- 関
- classic migraine、complicated migraine、familial hemiplegic migraine、migraine with aura、migraine with prolonged aura
WordNet
- any of several Old World tropical aromatic annual or perennial herbs of the genus Ocimum
- leaves of the common basil; used fresh or dried (同)sweet_basil
- of or relating to or located at the base; "the basilar membrane of the cochlea" (同)basilary
- a severe recurring vascular headache; occurs more frequently in women than men (同)megrim, sick_headache, hemicrania
PrepTutorEJDIC
- 〈C〉メボウキ(芳香のある草) / 〈U〉バジル(メボウキの葉…香辛料)
- 偏頭痛
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/08/29 01:21:33」(JST)
wiki en
This article is about the disorder. For other uses, see Migraine (disambiguation).
| Migraine | |
|---|---|
| Classification and external resources | |
The pain of a migraine headache can be debilitating. |
|
| ICD-10 | G43 |
| ICD-9 | 346 |
| OMIM | 157300 |
| DiseasesDB | 8207 (Migraine) 31876 (Basilar) |
| MedlinePlus | 000709 |
| eMedicine | neuro/218 neuro/517 emerg/230 neuro/529 |
| MeSH | D008881 |
Migraine is a chronic disorder characterized by recurrent moderate to severe headaches often in association with a number of autonomic symptoms. The word derives from the Greek ἡμικρανία (hemikrania), "pain on one side of the head",[1] from ἡμι- (hemi-), "half", and κρανίον (kranion), "skull".[2]
Typically the headache is unilateral (affecting one half of the head) and pulsating in nature, lasting from 2 to 72 hours. Associated symptoms may include nausea, vomiting, photophobia (increased sensitivity to light), phonophobia (increased sensitivity to sound) and the pain is generally aggravated by physical activity.[3] Up to one-third of people with migraine headaches perceive an aura: a transient visual, sensory, language, or motor disturbance which signals that the headache will soon occur.[3]
Migraines are believed to be due to a mixture of environmental and genetic factors.[4] About two-thirds of cases run in families.[5] Fluctuating hormone levels may also play a role: migraine affects slightly more boys than girls before puberty, but about two to three times more women than men.[6][7] Propensity for migraines usually decreases during pregnancy.[6] The exact mechanisms of migraines are not known. It is, however, believed to be a neurovascular disorder.[5] The primary theory is related to increased excitability of the cerebral cortex and abnormal control of pain neurons in the trigeminal nucleus of the brainstem.[8]
Initial recommended management is with simple analgesics such as ibuprofen and acetaminophen for the headache, an antiemetic for the nausea, and the avoidance of triggers. Specific agents such as triptans or ergotamines may be used by those for whom simple analgesics are not effective. Globally, more than 10% of the population is affected by migraine at some point in life.
Contents
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Signs and symptoms
Migraines typically present with self–limited, recurrent severe headache associated with autonomic symptoms.[5][9] About 15-30% of people experience migraines with an aura[10][11] and those who have migraines with aura also frequently have migraines without aura.[12] The severity of the pain, duration of the headache, and frequency of attacks is variable.[5] A migraine lasting longer than 72 hours is termed status migrainosus.[13] There are four possible phases to a migraine, although not all the phases are necessarily experienced:[3]
- The prodrome, which occurs hours or days before the headache
- The aura, which immediately precedes the headache
- The pain phase, also known as headache phase
- The postdrome
Prodrome phase
Prodromal or premonitory symptoms occur in ~60% of those with migraines[14][15] with an onset of two hours to two days before the start of pain or the aura [16] These symptoms may include a wide variety of phenomena[17] including: altered mood, irritability, depression or euphoria, fatigue, craving for certain food, stiff muscles (especially in the neck), constipation or diarrhea, and sensitivity to smells or noise.[14] This may occur in those with either migraine with aura or migraine without aura.[18]
Aura phase
An aura is a transient focal neurological phenomenon that occurs before or during the headache.[15] They appear gradually over a number of minutes and generally last fewer than 60 minutes.[19] Symptoms can be visual, sensory or motor in nature and many people experience more than one.[20] Visual effects are the most common, occurring in up to 99% of cases and exclusively in more than half.[20] Vision disturbances often consists of a scintillating scotoma (an area of partial alteration in the field of vision which flickers.)[15] These typically start near the center of vision and then spread out to the sides with zigzagging lines which have been described to look like fortifications or walls of a castle.[20] Usually the lines are in black and white but some people also see colored lines.[20] Some people lose part of their field of vision known as hemianopsia while others experience blurring.[20]
Sensory aura are the second most common occurring in 30-40% of people with auras.[20] Often a feeling of pins-and-needles begins on one side in the hand and arm and spreads to the nose-mouth area on the same side.[20] Numbness usually occurs after the tingling has passed with a loss of position sense.[20] Other symptoms of the aura phase can include: speech or language disturbances, world spinning, and less commonly motor problems.[20] Motor symptoms indicate that this is a hemiplegic migraine, and weakness often lasts longer than one hour unlike other auras.[20] An aura rarely occurs without a subsequent headache,[20] known as a silent migraine.
