WordNet

a stripe or stripes of contrasting color; "chromosomes exhibit characteristic bands"; "the black and yellow banding of bees and wasps" (同)banding, stria, striation
an adornment consisting of a strip of a contrasting color or material (同)banding, stripe
bind or tie together, as with a band
a driving belt in machinery
a restraint put around something to hold it together
a thin flat strip of flexible material that is worn around the body or one of the limbs (especially to decorate the body)
a thin flat strip or loop of flexible material that goes around or over something else, typically to hold it together or as a decoration
a range of frequencies between two limits
instrumentalists not including string players
100 bani equal 1 leu in Moldova
100 bani equal 1 leu in Romania
prohibit especially by legal means or social pressure; "Smoking is banned in this building"
an official prohibition or edict against something (同)banning, forbiddance, forbidding
forbid the public distribution of ( a movie or a newspaper) (同)censor
marked with bands or strips of contrasting color or texture; "a banded rock"
characterized by a band of especially white around the body; "banded cattle"
identified with a band especially around a leg; "kept watch for the return of their banded birds"

PrepTutorEJDIC

『帯』,『バンド』,ひも,(おけの)たが / (色の)すじ,しま / 周波数 / …‘に'バンドを付ける
(人の)『一隊』,『一団』,一群《+『of』+『名』》 / 『楽隊』,バンド / …'を'一隊(一団)にする / 団結する《+『together』》,(…と)一団になる《+『with』+『名』》
(法による)(…に対する)『禁止』,禁制(prohibition)《+『on』+『名』》 / (世論などの)反対,非難 / (教会の)破門 / (法律や社会的圧力によって)…'を'『禁ずる』,禁止する

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/02/19 02:19:37」(JST)

wiki en

Band 3 anion transport protein, also known as anion exchanger 1 (AE1) or band 3 or solute carrier family 4 member 1 (SLC4A1), is a protein that is encoded by the SLC4A1 gene in humans.

Band 3 anion transport protein is a phylogenetically-preserved transport protein responsible for mediating the exchange of chloride (Cl⁻) with bicarbonate (HCO₃⁻) across plasma membranes. Functionally similar members of the AE clade are AE2 and AE3.^[4]

Function

Band 3 is present in the basolateral face of the α-intercalated cells of the collecting ducts of the nephron, which are the main acid-secreting cells of the kidney. They generate hydrogen ions and bicarbonate ions from carbon dioxide and water - a reaction catalysed by carbonic anhydrase. The hydrogen ions are pumped into the collecting duct tubule by vacuolar H⁺ ATPase, the apical proton pump, which thus excretes acid into the urine. kAE1 exchanges bicarbonate for chloride on the basolateral surface, essentially returning bicarbonate to the blood. Here it performs two functions:

Electroneutral chloride and bicarbonate exchange across the plasma membrane on a one-for-one basis. This is crucial for CO₂ uptake by the red blood cell and conversion (by hydration catalysed by carbonic anhydrase) into a proton and a bicarbonate ion. The bicarbonate is then excreted (in exchange for a chloride) from the cell by band 3.
Physical linkage of the plasma membrane to the underlying membrane skeleton (via binding with ankyrin and protein 4.2). This appears to be to prevent membrane surface loss, rather than being to do with membrane skeleton assembly.

Distribution

It is ubiquitous throughout the vertebrates. In mammals, it is present in two specific sites:

the erythrocyte (red blood cell) cell membrane and
the basolateral surface of the alpha-intercalated cell (the acid secreting cell type) in the collecting duct of the kidney.

Gene products

The erythrocyte and kidney forms are different isoforms of the same protein.^[5]

The erythrocyte isoform of AE1, known as eAE1, is composed of 911 amino acids. eAE1 is an important structural component of the erythrocyte cell membrane, making up to 25% of the cell membrane surface. Each red cell contains approximately one million copies of eAE1.

The kidney isoform of AE1, known as kAE1 (which is 65 amino acids shorter than erythroid AE1) is found in the basolateral membrane of alpha-intercalated cells in the cortical collecting duct of the kidney.

Clinical significance

Mutations of kidney AE1 cause distal (type 1) renal tubular acidosis, which is an inability to acidify the urine, even if the blood is too acidic. These mutations are disease causing as they cause mistargetting of the mutant band 3 proteins so that they are retained within the cell or occasionally addressed to the wrong (i.e. apical) surface.

