抗U1-RNP抗体
WordNet
- not in favor of (an action or proposal etc.)
- a person who is opposed (to an action or policy or practice etc.); "the antis smelled victory after a long battle"
- social insect living in organized colonies; characteristically the males and fertile queen have wings during breeding season; wingless sterile females are the workers (同)emmet, pismire
- the 18th letter of the Roman alphabet (同)r
- the 21st letter of the Roman alphabet (同)u
- any of a large variety of proteins normally present in the body or produced in response to an antigen which it neutralizes, thus producing an immune response
PrepTutorEJDIC
- 《話》(特定の慣習・政策・行動などに)反対する人
- 『アリ』
- =ain't
- resistance / 17歳以下父兄同伴映画の表示 / rook
- uraniumの化学記号
- 上流の,上流階級にふさわしい / (映画が)児童観覧用の
- 抗体,免疫体,抗毒素
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/15 18:48:20」(JST)
[Wiki en表示]
| Small nuclear ribonucleoprotein 70kDa (U1) |
| Available structures |
| PDB |
Ortholog search: PDBe, RCSB |
| List of PDB id codes |
|
2L5I, 2L5J, 3CW1, 3PGW
|
|
|
| Identifiers |
| Symbols |
SNRNP70 ; RNPU1Z; RPU1; SNRP70; Snp1; U1-70K; U170K; U1AP; U1RNP |
| External IDs |
OMIM: 180740 MGI: 98341 HomoloGene: 20672 GeneCards: SNRNP70 Gene |
| Gene ontology |
| Molecular function |
• nucleotide binding
• RNA binding
• protein binding
• poly(A) RNA binding
|
| Cellular component |
• nucleus
• nucleoplasm
• spliceosomal complex
• U1 snRNP
• nucleolus
• nuclear speck
|
| Biological process |
• mRNA splicing, via spliceosome
• mRNA processing
• RNA splicing
• gene expression
• regulation of RNA splicing
|
| Sources: Amigo / QuickGO |
|
| RNA expression pattern |
|
| More reference expression data |
| Orthologs |
| Species |
Human |
Mouse |
|
| Entrez |
6625 |
20637 |
|
| Ensembl |
ENSG00000104852 |
ENSMUSG00000063511 |
|
| UniProt |
P08621 |
Q62376 |
|
| RefSeq (mRNA) |
NM_001009820 |
NM_009224 |
|
| RefSeq (protein) |
NP_001287998 |
NP_033250 |
|
| Location (UCSC) |
Chr 19:
49.59 – 49.61 Mb |
Chr 7:
45.38 – 45.4 Mb |
|
| PubMed search |
[1] |
[2] |
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|
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snRNP70 also known as U1 small nuclear ribonucleoprotein 70 kDa is a protein[1] that in humans is encoded by the SNRNP70 gene.[2][3] snRNP70 is a small nuclear ribonucleoprotein that associates with U1 spliceosomal RNA, forming part of the spliceosome.
Contents
- 1 Interactions
- 2 Role in autoimmunity
- 3 References
- 4 Further reading
Interactions
snRNP70 has been shown to interact with ASF/SF2,[4][5] SRPK1,[6][7] and ZRANB2.[8]
Role in autoimmunity
Antibodies towards snRNP70 are associated with mixed connective tissue disease.[9]
References
- ^ Spritz RA, Strunk K, Surowy CS, Hoch SO, Barton DE, Francke U (December 1987). "The human U1-70K snRNP protein: cDNA cloning, chromosomal localization, expression, alternative splicing and RNA-binding". Nucleic Acids Res. 15 (24): 10373–91. doi:10.1093/nar/15.24.10373. PMC 339950. PMID 2447561.
- ^ "Entrez Gene: SNRP70 small nuclear ribonucleoprotein 70kDa polypeptide (RNP antigen)".
- ^ Spritz RA, Strunk K, Surowy CS, Mohrenweiser HW (October 1990). "Human U1-70K ribonucleoprotein antigen gene: organization, nucleotide sequence, and mapping to locus 19q13.3". Genomics 8 (2): 371–9. doi:10.1016/0888-7543(90)90295-6. PMID 2147422.
