WordNet

any of various antibiotics obtained from Penicillium molds (or produced synthetically) and used in the treatment of various infections and diseases
a unit of force equal to the force exerted by gravity; used to indicate the force to which a body is subjected when it is accelerated (同)gee, g-force
the 7th letter of the Roman alphabet (同)g

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ペニシリン(坑生物質の一種)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/21 22:26:17」(JST)

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Benzathine benzylpenicillin (rINN) is a form of penicillin also known as benzathine penicillin. It is an antibiotic useful for the treatment of a number of bacterial infections.

It is slowly absorbed into the circulation, after intramuscular injection, and hydrolysed to benzylpenicillin in vivo. It is the drug-of-choice when prolonged low concentrations of benzylpenicillin are required and appropriate, allowing prolonged antibiotic action over 2–4 weeks after a single IM dose. It is marketed by Wyeth under the trade name Bicillin L-A.

Medical uses for benzathine penicillin include: prevention of rheumatic fever and early or latent syphilis.^[1]

It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.^[2]

Adverse effects

Compendial status

British Pharmacopoeia ^[3]

References

^ Rossi S, editor, ed. (2006). Australian Medicines Handbook. Adelaide: Australian Medicines Handbook. ISBN 0-9757919-2-3.
^ "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.
^ British Pharmacopoeia Commission Secretariat. "Index (BP 2009)" (PDF). Retrieved 26 March 2010.

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1. イチゴ腫、ベジェル、およびピンタ yaws bejel and pinta
2. 早期梅毒の病因、臨床症状、および治療 pathogenesis clinical manifestations and treatment of early syphilis
3. 連鎖球菌扁桃咽頭炎の治療および予防 treatment and prevention of streptococcal tonsillopharyngitis
4. 後期梅毒の病因、臨床症状、および治療 pathogenesis clinical manifestations and treatment of late syphilis
5. 先天梅毒：評価、マネージメント、および予防 congenital syphilis evaluation management and prevention

English Journal

Supply of benzathine penicillin G: the 20-year experience in Australia.

Wyber R1, Johnson TD1, Patel B2.
Australian and New Zealand journal of public health.Aust N Z J Public Health.2015 Aug 10. doi: 10.1111/1753-6405.12415. [Epub ahead of print]
PMID 26260574

Primary syphilis of the oropharynx: an unusual location of a chancre.

Drago F1, Ciccarese G2, Cogorno L1, Tomasini CF3, Cozzani EC1, Riva SF1, Parodi A1.
International journal of STD & AIDS.Int J STD AIDS.2015 Aug;26(9):679-81. doi: 10.1177/0956462414551235. Epub 2014 Sep 4.
A 33-year-old man presented with a two-week history of an asymptomatic ulcer of the oropharynx and submandibular lymph nodes swelling. Laboratory examinations were normal, but serological tests revealed positivity for rapid plasma reagin, Treponema pallidum haemagglutination assay and anti-T. pallid
PMID 25193247

High-dose oral amoxicillin plus probenecid is highly effective for syphilis in patients with HIV infection.

Tanizaki R1, Nishijima T2, Aoki T1, Teruya K1, Kikuchi Y1, Oka S2, Gatanaga H2.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.Clin Infect Dis.2015 Jul 15;61(2):177-83. doi: 10.1093/cid/civ270. Epub 2015 Mar 31.
BACKGROUND: Intramuscular benzathine penicillin G (BPG) is widely used for the treatment of syphilis. However, BPG is not available in some countries. This study examined the effectiveness and safety of high-dose oral amoxicillin plus probenecid for the treatment of syphilis in patients with human i
PMID 25829004

Japanese Journal

Investigation of DNA damage in lymphocytes exposed to benzathine penicillin G

KOSEOGLU VEDAT,KISMET EROL,SOYSAL YASEMIN,ULUCAN HAKAN,DUNDAROZ RUSEN,IMIRZAHOGLU NECAT,GOKCAY ERDAL
Pediatrics international : official journal of the Japan Pediatric Society 46(4), 415-418, 2004-08-01
NAID 10018369034

Evaluation of DNA damage using the comet assay in children on long-term benzathine penicillin for secondary prophylaxis of rheumatic fever

DUNDAROZ RUSEN,ULUCAN HAKAN,DENLI METIN,KARAPINAR KASIM,AYDIN HALIL IBRAHIM,BALTACI VOLKAN
Pediatrics international : official journal of the Japan Pediatric Society 43(3), 276-280, 2001-06-01
NAID 10010092369

Interferon alfa-2b, colchicine, and benzathine penicillin versus colchicine and benzathine penicillin in Behcet's disease : a randomised trial

DEMIROGLU H.
Lancet 355, 605-609, 2000
NAID 30005701216

「benzathine benzylpenicillin」

Benzathine benzylpenicillin
Combination of
Benzylpenicillin	Antibiotic
Benzathine	Stabilizer
Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Number	1538-09-6
ATC code	J01CE08
PubChem	CID: 15232
ChemSpider	14498
UNII	SSZ1S4I0US
ChEBI	CHEBI:51352
ChEMBL	CHEMBL1200651
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