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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/12/25 02:37:30」(JST)

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Bifonazole is an imidazole antifungal drug. Bifonazole is marketed by Bayer under the trade mark Canespor in ointment form.

Mechanism of action

Bifonazole has dual mode of action. It blocks transformation of 24-methylendihydrolanosterol to desmethylsterol in fungi together with inhibition of HMG-CoA. This enables fungicidal properties against dermatophytes and distinguishes bifonazole from other antifungal drugs.

This dermatologic drug article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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1. 思春期および成人における脂漏性皮膚炎 seborrheic dermatitis in adolescents and adults
2. INRコントロールに対するワルファリンとモジュレーターの生物学 biology of warfarin and modulators of inr control

English Journal

Efficacy of 4 weeks topical bifonazole treatment for onychomycosis after nail ablation with 40% urea: a double-blind, randomized, placebo-controlled multicenter study.

Tietz HJ, Hay R, Querner S, Delcker A, Kurka P, Merk HF.SourceInstitut für Pilzkrankheiten, Berlin, Germany Infectious Disease Clinic, Dermatology Department, King's College Hospital NHS Trust, London, UK Global R&D, Bayer Consumer Care AG, Basel, Switzerland Department of Dermatology and Allergology, University Clinic RWTH, Aachen, Germany.
Mycoses.Mycoses.2013 Jul;56(4):414-21. doi: 10.1111/myc.12037. Epub 2013 Apr 16.
Onychomycosis is a common fungal infection most often affecting the toenails. If untreated, it can cause discomfort sufficient to reduce quality of life. To evaluate efficacy and safety of bifonazole cream vs. placebo in onychomycosis treatment after non-surgical nail ablation with urea paste. Fifty
PMID 23586591

Luliconazole for the treatment of interdigital tinea pedis: A double-blind, vehicle-controlled study.

Jarratt M, Jones T, Kempers S, Rich P, Morton K, Nakamura N, Tavakkol A.SourceDermResearch Inc, Austin, Texas, USA.
Cutis; cutaneous medicine for the practitioner.Cutis.2013 Apr;91(4):203-10.
Tinea pedis (TP) typically is treated with topical antifungal agents. Luliconazole, a novel imidazole drug, is shown to be as or more effective in vitro and in vivo than bifonazole, terbinafine, and lanoconazole. Two treatment durations with luliconazole cream 1% were evaluated for treatment of TP.
PMID 23763082

The effect of topically applied antimycotic agents on inner ear vestibular and cochlear function.

Perez R, Nazarian Y, Sohmer H, Sichel JY.SourceDepartment of Otolaryngology and Head and Neck Surgery, Shaare Zedek Medical Center, Hebrew University Medical School, Jerusalem. perezro@zahav.net.il
The Laryngoscope.Laryngoscope.2013 Apr;123(4):1033-9. doi: 10.1002/lary.23718. Epub 2012 Sep 18.
OBJECTIVES/HYPOTHESIS: To assess and compare the effect of commonly used topical antimycotic agents and their solvents on the function of the vestibular and cochlear parts of the sand rat's inner ear.STUDY DESIGN: Prospective, controlled, animal study.METHODS: Forty-five fat sand rats were randomly
PMID 22991276

Japanese Journal

Sulfonamide-1,2,4-thiadiazole Derivatives as Antifungal and Antibacterial Agents: Synthesis, Biological Evaluation, Lipophilicity, and Conformational Studies

Camoutsis Charalabos,Geronikaki Athina,Ciric Ana,Soković Marina,Zoumpoulakis Panagiotis,Zervou Maria
Chemical and Pharmaceutical Bulletin 58(2), 160-167, 2010
… All compound tested showed significant antifungal activity against all the micromycetes, compared to the commercial fungicide bifonazole. …
NAID 130000161586

皮膚真菌症の診断と治療のガイドライン-カンジダ症

加藤卓朗
日本医真菌学会雑誌 = Japanese journal of medical mycology 50(4), 207-212, 2009-10-30
皮膚と口腔カンジダ症の診断と治療について解説する．本症は年齢や病変部位により，カンジダ性間擦疹，乳児寄生菌性紅斑，カンジダ性指間びらん，カンジダ性爪囲爪炎，爪カンジダ症，口腔カンジダ症などに分類される．本症の診断は直接鏡検で菌要素を認めることで確定する．主要原因菌の<I>Candida albicans</I> は粘膜の常在菌であるため，培養陽性のみでは診断の根拠にならない …
NAID 10026094530

承認後20年目におけるビホナゾールの足白癬に対する有用性について

三井浩,神田奈緒子,大西誉光,中居賢司,鈴木拓,渡辺晋一
The Japanese journal of antibiotics 62(2), 79-89, 2009-04-25
NAID 10028254626

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Bifonazole
Systematic (IUPAC) name
	(RS)-1-[Phenyl(4-phenylphenyl)methyl]-1H-imidazole
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	US: OTC;
Routes	topic
Identifiers
CAS number	60628-96-8
ATC code	D01AC10
PubChem	CID 2378
DrugBank	DB04794
ChemSpider	2287
UNII	QYJ305Z91O
KEGG	D01775
ChEBI	CHEBI:31286
ChEMBL	CHEMBL277535
Chemical data
Formula	C22H18N2
Mol. mass	310.392 g/mol
	SMILES n1ccn(c1)C(c3ccc(c2ccccc2)cc3)c4ccccc4;
	InChI InChI=1S/C22H18N2/c1-3-7-18(8-4-1)19-11-13-21(14-12-19)22(24-16-15-23-17-24)20-9-5-2-6-10-20/h1-17,22H ; Key:OCAPBUJLXMYKEJ-UHFFFAOYSA-N ;
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