antianginal agent

• 抗狭心症薬

関

antianginal drug

WordNet

1. a substance that exerts some force or effect
2. a businessman who buys or sells for another in exchange for a commission (同)factor, broker
3. any agent or representative of a federal agency or bureau (同)federal agent
4. a representative who acts on behalf of other persons or organizations
5. an active and efficient cause; capable of producing a certain effect; "their research uncovered new disease agents"
6. how long something has existed; "it was replaced because of its age"
7. a time of life (usually defined in years) at which some particular qualification or power arises; "she was now of school age"; "tall for his eld" (同)eld
8. begin to seem older; get older; "The death of his wife caused him to age fast"
9. make older; "The death of his child aged him tremendously"

PrepTutorEJDIC

1. 『代理人』;周旋人 / 働き(作用)を起こすもの;作用物,薬剤 / (政府機関,特にFBI,CIAなどの)部員,機関員
2. 〈U〉(一般に)『年齢』,寿命;〈C〉(個々の)『年齢』,年 / 〈U〉成年(おとなとしての資格・権利を得る年齢;通例18または21歳) / 〈U〉『老齢』;《集合的に》老人たち / 〈U〉(人生の)『一時期』;〈C〉世代(generation) / 〈U〉〈C〉《しばしばA-》(歴史上の)『時代』 / 〈C〉《話》長い間 / 年をとる,ふける;〈物が〉古くなる / 〈年〉'を'とらせる;〈物〉'を'古びさせる

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/23 14:43:46」(JST)

wiki en

[Wiki en表示]

An antianginal is any drug used in the treatment of angina pectoris, a symptom of ischaemic heart disease.

Types

Stable Angina

Pain due to atherosclerosis causing incomplete coronary artery occlusion. Pain onset with strenuous activity or emotional strain due to increased myocardial oxygen demand.

Unstable Angina

Pain due to atherosclerotic plaque rupture and subsequent embolization causing incomplete coronary arterial occlusion.

Variant (Prinzmetal's) Angina

Pain due to transient vasospasm causing coronary artery vasoconstriction.

Examples

Drugs used are nitrates, beta blockers, or calcium channel blockers.

Nitrates

Main article: Nitrovasodilator

Nitrates cause vasodilation of the venous capacitance vessels by stimulating the endothelium-derived relaxing factor (EDRF). Used to relieve both exertional and vasospastic angina by allowing venous pooling, reducing the pressure in the ventricles and so reducing wall tension and oxygen requirements in the heart. Short-acting nitrates are used to abort angina attacks that have occurred, while longer-acting nitrates are used in the prophylactic management of the condition.

Agents include nitroglycerin (glyceryl trinitrate) or pentaerythritol tetranitrate, isosorbide dinitrate and isosorbide mononitrate.

Beta blockers

Beta blockers are used in the prophylaxis of exertional angina by reducing the myocardial oxygen demand below the level that would provoke an angina attack.

They are contraindicated in variant angina and can precipitate heart failure. They are also contraindicated in severe asthmatics due to bronchoconstriction, and should be used cautiously in diabetics as they can cause hypoglycemia

Agents include either cardioselectives such as acebutolol or metoprolol, or non-cardioselectives such as oxprenolol or sotalol.

Calcium channel blockers

Calcium ion (Ca⁺⁺) antagonists (Calcium channel blockers) are used in the treatment of chronic stable angina, and most effectively in the treatment of variant angina (directly preventing coronary artery vasospasm). They are not used in the treatment of unstable angina .

In vitro, they dilate the coronary and peripheral arteries and have negative inotropic and chronotropic effects - decreasing afterload, improving myocardial efficiency, reducing heart rate and improving coronary blood flow. In vivo, the vasodilation and hypotension trigger the baroreceptor reflex. Therefore the net effect is the interplay of direct and reflex actions.

• Class I agents have the most potent negative inotropic effect and may cause heart failure.
• Class II agents do not depress conduction or contractility.
• Class III agent has negligible inotropic effect and causes almost no reflex tachycardia.

Examples include Class I agents (e.g., verapamil), Class II agents (e.g., amlodipine, nifedipine), or the Class III agent diltiazem.

Nifedipine is more a potent vasodilator and more effective in angina. It is in the class of dihydropyridines and does not affect refrectory period on SA node conduction.

References

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 末期腎不全（透析）における冠動脈疾患の治療 treatment of coronary heart disease in end stage renal disease dialysis
• 2. 安定狭心症の管理におけるβ遮断剤 beta blockers in the management of stable angina pectoris
• 3. 狭心症の新しい治療法 new therapies for angina pectoris
• 4. 安定狭心症の管理における硝酸塩 nitrates in the management of stable angina pectoris
• 5. 負荷試験に対する薬剤およびメチルキサンチンの影響 impact of medications and methylxanthines on stress testing

English Journal

• Effects of trimetazidine in patients with acute myocardial infarction: data from the Korean Acute Myocardial Infarction Registry.

