同: ACS

WordNet

of critical importance and consequence; "an acute (or critical) lack of research funds"
having or demonstrating ability to recognize or draw fine distinctions; "an acute observer of politics and politicians"; "incisive comments"; "icy knifelike reasoning"; "as sharp and incisive as the stroke of a fang"; "penetrating insight"; "frequent penetrative observations" (同)discriminating, incisive, keen, knifelike, penetrating, penetrative, piercing, sharp
extremely sharp or intense; "acute pain"; "felt acute annoyance"; "intense itching and burning" (同)intense
having or experiencing a rapid onset and short but severe course; "acute appendicitis"; "the acute phase of the illness"; "acute patients"
of an angle; less than 90 degrees
box with a lid; used for storage; usually large and sturdy
a pattern of symptoms indicative of some disease
a complex of concurrent things; "every word has a syndrome of meanings"

PrepTutorEJDIC

(先の)『鋭い』,とがった / (痛み・感情などが)『激しい』,強い / (知力・感覚などが)『鋭い』,鋭敏な / (事態が)重大な / (病気が)急性の / (音が)高い,鋭い / 鋭角の
(ふた付きのじょうぶな)『大箱』,ひつ / 《米》たんす(=chest of drawers) / (…の)たんすいっぱい《+『of』+『名』》 / 『胸[部]』,肺
(疾患の徴候となる一群の)症徴候,症候群 / (事件・社会的状態などのパターンを示す)徴候形態

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/13 04:07:59」(JST)

wiki en

The acute chest syndrome is a vaso-occlusive crisis of the pulmonary vasculature commonly seen in patients with sickle cell anemia. This condition commonly manifests with pulmonary infiltrate on a chest x-ray.^[1]

Signs and symptoms

The crisis is a common complication in sickle-cell patients and can be associated with one or more symptoms including fever, cough, excruciating pain, sputum production, shortness of breath, or low oxygen levels.^[2]

Cause

Acute chest syndrome is often precipitated by a lung infection, and the resulting inflammation and loss of oxygen saturation leads to further sickling of red cells, thus exacerbating pulmonary and systemic hypoxemia, sickling, and vaso-occlusion.

Treatment

Broad spectrum antibiotics to cover common infections like strep pneumoniae and mycoplasma, pain control, and blood transfusion. Acute chest syndrome is an indication for exchange transfusion.

Bronchodilators may be useful but have not been well studied.^[3]

Prognosis

It may result in death,^[4] and it is one of the most common causes of death for sickle cell patients.^[5]

Prevention

Hydroxyurea is a medication that can help to prevent chest syndrome. It may cause a low white blood cell count, which can predispose the patient to some types of infection.^[6]

References

^ Betty Pace (2007). Renaissance of Sickle Cell Disease Research in the Genome Era. Imperial College Press. pp. 81–. ISBN 978-1-86094-645-5. Retrieved 15 June 2010.
^ Johnson, CS (1995). "Sickle-Cell Disease: The Acute Chest Syndrome".
^ Knight-Madden, JM; Hambleton, IR (Aug 2, 2014). "Inhaled bronchodilators for acute chest syndrome in people with sickle cell disease.". The Cochrane database of systematic reviews 8: CD003733. doi:10.1002/14651858.CD003733.pub3. PMID 25086371.
^ "acute chest syndrome" at Dorland's Medical Dictionary
^ Kumar, Abbas, Fausto. Robbins and Cotran: The Pathologic Basis of Disease, Page 631
^ Sickle cell disease (SCD). Centers for Disease Control and Prevention. Retrieved January 7, 2015.

This article about a disease of the blood or immune system is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 鎌状赤血球症を伴う成人における急性胸部症候群 acute chest syndrome in adults with sickle cell disease
2. 鎌状赤血球症を有する小児および思春期における急性胸部症候群 the acute chest syndrome in children and adolescents with sickle cell disease
3. 鎌状赤血球症の肺合併症の概要 overview of the pulmonary complications of sickle cell disease
4. 鎌状赤血球症の臨床症状の概要 overview of the clinical manifestations of sickle cell disease
5. Adenotonsillectomy for obstructive sleep apnea in children

English Journal

Association between the genetic polymorphisms of glutathione S-transferase (GSTM1 and GSTT1) and the clinical manifestations in sickle cell anemia.

de Oliveira Filho RA, Silva GJ, de Farias Domingos I, Hatzlhofer BL, da Silva Araújo A, de Lima Filho JL, Bezerra MA, Martins DB, de Araújo RF.SourceLaboratory of Immunopathology Keizo Asami, Federal University of Pernambuco, Recife -PE, Brazil.
Blood cells, molecules & diseases.Blood Cells Mol Dis.2013 Aug;51(2):76-9. doi: 10.1016/j.bcmd.2013.03.003. Epub 2013 Apr 13.
The hereditary deficiency of antioxidant enzymes when associated with sickle cell anemia (SCA) further contributes to the oxidation of hemoglobin S, which increases the formation of degradation products of this hemoglobin. The glutathione S transferases play an important role in the conjugation of g
PMID 23590899

Combined use of exercise electrocardiography, coronary calcium score and cardiac CT angiography for the prediction of major cardiovascular events in patients presenting with stable chest pain.

Versteylen MO, Joosen IA, Winkens MH, Laufer EM, Snijder RJ, Wildberger JE, Crijns HJ, Narula J, Hofstra L.SourceDepartment of Cardiology, Maastricht University Medic\al Center, Maastricht, The Netherlands. Electronic address: mathijs.versteylen@mumc.nl.
International journal of cardiology.Int J Cardiol.2013 Jul 15;167(1):121-5. doi: 10.1016/j.ijcard.2011.12.016. Epub 2012 Jan 5.
BACKGROUND: The usual diagnostic work-up of chest pain patients includes clinical risk profiling and exercise-ECG, possibly followed by additional tests. Recently cardiac computed tomographic angiography (CCTA) has been employed. We evaluated the prognostic value of the combined use of exercise-ECG
PMID 22225760

Coronary and Cardiac Computed Tomography in the Emergency Room: Current Status and Future Directions.

Cook TS, Galperin-Aizenberg M, Litt HI.SourceDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Journal of thoracic imaging.J Thorac Imaging.2013 Jun 6. [Epub ahead of print]
In the United States, chest pain is the second leading reason for patients to present to an emergency department (ED). Previously, those patients suspected to have acute coronary syndrome were monitored for 24 hours to determine the presence of serum biomarkers consistent with myocardial injury. How
PMID 23744126