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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/22 03:51:54」(JST)
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- 1. 神経筋疾患の評価における筋酵素 muscle enzymes in the evaluation of neuromuscular diseases
- 2. グリコーゲン代謝のその他の障害：GLUT2欠損症およびアルドラーゼA欠損症 other disorders of glycogen metabolism glut2 deficiency and aldolase a deficiency
- 3. 肝機能検査値異常が認められた患者に対するアプローチ approach to the patient with abnormal liver function tests
- 4. 成人の皮膚筋炎および多発性筋炎の臨床症状と診断 clinical manifestations and diagnosis of adult dermatomyositis and polymyositis
- 5. 筋力低下患者へのアプローチ approach to the patient with muscle weakness
English Journal
- Evaluation of ionic liquids as alternative solvents for aldolase activity: Use of a new automated SIA methodology.
- Cunha E1, Pinto PC2, Saraiva ML3.
- Talanta.Talanta.2015 Aug 15;141:293-9. doi: 10.1016/j.talanta.2015.04.028. Epub 2015 Apr 16.
- An automated methodology is proposed for the evaluation of a set of ionic liquids (ILs) as alternative reaction media for aldolase based synthetic processes. For that, the effect of traditionally used organic solvents and ILs on the activity of aldolase was studied by means of a novel automated meth
- PMID 25966417
- Overexpression of the phosphofructokinase encoding gene is crucial for achieving high production of D-lactate in Corynebacterium glutamicum under oxygen deprivation.
- Tsuge Y1, Yamamoto S, Kato N, Suda M, Vertès AA, Yukawa H, Inui M.
- Applied microbiology and biotechnology.Appl Microbiol Biotechnol.2015 Jun;99(11):4679-89. doi: 10.1007/s00253-015-6546-9. Epub 2015 Mar 31.
- We previously reported on the impacts of the overexpression of individual genes of the glycolytic pathway encoding glucokinase (GLK), glyceraldehyde phosphate dehydrogenase (GAPDH), phosphofructokinase (PFK), triosephosphate isomerase (TPI), and bisphosphate aldolase (FBA) on D-lactate productivity
- PMID 25820644
- Quantitative expression proteomics and phosphoproteomics profile of brain from PINK1 knockout mice: insights into mechanisms of familial Parkinson's disease.
- Triplett JC1, Zhang Z, Sultana R, Cai J, Klein JB, Büeler H, Butterfield DA.
- Journal of neurochemistry.J Neurochem.2015 Jun;133(5):750-65. doi: 10.1111/jnc.13039. Epub 2015 Mar 1.
- Parkinson's disease (PD) is an age-related, neurodegenerative motor disorder characterized by progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta and presence of α-synuclein-containing protein aggregates. Mutations in the mitochondrial Ser/Thr kinase PTEN-induced
- PMID 25626353
Japanese Journal
- Proteomic analysis for neuronal vacuolation induced by MK-801 in rat retrosplenial cortex
- Shiotani Motohiro,Nakano Kyoko,Yamauchi Emiko,Oda Yoshiya,Hosokawa Satoru,Aoki Toyohiko
- The Journal of Toxicological Sciences 36(1), 131-133, 2011
- … Comparison of changes in proteins in the RSC region between MK-801- and saline-treated groups revealed that MK-801 induced changes in six proteins involved in vesicular transport (vesicle-fusing ATPase) and glycolysis (fructose-bisphosphate aldolase C, triosephosphate isomerase, and glyceraldehyde-3-phosphate dehydrogenase). …
- NAID 130000438649
- アルギン酸代謝酵素の構造と機能
- 落合 秋人,高瀬 隆一,三上 文三,橋本 渉,村田 幸作
- ビタミン 84(11), 525-531, 2010-11-25
- … KDG is eventually metabolized to glyceraldehyde-3-phosphate and pyruvate through the sequential reaction catalyzed by KDG kinase (A1-K) and 2-keto-3-deoxy 6-phosphogluconate aldolase (A1-A). …
- NAID 110007989343
Related Links
- These tests are covered by medical insurance when necessary. Results are usually available the next day. muscle weakness caused by neurological diseases, such as polio or multiple sclerosis, but levels of aldolase will increase in ...
- bisphosphate aldolase class II signature 2 as highlighted in red color A multi allignment comparision was carried out like in GAPDH using the same species The dendrogram is shown here Notice that in this dendrogram A eutrophus is ...
