |
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RefSeq (mRNA) |
NM_001271751 |
NM_018782 |
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RefSeq (protein) |
NP_001258680 |
NP_061252 |
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Location (UCSC) |
Chr 2:
188.21 – 188.31 Mb |
Chr 2:
84.33 – 84.43 Mb |
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PubMed search |
[1] |
[2] |
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Calcitonin receptor-like (CALCRL), also known as the calcitonin receptor-like receptor (CRLR), is a human protein.[2]
Contents
- 1 Function
- 2 Structure
- 3 References
- 4 Further reading
- 5 External links
Function
The protein encoded by the CALCRL gene is a G protein-coupled receptor related to the calcitonin receptor. CALCRL is linked to one of three single transmembrane domain receptor activity-modifying proteins (RAMPs) that are essential for functional activity.
The association of CALCRL with different RAMP proteins produces different receptors:[3][4]
- with RAMP1: produces a CGRP receptor
- with RAMP2: produces an adrenomedullin (AM) receptor, designated AM1[5]
- with RAMP3: produces a dual CGRP/AM receptor designated AM2
These receptors are linked to the G protein Gs,[6] which activates adenylate cyclase and activation results in the generation of intracellular cyclic adenosine monophosphate (cAMP).
Structure
CALCRL associated with RAMP 1 produces the CGRP receptor which is a trans-membrane protein receptor that is made up of four chains. Two of the four chains contain unique sequences. It is a heterodimer protein composed of two polypeptide chains differing in composition of their amino acid residues. The sequence reveals multiple hydrophobic and hydrophilic regions throughout the four chains in the protein. These G-protein coupled receptor (GPCRs) proteins play an important role in pharmaceutical targets. Many drugs used today alter the GPCR signaling pathways.[1]
References
- ^ a b PDB 3N7S; ter Haar E, Koth CM, Abdul-Manan N, Swenson L, Coll JT, Lippke JA, Lepre CA, Garcia-Guzman M, Moore JM (2010). "Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism". Structure 18 (9): 1083–93. doi:10.1016/j.str.2010.05.014. PMID 20826335.
- ^ Aiyar N, Rand K, Elshourbagy NA, Zeng Z, Adamou JE, Bergsma DJ, Li Y (May 1996). "A cDNA encoding the calcitonin gene-related peptide type 1 receptor". J. Biol. Chem. 271 (19): 11325–9. doi:10.1074/jbc.271.19.11325. PMID 8626685.
- ^ McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM (May 1998). "RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor". Nature 393 (6683): 333–9. doi:10.1038/30666. PMID 9620797.
- ^ Foord SM, Marshall FH (May 1999). "RAMPs: accessory proteins for seven transmembrane domain receptors". Trends Pharmacol. Sci. 20 (5): 184–7. doi:10.1016/S0165-6147(99)01347-4. PMID 10354609.
- ^ Kamitani S, Asakawa M, Shimekake Y, Kuwasako K, Nakahara K, Sakata T (April 1999). "The RAMP2/CRLR complex is a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells". FEBS Lett. 448 (1): 111–4. doi:10.1016/S0014-5793(99)00358-0. PMID 10217420.
- ^ "Receptor properties". SenseLab Project: Membrane properties resource. Yale University. Retrieved 2008-09-28.
Further reading
- Born W, Muff R, Fischer JA (2002). "Functional interaction of G protein-coupled receptors of the adrenomedullin peptide family with accessory receptor-activity-modifying proteins (RAMP).". Microsc. Res. Tech. 57 (1): 14–22. doi:10.1002/jemt.10051. PMID 11921352.
- Yallampalli C, Chauhan M, Thota CS, et al. (2003). "Calcitonin gene-related peptide in pregnancy and its emerging receptor heterogeneity.". Trends Endocrinol. Metab. 13 (6): 263–9. doi:10.1016/s1043-2760(02)00563-5. PMID 12128288.
- Foord SM, Craig RK (1988). "Isolation and characterisation of a human calcitonin-gene-related-peptide receptor.". Eur. J. Biochem. 170 (1-2): 373–9. doi:10.1111/j.1432-1033.1987.tb13710.x. PMID 2826160.
- Skofitsch G, Jacobowitz DM (1986). "Autoradiographic distribution of 125I calcitonin gene-related peptide binding sites in the rat central nervous system.". Peptides 6 (5): 975–86. doi:10.1016/0196-9781(85)90331-6. PMID 3001670.
- Flühmann B, Muff R, Hunziker W, et al. (1995). "A human orphan calcitonin receptor-like structure.". Biochem. Biophys. Res. Commun. 206 (1): 341–7. doi:10.1006/bbrc.1995.1047. PMID 7818539.
- Aiyar N, Rand K, Elshourbagy NA, et al. (1996). "A cDNA encoding the calcitonin gene-related peptide type 1 receptor.". J. Biol. Chem. 271 (19): 11325–9. doi:10.1074/jbc.271.19.11325. PMID 8626685.
- McLatchie LM, Fraser NJ, Main MJ, et al. (1998). "RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor.". Nature 393 (6683): 333–9. doi:10.1038/30666. PMID 9620797.
- Sams A, Jansen-Olesen I (1999). "Expression of calcitonin receptor-like receptor and receptor-activity-modifying proteins in human cranial arteries.". Neurosci. Lett. 258 (1): 41–4. doi:10.1016/S0304-3940(98)00844-1. PMID 9876047.
- Kamitani S, Asakawa M, Shimekake Y, et al. (1999). "The RAMP2/CRLR complex is a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells.". FEBS Lett. 448 (1): 111–4. doi:10.1016/S0014-5793(99)00358-0. PMID 10217420.
- Aldecoa A, Gujer R, Fischer JA, Born W (2000). "Mammalian calcitonin receptor-like receptor/receptor activity modifying protein complexes define calcitonin gene-related peptide and adrenomedullin receptors in Drosophila Schneider 2 cells.". FEBS Lett. 471 (2-3): 156–60. doi:10.1016/S0014-5793(00)01387-9. PMID 10767413.
- Frayon S, Cueille C, Gnidéhou S, et al. (2000). "Dexamethasone increases RAMP1 and CRLR mRNA expressions in human vascular smooth muscle cells.". Biochem. Biophys. Res. Commun. 270 (3): 1063–7. doi:10.1006/bbrc.2000.2552. PMID 10772950.
- Kuwasako K, Shimekake Y, Masuda M, et al. (2000). "Visualization of the calcitonin receptor-like receptor and its receptor activity-modifying proteins during internalization and recycling.". J. Biol. Chem. 275 (38): 29602–9. doi:10.1074/jbc.M004534200. PMID 10882736.
- Evans BN, Rosenblatt MI, Mnayer LO, et al. (2000). "CGRP-RCP, a novel protein required for signal transduction at calcitonin gene-related peptide and adrenomedullin receptors.". J. Biol. Chem. 275 (40): 31438–43. doi:10.1074/jbc.M005604200. PMID 10903324.
- Hilairet S, Foord SM, Marshall FH, Bouvier M (2001). "Protein-protein interaction and not glycosylation determines the binding selectivity of heterodimers between the calcitonin receptor-like receptor and the receptor activity-modifying proteins.". J. Biol. Chem. 276 (31): 29575–81. doi:10.1074/jbc.M102722200. PMID 11387328.
- Kamitani S, Sakata T (2001). "Glycosylation of human CRLR at Asn123 is required for ligand binding and signaling.". Biochim. Biophys. Acta 1539 (1-2): 131–9. doi:10.1016/S0167-4889(01)00100-8. PMID 11389975.
- Nikitenko LL, Brown NS, Smith DM, et al. (2001). "Differential and cell-specific expression of calcitonin receptor-like receptor and receptor activity modifying proteins in the human uterus.". Mol. Hum. Reprod. 7 (7): 655–64. doi:10.1093/molehr/7.7.655. PMID 11420389.
