Sertoli cell-only syndrome

セルトリ細胞遺残症候群

WordNet

1. indicates continuity or persistence or concentration; "his spirit lives on"; "shall I read on?"
2. (of events) planned or scheduled; "the picnic is on, rain or shine"; "we have nothing on for Friday night"
3. in a state required for something to function or be effective; "turn the lights on"; "get a load on"
4. in operation or operational; "left the oven on"; "the switch is in the on position"
5. with nevertheless the final result; "He arrived only to find his wife dead"; "We won only to lose again in the next round"
6. never except when; "call me only if your cold gets worse" (同)only if, only when
7. as recently as; "I spoke to him only an hour ago"
8. except that; "It was the same story; only this time she came out better"
9. in the final outcome; "These news will only make you more upset"
10. small room in which a monk or nun lives (同)cubicle
11. a device that delivers an electric current as the result of a chemical reaction (同)electric cell
12. a room where a prisoner is kept (同)jail cell, prison cell
13. (biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
14. any small compartment; "the cells of a honeycomb"
15. a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
16. a pattern of symptoms indicative of some disease
17. a complex of concurrent things; "every word has a syndrome of meanings"

PrepTutorEJDIC

1. (また《文》upon)《位置・場所》…『の上に』,の上で,の上の / (また《文》upon)《運動・動作の方向・対象》…『に』[向かって] / 《話》…を身につけて / (また《文》upon)《近接して場所》…の近くに,…に面して,…の側に / 《特定の日時》…『に』 / 《状態》…『して』,…中で,…すると / (また《文》upon)…『について』,…に関して / 《目的》…『で』,…に / (また《文》upon)…に基づいて,…によって,…の支え(助け)で / 《所属を表して》(委員会・チームなどの)一員で / (また《文》upon)…を軸にして,…で / (また《文》upon)《前後に同じ名詞を並べて》…に加えて,…についで / 『上に』,『身につけて』 / (電気・水道・ガス・ラジオなどが)『ついて』,通じて / 行われて,続けて,従事して / 《時の副詞[句]を伴って》前方へ,ずっと
2. 『唯一の』,たった一つ(一人)の;《複数名詞に付けて》ただ…だけ / 『最適の』,最良の(best) / 《数量に関して》『たった』,わずか / 『ただ…だけ』(『ばかり』),単に…に過ぎない / ただし,だが / 《英》《thatを伴って》…ということさえなければ
3. (刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
4. (疾患の徴候となる一群の)症徴候,症候群 / (事件・社会的状態などのパターンを示す)徴候形態

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/07/22 12:24:52」(JST)

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Sertoli cell-only syndrome
Classification and external resources
Specialty	endocrinology, andrology
OMIM	305700 400042
DiseasesDB	31907
eMedicine	med/2104
MeSH	D054331

Sertoli cell-only syndrome (a.k.a. Del Castillo syndrome and germ cell aplasia ) is a disorder characterized by male sterility without sexual abnormality. It describes a condition of the testes in which only Sertoli cells line the seminiferous tubules.

Features

The Sertoli cell-only syndrome patients normally have normal secondary male features and have normal- or small-sized testes.

Diagnosis

Testicular biopsy would confirm the absence of spermatozoa. Seminal plasma protein TEX101 was proposed for differentiation of Sertoli cell-only syndrome from maturation arrest and hypospermatogenesis. And a clinical trial at Mount Sinai Hospital, Canada started testing this hypothesis in 2016.

Pathophysiology

Sertoli cell only syndrome is likely multifactorial, and characterized by severely reduced or absent spermatogenesis despite the presence of both Sertoli and Leydig cells. A substantial subset of men with this uncommon syndrome have microdeletions in the Yq11 region of the Y chromosome, an area known as the AZF (azoospermia factor) region. Generally speaking, testosterone and LH levels are normal, but due to lack of inhibin, FSH levels are increased.

Treatment

Sertoli cell only syndrome is like other non-obstructive azoospermia (NOA) cases are managed by sperm retrieval through testicular sperm extraction (mTESE), micro-surgical testicular sperm extraction (mTESE), or testicular biopsy. On retrieval of viable sperm this could be used in Intracytoplasmic Sperm injection ICSI

In 1979, Levin described germinal cell aplasia with focal spermatogenesis where a variable percentage of seminiferous tubules contain germ cells. It is important to discriminate between both in view of ICSI.

A retrospective analysis performed in 2015 detailed the outcomes of N=148 men with non-obstructive azoospermia and diagnosed Sertoli cell-only syndrome:

• Men with SCOS: 148
• Testicular sperm was successfully retrieved: 35/148
• Successful ICSI: 20/148
• Clinical pregnancy: 4/148

This study considers the effect of FSH levels on clinical success, and it excludes abnormal karyotypes. All patients underwent MD-TESE in Iran. Ethnicity and genetic lineage may have an impact on treatment of azoospermia [citation needed].

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 男性不妊症の原因 causes of male infertility
• 2. 男性不妊症の治療 treatment of male infertility
• 3. アンドロゲン受容体障害の診断および治療 diagnosis and treatment of disorders of the androgen receptor
• 4. 男性不妊症の評価 evaluation of male infertility
• 5. Evaluation of the infant with atypical genitalia (disorder of sex development)

English Journal

• Fold-change correction values for testicular somatic transcripts in gene expression studies of human spermatogenesis.

• