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Clinical efficacy and safety of arbekacin sulfate in patients with MRSA sepsis or pneumonia: a multi-institutional study.

Matsumoto T, Hanaki H, Kimura T, Nemoto M, Higashihara M, Yokota H, Oda S, Akiyama N, Miyao N, Yoshida M, Yukioka T, Soma K, Ohyashiki K, Suzuki Y, Arai T, Ikegami K, Ichiwata T, Otsuka Y, Kobayashi M, Totsuka K, Sunakawa K; ABK Dose Finding Study Group.SourceDepartment of Microbiology, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo, 160-8402, Japan. tetsuya@tokyo-med.ac.jp
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.J Infect Chemother.2013 Feb;19(1):128-37. doi: 10.1007/s10156-012-0519-z. Epub 2012 Dec 22.
Arbekacin (ABK) is an aminoglycoside and widely used in Japan for treatment of patients infected with methicillin-resistant Staphylococcus aureus (MRSA). Although, ABK has concentration-dependent antibacterial activity, the peak serum concentration (C (peak)) of ABK has not yet been fully investigat
PMID 23263188

novel 6'-n-aminoglycoside acetyltransferase AAC(6')-Iaj from a clinical isolate of Pseudomonas aeruginosa.

Tada T, Miyoshi-Akiyama T, Shimada K, Shimojima M, Kirikae T.SourceDepartment of Infectious Diseases, Research Institute, National Center for Global Health and Medicine, Shinjuku, Tokyo, Japan.
Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2013 Jan;57(1):96-100. doi: 10.1128/AAC.01105-12. Epub 2012 Oct 15.
Pseudomonas aeruginosa NCGM1588 has a novel chromosomal class 1 integron, In151, which includes the aac(6')-Iaj gene. The encoded protein, AAC(6')-Iaj, was found to consist of 184 amino acids, with 70% identity to AAC(6')-Ia. Escherichia coli transformed with a plasmid containing the aac(6')-Iaj gen
PMID 23070167

Aranorosin circumvents arbekacin-resistance in MRSA by inhibiting the bifunctional enzyme AAC(6')/APH(2″).

Suga T, Ishii T, Iwatsuki M, Yamamoto T, Nonaka K, Masuma R, Matsui H, Hanaki H, Omura S, Shiomi K.SourceGraduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan.
The Journal of antibiotics.J Antibiot (Tokyo).2012 Oct;65(10):527-9. doi: 10.1038/ja.2012.53. Epub 2012 Jul 4.
PMID 22760297

The efficacy and safety of high-dose arbekacin sulfate therapy (once-daily treatment) in patients with MRSA infection

YAMAMOTO Yoshihiro,IZUMIKAWA Koichi,HASHIGUCHI Koji,FUKUDA Yuichi,KOBAYASHI Tsutomu,KONDO Akira,INOUE Yuichi,MORINAGA Yoshitomo,NAKAMURA Shigeki,IMAMURA Yoshifumi,MIYAZAKI Taiga,KAKEYA Hiroshi,YANAGIHARA Katsunori,KOHNO Shigeru
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 18(2), 241-246, 2012-04-01
NAID 10030545719