- Hilairet S, Bélanger C, Bertrand J, et al. (2001). "Agonist-promoted internalization of a ternary complex between calcitonin receptor-like receptor, receptor activity-modifying protein 1 (RAMP1), and beta-arrestin.". J. Biol. Chem. 276 (45): 42182–90. doi:10.1074/jbc.M107323200. PMID 11535606.
- Aiyar N, Disa J, Pullen M, Nambi P (2002). "Receptor activity modifying proteins interaction with human and porcine calcitonin receptor-like receptor (CRLR) in HEK-293 cells.". Mol. Cell. Biochem. 224 (1-2): 123–33. doi:10.1023/A:1011907328682. PMID 11693189.
- Hagner S, Haberberger RV, Overkamp D, et al. (2002). "Expression and distribution of calcitonin receptor-like receptor in human hairy skin.". Peptides 23 (1): 109–16. doi:10.1016/S0196-9781(01)00586-1. PMID 11814625.
- Hill H, Pioszak, A. (2013). "Bacterial expression and purification of a heterodimeric adrenomedullin receptor extracellular domain complex using DsbC-assisted disulfide shuffling.". Protein Expr Purif. 88 (1): 107–13. doi:10.1016/j.pep.2012.11.019. PMID 23247088.
External links
- "Calcitonin receptors: CALCRL". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- calcitonin receptor-like receptor at the US National Library of Medicine Medical Subject Headings (MeSH)
- CALCRL human gene location in the UCSC Genome Browser.
- CALCRL human gene details in the UCSC Genome Browser.
Cell surface receptor: G protein-coupled receptors
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Class B: Secretin like
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Orphan |
- GPR (56
- 64
- 97
- 98
- 110
- 111
- 112
- 113
- 114
- 115
- 116
- 123
- 124
- 125
- 126
- 128
- 133
- 143
- 144
- 155
- 157)
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Other |
- Brain-specific angiogenesis inhibitor (1
- 2
- 3)
- Cadherin (1
- 2
- 3)
- Calcitonin
- CALCRL
- CD97
- Corticotropin-releasing hormone (1
- 2)
- EMR (1
- 2
- 3)
- Glucagon (GR
- GIPR
- GLP1R
- GLP2R)
- Growth hormone releasing hormone
- PACAPR1
- GPR
- Latrophilin (1
- 2
- 3
- ELTD1)
- Methuselah-like proteins
- Parathyroid hormone (1
- 2)
- Secretin
- Vasoactive intestinal peptide (1
- 2)
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Class C: Metabotropic glutamate / pheromone
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Taste |
- TAS1R (1
- 2
- 3)
- TAS2R (1
- 3
- 4
- 5
- 7
- 8
- 9
- 10
- 13
- 14
- 16
- 19
- 20
- 30
- 31
- 38
- 39
- 40
- 41
- 42
- 43
- 45
- 46
- 50
- 60)
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Other |
- Calcium-sensing receptor
- GABA B (1
- 2)
- Glutamate receptor (Metabotropic glutamate (1
- 2
- 3
- 4
- 5
- 6
- 7
- 8))
- GPRC6A
- GPR (156
- 158
- 179)
- RAIG (1
- 2
- 3
- 4)
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Class F: Frizzled / Smoothened
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Frizzled |
- Frizzled (1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
- 10)
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Smoothened |
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B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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Neuropeptide receptors
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G protein-coupled receptor |
Hormone receptors |
Hypothalamic |
- CRH
- FSH
- LHRH
- TRH
- Somatostatin
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Pituitary |
- Vasopressin
- Oxytocin
- LHCG
- TSH
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Other |
- Atrial natriuretic factor
- Calcitonin
- Cholecystokinin
- VIP
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Opioid receptors |
- Delta
- Kappa
- Mu
- Nociceptin
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Other neuropeptide receptors |
- Angiotensin
- Bradykinin
- Tachykinin
- Calcitonin gene-related peptide
- Galanin
- GPCR neuropeptide
- Neurotensin
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Type I cytokine receptor |
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Enzyme-linked receptor |
- Atrial natriuretic factor
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Other |
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B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO-TRPA1-CGRP signalling pathway.
