WordNet

not in favor of (an action or proposal etc.)
a person who is opposed (to an action or policy or practice etc.); "the antis smelled victory after a long battle"
social insect living in organized colonies; characteristically the males and fertile queen have wings during breeding season; wingless sterile females are the workers (同)emmet, pismire
the 18th letter of the Roman alphabet (同)r
any of a large variety of proteins normally present in the body or produced in response to an antigen which it neutralizes, thus producing an immune response

PrepTutorEJDIC

《話》(特定の慣習・政策・行動などに)反対する人
『アリ』
=ain't
resistance / 17歳以下父兄同伴映画の表示 / rook
抗体,免疫体,抗毒素
(次にくる語の発音が母音で始まるときに用いる) / (子音[h]で始まり第1音節に強勢のない語の場合はanを用いることがある.ただし,この場合は[h]を発音しない)

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1. 混合性結合組織病における抗U1-RNP抗体 anti u1 rnp antibodies in mixed connective tissue disease
2. 2本鎖（ds）DNA、Sm、およびU1 RNPに対する抗体 antibodies to double stranded ds dna sm and u1 rnp
3. 混合性結合組織病の定義および診断 definition and diagnosis of mixed connective tissue disease
4. 抗核抗体の測定および臨床的意義 measurement and clinical significance of antinuclear antibodies
5. 混合性結合組織病の臨床症状 clinical manifestations of mixed connective tissue disease

English Journal

Infection and autoimmunity in Sjogren's syndrome: A clinical study and comprehensive review.

Kivity S1, Arango MT2, Ehrenfeld M3, Tehori O4, Shoenfeld Y5, Anaya JM6, Agmon-Levin N4.Author information 1The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel; Rheumatic Disease Unit, Sheba Medical Center, Tel-Hashomer, Israel; The Dr. Pinchas Borenstein Talpiot Medical Leadership Program 2013, Sheba Medical Center, Tel-Hashomer, Israel. Electronic address: kivitys@gmail.com.2The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel; Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia; Doctoral Program in Biomedical Sciences, Universidad del Rosario, Bogotá, Colombia.3The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel; Rheumatic Disease Unit, Sheba Medical Center, Tel-Hashomer, Israel.4The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Israel.5The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel; Incumbent of the Laura Schwarz-Kip Chair for Research of Autoimmune Diseases, Sackler Faculty of Medicine, Tel-Aviv University, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Israel. Electronic address: shoenfel@post.tau.ac.il.6Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.AbstractSjögren's syndrome (SS) is an autoimmune disease characterized primarily by lymphocytic infiltration of the exocrine glands, and autoantibody production. Multiple environmental factors affecting an individual with a genetic susceptibility may trigger the development of SS. Herein, we aimed to evaluate links between the different pebbles in the mosaic of SS. Demographic, clinical data and blood samples were gathered from 82 consecutive patients with SS, and 139 healthy controls. Samples were analyzed for infectious serology and auto-antibodies as well as for relevant genetic mutations (TAP genes) and cytokines levels. An immune response (IgG) against Epstein-Barr virus (EBV) early antigen (EA) was positively associated with SS (OR 4; 95% CI: 1.82-8.83, p = 0.001) while a protective effect of IgG anti-cytomegalovirus (CMV) was observed (OR 0.3; 95%CI: 0.16-0.74, p = 0.009). Anti-Ro/SSA, anti-LA/SSB, anti-nuclear, anti-gliadin, anti-TTG-IgG and anti-RNP antibodies were statistically more prevalent among SS patients than controls. Notably, the presence of anti-Ro/SSA and anti La/SSB correlated with anti-EBVEA IgG (OR 3.1; 95%CI: 1.08-8.74) and (OR 3.9; 95%CI: 1.37-10.96) respectively. Autoantibodies, cytokines and several genetic markers correlated with clinical manifestation of SS. Our data suggest that infectious agents may play both a causative and protective role in the pathogenesis of SS. Moreover certain autoantibodies, cytokines and specific TAP alleles correlate with clinical manifestations of SS, and may enable better prediction and/or directed therapy once confirmed in future studies.
Journal of autoimmunity.J Autoimmun.2014 Mar 14. pii: S0896-8411(14)00053-5. doi: 10.1016/j.jaut.2014.02.008. [Epub ahead of print]
Sjögren's syndrome (SS) is an autoimmune disease characterized primarily by lymphocytic infiltration of the exocrine glands, and autoantibody production. Multiple environmental factors affecting an individual with a genetic susceptibility may trigger the development of SS. Herein, we aimed to evalu
PMID 24637076