Pain phase
Classically the headache is unilateral, throbbing, and moderate to severe in intensity.[19] It usually comes on gradually[19] and is aggravated by physical activity.[3] In more than 40% of cases however the pain may be bilateral, and neck pain is commonly associated.[21] Bilateral pain is particularly common in those who have migraines without an aura.[15] Less commonly pain may occur primarily in the back or top of the head.[15] The pain usually lasts 4 to 72 hours in adults[19] however in young children frequently lasts less than 1 hour.[22] The frequency of attacks is variable, from a few in a lifetime to several a week, with the average being about one a month.[23][24]
The pain is frequently accompanied by nausea, vomiting, sensitivity to light, sensitivity to sound, sensitivity to smells, fatigue and irritability.[15] In a basilar migraine common effects include: a sense of the world spinning, light-headedness, and confusion.[15] Nausea occurs in almost 90 percent of people, and vomiting occurs in about one-third.[25] Many thus seek a dark and quiet room.[25] Other symptoms may include: blurred vision, nasal stuffiness, diarrhea, frequent urination, pallor, or sweating.[26] Swelling or tenderness of the scalp may occur as can neck stiffness.[26] Associated symptoms are less common in the elderly.[27]
Postdrome
The effects of migraine may persist for some days after the main headache has ended; this is called the migraine postdrome. Many report a sore feeling in the area where the migraine was, and some report impaired thinking for a few days after the headache has passed. The patient may feel tired or "hung over" and have head pain, cognitive difficulties, gastrointestinal symptoms, mood changes, and weakness.[28] According to one summary, "Some people feel unusually refreshed or euphoric after an attack, whereas others note depression and malaise."[29]
Abdominal migraine
The diagnosis of abdominal migraines is controversial.[30] Some evidence indicates that recurrent episodes of abdominal pain in the absence of a headache may be a type of migraine.[30][31] Or are at least a precursor to migraines.[12] These episodes of pain may or may not follow a migraine like prodrome and typically last minutes to hours.[30] They often occur in those with either a personal or family history of typical migraines.[30] Other syndromes that are believed to be precursors include: cyclical vomiting syndrome and benign paroxysmal vertigo of childhood.[12]
Cause
The underlying cause of migraines is unknown[32] however they are believed to be related to a mix of environmental and genetic factors.[4] They do run in families in about two-thirds of cases[5] and rarely occur due to a single gene defect.[33] A number of psychological conditions are associated including: depression, anxiety, and bipolar disorder[34] as are many biological events or triggers.