- Eberhardt M1, Dux M2, Namer B3, Miljkovic J4, Cordasic N5, Will C3, Kichko TI3, de la Roche J6, Fischer M7, Suárez SA8, Bikiel D8, Dorsch K9, Leffler A6, Babes A10, Lampert A11, Lennerz JK9, Jacobi J5, Martí MA12, Doctorovich F8, Högestätt ED13, Zygmunt PM13, Ivanovic-Burmazovic I4, Messlinger K3, Reeh P11, Filipovic MR14.
- Nature communications.Nat Commun.2014 Jul 15;5:4381. doi: 10.1038/ncomms5381.
- Nitroxyl (HNO) is a redox sibling of nitric oxide (NO) that targets distinct signalling pathways with pharmacological endpoints of high significance in the treatment of heart failure. Beneficial HNO effects depend, in part, on its ability to release calcitonin gene-related peptide (CGRP) through an
- PMID 25023795
- α2A-Adrenergic Receptors Filter Parabrachial Inputs to the Bed Nucleus of the Stria Terminalis.
- Flavin SA1, Matthews RT2, Wang Q3, Muly EC4, Winder DG5.
- The Journal of neuroscience : the official journal of the Society for Neuroscience.J Neurosci.2014 Jul 9;34(28):9319-31. doi: 10.1523/JNEUROSCI.0822-14.2014.
- α2-adrenergic receptors (AR) within the bed nucleus of the stria terminalis (BNST) reduce stress-reward interactions in rodent models. In addition to their roles as autoreceptors, BNST α2A-ARs suppress glutamatergic transmission. One prominent glutamatergic input to the BNST originates from the pa
- PMID 25009265
- Distribution of transient receptor potential cation channel subfamily V member 1-expressing nerve fibers in mouse esophagus.
- Matsumoto K1, Hosoya T, Ishikawa E, Tashima K, Amagase K, Kato S, Murayama T, Horie S.
- Histochemistry and cell biology.Histochem Cell Biol.2014 Jul 8. [Epub ahead of print]
- Transient receptor potential cation channel subfamily V member 1 (TRPV1) plays a role in esophageal function. However, the distribution of TRPV1 nerve fibers in the esophagus is currently not well understood. In the present study, we investigated the distribution of TRPV1 and neurotransmitters relea
- PMID 25002127
Japanese Journal
- The potentiating effect of calcitonin gene-related peptide on transient receptor potential vanilloid-1 activity and the electrophysiological responses of rat trigeminal neurons to nociceptive stimuli
- Osteoporotic Pain is Associated with Increased Transient Receptor Vanilloid 4 Expression in the Dorsal Root Ganglia of Ovariectomized Osteoporotic Rats: A Pilot Basic Study
- Osteoporotic pain is associated with increased transient receptor vanilloid 4 expression in the dorsal root ganglia of ovariectomized osteoporotic rats
Related Pictures
![Gene-Related Peptide; Calcitonin Gene](https://1mg.info/0/g/w/2159.jpg)
![Gene-Related Peptide; Calcitonin Gene](https://1mg.info/0/g/w/2160.jpg)
![Receptors, Calcitonin Gene-Related Peptide](https://1mg.info/0/g/w/2161.jpg)
![Gene-Related Peptide; Calcitonin Gene](https://1mg.info/0/g/w/2162.jpg)
![Calcitonin gene-related peptide in](https://1mg.info/0/g/w/2163.jpg)
★リンクテーブル★
[★]
- 関
- calcitonin gene-related peptide receptor
[★]
- 英
- calcitonin gene-related peptide receptor、CGRP receptor
- 関
- カルシトニン遺伝子関連ペプチドレセプター、CGRP受容体、CGRPレセプター
[★]
- 英
- calcitonin gene-related peptide receptor、CGRP receptor
- 関
- カルシトニン遺伝子関連ペプチド受容体、CGRP受容体、CGRPレセプター
[★]
- 関
- associate、association、attach、bearing、concern、connect、connection、correlate、correlation、germane、implicate、implication、interplay、link、pertain、pertinent、referable、reference、relation、relationship、relative、relevance、relevant、respect
[★]
- 関
- peptide hormone receptor