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the 3rd letter of the Roman alphabet (同)c
(music) the keynote of the scale of C major
a general-purpose programing language closely associated with the UNIX operating system

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carbonの化学記号
cesiumの化学記号
cadmiumの化学記号

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/12/26 20:43:45」(JST)

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Vascular endothelial growth factor C is a VEGF. The human gene encoding it is VEGFC.

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis, lymphangiogenesis ^[1] and endothelial cell growth and survival, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms that bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. The structure and function of this protein is similar to those of vascular endothelial growth factor D (VEGF-D).^[2]

Mutations in VEGFC cause Milroy disease .Balboa-Beltran, E; Fernández-Seara, M. J.; Pérez-Muñuzuri, A; Lago, R; García-Magán, C; Couce, M. L.; Sobrino, B; Amigo, J; Carracedo, A; Barros, F (2014). "A novel stop mutation in the vascular endothelial growth factor-C gene (VEGFC) results in Milroy-like disease". Journal of Medical Genetics 51 (7): 475–8. doi:10.1136/jmedgenet-2013-102020. PMID 24744435. edit

Pathological VEGF-C Expression

Lymphedema is caused by an imbalance between lymphatic vessel formation and absorption. Experimentally this can be created by overexpression of VEGF-C Lymphangioma: Overexpression of VEGF-C causes lymphatics to enlarge possibly facilitates metastasis.

References

^ "Oncogene: Vascular endothelial growth factor receptors in the regulation of angiogenesis and lymphangiogenesis".
^ "Entrez Gene: VEGFC vascular endothelial growth factor C".

UpToDate Contents

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1. 血管新生阻害剤の概要 overview of angiogenesis inhibitors
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English Journal

Elevated plasma levels of vascular permeability factors in C1 inhibitor-deficient hereditary angioedema.

Loffredo S1, Bova M1, Suffritti C2, Borriello F1, Zanichelli A2, Petraroli A1, Varricchi G1, Triggiani M3, Cicardi M2, Marone G1,4.
Allergy.Allergy.2016 Jul;71(7):989-96. doi: 10.1111/all.12862. Epub 2016 Mar 17.
BACKGROUND: Hereditary angioedema with C1 inhibitor deficiency (C1-INH-HAE) is a rare inherited genetic disease characterized by recurrent swelling episodes of the skin, gastrointestinal tract, and upper airways. Angioedema attacks result from increased vascular permeability due to the release of br
PMID 26873113

Prognostic significance of VEGF-C immunohistochemical expression in colorectal cancer: A meta-analysis.

Zong S1, Li H2, Shi Q2, Liu S2, Li W3, Hou F4.
Clinica chimica acta; international journal of clinical chemistry.Clin Chim Acta.2016 Jul 1;458:106-14. doi: 10.1016/j.cca.2016.04.037. Epub 2016 May 4.
BACKGROUND: We sought to comprehensively summarize available evidence for the use of VEGF-C protein to evaluate the clinicopathological and prognostic role of VEGF-C in colorectal cancer.METHODS: Electronic databases from inception to February 2016 were used to search without language restrictions f
PMID 27155587

Leptin promotes proliferation and metastasis of human gallbladder cancer through OB-Rb leptin receptor.

Zou H1, Liu Y2, Wei D1, Wang T1, Wang K1, Huang S1, Liu L1, Li Y1, Ge J1, Li X1, Zhu H1, Wang L1, Zhao S1, Zhang X1, Wang L1.
International journal of oncology.Int J Oncol.2016 Jul;49(1):197-206. doi: 10.3892/ijo.2016.3530. Epub 2016 May 18.
Emerging evidence has shown that leptin, an adipocyte-derived cytokine that is closely associated with obesity, play a significant role in carcinogenesis and tumorigenesis. However, its impact on gallbladder cancer (GBC) remains unclear. In this study, we firstly found that leptin and its functional
PMID 27211817

Japanese Journal

Chrysin Inhibits Lymphangiogenesis in Vitro

Biological and Pharmaceutical Bulletin 39(4), 466-472, 2016
NAID 130005141688

Concurrent Expression of VEGF-C and Neuropilin-2 Is Correlated with Poor Prognosis in Glioblastoma

The Tohoku Journal of Experimental Medicine 238(2), 85-91, 2016
NAID 130005118557

Primary tumor-secreted lymphangiogenic factors induce pre-metastatic lymphvascular niche formation at sentinel lymph nodes in oral squamous cell carcinoma

PLoS ONE 10(12), e0144056, 2015-12-01
NAID 120005743890

Related Pictures

Types of VEGF and their VEGF receptors fits snugly into the vegf c cleft as shown of VEGF-C in mouse models of breast cancer VEGF-C (F-10): sc-74585. Western blot VEGF-C Rabbit Polyclonal Antibody (PAD Z Inhibitors of VEGF, VEGF-C, Ang2 and their VEGF Signaling VEGF-C Antibody #2445

★リンクテーブル★

リンク元	「血管内皮増殖因子C」「vascular endothelial growth factor C」
関連記事	「C」「VEGF」「Cs」「Cd」「c」

「血管内皮増殖因子C」

Vascular endothelial growth factor C
	; Rendering based on PDB 2X1W.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	2X1W, 2X1X, 4BSK
Identifiers
Symbols	VEGFC ; Flt4-L; VRP
External IDs	OMIM: 601528 MGI: 109124 HomoloGene: 3962 GeneCards: VEGFC Gene
Gene ontology
Molecular function	• protein binding; • growth factor activity; • chemoattractant activity; • vascular endothelial growth factor receptor 3 binding;
Cellular component	• extracellular region; • extracellular space; • membrane; • platelet alpha granule lumen;
Biological process	• angiogenesis; • positive regulation of neuroblast proliferation; • platelet degranulation; • substrate-dependent cell migration; • signal transduction; • blood coagulation; • positive regulation of cell proliferation; • organ morphogenesis; • morphogenesis of embryonic epithelium; • platelet activation; • regulation of vascular endothelial growth factor receptor signaling pathway; • positive regulation of protein autophosphorylation; • response to drug; • positive regulation of blood vessel endothelial cell migration; • negative regulation of blood pressure; • vascular endothelial growth factor receptor signaling pathway; • positive regulation of epithelial cell proliferation; • positive regulation of protein secretion; • positive chemotaxis; • induction of positive chemotaxis; • positive regulation of cell division; • positive regulation of mast cell chemotaxis; • positive regulation of lymphangiogenesis;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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