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a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

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=sense organ / 受信装置

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/01/08 14:54:43」(JST)

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Calcitonin receptor-like (CALCRL), also known as the calcitonin receptor-like receptor (CRLR), is a human protein.^[2]

Function[edit]

The protein encoded by the CALCRL gene is a G protein-coupled receptor related to the calcitonin receptor. CALCRL is linked to one of three single transmembrane domain receptor activity-modifying proteins (RAMPs) that are essential for functional activity.

The association of CALCRL with different RAMP proteins produces different receptors:^[3]^[4]

with RAMP1: produces a CGRP receptor
with RAMP2: produces an adrenomedullin (AM) receptor, designated AM₁^[5]
with RAMP3: produces a dual CGRP/AM receptor designated AM₂

These receptors are linked to the G protein G_s,^[6] which activates adenylate cyclase and activation results in the generation of intracellular cyclic adenosine monophosphate (cAMP).

Structure[edit]

CALCRL associated with RAMP 1 produces the CGRP receptor which is a trans-membrane protein receptor that is made up of four chains. Two of the four chains contain unique sequences. It is a heterodimer protein composed of two polypeptide chains differing in composition of their amino acid residues. The sequence reveals multiple hydrophobic and hydrophilic regions throughout the four chains in the protein. These G-protein coupled receptor (GPCRs) proteins play an important role in pharmaceutical targets. Many drugs used today alter the GPCR signaling pathways.^[1]

References[edit]

^ ^a ^b PDB 3N7S; ter Haar E, Koth CM, Abdul-Manan N, Swenson L, Coll JT, Lippke JA, Lepre CA, Garcia-Guzman M, Moore JM (2010). "Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism". Structure 18 (9): 1083–93. doi:10.1016/j.str.2010.05.014. PMID 20826335.
^ Aiyar N, Rand K, Elshourbagy NA, Zeng Z, Adamou JE, Bergsma DJ, Li Y (May 1996). "A cDNA encoding the calcitonin gene-related peptide type 1 receptor". J. Biol. Chem. 271 (19): 11325–9. doi:10.1074/jbc.271.19.11325. PMID 8626685. Cite uses deprecated parameters (help)
^ McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM (May 1998). "RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor". Nature 393 (6683): 333–9. doi:10.1038/30666. PMID 9620797. Cite uses deprecated parameters (help)
^ Foord SM, Marshall FH (May 1999). "RAMPs: accessory proteins for seven transmembrane domain receptors". Trends Pharmacol. Sci. 20 (5): 184–7. doi:10.1016/S0165-6147(99)01347-4. PMID 10354609. Cite uses deprecated parameters (help)
^ Kamitani S, Asakawa M, Shimekake Y, Kuwasako K, Nakahara K, Sakata T (April 1999). "The RAMP2/CRLR complex is a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells". FEBS Lett. 448 (1): 111–4. doi:10.1016/S0014-5793(99)00358-0. PMID 10217420. Cite uses deprecated parameters (help)
^ "Receptor properties". SenseLab Project: Membrane properties resource. Yale University. Retrieved 2008-09-28.

External links[edit]

"Calcitonin receptors: CALCRL". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
calcitonin receptor-like receptor at the US National Library of Medicine Medical Subject Headings (MeSH)
CALCRL human gene location in the UCSC Genome Browser.
CALCRL human gene details in the UCSC Genome Browser.

This article on a gene on chromosome 2 is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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1. 成人における片頭痛の急性期治療 acute treatment of migraine in adults
2. 小児における片頭痛の病態生理、臨床的特徴、および診断 pathophysiology clinical features and diagnosis of migraine in children
3. 成人における片頭痛の病態生理、臨床症状、および診断 pathophysiology clinical manifestations and diagnosis of migraine in adults
4. 成人における片頭痛の予防的治療 preventive treatment of migraine in adults
5. 急性周術期疼痛のマネージメント management of acute perioperative pain

English Journal

Pharmacological modulation of spreading depolarizations.