- ^ Xiao SH, Manley JL (November 1998). "Phosphorylation-dephosphorylation differentially affects activities of splicing factor ASF/SF2". EMBO J. 17 (21): 6359–67. doi:10.1093/emboj/17.21.6359. PMC 1170960. PMID 9799243.
- ^ Cao W, Garcia-Blanco MA (August 1998). "A serine/arginine-rich domain in the human U1 70k protein is necessary and sufficient for ASF/SF2 binding". J. Biol. Chem. 273 (32): 20629–35. doi:10.1074/jbc.273.32.20629. PMID 9685421.
- ^ Wang HY, Lin W, Dyck JA, Yeakley JM, Songyang Z, Cantley LC, Fu XD (February 1998). "SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells". J. Cell Biol. 140 (4): 737–50. doi:10.1083/jcb.140.4.737. PMC 2141757. PMID 9472028.
- ^ Kamachi M, Le TM, Kim SJ, Geiger ME, Anderson P, Utz PJ (November 2002). "Human autoimmune sera as molecular probes for the identification of an autoantigen kinase signaling pathway". J. Exp. Med. 196 (9): 1213–25. doi:10.1084/jem.20021167. PMC 2194102. PMID 12417631.
- ^ Adams DJ, van der Weyden L, Mayeda A, Stamm S, Morris BJ, Rasko JE (July 2001). "ZNF265--a novel spliceosomal protein able to induce alternative splicing". J. Cell Biol. 154 (1): 25–32. doi:10.1083/jcb.200010059. PMC 2196870. PMID 11448987.
- ^ Sato, T; Fujii, T; Yokoyama, T; Fujita, Y; Imura, Y; Yukawa, N; Kawabata, D; Nojima, T; Ohmura, K; Usui, T; Mimori, T (Dec 2010). "Anti-U1 RNP antibodies in cerebrospinal fluid are associated with central neuropsychiatric manifestations in systemic lupus erythematosus and mixed connective tissue disease.". Arthritis and rheumatism 62 (12): 3730–40. doi:10.1002/art.27700. PMID 20722023.
Further reading
- Wilk HE, Schaefer KP, Agris PF et al. (1991). "U1 SnRNP association with HnRNP involves an initial non-specific splice-site independent interaction of U1 SnRNP protein with HnRNA.". Mol. Cell. Biochem. 106 (1): 55–66. doi:10.1007/BF00231189. PMID 1833625.
- Query CC, Bentley RC, Keene JD (1989). "A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein.". Cell 57 (1): 89–101. doi:10.1016/0092-8674(89)90175-X. PMID 2467746.
- Du Clos TW (1989). "C-reactive protein reacts with the U1 small nuclear ribonucleoprotein.". J. Immunol. 143 (8): 2553–9. PMID 2477447.
- Theissen H, Etzerodt M, Reuter R et al. (1987). "Cloning of the human cDNA for the U1 RNA-associated 70K protein.". EMBO J. 5 (12): 3209–17. PMC 1167314. PMID 3028775.
- Romac JM, Graff DH, Keene JD (1994). "The U1 small nuclear ribonucleoprotein (snRNP) 70K protein is transported independently of U1 snRNP particles via a nuclear localization signal in the RNA-binding domain.". Mol. Cell. Biol. 14 (7): 4662–70. PMC 358839. PMID 7516470.
- Wu JY, Maniatis T (1994). "Specific interactions between proteins implicated in splice site selection and regulated alternative splicing.". Cell 75 (6): 1061–70. doi:10.1016/0092-8674(93)90316-I. PMID 8261509.
- Woppmann A, Will CL, Kornstädt U et al. (1993). "Identification of an snRNP-associated kinase activity that phosphorylates arginine/serine rich domains typical of splicing factors.". Nucleic Acids Res. 21 (12): 2815–22. doi:10.1093/nar/21.12.2815. PMC 309659. PMID 8332490.
- Northemann W, Berg H, Stahnke G et al. (1996). "Identification of an inhibitory element within the human 68-kDa (U1) ribonucleoprotein antigen.". Protein Expr. Purif. 6 (6): 748–56. doi:10.1006/prep.1995.0005. PMID 8746626.