Genetics
Studies of twins indicate a 34 to 51 percent genetic influence of likelihood to develop migraine headaches.[4] This genetic relationship is stronger for migraines with aura than for migraines without aura.[12] A number of specific variants of genes increase the risk by a small to moderate amount.[35]
Single gene disorders that result in migraines are rare.[35] One of these is known as familial hemiplegic migraine, a type of migraine with aura, which is inherited in a autosomal dominant fashion.[36][37] It is related to disorders of gene coding for proteins involved in ion transport.[15] Another is CADASIL syndrome or cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.[15]
Triggers
Migraines may be induced by triggers, with some reporting it as an influence in a minority of cases[5] and others the majority.[38] Many things have been labeled as triggers, however the strength and significance of these relationships are uncertain.[38][39] A trigger may occur up to 24 hours prior to the onset of symptoms.[5]
Physiological
Common triggers quoted are stress, hunger, and fatigue (these equally contribute to tension headaches).[38] Migraines are more likely to occur around menstruation.[40] Other hormonal influences, such as menarche, oral contraceptive use, pregnancy, perimenopause, and menopause, also play a role.[41] These hormonal influences seem to play a greater role in migraine without aura.[42] Migraines typically do not occur during the second and third trimesters or following menopause.[15]
Dietary
Reviews of dietary triggers have found that evidence mostly relies on subjective assessments and is not rigorous enough to prove or disprove any particular triggers.[43][44] Regarding specific agents there does not appear to be evidence for an effect of tyramine on migraine[45] and while monosodium glutamate (MSG) is frequently reported as a dietary trigger[46] evidence does not consistently support this.[47]
Environmental
Potential triggers in the indoor and outdoor environment concluded the overall evidence was of poor quality, but nevertheless suggested people with migraines take some preventive measures related to indoor air quality and lighting.[48] While once believed to be more common in those of high intelligence this does not appear to be true.[42]
Pathophysiology
Animation of cortical spreading depression
Migraines are believed to be a neurovascular disorder[5] with evidence supporting it mechanisms starting within the brain and than spreading to the blood vessels.[49] Some researchers feel neuronal mechanisms play a greater role,[50] while others feel blood vessels play the key role.[51] Others feel both are likely important.[52] High levels of the neurotransmitter serotonin, also known as 5-hydroxytryptamine, is believed to be involved.[49]
Aura
Cortical spreading depression or spreading depression of Leão is bursts of neuronal activity followed by a period of inactivity, which is seen in those with migraines with an aura.[53] There are a number of explanations for its occurrence including activation of NMDA receptors leading to calcium entering the cell.[53] After the burst of activity blood flow to the cerebral cortex in the area affected is decreased for two to six hours.[53] It is believed that when depolarization travels down the underside of the brain nerves that sense pain in the head and neck are triggered.[53]
Pain
The exact mechanism of the head pain which occurs during a migraine is unknown.[54] Some evidence supports a primary role for central nervous system structures (such as the brainstem and diencephalon)[55] while other data support the role peripheral activation (such as via the sensory nerves that surround blood vessels of the head and neck).[54] The potential candidates vessels include: dural arteries, pial arteries and extracranial arteries such as those of the scalp.[54] The role of vasodilatation of the extracranial arteries, in particular, is believed to be significant.[56]
Diagnosis
The diagnosis of a migraine is based on signs and symptoms.[5] Imaging test are occasionally performed to exclude other causes of headaches.[5] It is believed that a substantial number of people with the condition have not been diagnosed.[5]
The diagnosis of migraine without aura, according to the International Headache Society, can be made according to the following criteria, the "5, 4, 3, 2, 1 criteria":[3]
- Five or more attacks — for migraine with aura, two attacks are sufficient for diagnosis.
- Four hours to three days in duration
- Two or more of the following:
- Unilateral (affecting half the head);
- Pulsating;
- "Moderate or severe pain intensity";
- "Aggravation by or causing avoidance of routine physical activity"
- One or more of the following:
- Nausea and/or vomiting;
- Sensitivity to both light (photophobia) and sound (phonophobia)
If someone experiences two of the following: photophobia, nausea, or inability to work / study for a day the diagnosis is more likely.[57] In those with four out of five of the following: pulsating headache, duration of 4–72 hours, pain on one side of the head, nausea, or symptoms that interfere with the person's life, the probability that this is a migraine is 92%.[11] In those with less than three of these symptoms the probability is 17%.[11]
Classification
Main article: ICHD classification and diagnosis of migraine
Migraines were first comprehensively classified in 1988.[12] The International Headache Society most recently updated their classification of headaches in 2004.[3] According to this classification migraines are primary headaches along with tension-type headaches and cluster headaches, among others.[58]
Migraines are divided into seven subclasses (some of which include further subdivisions):
- Migraine without aura, or "common migraine", involves migraine headaches that are not accompanied by an aura
- Migraine with aura, or "classic migraine", usually involves migraine headaches accompanied by an aura. Less commonly, an aura can occur without a headache, or with a nonmigraine headache. Two other varieties are familial hemiplegic migraine and sporadic hemiplegic migraine, in which a person has migraines with aura and with accompanying motor weakness. If a close relative has had the same condition, it is called "familial", otherwise it is called "sporadic". Another variety is basilar-type migraine, where a headache and aura are accompanied by difficulty speaking, vertigo, ringing in ears, or a number of other brainstem-related symptoms, but not motor weakness.
