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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/06/26 11:48:23」(JST)

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3-Phosphoglyceric acid (3PG), or glycerate 3-phosphate (GP), is a biochemically significant 3-carbon molecule that is a metabolic intermediate in both glycolysis and the Calvin cycle.^{[citation needed]} This chemical is often termed PGA when referring to the Calvin cycle. In the Calvin cycle, 3-Phosphoglycerate is the product of the spontaneous split of an unstable 6-carbon intermediate formed by CO₂ fixation. Thus, two 3-phosphoglycerate molecules are produced for each molecule of CO₂ fixed.

Glycolysis[edit]

1,3-bisphospho-D-glycerate	3-phosphoglycerate kinase		3-phospho-D-glycerate	Phosphoglyceromutase	2-phospho-D-glycerate

	ADP	ATP

	ADP	ATP

	3-phosphoglycerate kinase			Phosphoglyceromutase

Compound C00236 at KEGG Pathway Database. Enzyme 2.7.2.3 at KEGG Pathway Database. Compound C00197 at KEGG Pathway Database. Enzyme 5.4.2.1 at KEGG Pathway Database. Compound C00631 at KEGG Pathway Database.

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

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Glycolysis and Gluconeogenesis edit

^ The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".

Calvin cycle[edit]

In the Calvin cycle, two glycerate 3-phosphate molecules are reduced to form two molecules of glyceraldehyde 3-phosphate (PGAL). This is the first compound formed during the C3 or Calvin cycle. It is a reactive biomolecule that is easily reduced.

Amino acid synthesis[edit]

Glycerate 3-phosphate is also a precursor for serine, which, in turn, can create cysteine and glycine through the homocysteine cycle.

Notes[edit]

This article about metabolism is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. ホスホグリセリン酸キナーゼ欠損症およびホスホグリセリン酸ムターゼ欠損症 phosphoglycerate kinase deficiency and phosphoglycerate mutase deficiency
2. グルコースおよびグリコーゲン代謝の遺伝性疾患の概要 overview of inherited disorders of glucose and glycogen metabolism
3. 小児における溶血性貧血の概要 overview of hemolytic anemias in children
4. 新生児における筋緊張低下を引き起こす末梢神経および筋肉の障害に関する概要 overview of peripheral nerve and muscle disorders causing hypotonia in the newborn
5. 代謝性ミオパチーへのアプローチ approach to the metabolic myopathies

English Journal

The Peculiar Glycolytic Pathway in Hyperthermophylic Archaea: Understanding Its Whims by Experimentation In Silico.

Zhang Y1, Kouril T2,3, Snoep JL4,5,6, Siebers B7, Barberis M8, Westerhoff HV9,10,11.
International journal of molecular sciences.Int J Mol Sci.2017 Apr 20;18(4). pii: E876. doi: 10.3390/ijms18040876.
PMID 28425930

Proteomic studies on anti-tumor agent ansamitocin P-3 producer Actinosynnema pretiosum in response to ammonium and isobutanol.

Lin J1, Zhong JJ2.
Bioprocess and biosystems engineering.Bioprocess Biosyst Eng.2017 Apr 5. doi: 10.1007/s00449-017-1763-5. [Epub ahead of print]
PMID 28382459

Molecular cloning, purification and characterization of Brugia malayi phosphoglycerate kinase.

Kumar R1, Doharey PK2, Saxena JK2, Rathaur S3.
Protein expression and purification.Protein Expr Purif.2017 Apr;132:152-163. doi: 10.1016/j.pep.2017.02.005. Epub 2017 Feb 10.
PMID 28192198

Japanese Journal

Down Regulation of Asparagine Synthetase and 3-Phosphoglycerate Dehydrogenase, and the Up-Regulation of Serine Dehydratase in Rat Liver from Intake of Excess Amount of Leucine Are Not Related to Leucine-Caused Amino Acid Imbalance

Journal of Nutritional Science and Vitaminology 61(6), 441-448, 2015
NAID 130005125480

Differentially expressed proteins in fluconazole-susceptible and fluconazole-resistant isolates of <i>Candida glabrata </i>

Drug Discoveries & Therapeutics 9(3), 191-196, 2015
NAID 130005088589

Modulation of Allosteric Regulation by E38K and G101N Mutations in the Potato Tuber ADP-glucose Pyrophosphorylase