Mutations of erythroid AE1 affecting the extracellular domains of the molecule may cause alterations in the individual's blood group, as band 3 determines the Diego blood group.

More importantly erythroid AE1 mutations cause 15–25% of cases of Hereditary spherocytosis (a disorder associated with progressive red cell membrane loss), and also cause the hereditary conditions of Hereditary stomatocytosis^[6] and Southeast Asian Ovalocytosis^[7]

Interactions

Band 3 has been shown to interact with CA2^[8]^[9]^[10]^[11] and CA4.^[12]

Discovery

AE1 was discovered following SDS-PAGE ( sodium dodecyl sulfate polyacrylamide gel electrophoresis ) of erythrocyte cell membrane. The large 'third' band on the electrophoresis gel represented AE1, which was thus initially termed 'Band 3'.

References

^ "Diseases that are genetically associated with SLC4A1 view/edit references on wikidata".
^ "Human PubMed Reference:".
^ "Mouse PubMed Reference:".
^ Alper SL (2009). "Molecular physiology and genetics of Na+-independent SLC4 anion exchangers". Journal of Experimental Biology. 212 (11): 1672–1683. doi:10.1242/jeb.029454. PMC 2683012. PMID 19448077.
^ Schlüter K, Drenckhahn D (August 1986). "Co-clustering of denatured hemoglobin with band 3: its role in binding of autoantibodies against band 3 to abnormal and aged erythrocytes". Proc. Natl. Acad. Sci. U.S.A. 83 (16): 6137–41. Bibcode:1986PNAS...83.6137S. doi:10.1073/pnas.83.16.6137. PMC 386454. PMID 3461480.
^ Bruce LJ, Robinson HC, Guizouarn H, Borgese F, Harrison P, King MJ, Goede JS, Coles SE, Gore DM, Lutz HU, Ficarella R, Layton DM, Iolascon A, Ellory JC, Stewart GW (2005). "Monovalent cation leaks in human red cells caused by single amino-acid substitutions in the transport domain of the band 3 chloride-bicarbonate exchanger, AE1". Nat. Genet. 37 (11): 1258–63. doi:10.1038/ng1656. PMID 16227998.
^ Jarolim P, Palek J, Amato D, Hassan K, Sapak P, Nurse GT, Rubin HL, Zhai S, Sahr KE, Liu SC (1991). "Deletion in erythrocyte band 3 gene in malaria-resistant Southeast Asian ovalocytosis". Proc. Natl. Acad. Sci. U.S.A. 88 (24): 11022–6. Bibcode:1991PNAS...8811022J. doi:10.1073/pnas.88.24.11022. PMC 53065. PMID 1722314.
^ Sterling D, Reithmeier RA, Casey JR (Dec 2001). "A transport metabolon. Functional interaction of carbonic anhydrase II and chloride/bicarbonate exchangers". J. Biol. Chem. 276 (51): 47886–94. doi:10.1074/jbc.M105959200 (inactive 2017-01-15). PMID 11606574.
^ Vince JW, Reithmeier RA (October 1998). "Carbonic anhydrase II binds to the carboxyl terminus of human band 3, the erythrocyte C1-/HCO3- exchanger". J. Biol. Chem. 273 (43): 28430–7. doi:10.1074/jbc.273.43.28430. PMID 9774471.
^ Vince JW, Carlsson U, Reithmeier RA (November 2000). "Localization of the Cl-/HCO3- anion exchanger binding site to the amino-terminal region of carbonic anhydrase II". Biochemistry. 39 (44): 13344–9. doi:10.1021/bi0015111. PMID 11063570.
^ Vince JW, Reithmeier RA (May 2000). "Identification of the carbonic anhydrase II binding site in the Cl(-)/HCO(3)(-) anion exchanger AE1". Biochemistry. 39 (18): 5527–33. doi:10.1021/bi992564p. PMID 10820026.
^ Sterling D, Alvarez BV, Casey JR (July 2002). "The extracellular component of a transport metabolon. Extracellular loop 4 of the human AE1 Cl-/HCO3- exchanger binds carbonic anhydrase IV". J. Biol. Chem. 277 (28): 25239–46. doi:10.1074/jbc.M202562200. PMID 11994299.