A69: Lupus Nephritis and Autoantibody Characteristics of a Single Center Cohort of Male Pediatric SLE Patients.

Wenderfer SE1, Canter D, Deguzman M, Muscal E.Author information 1Texas Children's Hospital, Houston, TX.AbstractBACKGROUND/PURPOSE: Males represent 4-22% of all SLE patients, but it is unclear if gender should influence management. A number of studies of mostly adult patients suggest genetic, hormonal and environmental aspects of gender differences contribute to differences in presentation, clinical course and outcome, including a positive association between male gender and nephritis and a negative association with disease activity and outcome. While differences may exist, these findings are supported by limited evidence, particularly for children and adolescents with SLE.
Arthritis & rheumatology (Hoboken, N.J.).Arthritis Rheumatol.2014 Mar;66 Suppl 11:S101. doi: 10.1002/art.38485.
BACKGROUND/PURPOSE: Males represent 4-22% of all SLE patients, but it is unclear if gender should influence management. A number of studies of mostly adult patients suggest genetic, hormonal and environmental aspects of gender differences contribute to differences in presentation, clinical course an
PMID 24677818

Epigenetic modulation of RFC1, MHC2TA and HLA-DR in systemic lupus erythematosus: association with serological markers and six functional polymorphisms of one-carbon metabolic pathway.

Rupasree Y1, Naushad SM2, Rajasekhar L3, Kutala VK4.Author information 1Department of Clinical Pharmacology & Therapeutics, Nizam's Institute of Medical Sciences (NIMS), Hyderabad 500082, India.2School of Chemical & Biotechnology, SASTRA University, Tirumalaisamudram, Thanjavur 613401, India.3Department of Rheumatology, Nizam's Institute of Medical Sciences (NIMS), Hyderabad 500082, India.4Department of Clinical Pharmacology & Therapeutics, Nizam's Institute of Medical Sciences (NIMS), Hyderabad 500082, India. Electronic address: vijaykutala@gmail.com.AbstractThe current study was conducted to elucidate the effect of genetic variations in one-carbon metabolism on the epigenetic regulation of major histocompatibility complex II transactivator (MHC2TA), reduced folate carrier 1 (RFC1/SLC19A1) and human leukocyte antigen (HLA)-DR in systemic lupus erythematosus (SLE). PCR-RFLP/AFLP, bisulfite-sequencing and real-time PCR approaches were used for genetic, epigenetic and expression analysis respectively. SLE cases exhibited elevated plasma homocysteine levels compared to healthy controls (24.93 ± 1.3 vs. 11.67 ± 0.48 μmol/l), while plasma folate levels showed no association (7.10 ± 2.49 vs. 7.64 ± 2.09 ng/ml). The RFC1 80G>A polymorphism showed 1.32-fold risk (95% CI: 1.02-1.72) for SLE, while glutamate carboxypeptidase II (GCPII) 1561C>T showed reduced risk (OR: 0.47, 95% CI: 0.24-0.90). The expression of RFC1 (0.37 ± 0.09 vs. 0.60 ± 0.17) and HLA-DR (0.68 ± 0.17 vs. 0.98 ± 0.02) was down regulated in the SLE cases. The hypermethylation of RFC1 as observed in the current study may contribute for its down regulation. Plasma folate and thymidylate synthase (TYMS) 5'-UTR 28 bp tandem repeat showed an inverse association with methylation of RFC1 and MHC2TA. SLE cases with hypocomplementemia showed hypermethylation of RFC1, hypomethylation/up regulation of MHC2TA and down regulation of HLA-DR. The hypermethylation of MHC2TA and down regulation of RFC1, MHC2TA and HLA-DR were observed in anti-cardiolipin antibody positive SLE cases. The up regulation of RFC1 and HLA-DR was observed in anti-dsDNA antibody positive SLE cases. The hypomethylation/upregulation of RFC1 and MHC2TA was observed in anti-RNP antibody positive cases. To conclude, one-carbon genetic variants influence epigenetic of MHC2TA and RFC1, thus contributing to phenotypic heterogeneity of SLE.
Gene.Gene.2014 Feb 15;536(1):45-52. doi: 10.1016/j.gene.2013.11.094. Epub 2013 Dec 12.
The current study was conducted to elucidate the effect of genetic variations in one-carbon metabolism on the epigenetic regulation of major histocompatibility complex II transactivator (MHC2TA), reduced folate carrier 1 (RFC1/SLC19A1) and human leukocyte antigen (HLA)-DR in systemic lupus erythemat
PMID 24333266