- Zhang WJ, Wu JY (1996). "Functional properties of p54, a novel SR protein active in constitutive and alternative splicing.". Mol. Cell. Biol. 16 (10): 5400–8. PMC 231539. PMID 8816452.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Hong W, Bennett M, Xiao Y et al. (1997). "Association of U2 snRNP with the spliceosomal complex E.". Nucleic Acids Res. 25 (2): 354–61. doi:10.1093/nar/25.2.354. PMC 146436. PMID 9016565.
- Klein Gunnewiek JM, van Aarssen Y, van der Kemp A et al. (1997). "Nuclear accumulation of the U1 snRNP-specific protein C is due to diffusion and retention in the nucleus.". Exp. Cell Res. 235 (1): 265–73. doi:10.1006/excr.1997.3663. PMID 9281376.
- Zhang WJ, Wu JY (1998). "Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing.". Mol. Cell. Biol. 18 (2): 676–84. PMC 108778. PMID 9447963.
- Blencowe BJ, Issner R, Nickerson JA, Sharp PA (1998). "A coactivator of pre-mRNA splicing.". Genes Dev. 12 (7): 996–1009. doi:10.1101/gad.12.7.996. PMC 316672. PMID 9531537.
- Cao W, Garcia-Blanco MA (1998). "A serine/arginine-rich domain in the human U1 70k protein is necessary and sufficient for ASF/SF2 binding.". J. Biol. Chem. 273 (32): 20629–35. doi:10.1074/jbc.273.32.20629. PMID 9685421.
- Neubauer G, King A, Rappsilber J et al. (1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex.". Nat. Genet. 20 (1): 46–50. doi:10.1038/1700. PMID 9731529.
- Xiao SH, Manley JL (1999). "Phosphorylation-dephosphorylation differentially affects activities of splicing factor ASF/SF2.". EMBO J. 17 (21): 6359–67. doi:10.1093/emboj/17.21.6359. PMC 1170960. PMID 9799243.
- Dumortier H, Klein Gunnewiek J, Roussel JP et al. (1999). "At least three linear regions but not the zinc-finger domain of U1C protein are exposed at the surface of the protein in solution and on the human spliceosomal U1 snRNP particle.". Nucleic Acids Res. 26 (23): 5486–91. doi:10.1093/nar/26.23.5486. PMC 147990. PMID 9826776.
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RNA-binding protein: Ribonucleoproteins
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|
| snRNP |
- A
- A1
- B
- B2
- C
- D1
- D2
- D3
- E
- F
- G
- N
|
|
| hnRNP |
|
|
| Other transcription |
|
|
| Translation |
|
|
Vault ribonucleoprotein
particles |
|
|
| Other |
- Signal recognition particle
|
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Index of genetics
|
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| Description |
- Gene expression
- DNA
- replication
- cycle
- recombination
- repair
- binding proteins
- Transcription
- factors
- regulators
- nucleic acids
- RNA
- RNA binding proteins
- ribonucleoproteins
- repeated sequence
- modification
- Translation
- ribosome
- modification
- nexins
- Proteins
- domains
- Structure
- primary
- secondary
- tertiary
- quaternary
|
|
| Disease |
- Replication and repair
- Transcription factor
- Transcription
- Translation
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UpToDate Contents
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English Journal
- Gastric Antral Vascular Ectasia and Its Clinical Correlates in Patients with Early Diffuse Systemic Sclerosis in the SCOT Trial.