External links

Diego blood group system at BGMUT Blood Group Antigen Gene Mutation Database at NCBI, NIH
Band 3 Protein at the US National Library of Medicine Medical Subject Headings (MeSH)
Chloride-Bicarbonate Antiporters at the US National Library of Medicine Medical Subject Headings (MeSH)
Human SLC4A1 genome location and SLC4A1 gene details page in the UCSC Genome Browser.

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Use of MPA-capped CdS quantum dots for sensitive detection and quantification of Co²⁺ ions in aqueous solution.

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Analytica chimica acta.Anal Chim Acta.2018 Oct 22;1028:50-58. doi: 10.1016/j.aca.2018.04.041. Epub 2018 Apr 27.
PMID 29884353

Preferential solvation bromophenol blue in water-alcohol binary mixture.

Dangui AZ1, Santos VMS1, Gomes BS1, de Castilho TS1, Nicolini KP1, Nicolini J2.
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Identification of tautomeric intermediates of a novel thiazolylazonaphthol dye - A density functional theory study.

Karaush NN1, Minaeva VA2, Baryshnikov GV3, Minaev BF3, Ågren H4.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.Spectrochim Acta A Mol Biomol Spectrosc.2018 Oct 5;203:324-332. doi: 10.1016/j.saa.2018.05.096. Epub 2018 May 29.
PMID 29879648

Japanese Journal

Climbing end image algorithm to locate transition states

Asada Toshio,Sawada Nozomi,Haruta Mamoru,Koseki Shiro
Chemical Physics Letters (775), 138658, 2021-07-16
NAID 120007044345

部分構造を対象に結合損失率を目的関数とした構造最適化に関する研究

黒田勝彦
長崎総合科学大学紀要 = Bulletin of the Nagasaki Institute of Applied Science 61(1), 29-35, 2021-06-25
… As a result of applying the proposed method to a simple structure consisting of two flat plates connected in an L shaped configuration, the design variable is taken as the thickness of the FEM element, a subsystem structure with the desired value of the CLF or power flow between subsystems for the one frequency band or multi frequency bands were constructed. …
NAID 120007089656

特集超高速インターネット衛星(WINDS)の実験成果(第3回)WINDSを使用した信号歪補償実験成果報告

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NAID 40022614511

「CD233」

solute carrier family 4 (anion exchanger), member 1, adapter protein
Identifiers
Symbol	SLC4A1AP
Entrez	22950
HUGO	13813
OMIM	602655
RefSeq	NM_018158
UniProt	P02730
Other data
Locus	Chr. 2 p23.3

SLC4A1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1BH7, 1BNX, 1BTQ, 1BTR, 1BTS, 1BTT, 1BZK, 1HYN, 3BTB, 2BTA, 2BTB, 4KY9, 4YZF
Identifiers
Aliases	SLC4A1, solute carrier family 4 (anion exchanger), member 1 (Diego blood group), AE1, BND3, CD233, DI, EMPB3, EPB3, FR, RTA1A, SW, WD, WD1, WR, CHC, SAO, SPH4, solute carrier family 4 member 1 (Diego blood group)
External IDs	OMIM: 109270 MGI: 109393 HomoloGene: 133556 GeneCards: SLC4A1
Genetically Related Diseases
	Obesity
Gene ontology
Molecular function	• protein homodimerization activity; • protein anchor; • chloride transmembrane transporter activity; • transporter activity; • anion transmembrane transporter activity; • anion:anion antiporter activity; • bicarbonate transmembrane transporter activity; • protein binding; • ankyrin binding; • inorganic anion exchanger activity;
Cellular component	• integral component of membrane; • blood microparticle; • membrane; • cortical cytoskeleton; • plasma membrane; • integral component of plasma membrane; • basolateral plasma membrane; • extracellular exosome; • Z disc;
Biological process	• anion transport; • bicarbonate transport; • transport; • cellular ion homeostasis; • chloride transport; • ion transport; • regulation of intracellular pH; • anion transmembrane transport; • chloride transmembrane transport;
	Sources:Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	6521
	20533
	ENSG00000004939
	ENSMUSG00000006574
	P02730
	P04919
	NM_000342
	NM_011403
	NP_000333
	NP_035533.1; NP_035533
	Wikidata
View/Edit Human	View/Edit Mouse

　　[★]

関: band 3 erythrocyte membrane protein band 3 anion exchanger 1 Diego blood group, solute carrier family 4, ion exchanger member 1

「band」

　　[★]

n.