Bioscience, biotechnology, and biochemistry 77(9), 1854-1859, 2013-09-23
NAID 10031202734

Related Pictures

image https://classconnection.s3.amazonaws Datei:1-Arseno-3-phosphoglycerate.svg this article compound 1 3 phosphoglycerate bisphosphoglycerate to 3 phosphoglycerate bisphosphoglycerate + ADP Description 3-phosphoglycerate.png

★リンクテーブル★

リンク元	「解糖系」「3PG」
関連記事	「phosphoglycerate」

「解糖系」

3-Phosphoglyceric acid
	IUPAC name (2R)-2-Hydroxy-3-phosphonooxypropanoic acid
Identifiers
CAS number	820-11-1
PubChem	439183
ChemSpider	388326
ChEBI	CHEBI:17794
ChEMBL	CHEMBL1160563
Jmol-3D images	Image 1
	SMILES C([C@H](C(=O)O)O)OP(=O)(O)O ;
	InChI InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/t2-/m1/s1 ; Key: OSJPPGNTCRNQQC-UWTATZPHSA-N ;
Properties
Molecular formula	C3H7O7P
Molar mass	186.06 g mol−1
	(verify) (what is: /?); Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
	Infobox references

　　[★]

英: glycolytic pathway
同: エムデン-マイヤーホフ経路 Embden-Meyerhof pathway
関: 解糖、TCA回路

CH(OH)-CH(OH)-C(OH)H-CH(OH)-C(CH2OH)H-O- グルコース (OHが↓↓↑↓↑)
CH(OH)-CH(OH)-C(OH)H-CH(OH)-C(CH2O-PO3)H-O- グルコース-6-リン酸 (OHが↓↓↑↓↑)
C(CH2OH)OH-C(OH)H-CH(OH)-C(CH2O-PO3)H-O- フルクトース-6-リン酸
C(CH2O-PO3)OH-C(OH)H-CH(OH)-C(CH2O-PO3)H-O- フルクトース-1,6-リン酸

glucose
↓-hexokinase/glucokinase(liver)
glucose 6-phosphate
↓-phosphohexose isomerase
fructose 6-phosphate
↓-phosphofructokinase
fructose 1,6-bisphosphate
↓-aldolase
glyceraldehyde 3-phosphate
↓-glyceraldehyde-3-phosphate dehydrogenase
1,3-bisphosphoglycerate
↓-phosphoglycerate kinase →ATP
3-phosphoglycerate
↓-phosphoglyceate mutase
2-phosphoglycerate
↓-enolase
phosphoenolpyruvate
↓-pyruvate kinase → ATP
pyruvate
　－(pyruvate dehydrogenase)→acetyl-CoA
　－(pyruvate carboxylase)→oxaloacetate－(NADH+H+)→malate

解糖系の酵素 (first aid step1 2006 p.87, FASTEP1_87_酵素一覧.xls)

1	galactokinase	キナーゼ
2	galactose-1-phosphate uridyltransferase	転移酵素
3	hexokinase/glucokinase	キナーゼ
4	glucose-6-phosphatase	ホスファターゼ
5	glucose-6-phosphate dehydrogenase	脱水素酵素
6	transketolase
7	phosphofructokinase	キナーゼ
8	fructose-1,6-bisphosphatase	ホスファターゼ
9	fructokinase	キナーゼ	フルクトキナーゼ
10	aldolase B		アルドラーゼ
11	pyruvate kinase	キナーゼ	ピルビン酸キナーゼ
12	pyruvate dehydrogenase	脱水素酵素	ピルビン酸デヒドロゲナーゼ
13	HMG-CoA reductase	還元酵素	HMG-CoA還元酵素
14	pyruvate carboxylase	カルボキシラーゼ	ピルビン酸カルボキシラーゼ
15	PEP carboxykinase	キナーゼ	PEPカルボキシキナーゼ
16	citrate synthase	合成酵素	クエン酸合成酵素
17	α-ketoglutarate dehydrogenase	脱水素酵素	α-ケトグルタミン酸脱水素酵素
18	ornithine transcarbamylase	転移酵素	オルニチンカルバモイルトランスフェラーゼ