- 関
- calcitonin gene-related peptide receptor
WordNet
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
PrepTutorEJDIC
- =sense organ / 受信装置
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/01/08 14:54:43」(JST)
[Wiki en表示]
Calcitonin receptor-like |
Crystallographic structure of the ectodomain complex of the CGRP type 1 receptor and RAMP1.[1] |
Available structures |
PDB |
Ortholog search: PDBe, RCSB |
List of PDB id codes |
3AQF, 3N7P, 3N7R, 3N7S
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Identifiers |
Symbols |
CALCRL; CGRPR; CRLR |
External IDs |
OMIM: 114190 MGI: 1926944 HomoloGene: 21179 IUPHAR: calcitonin receptor-like ChEMBL: 3798 GeneCards: CALCRL Gene |
Gene Ontology |
Molecular function |
• adrenomedullin receptor activity
• calcitonin gene-related polypeptide receptor activity
• G-protein coupled receptor activity
• calcitonin receptor activity
• protein binding
• protein transporter activity
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Cellular component |
• lysosome
• endosome
• endoplasmic reticulum
• plasma membrane
• integral to plasma membrane
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Biological process |
• angiogenesis
• cAMP biosynthetic process
• calcium ion transport
• regulation of muscle contraction
• G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
• adenylate cyclase-activating G-protein coupled receptor signaling pathway
• heart development
• protein transport
• positive regulation of cAMP biosynthetic process
• receptor internalization
• positive regulation of smooth muscle cell proliferation
• negative regulation of inflammatory response
• cellular response to sucrose stimulus
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Sources: Amigo / QuickGO |
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RNA expression pattern |
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More reference expression data |
Orthologs |
Species |
Human |
Mouse |
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Entrez |
10203 |
54598 |
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Ensembl |
ENSG00000064989 |
ENSMUSG00000059588 |
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UniProt |
Q16602 |
Q9R1W5 |
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RefSeq (mRNA) |
NM_001271751 |
NM_018782 |
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RefSeq (protein) |
NP_001258680 |
NP_061252 |
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Location (UCSC) |
Chr 2:
188.21 – 188.31 Mb |
Chr 2:
84.33 – 84.43 Mb |
|
PubMed search |
[1] |
[2] |
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Calcitonin receptor-like (CALCRL), also known as the calcitonin receptor-like receptor (CRLR), is a human protein.[2]
Contents
- 1 Function
- 2 Structure
- 3 References
- 4 Further reading
- 5 External links
Function[edit]
The protein encoded by the CALCRL gene is a G protein-coupled receptor related to the calcitonin receptor. CALCRL is linked to one of three single transmembrane domain receptor activity-modifying proteins (RAMPs) that are essential for functional activity.
The association of CALCRL with different RAMP proteins produces different receptors:[3][4]
- with RAMP1: produces a CGRP receptor
- with RAMP2: produces an adrenomedullin (AM) receptor, designated AM1[5]
- with RAMP3: produces a dual CGRP/AM receptor designated AM2
These receptors are linked to the G protein Gs,[6] which activates adenylate cyclase and activation results in the generation of intracellular cyclic adenosine monophosphate (cAMP).
Structure[edit]
CALCRL associated with RAMP 1 produces the CGRP receptor which is a trans-membrane protein receptor that is made up of four chains. Two of the four chains contain unique sequences. It is a heterodimer protein composed of two polypeptide chains differing in composition of their amino acid residues. The sequence reveals multiple hydrophobic and hydrophilic regions throughout the four chains in the protein. These G-protein coupled receptor (GPCRs) proteins play an important role in pharmaceutical targets. Many drugs used today alter the GPCR signaling pathways.[1]
References[edit]
- ^ a b PDB 3N7S; ter Haar E, Koth CM, Abdul-Manan N, Swenson L, Coll JT, Lippke JA, Lepre CA, Garcia-Guzman M, Moore JM (2010). "Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism". Structure 18 (9): 1083–93. doi:10.1016/j.str.2010.05.014. PMID 20826335.
- ^ Aiyar N, Rand K, Elshourbagy NA, Zeng Z, Adamou JE, Bergsma DJ, Li Y (May 1996). "A cDNA encoding the calcitonin gene-related peptide type 1 receptor". J. Biol. Chem. 271 (19): 11325–9. doi:10.1074/jbc.271.19.11325. PMID 8626685.
- ^ McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM (May 1998). "RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor". Nature 393 (6683): 333–9. doi:10.1038/30666. PMID 9620797.
- ^ Foord SM, Marshall FH (May 1999). "RAMPs: accessory proteins for seven transmembrane domain receptors". Trends Pharmacol. Sci. 20 (5): 184–7. doi:10.1016/S0165-6147(99)01347-4. PMID 10354609.