バンド、帯、バンド形成する
桿状核球桿状核好中球

関: banding、cingulum、zona、zonae、zone

「ban」

　　[★]

n.

禁止

v.

禁止する

関: abstinent、forbid、interdict、prohibit、prohibition、prohibitive

「banding」

　　[★]

n.

バンド形成、結紮、絞扼

関: band、ligate、ligation、strangulation

[1] "Diseases that are genetically associated with SLC4A1 view/edit references on wikidata".

[2] "Human PubMed Reference:".

[3] "Mouse PubMed Reference:".

[4] Alper SL (2009). "Molecular physiology and genetics of Na+-independent SLC4 anion exchangers". Journal of Experimental Biology. 212 (11): 1672–1683. doi:10.1242/jeb.029454. PMC 2683012. PMID 19448077.

[pmid3461480-5] Schlüter K, Drenckhahn D (August 1986). "Co-clustering of denatured hemoglobin with band 3: its role in binding of autoantibodies against band 3 to abnormal and aged erythrocytes". Proc. Natl. Acad. Sci. U.S.A. 83 (16): 6137–41. Bibcode:1986PNAS...83.6137S. doi:10.1073/pnas.83.16.6137. PMC 386454. PMID 3461480.

[pmid16227998-6] Bruce LJ, Robinson HC, Guizouarn H, Borgese F, Harrison P, King MJ, Goede JS, Coles SE, Gore DM, Lutz HU, Ficarella R, Layton DM, Iolascon A, Ellory JC, Stewart GW (2005). "Monovalent cation leaks in human red cells caused by single amino-acid substitutions in the transport domain of the band 3 chloride-bicarbonate exchanger, AE1". Nat. Genet. 37 (11): 1258–63. doi:10.1038/ng1656. PMID 16227998.

[pmid1722314-7] Jarolim P, Palek J, Amato D, Hassan K, Sapak P, Nurse GT, Rubin HL, Zhai S, Sahr KE, Liu SC (1991). "Deletion in erythrocyte band 3 gene in malaria-resistant Southeast Asian ovalocytosis". Proc. Natl. Acad. Sci. U.S.A. 88 (24): 11022–6. Bibcode:1991PNAS...8811022J. doi:10.1073/pnas.88.24.11022. PMC 53065. PMID 1722314.

[pmid11606574-8] Sterling D, Reithmeier RA, Casey JR (Dec 2001). "A transport metabolon. Functional interaction of carbonic anhydrase II and chloride/bicarbonate exchangers". J. Biol. Chem. 276 (51): 47886–94. doi:10.1074/jbc.M105959200 (inactive 2017-01-15). PMID 11606574.

[pmid9774471-9] Vince JW, Reithmeier RA (October 1998). "Carbonic anhydrase II binds to the carboxyl terminus of human band 3, the erythrocyte C1-/HCO3- exchanger". J. Biol. Chem. 273 (43): 28430–7. doi:10.1074/jbc.273.43.28430. PMID 9774471.

[pmid11063570-10] Vince JW, Carlsson U, Reithmeier RA (November 2000). "Localization of the Cl-/HCO3- anion exchanger binding site to the amino-terminal region of carbonic anhydrase II". Biochemistry. 39 (44): 13344–9. doi:10.1021/bi0015111. PMID 11063570.

[pmid10820026-11] Vince JW, Reithmeier RA (May 2000). "Identification of the carbonic anhydrase II binding site in the Cl(-)/HCO(3)(-) anion exchanger AE1". Biochemistry. 39 (18): 5527–33. doi:10.1021/bi992564p. PMID 10820026.

[pmid11994299-12] Sterling D, Alvarez BV, Casey JR (July 2002). "The extracellular component of a transport metabolon. Extracellular loop 4 of the human AE1 Cl-/HCO3- exchanger binds carbonic anhydrase IV". J. Biol. Chem. 277 (28): 25239–46. doi:10.1074/jbc.M202562200. PMID 11994299.

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)

1-50	CD1 a-c 1A 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50

51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100

101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150

151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200

201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249

251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299

301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

リンク元	「CD233」
関連記事	「band」「ban」「banding」

匿名

検索

案内

案内

band 3