抗原結合部位
WordNet
- serve in a specific professional capacity; "the priest sat for confession"; "she sat on the jury"
- be around, often idly or without specific purpose; "The object sat in the corner"; "We sat around chatting for another hour" (同)sit around
- be seated (同)sit_down
- be in session; "When does the court of law sit?"
- be located or situated somewhere; "The White House sits on Pennsylvania Avenue"
- executed with proper legal authority; "a binding contract"
- the protective covering on the front, back, and spine of a book; "the book had a leather binding" (同)book binding, cover, back
- strip sewn over or along an edge for reinforcement or decoration
- the capacity to attract and hold something
- the piece of land on which something is located (or is to be located); "a good site for the school" (同)land site
- physical position in relation to the surroundings; "the sites are determined by highly specific sequences of nucleotides" (同)situation
- any substance (as a toxin or enzyme) that stimulates an immune response in the body (especially the production of antibodies)
PrepTutorEJDIC
- (…に)『座る』,座っている《+『at』(『on, in』)+『名』》・着席する《+『down』》・(…に)〈鳥などが〉『止まる』,休む《+『on』+『名』》・〈めんどりが〉卵を抱く,巣に就く / 《場所の副詞[句]を伴って》(ある場所に)『位置する』・ (画家・写真家のために)ポーズをとる・しっとしている,動かないでいる・(議員・委員などの)職に就いている《+『on』+『名』》・〈議会・法廷などが〉開会(開廷)される・(…に)負担となる,重荷となる《+『on』(『upon』)+『名』》・〈衣服などが〉(…に)合う,似合う《+『on』+『名』》・〈人〉‘を'座らせる,着席させる《+『down』+『名,』+『名』+『down』》・〈馬〉‘に'乗る・《英》〈試験〉‘を'受ける
- 義務的な,拘束力ある / 〈U〉しばること;〈C〉しばる物 / 〈C〉製本,装丁 / 〈U〉縁(‘ふち')取り材料
- (町・建物などの)『場所』;敷地,用地 / 遺跡;(事件などの)現場 / 〈建物など〉‘を'位置させる(locate)
- 抗原(生物の体内にはいって免疫体を作る物質)
- =ti
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- On plasma cell longevity or brevity.
- Zinkernagel R.
- Expert review of vaccines.Expert Rev Vaccines.2014 Jul;13(7):821-3. doi: 10.1586/14760584.2014.924402. Epub 2014 Jun 7.
- The seemingly long half-life of antibody-producing plasma cells demonstrated by antigen-binding (ELISA type of) assays as compared with the short-livedness of neutralizing and protective antibody-producing plasma cells is explained here by the heterogeneity and multiple crossreactive antibodies dete
- PMID 24909054
- Efficient refolding and immobilization of PMMA-tag-fused single-chain Fv antibodies for sensitive immunological detection on a PMMA plate.
- Kumada Y1, Ishikawa Y2, Fujiwara Y2, Takeda R3, Miyamoto R2, Niwa D4, Momose S4, Kang B2, Kishimoto M2.
- Journal of immunological methods.J Immunol Methods.2014 Jun 6. pii: S0022-1759(14)00177-X. doi: 10.1016/j.jim.2014.05.015. [Epub ahead of print]
- In this study, we investigated the efficient refolding and site-specific immobilization of single-chain variable fragments (scFvs) genetically fused with a poly(methylmethacrylate)-binding peptide (PMMA-tag). According to the results of an aggregation test of a scFv-PM in the presence of 0.5M urea,
- PMID 24910412
- In vivo and in vitro activity of an immunoglobulin Fc fragment (Fcab) with engineered Her-2/neu binding sites.
- Woisetschläger M1, Antes B, Borrowdale R, Wiederkum S, Kainer M, Steinkellner H, Wozniak-Knopp G, Moulder K, Rüker F, Mudde GC.
- Biotechnology journal.Biotechnol J.2014 Jun;9(6):844-51. doi: 10.1002/biot.201300387. Epub 2014 May 8.
- Antigen-binding Fc fragments (Fcabs) are a new unique class of immunotherapeutics. They are small (50 kD) fully functional antibody alternatives that bind antigen and elicit effector functions such as antibody-dependent cytotoxicity (ADCC) and complement-dependent cytotoxicity. Since Fcabs carry the
- PMID 24806546
Japanese Journal
- Preparation of scFv-immobilized quartz crystal microbalance sensor by PS-tag-mediated solid-phase refolding(BIOCHEMICAL ENGINEERING)
- Kumada Yoichi,Sasaki Eiju,Kishimoto Michimasa
- Journal of bioscience and bioengineering 111(4), 459-464, 2011-04
- … On the bare gold surface of a QCM sensor chip, approximately 60nm of hydrophilic polystyrene (phi-PS) thin film that specifically binds the polystyrene-binding peptide (PS-tag) was prepared by spin-coating and O_2-plasma irradiation. … The specific antigen-binding activity of scFv-PS after solid-phase refolding increased with the density of immobilized scFv-PS, and, consequently, activity 1.7 times higher than that of scFv was retained. …
- NAID 110008607503
- Immobilization of antibodies on mesoporous silica materials and their binding abilities to antigens
- Orita Toru,Kato Katsuya,Tomita Masahiro
- Journal of the Ceramic Society of Japan 119(1387), 238-245, 2011
- … However, the binding activities of antibodies to antigens were high only on MPS with 3.4 and 5.8 nm pores. … These results indicated that the Fab fragment, which is an antigen binding site of the antibody, was incorporated inside larger pores but remained outside smaller pores. …
- NAID 130000662349
- Site-Directed Mutagenesis Study of the Antibody 2D7 which Catalyzes a Reaction for Insertion of Cu^<2+> into Mesoporphyrin(Enzymology, Protein Engineering, and Enzyme Technology)
- Hosomi Naoki,Kawamura-Konishi Yasuko,Kawano Ryota [他],FUJII IKUO,SUZUKI HARUO
- Journal of bioscience and bioengineering 99(3), 222-229, 2005-03-25
- … To investigate amino acid residues responsible for the catalytic activity, site-directed mutagenesis of the amino acid residues in the third complementarity determining region of the heavy chain (CDRH3) was performed on the antigen-binding fragment (Fab) of the antibody. …
- NAID 110002695651
Related Links
- At the tip of each arm of the Y-shaped molecule is an area called the antigen-binding, or antibody-combining, site, which is formed by a portion of the heavy and light chains. Every immunoglobulin molecule has at least two of these ...
- When two polypeptide chains, VHA-VLB and VHB-VLA, linked by the short linkers are expressed in the same cells, dual-functional antigen-binding sites are formed by crossover pairing of the variable light-chains and heavy-chains.
★リンクテーブル★
[★]
- 英
- antigen-binding site, antigen-combining site
- 関
- 抗原
[★]
- 関
- affinity、associate、bind、bond、bonding、combine、conjoin、conjugate、conjugation、conjunction、connect、connection、connective、connectivity、couple、dock、engage、engagement、join、ligate、linkage、symphysial、symphysic、union
[★]
- 関
- lie、locate、location、loci、locus、map、position、rank、seat、situated、situation、stand、topo
[★]
- 関
- location、loci、locus、place、topo