- Hung EW, Mayes MD, Sharif R, Assassi S, Machicao VI, Hosing C, St Clair EW, Furst DE, Khanna D, Forman S, Mineishi S, Phillips K, Seibold JR, Bredeson C, Csuka ME, Nash RA, Wener MH, Simms R, Ballen K, Leclercq S, Storek J, Goldmuntz E, Welch B, Keyes-Elstein L, Castina S, Crofford LJ, McSweeney P, Sullivan KM.SourceFrom the Rheumatology Associates of Houston, a Division of Northwest Diagnostic Clinic, Houston, Texas; University of Texas Health Science Center at Houston, Houston, Texas; University of Texas Medical Branch, Galveston, Texas; MD Anderson Cancer Center, Houston, Texas; Duke University, Durham, North Carolina; University of California at Los Angeles, Los Angeles, California; University of Michigan, Ann Arbor, Michigan; City of Hope National Medical Center, Duarte, California; Scleroderma Research Consultants LLC, Avon, Connecticut, USA; Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Medical College of Wisconsin, Milwaukee, Wisconsin; Colorado Blood Cancer Institute, Rocky Mountain Blood and Marrow Transplant Program, Denver, Colorado; University of Washington, Seattle, Washington; Boston University School of Medicine, Boston, Massachusetts; Massachusetts General Hospital, Boston, Massachusetts, USA; University of Calgary, Calgary, Alberta, Canada; NIH/NIAID, Bethesda, Maryland; Rho, Chapel Hill, North Carolina; and the University of Kentucky, Lexington, Kentucky, USA.
- The Journal of rheumatology.J Rheumatol.2013 Apr;40(4):455-460. Epub 2013 Feb 15.
- OBJECTIVE: To describe the prevalence and clinical correlates of endoscopic gastric antral vascular ectasia (GAVE; "watermelon stomach") in early diffuse systemic sclerosis (SSc).METHODS: Subjects with early, diffuse SSc and evidence of specific internal organ involvement were considered for the Scl
- PMID 23418384
- Systemic sclerosis: demographic, clinical and serological features in 100 Iranian patients.
- Poormoghim H, Moghadam AS, Moradi-Lakeh M, Jafarzadeh M, Asadifar B, Ghelman M, Andalib E.SourceRheumatology Research Center, Firoozgar Hospital Tehran, Tehran University of Medical Sciences, Tehran, Iran, h-poormoghim@tums.ac.ir.
- Rheumatology international.Rheumatol Int.2013 Jan 24. [Epub ahead of print]
- To evaluate demographic, clinical and laboratory features associated with scleroderma-specific auto-antibodies. Sera of 100 patients with systemic sclerosis (SSc) were analyzed by an indirect immunofluorescence technique with HEp-2 cells as a substrate. Specific ANA such as anti-centromere antibodie
- PMID 23344826
- Correlation of interferon-inducible chemokine plasma levels with disease severity in systemic sclerosis.
- Liu X, Mayes MD, Tan FK, Wu M, Reveille JD, Harper BE, Draeger HT, Gonzalez EB, Assassi S.SourceUniversity of Texas Health Science Center at Houston, Houston, TX 77030, USA.
- Arthritis and rheumatism.Arthritis Rheum.2013 Jan;65(1):226-35. doi: 10.1002/art.37742.
- OBJECTIVE: To measure interferon (IFN)-inducible chemokines in the plasma of patients with systemic sclerosis (SSc) and investigate whether the chemokine levels are correlated with disease severity.METHODS: Plasma levels of the IFN-inducible chemokines IFNγ-inducible protein 10 (IP-10/CXCL10), IFN-
- PMID 23055137
Japanese Journal
- 混合性結合組織病と肺高血圧症 (特集 肺高血圧症の新展開)
- 自己抗体研究の新たな展開(第6回)混合性結合組織病 : 抗U1 RNP抗体
Related Links
- ... presented by human leukocyte antigen (HLA) molecules is a critical event in the generation of autoimmunity. The 70 kD anti-U1 RNP antibody response is associated with CD4/Th1 T cells. HLA-B*08 and DRB1*04:01 have 8 9 ...
- 抗RNP抗体, anti-ribonucleoprotein antibody 臨床的意義 抗U1-RNP抗体が対応するU1-RNP分子は、U1-RNAと9種の蛋白(70k，A，B'/B，C，D，E，F，G)の複合体である。この中で直接に反応する抗原は、70k，A，C蛋白で ...
★リンクテーブル★
[★]
- 英
- anti-U1-ribonucleoprotein antibody, anti-U1-RNP antibody
- 同
- 抗RNP抗体 anti-RNP antibody
[★]
[★]
[★]
- 同
- ants, stinging
[★]
リボ核タンパク質 ribonucleoprotein
[★]