Sánchez-Porras R1, Zheng Z, Sakowitz OW.
Acta neurochirurgica. Supplement.Acta Neurochir Suppl.2015;120:153-7. doi: 10.1007/978-3-319-04981-6_26.
Spreading depolarization (SD) is a wave of almost complete depolarization of the neuronal and glial cells. Nowadays there is sufficient evidence demonstrating its pathophysiological effect in migraine with aura, transient global amnesia, stroke, subarachnoid hemorrhage, intracerebral hemorrhage, and
PMID 25366616

CGRP antagonists and antibodies for the treatment of migraine.

Vécsei L1, Szok D, Csáti A, Tajti J.
Expert opinion on investigational drugs.Expert Opin Investig Drugs.2015 Jan;24(1):31-41. Epub 2014 Sep 15.
Introduction: Migraine is a highly devastating neurovascular disorder that affects up to 16% of the population worldwide. In spite of intensive research, its origin remains enigmatic with no therapeutic option appropriate for all migraine patients. One of the leading hypotheses is related to the fun
PMID 25219387

αCGRP is essential for algesic exocytotic mobilization of TRPV1 channels in peptidergic nociceptors.

Devesa I1, Ferrándiz-Huertas C1, Mathivanan S1, Wolf C1, Luján R2, Changeux JP3, Ferrer-Montiel A4.
Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2014 Dec 8. pii: 201420252. [Epub ahead of print]
Proalgesic sensitization of peripheral nociceptors in painful syndromes is a complex molecular process poorly understood that involves mobilization of thermosensory receptors to the neuronal surface. However, whether recruitment of vesicular thermoTRP channels is a general mechanism underlying sensi
PMID 25489075

Japanese Journal

片頭痛の病態研究および治療に関する最近の知見

清水利彦,柴田護,鈴木則宏
臨床神経学 51(2), 103-109, 2011-02
NAID 40018714151

血管周囲神経リモデリングにおけるアンジオテンシン受容体の役割

芳原成美,合田光寛,橋川直也,金鑫,座間味義人,高取真吾,川﨑博己
YAKUGAKU ZASSHI 130(11), 1421-1425, 2010
… The aim of this study was to investigate age-related changes in the density of calcitonin gene-related peptide (CGRP)-containing nerve fibers in spontaneously hypertensive rats (SHR) and the effects of long-term inhibition of the renin-angiotensin system on these changes. … An age-related decrease in the density of CGRP-like immunoreactive (LI)-containing nerve fibers but not neuropeptide Y (NPY)-LI-containing sympathetic nerve fibers was found in the mesenteric artery of SHR but not Wistar-Kyoto rats (WKY). …
NAID 130000451690

Related Pictures

★リンクテーブル★

リンク元	「カルシトニン遺伝子関連ペプチド受容体」「CGRP受容体」「カルシトニン遺伝子関連ペプチドレセプター」「CGRPレセプター」「calcitonin gene-related peptide receptor」
関連記事	「CGRP」

「カルシトニン遺伝子関連ペプチド受容体」

Calcitonin receptor-like
	; Crystallographic structure of the ectodomain complex of the CGRP type 1 receptor and RAMP1.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	3AQF, 3N7P, 3N7R, 3N7S
Identifiers
Symbols	CALCRL; CGRPR; CRLR
External IDs	OMIM: 114190 MGI: 1926944 HomoloGene: 21179 IUPHAR: calcitonin receptor-like ChEMBL: 3798 GeneCards: CALCRL Gene
Gene Ontology
Molecular function	• adrenomedullin receptor activity; • calcitonin gene-related polypeptide receptor activity; • G-protein coupled receptor activity; • calcitonin receptor activity; • protein binding; • protein transporter activity;
Cellular component	• lysosome; • endosome; • endoplasmic reticulum; • plasma membrane; • integral to plasma membrane;
Biological process	• angiogenesis; • cAMP biosynthetic process; • calcium ion transport; • regulation of muscle contraction; • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; • adenylate cyclase-activating G-protein coupled receptor signaling pathway; • heart development; • protein transport; • positive regulation of cAMP biosynthetic process; • receptor internalization; • positive regulation of smooth muscle cell proliferation; • negative regulation of inflammatory response; • cellular response to sucrose stimulus;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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