WordNet
- locate (a moving entity) by means of a tracking system such as radar
- win something through ones efforts; "I acquired a passing knowledge of Chinese"; "Gain an understanding of international finance" (同)win, gain
- partial or complete loss of hearing (同)hearing_loss
- gotten through environmental forces; "acquired characteristics (such as a suntan or a broken nose) cannot be passed on"
PrepTutorEJDIC
- (不断の努力・習慣などで)…'を'『習得する』,身につける / 〈財産・権利など〉'を'手に入れる,取得する
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- 1. 小児における聴覚障害：病因 hearing impairment in children etiology
- 2. 突発性難聴 sudden sensorineural hearing loss
- 3. 新生児における難聴スクリーニング screening the newborn for hearing loss
- 4. 成人における難聴の病因 etiology of hearing loss in adults
- 5. 成人における難聴の評価 evaluation of hearing loss in adults
English Journal
- Methionine sulfoxide reductase B3 deficiency causes hearing loss due to stereocilia degeneration and apoptotic cell death in cochlear hair cells.
- Kwon TJ1, Cho HJ, Kim UK, Lee E, Oh SK, Bok J, Bae YC, Yi JK, Lee JW, Ryoo ZY, Lee SH, Lee KY, Kim HY.Author information 1Department of Biology, College of Natural Sciences.AbstractMethionine sulfoxide reductase B3 (MsrB3) is a protein repair enzyme that specifically reduces methionine-R-sulfoxide to methionine. A recent genetic study showed that the MSRB3 gene is associated with autosomal recessive hearing loss in human deafness DFNB74. However, the precise role of MSRB3 in the auditory system and the pathogenesis of hearing loss have not yet been determined. This work is the first to generate MsrB3 knockout mice to elucidate the possible pathological mechanisms of hearing loss observed in DFNB74 patients. We found that homozygous MsrB3(-/-) mice were profoundly deaf and had largely unaffected vestibular function, whereas heterozygous MsrB3(+/-) mice exhibited normal hearing similar to that of wild-type mice. The MsrB3 protein is expressed in the sensory epithelia of the cochlear and vestibular tissues, beginning at E15.5 and E13.5, respectively. Interestingly, MsrB3 is densely localized at the base of stereocilia on the apical surface of auditory hair cells. MsrB3 deficiency led to progressive degeneration of stereociliary bundles starting at P8, followed by a loss of hair cells, resulting in profound deafness in MsrB3(-/-) mice. The hair cell loss appeared to be mediated by apoptotic cell death, which was measured using TUNEL and caspase 3 immunocytochemistry. Taken together, our data suggest that MsrB3 plays an essential role in maintaining the integrity of hair cells, possibly explaining the pathogenesis of DFNB74 deafness in humans caused by MSRB3 deficiency.
- Human molecular genetics.Hum Mol Genet.2014 Mar 15;23(6):1591-601. doi: 10.1093/hmg/ddt549. Epub 2013 Nov 3.
- Methionine sulfoxide reductase B3 (MsrB3) is a protein repair enzyme that specifically reduces methionine-R-sulfoxide to methionine. A recent genetic study showed that the MSRB3 gene is associated with autosomal recessive hearing loss in human deafness DFNB74. However, the precise role of MSRB3 in t
- PMID 24191262
- Clinical and genetic aspects of hypophosphatasia in Japanese patients.
- Taketani T1, Onigata K, Kobayashi H, Mushimoto Y, Fukuda S, Yamaguchi S.Author information 1Division of Blood Transfusion, Shimane University Hospital, , Shimane, Japan.AbstractOBJECTIVE: We examined the clinical and genetic features of hypophosphatasia (HPP) in Japanese patients. HPP is a rare metabolic bone disorder of bone mineralisation caused by mutations in the liver/bone/kidney alkaline phosphatase (ALPL) gene, which encodes tissue-non-specific alkaline phosphatase isoenzyme.
- Archives of disease in childhood.Arch Dis Child.2014 Mar;99(3):211-5. doi: 10.1136/archdischild-2013-305037. Epub 2013 Nov 25.
- OBJECTIVE: We examined the clinical and genetic features of hypophosphatasia (HPP) in Japanese patients. HPP is a rare metabolic bone disorder of bone mineralisation caused by mutations in the liver/bone/kidney alkaline phosphatase (ALPL) gene, which encodes tissue-non-specific alkaline phosphatase
- PMID 24276437
- Role of cerebral ultrasound and magnetic resonance imaging in newborns with congenital cytomegalovirus infection.