• Kim JS, Kim CH, Chun KJ, Kim JH, Park YH, Kim J, Choi JH, Lee SH, Kim EJ, Yu DG, Ahn EY, Jeong MH.SourceDivision of Cardiology, Department of Internal Medicine and Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, 626-770, Korea.
• Clinical research in cardiology : official journal of the German Cardiac Society.Clin Res Cardiol.2013 Aug 28. [Epub ahead of print]
• BACKGROUND: Excess myocardial fatty acid oxidation can cause a range of deleterious myocardial effects. Trimetazidine (TMZ) is a clinically effective antianginal agent that selectively inhibits long-chain 3-ketoacyl CoA thiolase, reducing fatty acid oxidation and stimulating glucose oxidation. The r
• PMID 23982468

• Nitroglycerine and sodium trioxodinitrate: from the discovery to the preconditioning effect.

• Pagliaro P, Gattullo D, Penna C.SourceDipartimento di Scienze Cliniche e Biologiche, Università di Torino, Torino, Italy.
• Journal of cardiovascular medicine (Hagerstown, Md.).J Cardiovasc Med (Hagerstown).2013 May 20. [Epub ahead of print]
• The history began in the 19th century with Ascanio Sobrero (1812-1888), the discoverer of glycerol trinitrate (nitroglycerine, NTG), and with Angelo Angeli (1864-1931), the discoverer of sodium trioxodinitrate (Angeli's salt). It is likely that Angeli and Sobrero never met, but their two histories w
• PMID 23695182

• Ranolazine: a review of its use as add-on therapy in patients with chronic stable angina pectoris.

• Keating GM.SourceAdis, Mairangi Bay, North Shore, Auckland, New Zealand. DRU@adis.com
• Drugs.Drugs.2013 Jan;73(1):55-73. doi: 10.1007/s40265-012-0005-z.
• Extended-release ranolazine (ranolazine ER) [Ranexa(®)] is an antianginal agent that achieves its effects via a novel mechanism of action (inhibition of the late phase of the inward sodium current), without affecting heart rate or blood pressure (BP). This article reviews the efficacy, safety and t
• PMID 23329466

Japanese Journal

• 安定狭心症に対するニコランジルの短期的有効性・安全性に関するシステマティック・レビュー：β遮断薬・持続性亜硝酸薬・Ca拮抗薬との比較

• 花井 雄貴,三田 充男,菱沼 滋,庄司 優
• YAKUGAKU ZASSHI 130(11), 1549-1563, 2010
• … We performed a meta-analysis of the short-term efficacy of nicorandil compared with antianginal drugs for stable angina. … Compared with antianginal drugs, nicorandil did not show significant reduction of angina episodes per week (vs. β-blockers, −1.50 [95% confidence interval (CI): −4.09, 1.09]; …
• NAID 130000451708

• Antianginal Effects of Lercanidipine on the Vasopressin or Methacholine Induced Anginal Model in Rats(Pharmacology)

• SASAKI Toshinobu,MARUYAMA Hirofumi,KASE Yoshio,TAKEDA Shuichi,ABURADA Masaki
• Biological & pharmaceutical bulletin 28(5), 811-816, 2005-05-01
• … The antianginal effects of lercanidipine, a newly synthesized 1,4-dihydropyridine derivative calcium channel antagonist, were evaluated in experimental angina model rats and the effects were compared with those of nifedipine, benidipine and amlodipine. … It is expected that lercanidipine will be useful as an antianginal agent. …
• NAID 10016663116

Related Links

• List of Antianginal agents - Drugs.com

Compare antianginal agents. View important safety information, ratings, user reviews, popularity and more... ... Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter ...

• Antianginal agents | definition of antianginal agents by Medical ...

Based on CAPISA and the earlier phase III Monotherapy Assessment of Ranolazine n Stable Angina (MARISA), ranolazine has the potential to become the first drug in what would be the first new class of antianginal agents approved ...

---

★リンクテーブル★

リンク元	「antianginal drug」
関連記事	「agent」「age」

「antianginal drug」

　　[★]

• 抗狭心症薬

関

antianginal agent

「agent」

　　[★]

• n.

• 代行者、代理人。代理業者
• 政府職員、官吏
• ある後位をする人、ある作用をするもの。動員、動力因、作用因。(文法)動作主。科学的変化を起こさせるもの、薬品、～剤。病原体

関

agonist、agonistic、attorney、delegate、drug、etiologic agent、fomes、fomites、mediator、pathogen、pathogenic、pharmaceutical preparation、vector、vehicle

　 　 　 　 　 　

「age」

　　[★]

• n.

• 年齢、歳

• v.

• 加齢する、熟成する

関

aged、ageing、aging、year old