- Childhood periodic syndromes that are commonly precursors of migraine include cyclical vomiting (occasional intense periods of vomiting), abdominal migraine (abdominal pain, usually accompanied by nausea), and benign paroxysmal vertigo of childhood (occasional attacks of vertigo).
- Retinal migraine involves migraine headaches accompanied by visual disturbances or even temporary blindness in one eye.
- Complications of migraine describe migraine headaches and/or auras that are unusually long or unusually frequent, or associated with a seizure or brain lesion.
- Probable migraine describes conditions that have some characteristics of migraines, but where there is not enough evidence to diagnose it as a migraine with certainty (in the presence of concurrent medication overuse).
- Chronic migraine is a complication of migraines, and is a headache that fulfills diagnostic criteria for migraine headache and occurs for a greater time interval. Specifically, greater or equal to 15 days/month for longer than 3 months.[59]
Differential diagnosis
Other conditions that can cause similar symptoms to a migraine headache include: temporal arteritis, cluster headaches, acute glaucoma, meningitis and subarachnoid hemorrhage.[11] Temporal arteritis typically occurs in people over 50 years old and presents with tenderness over the temple, cluster headaches presents with one-sided nose stuffiness, tears and severe pain around the orbits, acute glaucoma is associated with vision problems, meningitis with fevers, and subaracchnoid hemorrhage with a very fast onset.[11] Tension headaches typically occur on both sides, are not pounding, and are less disabling.[11]
Prevention
Main article: Prevention of migraines
Preventive treatments of migraines include: medications, nutritional supplements, lifestyle alterations, and surgery. Prevention is recommended in those who have headaches more than two days a week, cannot tolerate the medications used to treat acute attacks, or those with severe attacks that are not easily controlled.[11]
The goal is to reduce the frequency, painfulness, and/or duration of migraines, and to increase the effectiveness of abortive therapy.[60] Another reason prevention is to avoid medication overuse headache. This is a common problem and can result in chronic daily headache.[61][62]
Medication
Preventive migraine medications are considered effective if they reduce the frequency or severity of the migraine attacks by at least 50%.[63] Guidelines are fairly consistent in rating topiramate, divalproex/sodium valproate, propranolol, and metoprolol as having the highest level of evidence for first-line use.[64] Recommendations regarding effectiveness varied however for gabapentin.[64] Timolol is also effective for migraine prevention and in reducing migraine attack frequency and severity, while frovatriptan is effective for prevention of menstrual migraine.[64] Amitriptyline and venlafaxine are probably also effective.[65] Botox has been found to be useful in those with chronic migraines but not those with episodic ones.[66]
Alternative therapies
Petasites hybridus (butterbur) root extract has proven effective for migraine prevention.[67]
Acupuncture is effective in the treatment of migraines.[68] The use of "true" acupuncture is not more efficient than sham acupuncture, however, both "true" and sham acupuncture appear more effective than routine care, with fewer adverse effects than prophylactic drug treatment.[69] Chiropractic manipulation, physiotherapy, massage and relaxation might be as effective as propranolol or topiramate in the prevention of migraine headaches; however, the research had some problems with methodology.[70] There is some tentative evidence of benefit for: magnesium, coenzyme Q(10), riboflavin, vitamin B(12),[71] and Fever-few, although better quality trials must be done to confirm these preliminary results.[72] Of the alternative medicines butterbur has the best evidence for its use.[73]
Devices and surgery
Medical devices, such as biofeedback and neurostimulators, have some advantages in migraine prevention, mainly when common anti-migraine medications are contraindicated or in case of medication overuse. Biofeedback helps people be conscious of some physiological parameters so as to control them and try to relax and may be efficient for migraine treatment.[74][75] Neurostimulation uses implantable neurostimulators similar to pacemakers for the treatment of intractable chronic migraines with encouraging results for severe cases.[76][77] Migraine surgery, which involves decompression of certain nerves around the head and neck, may be an option in certain people who do not improve with medications.[78]
Management
There are three main aspects of treatment: trigger avoidance, acute symptomatic control, and pharmacological prevention.[5] Medications are more effective if used earlier in an attack.[5] The frequent use of medications may result in medication overuse headache, in which the headaches become more severe and more frequent.[3] This may occur with triptans, ergotamines, and analgesics, especially narcotic analgesics.[3]
Analgesics
Recommended initial treatment for those with mild to moderate symptoms are simple analgesics such as non-steroidal anti-inflammatory drugs (NSAIDs) or the combination of acetaminophen, acetylsalicylic acid, and caffeine.[11] A number of NSAIDs have evidence to support their use. Ibuprofen has been found to provide effective pain relief in about half of people.[79] Diclofenac has been found effective.[80]