- Capretti MG1, Lanari M2, Tani G3, Ancora G4, Sciutti R3, Marsico C4, Lazzarotto T5, Gabrielli L5, Guerra B6, Corvaglia L4, Faldella G4.Author information 1Department of Obstetrical, Gynaecological and Paediatric Sciences, Operative Unit of Neonatology, St. Orsola-Malpighi General Hospital, University of Bologna, Italy. Electronic address: mariagrazia.capretti@virgilio.it.2Paediatric Department, S. Maria della Scaletta Hospital, Imola, Italy.3Department of Obstetrical, Gynaecological and Paediatric Sciences, Operative Unit of Paediatric Radiology, St. Orsola-Malpighi General Hospital, University of Bologna, Italy.4Department of Obstetrical, Gynaecological and Paediatric Sciences, Operative Unit of Neonatology, St. Orsola-Malpighi General Hospital, University of Bologna, Italy.5Department of Haematology, Oncology and Laboratory Medicine, Operative Unit of Microbiology and Virology, St. Orsola-Malpighi General Hospital, University of Bologna, Italy.6Department of Obstetrical, Gynaecological and Paediatric Sciences, Operative Unit of Obstetrics and Gynaecology, St. Orsola-Malpighi General Hospital, University of Bologna, Italy.AbstractPurpose: To assess the diagnostic and prognostic value of cerebral magnetic resonance imaging (cMRI) in comparison with that of cerebral ultrasound (cUS) in predicting neurodevelopmental outcome in newborns with congenital cytomegalovirus (CMV) infection. Methods: Forty CMV-congenitally infected newborns underwent cUS and cMRI within the first month of life. Clinical course, laboratory findings, visual/hearing function and neurodevelopmental outcome were documented. Results: Thirty newborns showed normal cMRI, cUS and hearing/visual function in the first month of life; none showed CMV-related abnormalities at follow-up. Six newborns showed pathological cMRI and cUS findings (pseudocystis, ventriculomegaly, calcifications, cerebellar hypoplasia) but cMRI provided additional information (white matter abnormalities in three cases, lissencephaly/polymicrogyria in one and a cyst of the temporal lobe in another one); cerebral calcifications were detected in 3/6 infants by cUS but only in 2/6 by cMRI. Four of these 6 infants showed severe neurodevelopmental impairment and five showed deafness during follow-up. Three newborns had a normal cUS, but cMRI documented white matter abnormalities and in one case also cerebellar hypoplasia; all showed neurodevelopmental impairment and two were deaf at follow-up. One more newborn showed normal cUS and cMRI, but brainstem auditory evoked responses were abnormal; psychomotor development was normal at follow-up. Conclusions: Compared with cUS, cMRI disclosed additional pathological findings in CMV-congenitally infected newborns. cUS is a readily available screening tool useful in the identification of infected newborns with major cerebral involvement. Further studies with a larger sample size are needed to determine the prognostic role of MRI, particularly regarding isolated white matter lesions.
- Brain & development.Brain Dev.2014 Mar;36(3):203-11. doi: 10.1016/j.braindev.2013.04.001. Epub 2013 May 3.
- Purpose: To assess the diagnostic and prognostic value of cerebral magnetic resonance imaging (cMRI) in comparison with that of cerebral ultrasound (cUS) in predicting neurodevelopmental outcome in newborns with congenital cytomegalovirus (CMV) infection. Methods: Forty CMV-congenitally infected new
- PMID 23647916
Japanese Journal
- 幼小児の人工内耳手術--先天性および後天性高度難聴児に聴覚を回復させる新しい医療 (未来をひらく 脳科学のススメ(第6回))
- 加我 君孝,竹腰 英樹,新正 由紀子 [他]
- バイオインダストリー 26(3), 92-98, 2009-03
- NAID 40016470319
- 復職に至った純粋語聾の1例に対するリハビリテーションの経験
- 後藤 杏里,佐々木 信幸,菅原 英和 [他],角田 亘,安保 雅博
- リハビリテーション医学 : 日本リハビリテーション医学会誌 45(4), 242-247, 2008-04-18
- … We report a 47-year-old right-handed male patient with pure word deafness after suffering an intracerebral hemorrhage. … After the diagnosis of pure word deafness was clinically made, we educated the patient and his family, as well as the associated medical staff at our department, about this condition so that they could understand his pathological situation. …
- NAID 110006656169
- 進行性難聴児に対する人工内耳装用指導の留意点 : 装用年齢の異なる2症例での比較
- 森 壽子,川崎 美香,森 尚彫,黒田 生子,藤本 政明,モリ トシコ,カワサキ ミカ,モリ ナオエ,クロダ セイコ,フジモト マサアキ,Toshiko MORI,Mika KAWASAKI,Naoe MORI,Seiko KURODA,Masaaki FUJIMOTO
- 北海道医療大学心理科学部研究紀要 : J Psychol Sci 3, 73-80, 2007
- … We examined a point to keep in mind of the guidance and the role of the speech therapist about the progressive nerve deafness children who varied in the discovery time and the wearing time of the cochlear implant. … We manage the periodical hearing ability and we can add it and an aural decrease and must perform cochlear implant wearing in the guidance of children with progressive nerve deafness in spite of being a thought. …
- NAID 120005452818
Related Links
- acquired deafness A term for non-inherited, non-congenital loss of hearing, which is often linked to chronic occupational or recreational exposure to loud noise (acoustic trauma). acquired deafness See Noise-induced hearing loss.
- Acquired deafness and hearing loss in dogs may be due to ear infections or other causes. ... Dogs with acquired deafness are born with the capability of developing and maintaining normal hearing, but hearing is lost as the animal ...
Related Pictures
★リンクテーブル★
| リンク元 | 「bilateral deafness」「後天性難聴」 |
| 関連記事 | 「deafness」「acquire」 |
「bilateral deafness」
「後天性難聴」
- 英
- acquired deafness
- 関
- 難聴、両側性難聴、聾唖
「deafness」
- n.
- 聴覚消失
- 難聴。(人の話を故意に)聞こうとしないこと。耳が聞こえないこと、ろう、聾
- 1. the quality of being unable to hear, either completely or partly. 2.an unwillingness to listen, or a lack of understanding about something(https://dictionary.cambridge.org/dictionary/english/deafness)
「acquire」
- v.
- 獲得する、取得する、得る