関: ALCAM

WordNet

small room in which a monk or nun lives (同)cubicle
a device that delivers an electric current as the result of a chemical reaction (同)electric cell
a room where a prisoner is kept (同)jail cell, prison cell
(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
any small compartment; "the cells of a honeycomb"
a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
aerate (sewage) so as to favor the growth of organisms that decompose organic matter (同)aerate
make (substances) radioactive
make active or more active; "activate an old file"
make more adsorptive; "activate a metal"
rendered active; e.g. rendered radioactive or luminescent or photosensitive or conductive
(of e.g. a molecule) made reactive or more reactive (同)excited
(military) set up and placed on active assignment; "a newly activated unit"
(of sewage) treated with aeration and bacteria to aid decomposition
a fibrous band of scar tissue that binds together normally separate anatomical structures
abnormal union of bodily tissues; most common in the abdomen
(physics and chemistry) the simplest structural unit of an element or compound

PrepTutorEJDIC

(刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
…'を'活動的にする / …‘に'放射能を与える / 〈物質〉'を'活性化する
粘着,付着
分子《略》『mol』) / (一般に)(…の)微量《+『of』+『名』》

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2018/03/01 15:40:51」(JST)

wiki en

CD166 antigen is a 100-105 kD typeI transmembrane glycoprotein that is a member of the immunoglobulin superfamily of proteins. In humans it is encoded by the ALCAM gene.^[5]^[6] It is also called CD166 (cluster of differentiation 166), MEMD,^[7] SC-1/DM-GRASP/BEN in the chicken, and KG-CAM in the rat.

Some literature sources have also cited it as the CD6 ligand (CD6L). It is expressed on activated T cells, activated monocytes, epithelial cells, fibroblasts, neurons, melanoma cells, and also in sweat and sebaceous glands.^{[citation needed]} CD166 protein expression is reported to be upregulated in a cell line deriving from a metastasizing melanoma.^[7] CD166 plays an important role in mediating adhesion interactions between thymic epithelial cells and CD6+ cells during intrathymic T cell development.^{[citation needed]}

Recently, CD166 has also been used as a potential cancer stem cell marker.^{[citation needed]}

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170017 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022636 - Ensembl, May 2017
^ "Human PubMed Reference:".
^ "Mouse PubMed Reference:".
^ Bowen MA, Patel DD, Li X, Modrell B, Malacko AR, Wang WC, Marquardt H, Neubauer M, Pesando JM, Francke U, et al. (Jun 1995). "Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand". J Exp Med. 181 (6): 2213–20. doi:10.1084/jem.181.6.2213. PMC 2192054 . PMID 7760007.
^ "Entrez Gene: ALCAM activated leukocyte cell adhesion molecule".
^ ^a ^b Degen WG, van Kempen LC, Gijzen EG, et al. (1998). "MEMD, a new cell adhesion molecule in metastasizing human melanoma cell lines, is identical to ALCAM (activated leukocyte cell adhesion molecule)". Am. J. Pathol. 152 (3): 805–13. PMC 1858405 . PMID 9502422.

External links

ALCAM at the US National Library of Medicine Medical Subject Headings (MeSH)
Human ALCAM genome location and ALCAM gene details page in the UCSC Genome Browser.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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1. 輸血関連急性肺障害（TRALI） transfusion related acute lung injury trali
2. 輸血合併症の予防のための白血球除去 leukoreduction to prevent complications of blood transfusion
3. リウマチ性疾患におけるサイトカインネットワーク：治療の意味 cytokine networks in rheumatic diseases implications for therapy
4. 複合免疫不全 combined immunodeficiencies
5. 炎症の病因における白血球内皮細胞接着 leukocyte endothelial adhesion in the pathogenesis of inflammation

English Journal

Hypoxia-preconditioned mesenchymal stem cells ameliorate ischemia/reperfusion-induced lung injury.

Liu YY1,2,3, Chiang CH1,2,4, Hung SC3,5,6,7,8, Chian CF9, Tsai CL9, Chen WC1,2, Zhang H10.
PloS one.PLoS One.2017 Nov 8;12(11):e0187637. doi: 10.1371/journal.pone.0187637. eCollection 2017.
PMID 29117205

Stromal Expression of Activated Leukocyte Cell Adhesion Molecule Promotes Lung Tumor Growth and Metastasis.

Willrodt AH1, Beffinger M2, Vranova M1, Protsyuk D3, Schuler K1, Jadhav M1, Heikenwalder M4, van den Broek M2, Borsig L3, Halin C5.
The American journal of pathology.Am J Pathol.2017 Nov;187(11):2558-2569. doi: 10.1016/j.ajpath.2017.07.008. Epub 2017 Aug 17.
PMID 28822802

Human endoglin as a potential new partner involved in platelet-endothelium interactions.