- ^ Kamitani S, Asakawa M, Shimekake Y, Kuwasako K, Nakahara K, Sakata T (April 1999). "The RAMP2/CRLR complex is a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells". FEBS Lett. 448 (1): 111–4. doi:10.1016/S0014-5793(99)00358-0. PMID 10217420.
- ^ "Receptor properties". SenseLab Project: Membrane properties resource. Yale University. Retrieved 2008-09-28.
Further reading[edit]
- Born W, Muff R, Fischer JA (2002). "Functional interaction of G protein-coupled receptors of the adrenomedullin peptide family with accessory receptor-activity-modifying proteins (RAMP).". Microsc. Res. Tech. 57 (1): 14–22. doi:10.1002/jemt.10051. PMID 11921352.
- Yallampalli C, Chauhan M, Thota CS, et al. (2003). "Calcitonin gene-related peptide in pregnancy and its emerging receptor heterogeneity.". Trends Endocrinol. Metab. 13 (6): 263–9. PMID 12128288.
- Foord SM, Craig RK (1988). "Isolation and characterisation of a human calcitonin-gene-related-peptide receptor.". Eur. J. Biochem. 170 (1-2): 373–9. doi:10.1111/j.1432-1033.1987.tb13710.x. PMID 2826160.
- Skofitsch G, Jacobowitz DM (1986). "Autoradiographic distribution of 125I calcitonin gene-related peptide binding sites in the rat central nervous system.". Peptides 6 (5): 975–86. doi:10.1016/0196-9781(85)90331-6. PMID 3001670.
- Flühmann B, Muff R, Hunziker W, et al. (1995). "A human orphan calcitonin receptor-like structure.". Biochem. Biophys. Res. Commun. 206 (1): 341–7. doi:10.1006/bbrc.1995.1047. PMID 7818539.
- Aiyar N, Rand K, Elshourbagy NA, et al. (1996). "A cDNA encoding the calcitonin gene-related peptide type 1 receptor.". J. Biol. Chem. 271 (19): 11325–9. doi:10.1074/jbc.271.19.11325. PMID 8626685.
- McLatchie LM, Fraser NJ, Main MJ, et al. (1998). "RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor.". Nature 393 (6683): 333–9. doi:10.1038/30666. PMID 9620797.
- Sams A, Jansen-Olesen I (1999). "Expression of calcitonin receptor-like receptor and receptor-activity-modifying proteins in human cranial arteries.". Neurosci. Lett. 258 (1): 41–4. doi:10.1016/S0304-3940(98)00844-1. PMID 9876047.
- Kamitani S, Asakawa M, Shimekake Y, et al. (1999). "The RAMP2/CRLR complex is a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells.". FEBS Lett. 448 (1): 111–4. doi:10.1016/S0014-5793(99)00358-0. PMID 10217420.
- Aldecoa A, Gujer R, Fischer JA, Born W (2000). "Mammalian calcitonin receptor-like receptor/receptor activity modifying protein complexes define calcitonin gene-related peptide and adrenomedullin receptors in Drosophila Schneider 2 cells.". FEBS Lett. 471 (2-3): 156–60. doi:10.1016/S0014-5793(00)01387-9. PMID 10767413.
- Frayon S, Cueille C, Gnidéhou S, et al. (2000). "Dexamethasone increases RAMP1 and CRLR mRNA expressions in human vascular smooth muscle cells.". Biochem. Biophys. Res. Commun. 270 (3): 1063–7. doi:10.1006/bbrc.2000.2552. PMID 10772950.
- Kuwasako K, Shimekake Y, Masuda M, et al. (2000). "Visualization of the calcitonin receptor-like receptor and its receptor activity-modifying proteins during internalization and recycling.". J. Biol. Chem. 275 (38): 29602–9. doi:10.1074/jbc.M004534200. PMID 10882736.
- Evans BN, Rosenblatt MI, Mnayer LO, et al. (2000). "CGRP-RCP, a novel protein required for signal transduction at calcitonin gene-related peptide and adrenomedullin receptors.". J. Biol. Chem. 275 (40): 31438–43. doi:10.1074/jbc.M005604200. PMID 10903324.
- Hilairet S, Foord SM, Marshall FH, Bouvier M (2001). "Protein-protein interaction and not glycosylation determines the binding selectivity of heterodimers between the calcitonin receptor-like receptor and the receptor activity-modifying proteins.". J. Biol. Chem. 276 (31): 29575–81. doi:10.1074/jbc.M102722200. PMID 11387328.
