proto-oncogene protein c-Bcr

WordNet

the 3rd letter of the Roman alphabet (同)c
(music) the keynote of the scale of C major
a general-purpose programing language closely associated with the UNIX operating system
the 2nd letter of the Roman alphabet (同)b
the blood group whose red cells carry the B antigen (同)type_B, group B

PrepTutorEJDIC

carbonの化学記号
cryの三人称単数現在形
case[s]

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 慢性骨髄性白血病の細胞生物学および分子生物学 cellular and molecular biology of chronic myeloid leukemia
2. 慢性骨髄性白血病に対するチロシンキナーゼ阻害剤の臨床使用 clinical use of tyrosine kinase inhibitors for chronic myeloid leukemia
3. 成人における抗癌剤の投与 dosing of anticancer agents in adults
4. 急性リンパ芽球性白血病における細胞遺伝学および分子遺伝学 cytogenetics and molecular genetics in acute lymphoblastic leukemia
5. 血液悪性腫瘍およびリンパ悪性腫瘍の遺伝的異常 genetic abnormalities in hematologic and lymphoid malignancies

English Journal

Exploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution.

Zhao B1, Sedlak JC2, Srinivas R3, Creixell P4, Pritchard JR5, Tidor B6, Lauffenburger DA7, Hemann MT8.
Cell.Cell.2016 Mar 24;165(1):234-46. doi: 10.1016/j.cell.2016.01.045. Epub 2016 Feb 25.
The prevailing approach to addressing secondary drug resistance in cancer focuses on treating the resistance mechanisms at relapse. However, the dynamic nature of clonal evolution, along with potential fitness costs and cost compensations, may present exploitable vulnerabilities-a notion that we ter
PMID 26924578

Initial diagnosis of chronic myelogenous leukemia based on quantification of M-BCR status using droplet digital PCR.

Lund HL1,2, Hughesman CB1, McNeil K3, Clemens S3, Hocken K3, Pettersson R3, Karsan A3, Foster LJ1,4, Haynes C5,6.
Analytical and bioanalytical chemistry.Anal Bioanal Chem.2016 Feb;408(4):1079-94. doi: 10.1007/s00216-015-9204-2. Epub 2015 Dec 2.
Formed from a reciprocal translocation t(9:22)(q34;q11) of genetic material between the long arms of human chromosomes 9 and 22, the constitutively active breakpoint cluster region (BCR) Abelson 1 (ABL) tyrosine kinase BCR-ABL is known to be causative of chronic myelogenous leukemia (CML). In 98% of
PMID 26631023

BCR-signaling-induced cell death demonstrates dependency on multiple BH3-only proteins in a murine model of B-cell lymphoma.

Carter MJ1, Cox KL1, Blakemore SJ1, Bogdanov YD1, Happo L2, Scott CL2, Strasser A2, Packham GK3, Cragg MS1.
Cell death and differentiation.Cell Death Differ.2016 Feb;23(2):303-12. doi: 10.1038/cdd.2015.97. Epub 2015 Jul 17.
Genetic recombination during B-cell development regularly results in the generation of autoreactive, potentially pathogenic B-cell receptors (BCRs). Consequently, multiple mechanisms link inappropriate BCR specificity to clonal deletion. Similar pathways remain in malignant B cells, offering the pot
PMID 26184912

Japanese Journal

Association of the protein kinases c-Bcr and Bcr-Abl with proteins of the 14-3-3 family.

REUTER G. W.
Science 266, 129-133, 1994
NAID 80007894056

Breakpoints in philadelphia chromosome (Ph1)-positive leukemias.

, , ,
Japanese Journal of Cancer Research GANN 78(6), 590-595, 1987
… Nineteen of 21 patients with chronic myelogenous leukemia (CML) possessed a chromosomal break within the 5.8 kilobase (kb) breakpoint cluster region (bcr). … Furthermore, in one of three cases of acute lymphocytic leukemia (ALL), we found a chromosomal rearrangement in the bcr locus. … The bcr rearrangement is highly specific for CML. … Further analyses will be necessary to determine whether some cases without bcr rearrangement have another specific locus of rearrangement. …
NAID 130003608982

Related Pictures

BCR-Ring mit Crystalstein, Ohr, Nase pathways leading to c rel activation and c Protonkogenproteiner c-bcr Description Bcr abl STI 1IEP.png 8MP R/C 2D BCR 8MP R/C SCR C/Guard H/Strap 301 Moved Permanently fig004awm: The c-Bcr, c-Abl and Bcr–Abl