Rossi E1,2,3,4, Pericacho M5,6, Bachelot-Loza C3,4, Pidard D3,4, Gaussem P3,4,7, Poirault-Chassac S3,4, Blanco FJ1,2, Langa C1,2, González-Manchón C1,2, Novoa JML5,6, Smadja DM3,4,7, Bernabeu C8,9.
Cellular and molecular life sciences : CMLS.Cell Mol Life Sci.2017 Oct 28. doi: 10.1007/s00018-017-2694-7. [Epub ahead of print]
PMID 29080903

Japanese Journal

9-24.ヒト胚および子宮内膜上皮におけるactivated leukocyte cell adhesion molecule(ALCAM/CD166)の発現(第40群生殖生理・病理5)(一般演題)

明坂治子,巽啓司,吉岡信也,樋口壽宏,小阪謙三,佐藤幸保,西岡良泰,江川美保,藤原浩,藤井信吾
日本産科婦人科學會雜誌 56(2), 438, 2004-02-01
NAID 110002101237

胚との相互作用における着床期子宮内膜の機能変化とその分子機構の解析(子宮内膜機能の調節機構 : 着床機構の視点から)

巽啓司
日本産科婦人科學會雜誌 55(8), 1047-1057, 2003-08-01
… ている可能性が示唆された.またEph-ephrin系などによって胚接着を抑制的に制御する機構の存在が示唆された.シグナル伝達作用をもつ接着分子であるALCAM (Activated leukocyte cell adhesion molecule)がヒト子宮内膜上皮細胞と胚に発現していた.またEph-ephrinにより分離ヒト子宮内膜上皮細胞の凝集が抑制されたことより,ひとたび胚着床が開始された後 …
NAID 110002100222

骨・軟骨--間葉系幹細胞からの分化誘導メカニズム (再生医学) -- (組織幹細胞)

新井文用,須田年生
Molecular medicine : 分子医学を臨床へ 40(-), 246-256, 2003
NAID 50000772252

「ALCAM」

ALCAM
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5A2F
Identifiers
Aliases	ALCAM, CD166, MEMD, activated leukocyte cell adhesion molecule
External IDs	MGI: 1313266 HomoloGene: 1229 GeneCards: ALCAM
Gene location (Human)
Chr.	Chromosome 3 (human)
End	105,576,900 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	52,454,074 bp
Gene ontology
Molecular function	• protein binding; • receptor binding; • identical protein binding;
Cellular component	• integral component of membrane; • cell projection; • membrane; • focal adhesion; • intrinsic component of plasma membrane; • plasma membrane; • integral component of plasma membrane; • T cell receptor complex; • extracellular region; • axon; • neuronal cell body; • dendrite; • immunological synapse; • extracellular exosome; • external side of plasma membrane;
Biological process	• heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; • adaptive immune response; • immune system process; • neuron projection extension; • cell adhesion; • motor neuron axon guidance; • axon extension involved in axon guidance; • signal transduction; • retinal ganglion cell axon guidance; • axon guidance;
	Sources:Amigo / QuickGO
Orthologs
	214
	11658
	ENSG00000170017
	ENSMUSG00000022636
	Q13740
	Q61490
	NM_001627; NM_001243280; NM_001243281; NM_001243283
	NM_009655; NM_001331110
	NP_001230209; NP_001230210; NP_001230212; NP_001618
	NP_001318039; NP_033785
	Wikidata
View/Edit Human	View/Edit Mouse

　　[★]

活性化白血球細胞接着分子

関: activated-leukocyte cell adhesion molecule

「活性化白血球細胞接着分子」

　　[★]

英: activated-leukocyte cell adhesion molecule、ALCAM

「adhesion」

　　[★]

n

接着、付着、粘着、粘着力、凝着、密着、溶着、癒着、支持、索状帯。固守、執着

「activated」

　　[★]

adj.

活性化の、活性化型の、賦活化の

関: activate、activated form、activation、turn on

「activate」

　　[★]

v.

活性化する、賦活化する、賦活する

関: activated、activation、turn on

「molecule」

　　[★]

分子

関: mol、molecular、numerator

「cell」

　　[★] 細胞　　　　　　　

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170017 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022636 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid7760007-5] Bowen MA, Patel DD, Li X, Modrell B, Malacko AR, Wang WC, Marquardt H, Neubauer M, Pesando JM, Francke U, et al. (Jun 1995). "Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand". J Exp Med. 181 (6): 2213–20. doi:10.1084/jem.181.6.2213. PMC 2192054 . PMID 7760007.

[entrez-6] "Entrez Gene: ALCAM activated leukocyte cell adhesion molecule".

[Degan1998-7] Degen WG, van Kempen LC, Gijzen EG, et al. (1998). "MEMD, a new cell adhesion molecule in metastasizing human melanoma cell lines, is identical to ALCAM (activated leukocyte cell adhesion molecule)". Am. J. Pathol. 152 (3): 805–13. PMC 1858405 . PMID 9502422.

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1-50	CD1 a-c 1A 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

リンク元	「ALCAM」「活性化白血球細胞接着分子」
関連記事	「adhesion」「activated」「activate」「molecule」「cell」

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案内

案内

activated-leukocyte cell adhesion molecule