- Kamitani S, Sakata T (2001). "Glycosylation of human CRLR at Asn123 is required for ligand binding and signaling.". Biochim. Biophys. Acta 1539 (1-2): 131–9. doi:10.1016/S0167-4889(01)00100-8. PMID 11389975.
- Nikitenko LL, Brown NS, Smith DM, et al. (2001). "Differential and cell-specific expression of calcitonin receptor-like receptor and receptor activity modifying proteins in the human uterus.". Mol. Hum. Reprod. 7 (7): 655–64. doi:10.1093/molehr/7.7.655. PMID 11420389.
- Hilairet S, Bélanger C, Bertrand J, et al. (2001). "Agonist-promoted internalization of a ternary complex between calcitonin receptor-like receptor, receptor activity-modifying protein 1 (RAMP1), and beta-arrestin.". J. Biol. Chem. 276 (45): 42182–90. doi:10.1074/jbc.M107323200. PMID 11535606.
- Aiyar N, Disa J, Pullen M, Nambi P (2002). "Receptor activity modifying proteins interaction with human and porcine calcitonin receptor-like receptor (CRLR) in HEK-293 cells.". Mol. Cell. Biochem. 224 (1-2): 123–33. doi:10.1023/A:1011907328682. PMID 11693189.
- Hagner S, Haberberger RV, Overkamp D, et al. (2002). "Expression and distribution of calcitonin receptor-like receptor in human hairy skin.". Peptides 23 (1): 109–16. doi:10.1016/S0196-9781(01)00586-1. PMID 11814625.
- Hill H, Pioszak, A. (2013). "Bacterial expression and purification of a heterodimeric adrenomedullin receptor extracellular domain complex using DsbC-assisted disulfide shuffling.". Protein Expr Purif. 88 (1): 107–13. doi:10.1016/j.pep.2012.11.019. PMID 23247088.
External links[edit]
- "Calcitonin receptors: CALCRL". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- calcitonin receptor-like receptor at the US National Library of Medicine Medical Subject Headings (MeSH)
- CALCRL human gene location in the UCSC Genome Browser.
- CALCRL human gene details in the UCSC Genome Browser.
Cell surface receptor: G protein-coupled receptors
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Class A:
Rhodopsin like |
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Class B: Secretin like |
Orphan
|
- GPR (56
- 64
- 97
- 98
- 110
- 111
- 112
- 113
- 114
- 115
- 116
- 123
- 124
- 125
- 126
- 128
- 133
- 143
- 144
- 155
- 157)
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Other
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- Brain-specific angiogenesis inhibitor (1
- 2
- 3)
- Cadherin (1
- 2
- 3)
- Calcitonin
- CALCRL
- CD97
- Corticotropin-releasing hormone (1
- 2)
- EMR (1
- 2
- 3)
- Glucagon (GR
- GIPR
- GLP1R
- GLP2R)
- Growth hormone releasing hormone
- PACAPR1
- GPR
- Latrophilin (1
- 2
- 3
- ELTD1)
- Methuselah-like proteins
- Parathyroid hormone (1
- 2)
- Secretin
- Vasoactive intestinal peptide (1
- 2)
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Class C: Metabotropic
glutamate / pheromone |
Taste
|
- TAS1R (1
- 2
- 3)
- TAS2R (1
- 3
- 4
- 5
- 7
- 8
- 9
- 10
- 13
- 14
- 16
- 19
- 20
- 30
- 31
- 38
- 39
- 40
- 41
- 42
- 43
- 45
- 46
- 50
- 60)
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Other
|
- Calcium-sensing receptor
- GABA B (1
- 2)
- Glutamate receptor (Metabotropic glutamate (1
- 2
- 3
- 4
- 5
- 6
- 7
- 8))
- GPRC6A
- GPR (156
- 158
- 179)
- RAIG (1
- 2
- 3
- 4)
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|
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Class F:
Frizzled / Smoothened |
Frizzled
|
- Frizzled (1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
- 10)
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Smoothened
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|
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B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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Neuropeptide receptors
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G protein-coupled receptor |
Hormone receptors
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Hypothalamic
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CRH · FSH · LHRH · TRH · Somatostatin
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Pituitary
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Vasopressin (1A, 1B, 2) · Oxytocin · LHCG · TSH
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Other
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Atrial natriuretic factor (NPR3) · Calcitonin · Cholecystokinin (A, B) · VIP
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Opioid receptors
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Delta · Kappa · Mu · Nociceptin
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Other neuropeptide receptors
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Angiotensin · Bradykinin (B1, B2) / Tachykinin (TACR1) · Calcitonin gene-related peptide · Galanin · GPCR neuropeptide (B/W, FF, S, Y) · Neurotensin
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Type I cytokine receptor |
GH · Prolactin
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Enzyme-linked receptor |
Atrial natriuretic factor (NPR1, NPR2)
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Other |
Sigma (1, 2)
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|
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Pharmacological modulation of spreading depolarizations.
