acyl-CoA-cholesterol acyltransferase

アシルCoA・コレステロールアシルトランスフェラーゼ、アシルCoA・コレステロールアシル基転移酵素

関

ACAT、cholesterol acyltransferase、sterol O-acyltransferase

WordNet

1. the 3rd letter of the Roman alphabet (同)c
2. (music) the keynote of the scale of C major
3. a general-purpose programing language closely associated with the UNIX operating system
4. an animal sterol that is normally synthesized by the liver; the most abundant steroid in animal tissues (同)cholesterin
5. any group or radical of the form RCO- where R is an organic group; "an example of the acyl group is the acetyl group" (同)acyl_group

PrepTutorEJDIC

1. carbonの化学記号
2. コレステロール(胆汁・血液・神経組織などの脂肪性成分)
3. cobaltの化学記号

UpToDate Contents

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• 1. リポ蛋白の分類、代謝、およびアテローム性動脈硬化症における役割 lipoprotein classification metabolism and role in atherosclerosis
• 2. HDL代謝およびHDLコレステロール値異常の患者に対するアプローチ hdl metabolism and approach to the patient with abnormal hdl cholesterol levels
• 3. ペルオキシソーム病 peroxisomal disorders
• 4. 代謝性ミオパチーの原因 causes of metabolic myopathies
• 5. 棘状細胞（棘状赤血球および有棘赤血球）と標的細胞 spiculated cells echinocytes and acanthocytes and target cells

English Journal

• Synthesis of 24(S)-hydroxycholesterol esters responsible for the induction of neuronal cell death.

• Shibuya K1, Watanabe T2, Urano Y3, Takabe W3, Noguchi N3, Kitagishi H4.
• Bioorganic & medicinal chemistry.Bioorg Med Chem.2016 Jun 1;24(11):2559-66. doi: 10.1016/j.bmc.2016.04.024. Epub 2016 Apr 12.
• We synthesized several candidates of 24(S)-hydroxycholesterol (24S-OHC) esters, which are involved in neuronal cell death, through catalysis with acyl-CoA:cholesterol acyltransferase-1 (ACAT-1). We studied the regioselectivity of the acylation of the secondary alcohol at the 3- or 24-position of 24S
• PMID 27117262

• D38-cholesterol as a Raman active probe for imaging intracellular cholesterol storage.

• Alfonso-García A1, Pfisterer SG2, Riezman H3, Ikonen E2, Potma EO4.
• Journal of biomedical optics.J Biomed Opt.2016 Jun;21(6):61003. doi: 10.1117/1.JBO.21.6.061003.
• We generated a highly deuterated cholesterol analog (D38-cholesterol) and demonstrated its use for selective vibrational imaging of cholesterol storage in mammalian cells. D38-cholesterol produces detectable signals in stimulated Raman scattering (SRS) imaging, is rapidly taken up by cells, and is e
• PMID 26719944

• Abrogating cholesterol esterification suppresses growth and metastasis of pancreatic cancer.

• Li J1, Gu D2, Lee SS1, Song B1, Bandyopadhyay S3, Chen S4, Konieczny SF3,5, Ratliff TL5,6, Liu X5,7, Xie J2, Cheng JX1,5.
• Oncogene.Oncogene.2016 May 2. doi: 10.1038/onc.2016.168. [Epub ahead of print]
• Cancer cells are known to execute reprogramed metabolism of glucose, amino acids and lipids. Here, we report a significant role of cholesterol metabolism in cancer metastasis. By using label-free Raman spectromicroscopy, we found an aberrant accumulation of cholesteryl ester in human pancreatic canc
• PMID 27132508

Japanese Journal

• Pharmacological Characterization of [trans-5′-(4-Amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)-2′,3′-dihydrospiro(cyclohexane-1,1′-inden)-4-yl]acetic Acid Monobenzenesulfonate (JTT-553), a Novel Acyl CoA:Diacylglycerol Transferase (DGAT) 1 Inhibitor

• Tomimoto Daisuke,Okuma Chihiro,Ishii Yukihito [他],Akiyama Yoshiyuki,Ohta Takeshi,Kakutani Makoto,Ohkuma Yoshiaki,Ogawa Nobuya
• Biological and Pharmaceutical Bulletin 38(2), 263-269, 2015
• … Acyl CoA:diacylglycerol acyltransferase (DGAT) 1 is an enzyme that catalyzes the final step in triglyceride (TG) synthesis. … To measure the inhibitory activity of JTT-553 against DGAT1, TG synthesis using [14C]-labeled oleoyl-CoA was evaluated. …
• NAID 130004872263

• アミド軸不斉の化学 : 生物活性発現に寄与する立体構造の解明研究

• 田畑 英嗣
• 薬学雑誌 133(8), 853-866, 2013
• NAID 40019778248

• The Mechanism of Action of Bufalin in Inhibition of Lipid Droplet Accumulation in Mouse Macrophages

• Kobayashi Keisuke,Ohshiro Taichi,Matsuda Daisuke [他],Jiang Wei,Hong Bin,Si Shuyi,Tomoda Hiroshi
• Biological and Pharmaceutical Bulletin 36(3), 364-369, 2013
• … Bufalin selectively inhibited synthesis of [14C]cholesteryl ester (CE), a main component of lipid droplet, from [14C]oleic acid and [14C]cholesterol with IC50 values of 8.6 µM and 10 µM, respectively. … The postlysosomal metabolism of cholesterol to CE in macrophages was also inhibited by the compound with a similar IC50 value of 13.2 µM. …
• NAID 130003382077

Related Links

• Sterol O-acyltransferase - Wikipedia, the free encyclopedia

Sterol O-acyltransferase is an intracellular protein located in the endoplasmic reticulum that forms cholesterol esters from ... Thus, the two substrates of this enzyme are acyl-CoA and cholesterol, whereas its two products are CoA and ...

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「アシルCoA・コレステロールアシルトランスフェラーゼ」

　　[★]

英

acyl-CoA-cholesterol acyltransferase、ACAT

関

アシルCoA・コレステロールアシル基転移酵素、ステロールO-アシルトランスフェラーゼ、コレステロールアシルトランスフェラーゼ

「sterol O-acyltransferase」

　　[★]

ステロールO-アシルトランスフェラーゼ、ステロールO-アシル基転移酵素、ステロールO-アシル転移酵素

関

acyl-CoA-cholesterol acyltransferase、cholesterol acyltransferase

「アシルCoA・コレステロールアシル基転移酵素」

　　[★]

英

acyl-CoA-cholesterol acyltransferase

関

アシルCoA・コレステロールアシルトランスフェラーゼ

「C」

　　[★]

• 炭素 carbon
• シトシン cytosine
• システイン cysteine
• シチジン
• セルシウス度 摂氏 degrees Celsius degree C
• 産婦人科領域で「子宮外頚 子宮外頚部 exocervix」を表現するための略語

　 　 　 　

「acyltransferase」

　　[★]

アシルトランスフェラーゼ、アシル転移酵素、アシル基転移酵素

関

transacylase

「CoA」

　　[★]

• 大動脈縮窄症 coactation of the aorta
• 補酵素A coenzyme A

「COA」

　　[★] 補酵素A coenzyme A CoA

「cholesterol」

　　[★] コレステロール