Japanese Journal

シェーグレン症候群・混合性結合組織病に蛋白漏出性胃腸症を合併した1例

柿ヶ尾佳奈,福嶋伸良,水谷孝弘,原口和大,岡本梨沙,澤村紀子,大橋朋子,光安彩,藤山隆,吉本剛志,國府島庸之,河邉顕,福泉公仁隆,中牟田誠,原田直彦
日本消化器病学会雑誌 109(10), 1770-1775, 2012
症例は58歳女性．腹部膨満感・下腿浮腫を主訴に，保存的加療にて改善しない著明な低蛋白血症を認めた．99mTc-DTPA結合ヒト血清アルブミンシンチグラフィー・α1-アンチトリプシンクリアランス試験などにて，消化管内腔への蛋白漏出が確認された．シェーグレン症候群と混合性結合組織病に続発した蛋白漏出性胃腸症の診断に至った．膠原病に合併した蛋白漏出性胃腸症の治療成績は一般に良好で，本症例もステロイドが奏 …
NAID 130001909422

高齢発症ループス膀胱炎の一例

湯川宗之助,太原恒一郎,林映,辻聡一郎,庄司亜樹,坪井紀興
日本臨床免疫学会会誌 = Japanese journal of clinical immunology 31(3), 183-189, 2008-06-30
… 症例は74歳，女性．平成10年レイノー現象出現．平成14年抗核抗体陽性を指摘され当科初診．白血球減少，抗DNA抗体陽性，抗RNP抗体陽性を認めたが，活動性病変を伴わず経過観察していた．平成17年2月より頻尿，残尿感が出現し，同年11月より下痢，嘔気を認め，当院入院．腹部CT上，両側水腎症，著明な水尿管および膀胱壁肥厚を認め，膀胱鏡では肉柱形成を認め，生検では間質性膀胱炎の所見を得た．また下 …
NAID 10021242762

Transforming Growth Factor Beta 1 Gene Polymorphism in Japanese Patients with Systemic Lupus Erythematosus

Wang Biao,Morinobu Akio,Kanagawa Sugayo,Nakamura Tomoko,Kawano Seiji,Koshiba Masahiro,Hashimoto Hiroshi,Kumagai Shunichi
The Kobe journal of the medical sciences 53(1), 15-23, 2007-02-00
… However, compared to the TC andCC genotypes, the TT genotype was associated with anti-SS-A/Ro antibody production(p=0.029) and a higher incidence of aseptic necrosis (p=0.0097); … the CC genotype had ahigher frequency of anti-RNP antibody production compared to the patients with theTC and TT genotypes (p=0.023). …
NAID 110006630184