Aspirin can relieve moderate to severe migraine pain, with an effectiveness similar to sumatriptan.[81] Ketorolac is available in an intravenous formulation.[11] Paracetamol (also known as acetaminophen), either alone or in combination with metoclopramide, is another effective treatment with a low risk of adverse effects.[82] In pregnancy acetaminophen and metoclopramide are deemed safe as are NSAIDs until the third trimester.[11]
Triptans
Triptans such as sumatriptan are effective for both pain and nausea in up to 75% of people.[5][83] They are the initially recommended treatments for those with moderate to severe pain or those with milder symptoms who do not respond to simple analgesics.[11] The different forms available include oral, injectable, nasal spray, and oral dissolving tablets.[5] In general, all the triptans appear equally effective, with similar side effects. However, individuals may respond better to specific ones.[11] Most side effects are mild, such as flushing; however, rare cases of myocardial ischemia have occurred.[5] They are thus not recommended for people with cardiovascular disease.[11] They are not addictive, but may cause medication overuse headaches if used more than 10 days per month.[84]
Ergotamines
Ergotamine and dihydroergotamine are older medications still prescribed for migraines, the latter in nasal spray and injectable forms.[5] They appear equally effective to the triptans,[85] are less expensive,[86] and experience adverse effects that typically are benign.[87] In the most debilitating cases, such as those with status migrainosus, they appear to be the most effective treatment option.[87]
Other
Intravenous metoclopramide or intranasal lidocaine are other potential options.[11] Metoclopramide is the recommended treatment for those who present to the emergency department.[11] A single dose of intravenous dexamethasone, when added to standard treatment of a migraine attack, is associated with a 26% decrease in headache recurrence in the following 72 hours.[88] Spinal manipulation for treating an ongoing migraine headache is not supported by evidence.[89] It is recommended that opioids and barbiturates not be used.[11]
Prognosis
Long term prognosis in people with migraines is variable.[9] Most people with migraines have periods of lost productivity due to their disease[5] however typically the condition is fairly benign[9] and is not associated with an increased risk of death.[90] There are four main patterns to the disease: symptoms can resolve completely, symptoms can continue but become gradually less with time, symptoms may continue at the same frequency and severity, or attacks may become worse and more frequent.[9]
Migraines with aura appears to be a risk factor for ischemic stroke[91] doubling the risk.[92] Being a young adult, being female, using hormonal contraception, and smoking further increases this risk.[91] There also appears to be an association with cervical artery dissection.[93] Migraines without aura do not appear to be a factor.[94] The relationship with heart problems is inconclusive with a single study supporting an association.[91] Overall however migraines do not appear to increase the risk of death from stroke or heart disease.[90] Preventative therapy of migraines in those with migraines with auras may prevent associated strokes.[95]
Epidemiology
Disability-adjusted life year for migraines per 100,000 inhabitants in 2002.
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no data
<45
45–65
65–85
85–105
105–125
125–145
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145–165
165–185
185–205
205–225
225–245
>245
|
Worldwide, migraines affect more than 10% of people.[32] In the United States, about 6% of men and 18% of women get a migraine in a given year, with a lifetime risk of about 18% and 43% respectively.[5] In Europe, migraines affect 12–28% of people at some point in their lives with about 6–15% of adult men and 14–35% of adult women getting at least one yearly.[7] Rates of migraines are slightly lower in Asia and Africa than in Western countries.[96][42] Chronic migraines occur in approximately 1.4 to 2.2% of the population.[97]
Incidence of migraine by age and sex
These figures vary substantially with age: migraines most commonly start between 15 and 24 years of age and occur most frequently in those 35 to 45 years of age.[5] In children, about 1.7% of 7 year olds and 3.9% of those between 7 and 15 years have migraines, with the condition being slightly more common in boys before puberty.[98] During adolescence migraines becomes more common among women[98] and this persists for the rest of the lifespan, being two times more common among elderly females than males.[99] In women migraines without aura is more common than migraines with aura, however in men the two types occur with similar frequency.[42]
During perimenopause symptoms often get worse before decreasing in severity.[99] While symptoms resolve in about two thirds of the elderly, in between 3 and 10% they persist.[27]
History
The Head Ache, George Cruikshank (1819)
An early description consistent with migraines is contained in the Ebers papyrus, written around 1200 BCE in ancient Egypt.[100] In 200 BC, writings from the Hippocratic school of medicine described the visual aura that can precede the headache and a partial relief occurring through vomiting.[101]
A trepanated skull, from the Iron age. The perimeter of the hole in the skull is rounded off by ingrowth of new bony tissue, indicating that the person survived the operation.