Related Pictures
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★リンクテーブル★
| リンク元 | 「解糖系」「アルドラーゼ」「フルクトース1,6-ビスリン酸」「ジヒドロキシアセトンリン酸」「ALD」 |
| 拡張検索 | 「deficiency of 1-phosphofructaldolase」「aldolase isozyme」「erythrocyte aldolase deficiency」「aldolase deficiency」「aldolase欠乏症」 |
「解糖系」
- CH(OH)-CH(OH)-C(OH)H-CH(OH)-C(CH2OH)H-O- グルコース (OHが↓↓↑↓↑)
- CH(OH)-CH(OH)-C(OH)H-CH(OH)-C(CH2O-PO3)H-O- グルコース-6-リン酸 (OHが↓↓↑↓↑)
- C(CH2OH)OH-C(OH)H-CH(OH)-C(CH2O-PO3)H-O- フルクトース-6-リン酸
- C(CH2O-PO3)OH-C(OH)H-CH(OH)-C(CH2O-PO3)H-O- フルクトース-1,6-リン酸
glucose ↓-hexokinase/glucokinase(liver) glucose 6-phosphate ↓-phosphohexose isomerase fructose 6-phosphate ↓-phosphofructokinase fructose 1,6-bisphosphate ↓-aldolase glyceraldehyde 3-phosphate ↓-glyceraldehyde-3-phosphate dehydrogenase 1,3-bisphosphoglycerate ↓-phosphoglycerate kinase →ATP 3-phosphoglycerate ↓-phosphoglyceate mutase 2-phosphoglycerate ↓-enolase phosphoenolpyruvate ↓-pyruvate kinase → ATP pyruvate －(pyruvate dehydrogenase)→acetyl-CoA －(pyruvate carboxylase)→oxaloacetate－(NADH+H+)→malate
解糖系の酵素 (first aid step1 2006 p.87, FASTEP1_87_酵素一覧.xls)
| 1 | galactokinase | キナーゼ | |
| 2 | galactose-1-phosphate uridyltransferase | 転移酵素 | |
| 3 | hexokinase/glucokinase | キナーゼ | |
| 4 | glucose-6-phosphatase | ホスファターゼ | |
| 5 | glucose-6-phosphate dehydrogenase | 脱水素酵素 | |
| 6 | transketolase | ||
| 7 | phosphofructokinase | キナーゼ | |
| 8 | fructose-1,6-bisphosphatase | ホスファターゼ | |
| 9 | fructokinase | キナーゼ | フルクトキナーゼ |
| 10 | aldolase B | アルドラーゼ | |
| 11 | pyruvate kinase | キナーゼ | ピルビン酸キナーゼ |
| 12 | pyruvate dehydrogenase | 脱水素酵素 | ピルビン酸デヒドロゲナーゼ |
| 13 | HMG-CoA reductase | 還元酵素 | HMG-CoA還元酵素 |
| 14 | pyruvate carboxylase | カルボキシラーゼ | ピルビン酸カルボキシラーゼ |
| 15 | PEP carboxykinase | キナーゼ | PEPカルボキシキナーゼ |
| 16 | citrate synthase | 合成酵素 | クエン酸合成酵素 |
| 17 | α-ketoglutarate dehydrogenase | 脱水素酵素 | α-ケトグルタミン酸脱水素酵素 |
| 18 | ornithine transcarbamylase | 転移酵素 | オルニチンカルバモイルトランスフェラーゼ |
「アルドラーゼ」
- first aid step1 2006 p.87,89,93,319
アイソザイム(アルドラーゼアイソザイム)
- aldolase A：筋、赤血球
- FBPに親和性が高い (fructose-1,6-bisphosphate)
- aldolase B：肝臓、腎、小腸 (aldolase B = fructose-1-phosphate aldolase, フルクトース-1-リン酸アルドラーゼ)
- FBPとF1Pを基質にできる (fructose-1-phosphate)
- aldolase C：神経組織
臨床関連
アルドラーゼ欠損症
- ALD Aの異常：遺伝性溶血性貧血
- ALD Bの異常：遺伝性果糖不耐症
「フルクトース1,6-ビスリン酸」
- 英
- fructose 1,6-bisphosphate FBP
- 同
- フルクトース1,6-二リン酸 fructose 1,6-diphosphate
- 関
- [[]]
解糖系
「ジヒドロキシアセトンリン酸」
CH2-OH | C=0 | CH2-O-H2PO4