- 関
- See TBP-associated factors
English Journal
- Cytoplasmic TAF2-TAF8-TAF10 complex provides evidence for nuclear holo-TFIID assembly from preformed submodules.
- Trowitzsch S1, Viola C1, Scheer E2, Conic S2, Chavant V3, Fournier M2, Papai G4, Ebong IO5, Schaffitzel C1, Zou J6, Haffke M1, Rappsilber J7, Robinson CV5, Schultz P4, Tora L2, Berger I8.
- Nature communications.Nat Commun.2015 Jan 14;6:6011. doi: 10.1038/ncomms7011.
- General transcription factor TFIID is a cornerstone of RNA polymerase II transcription initiation in eukaryotic cells. How human TFIID-a megadalton-sized multiprotein complex composed of the TATA-binding protein (TBP) and 13 TBP-associated factors (TAFs)-assembles into a functional transcription fac
- PMID 25586196
- Matrix Stiffening and β1 Integrin Drive Subtype-Specific Fibroblast Accumulation in Lung Cancer.
- Puig M1, Lugo R2, Gabasa M2, Giménez A2, Velásquez A2, Galgoczy R2, Ramírez J3, Gómez-Caro A4, Busnadiego Ó5, Rodríguez-Pascual F5, Gascón P6, Reguart N7, Alcaraz J8.
- Molecular cancer research : MCR.Mol Cancer Res.2014 Oct 3. [Epub ahead of print]
- The crucial role of tumor-associated fibroblasts (TAF) in cancer progression is now clear in non-small cell lung cancer (NSCLC). However, therapies against TAFs are limited due to a lack of understanding in the subtype-specific mechanisms underlying their accumulation. Here, the mechanical (i.e., ma
- PMID 25280968
- TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation.
- Alpern D1, Langer D1, Ballester B2, Le Gras S1, Romier C3, Mengus G1, Davidson I1.
- eLife.Elife.2014 Sep 10;3:e03613. doi: 10.7554/eLife.03613.
- The functions of the TAF subunits of mammalian TFIID in physiological processes remain poorly characterised. In this study, we describe a novel function of TAFs in directing genomic occupancy of a transcriptional activator. Using liver-specific inactivation in mice, we show that the TAF4 subunit of
- PMID 25209997
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