A second-century description by Aretaeus of Cappadocia divided headaches into three types: cephalalgia, cephalea, and heterocrania.[102] Galen of Pergamon used the term hemicrania (half-head), from which the word migraine was eventually derived.[102] He also proposed that the pain arose from the meninges and blood vessels of the head.[101] Migraines were first divided into the two now used types - migraine with aura (migraine ophthalmique) and migraine without aura (migraine vulgaire) in 1887 by Louis Hyacinthe Thomas a French Librarian.[101]
Trepanation, the deliberate drilling of holes into a skull, was practiced as early as 7,000 BCE.[100] While sometimes people survived, many would have died from the procedure due to infection.[103] It was believed to work via "letting evil spirits escape".[104] William Harvey recommended trepanation as a treatment for migraines in the 17th-century.[105]
While many treatments for migraines have been attempted, it was not until 1868 that use of a substance which eventually turned out to be effective began.[101] This substance was the fungus ergot from which ergotamine was isolated in 1918.[106] Methysergide was developed in 1959 and the first triptan, sumatriptan, was developed in 1988.[106] During the 20th century with better study design effective preventative measures where found and confirmed.[101]
Society and culture
Migraines are a significant source of both medical costs and lost productivity. It has been estimated that they are the most costly neurological disorder in the European Community, costing more than €27 billion per year.[107] In the United States direct costs have been estimated at 17 billion USD.[108] Nearly a tenth of this cost is due to the cost of triptans.[108] Indirect costs are around 15 Billion USD, of which missed work is the greatest component.[108] In those who do attend work with a migraine effectiveness is decreased by around a third.[107] Negative impacts also frequently occur for a person's family.[107]
Research
Calcitonin gene related peptides (CGRPs) have been found to play a role in the pathogenesis of the pain associated with migraine.[11] CGRP receptor antagonists, such as olcegepant and telcagepant, have been investigated both in vitro and in clinical studies for the treatment of migraine.[109] In 2011, Merck stopped phase III clinical trials for their investigational drug telcagepant.[110][111] Transcranial magnetic stimulation also shows promise.[11]
References
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Notes
- Olesen, Jes (2006). The headaches. (3. ed. ed.). Philadelphia: Lippincott Williams & Wilkins. ISBN 9780781754002. http://books.google.ca/books?id=F5VMlANd9iYC&.
External links
- Migraine at the Open Directory Project
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UpToDate Contents
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- 1. 脳底型片頭痛 basilar type migraine
- 2. 成人における片頭痛の病態生理、臨床症状、および診断 pathophysiology clinical manifestations and diagnosis of migraine in adults
- 3. 小児における片頭痛の分類 classification of migraine in children
- 4. 片麻痺性片頭痛 hemiplegic migraine
- 5. 成人における片頭痛の急性期治療 acute treatment of migraine in adults
English Journal
- Familial hemiplegic migraine type 1 mutations W1684R and V1696I alter G protein-mediated regulation of Ca(V)2.1 voltage-gated calcium channels.
- Garza-López E, Sandoval A, González-Ramírez R, Gandini MA, Van den Maagdenberg A, De Waard M, Felix R.SourceDepartment of Cell Biology, Center for Research and Advanced Studies of the National Polytechnic Institute (Cinvestav-IPN), Mexico City, Mexico.
- Biochimica et biophysica acta.Biochim Biophys Acta.2012 Aug;1822(8):1238-46. Epub 2012 Apr 20.
- Familial hemiplegic migraine type 1 (FHM-1) is a monogenic form of migraine with aura that is characterized by recurrent attacks of a typical migraine headache with transient hemiparesis during the aura phase. In a subset of patients, additional symptoms such as epilepsy and cerebellar ataxia are pa
- PMID 22549042
- Investigation of the role of the GABRG2 gene variant in migraine.
