acetyl-CoA hydrolase

アセチルCoA加水分解酵素、アセチルCoAヒドロラーゼ

WordNet

1. the 3rd letter of the Roman alphabet (同)c
2. (music) the keynote of the scale of C major
3. a general-purpose programing language closely associated with the UNIX operating system
4. the organic group of acetic acid (CH3CO-) (同)acetyl_group, acetyl radical, ethanoyl group, ethanoyl radical

PrepTutorEJDIC

1. carbonの化学記号
2. cobaltの化学記号

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/11/02 19:18:57」(JST)

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acetyl-CoA hydrolase
Identifiers
EC number	3.1.2.1
CAS number	9027-54-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, an acetyl-CoA hydrolase (EC 3.1.2.1) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + H₂O CoA + acetate + H+

Thus, the two substrates of this enzyme are acetyl-CoA and H₂O, whereas its two products are CoA and acetate.

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is acetyl-CoA hydrolase. Other names in common use include acetyl-CoA deacylase, acetyl-CoA acylase, acetyl coenzyme A hydrolase, acetyl coenzyme A deacylase, acetyl coenzyme A acylase, and acetyl-CoA thiol esterase. This enzyme participates in pyruvate metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2H4U.

References

• Gergely J, Hele P and Ramakrishnan CV (1952). "Succinyl and acetyl coenzyme A deacylases". J. Biol. Chem. 198 (1): 323–334. PMID 12999747. 

UpToDate Contents

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English Journal

• Identification and computational annotation of genes differentially expressed in pulp development of Cocos nucifera L. by suppression subtractive hybridization.

• Liang Y, Yuan Y, Liu T, Mao W, Zheng Y, Li D1.
• BMC plant biology.BMC Plant Biol.2014 Aug 2;14(1):205. doi: 10.1186/s12870-014-0205-7.
• BACKGROUND: Coconut (Cocos nucifera L.) is one of the world's most versatile, economically important tropical crops. Little is known about the physiological and molecular basis of coconut pulp (endosperm) development and only a few coconut genes and gene product sequences are available in public dat
• PMID 25084812

• Candida albicans utilizes a modified β-oxidation pathway for the degradation of toxic propionyl-CoA.

• Otzen C1, Bardl B, Jacobsen ID, Nett M, Brock M.
• The Journal of biological chemistry.J Biol Chem.2014 Mar 21;289(12):8151-69. doi: 10.1074/jbc.M113.517672. Epub 2014 Feb 4.
• Propionyl-CoA arises as a metabolic intermediate from the degradation of propionate, odd-chain fatty acids, and some amino acids. Thus, pathways for catabolism of this intermediate have evolved in all kingdoms of life, preventing the accumulation of toxic propionyl-CoA concentrations. Previous studi
• PMID 24497638

• Functional screening and in vitro analysis reveal thioesterases with enhanced substrate specificity profiles that improve short-chain fatty acid production in Escherichia coli.

• McMahon MD1, Prather KL.
• Applied and environmental microbiology.Appl Environ Microbiol.2014 Feb;80(3):1042-50. doi: 10.1128/AEM.03303-13. Epub 2013 Nov 22.
• Short-chain fatty acid (SCFA) biosynthesis is pertinent to production of biofuels, industrial compounds, and pharmaceuticals from renewable resources. To expand on Escherichia coli SCFA products, we previously implemented a coenzyme A (CoA)-dependent pathway that condenses acetyl-CoA to a diverse gr
• PMID 24271180

Japanese Journal

• Acetate generation in rat liver mitochondria ; acetyl-CoA hydrolase activity is demonstrated by 3-ketoacyl-CoA thiolase

• YAMASHITA H.
• Biochim. Biophys. Acta 1761, 17-23, 2006
• NAID 80019274547

• 脂質の新しい代謝調節酵素,マウス細胞質アセチルCoA水解酵素cDNAの塩基配列決定と組換えタンパク質の発現

• 末松 直也,岡本 一起,礒橋 文秀
• ビタミン 77(7), 359-360, 2003-07-25
• NAID 110002843240

Related Links

• GO:0003986 acetyl-CoA hydrolase activity

Type Synonym exact acetyl-CoA deacylase activity exact acetyl-CoA acylase activity exact acetyl coenzyme A hydrolase activity exact acetyl-CoA thiol esterase activity exact acetyl coenzyme A deacylase activity exact acetyl ...

• ACH1 - Acetyl-CoA hydrolase - Yarrowia lipolytica (strain ...

Acetyl-CoA hydrolase Gene ACH1 Organism Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) Sequence features View only features (sites, domains, PTMs ...) Status Reviewed-Annotation score: - i Display ...

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★リンクテーブル★

リンク元	「アセチルCoAヒドロラーゼ」「アセチルCoA加水分解酵素」
関連記事	「C」「CoA」「hydrolase」「hydrolases」「COA」

「アセチルCoAヒドロラーゼ」

　　[★]

英

acetyl-CoA hydrolase

関

アセチルCoA加水分解酵素

「アセチルCoA加水分解酵素」

　　[★]

英

acetyl-CoA hydrolase

関

アセチルCoAヒドロラーゼ

「C」

　　[★]

• 炭素 carbon
• シトシン cytosine
• システイン cysteine
• シチジン
• セルシウス度 摂氏 degrees Celsius degree C
• 産婦人科領域で「子宮外頚 子宮外頚部 exocervix」を表現するための略語

　 　 　 　

「CoA」

　　[★]

• 大動脈縮窄症 coactation of the aorta
• 補酵素A coenzyme A

「hydrolase」

　　[★]

• n.

• ヒドロラーゼ、加水分解酵素

「hydrolases」

　　[★]

• n.

• ヒドロラーゼ、加水分解酵素

「COA」

　　[★] 補酵素A coenzyme A CoA