- Sánchez-Porras R1, Zheng Z, Sakowitz OW.
- Acta neurochirurgica. Supplement.Acta Neurochir Suppl.2015;120:153-7. doi: 10.1007/978-3-319-04981-6_26.
- Spreading depolarization (SD) is a wave of almost complete depolarization of the neuronal and glial cells. Nowadays there is sufficient evidence demonstrating its pathophysiological effect in migraine with aura, transient global amnesia, stroke, subarachnoid hemorrhage, intracerebral hemorrhage, and
- PMID 25366616
- CGRP antagonists and antibodies for the treatment of migraine.
- Vécsei L1, Szok D, Csáti A, Tajti J.
- Expert opinion on investigational drugs.Expert Opin Investig Drugs.2015 Jan;24(1):31-41. Epub 2014 Sep 15.
- Introduction: Migraine is a highly devastating neurovascular disorder that affects up to 16% of the population worldwide. In spite of intensive research, its origin remains enigmatic with no therapeutic option appropriate for all migraine patients. One of the leading hypotheses is related to the fun
- PMID 25219387
- αCGRP is essential for algesic exocytotic mobilization of TRPV1 channels in peptidergic nociceptors.
- Devesa I1, Ferrándiz-Huertas C1, Mathivanan S1, Wolf C1, Luján R2, Changeux JP3, Ferrer-Montiel A4.
- Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2014 Dec 8. pii: 201420252. [Epub ahead of print]
- Proalgesic sensitization of peripheral nociceptors in painful syndromes is a complex molecular process poorly understood that involves mobilization of thermosensory receptors to the neuronal surface. However, whether recruitment of vesicular thermoTRP channels is a general mechanism underlying sensi
- PMID 25489075
Japanese Journal
- 血管周囲神経リモデリングにおけるアンジオテンシン受容体の役割
- 芳原 成美,合田 光寛,橋川 直也,金 鑫,座間味 義人,高取 真吾,川﨑 博己
- YAKUGAKU ZASSHI 130(11), 1421-1425, 2010
- … The aim of this study was to investigate age-related changes in the density of calcitonin gene-related peptide (CGRP)-containing nerve fibers in spontaneously hypertensive rats (SHR) and the effects of long-term inhibition of the renin-angiotensin system on these changes. … An age-related decrease in the density of CGRP-like immunoreactive (LI)-containing nerve fibers but not neuropeptide Y (NPY)-LI-containing sympathetic nerve fibers was found in the mesenteric artery of SHR but not Wistar-Kyoto rats (WKY). …
- NAID 130000451690
Related Links
- Discussion Restenosis is actually a process that benefits from accumulation of vascular smooth muscle cells in the intima following vessel injury. It can be presently imagined that injury induces vascular smooth muscle de ...
- Relative protein amounts were established by densitometry implementing Bio Rad Quantity One particular Software program, with normalization to your amount of cellular actin or tubulin current in every sample. Modifications in the ...
Related Pictures
![](http://ts2.mm.bing.net/th?id=H.5058415950562525&pid=15.1)
![](http://ts2.mm.bing.net/th?id=H.4660019124438609&pid=15.1)
![](http://ts1.mm.bing.net/th?id=H.5058828268471432&pid=15.1)
![](http://ts3.mm.bing.net/th?id=H.4967010451522062&pid=15.1)
![](http://ts1.mm.bing.net/th?id=H.4967010451522064&pid=15.1)
★リンクテーブル★
[★]
- 英
- calcitonin gene-related peptide receptor、CGRP receptor
- 関
- カルシトニン遺伝子関連ペプチドレセプター、CGRP受容体、CGRPレセプター
[★]
- 英
- CGRP receptor
- 関
- カルシトニン遺伝子関連ペプチド受容体、カルシトニン遺伝子関連ペプチドレセプター、CGRPレセプター
[★]
- 英
- calcitonin gene-related peptide receptor、CGRP receptor
- 関
- カルシトニン遺伝子関連ペプチド受容体、CGRP受容体、CGRPレセプター
[★]
- 英
- CGRP receptor
- 関
- カルシトニン遺伝子関連ペプチド受容体、カルシトニン遺伝子関連ペプチドレセプター、CGRP受容体
[★]
- 関
- CGRP receptor
[★]
カルシトニン遺伝子関連ペプチド calcitonin gene-related peptide