- Chen T, Murrell M, Fowdar J, Roy B, Grealy R, Griffiths LR.SourceGriffith Health Institute, Genomics Research Centre, Griffith University, Queensland, Australia.
- Journal of the neurological sciences.J Neurol Sci.2012 Jul 15;318(1-2):112-4. Epub 2012 May 7.
- Migraine is the most common neurological disorder worldwide affecting about 12% of the worldwide population. This disorder has been classed into two main types of migraine-with and without aura. While a number of factors can influence the onset of migraine, a major factor is that of genetics. The GA
- PMID 22572707
Japanese Journal
- 帝王切開後に可逆性脳血管攣縮症候群により脳底動脈先端症候群を来した1例
- 渡辺 淳志,濱田 真輝,田鹿 安彦,宮崎 一秀,川畠 弘子
- 脳卒中 37(1), 21-25, 2015
- 要旨：症例は31 歳女性．予定帝王切開術後にメチルエルゴメトリン内服開始．分娩後5 日目に雷鳴様頭痛の後，全身痙攣が出現した．MRI，MRA にて多発性脳梗塞と脳血管狭窄を認め，可逆性脳血管攣縮症候群（RCVS）による脳底動脈先端症候群を疑いシロスタゾール，エダラボン，ベラパミルにて加療を行った．第40 病日のMRI にて脳血管狭窄は改善し，RCVS と確定診断となった．後遺症として四肢不全麻痺， …
- NAID 130004873643
- 幼児期のめまい・平衡障害
- 坂田 英明,遠藤 まゆみ,加我 君孝
- Equilibrium research 71(4), 253-263, 2012-08-01
- … The mechanism of migraine may be involved. … For diagnosis, a detailed inquiry is conducted, and children's parents are requested to record their states during vertigo attacks using a home video camera.Benign paroxysmal torticollis has been recognized as a type of vertigo resembling migraine. …
- NAID 10031026794
- 片頭痛関連めまい4症例—その臨床的特徴と検討—
- 井上 雄太,矢部 多加夫,平石 光俊
- 耳鼻咽喉科展望 55(2), 92-98, 2012
- 片頭痛に関連してみられるめまい症例に対し, 片頭痛関連めまいという疾患概念が提唱されているが我が国ではあまり認知されていなかった。片頭痛関連めまいは国際頭痛分類第2版に診断基準の記載がなく, いくつか診断基準が提唱されているがNeuhauserらによるものが一般的である。この度片頭痛関連めまい4症例を経験したので文献的考察と既に診断基準がある小児良性発作性めまい症, 脳底型片頭痛等との関連について …
- NAID 130004546426
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- Learn about basilar migraine causes, symptoms, facts and more. ... Basilar migraine is recognized as a distinct form of migraine disorder. It is a type of migraine with aura and both have several of the same migraine symptoms.
- WebMD explains basilar migraines, a form of intense headache, including symptoms, causes, diagnostic tests, and treatments. ... When someone has a basilar migraine, there is a disturbance in the brainstem or lower part of the ...
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★リンクテーブル★
| リンク元 | 「脳底型片頭痛」「脳底動脈型片頭痛」「familial hemiplegic migraine」「migraine with aura」「complicated migraine」 |
| 関連記事 | 「basilar」「basil」 |
「脳底型片頭痛」
- 英
- basilar migraine
- 同
- 脳底動脈片頭痛 basilar artery migraine、ビッカースタッフ型片頭痛 Bickerstaff migraine
- 関
- 失神性片頭痛、片頭痛、頭痛
「脳底動脈型片頭痛」
「familial hemiplegic migraine」
- 関
- basilar migraine、classic migraine、complicated migraine、migraine with aura、migraine with prolonged aura
- 同
- FHM
「migraine with aura」
- 関
- basilar migraine、classic migraine、complicated migraine、familial hemiplegic migraine、migraine with prolonged aura
「complicated migraine」
- 関
- basilar migraine、classic migraine、familial hemiplegic migraine、migraine with aura、migraine with prolonged aura
「basilar」
- adj.
- 基部の、脳底の、頭蓋底の
- 関
- base of skull、basicranium、basilaris、cerebral base、cranial base、proximal、proximal region、skull base、stem
「basil」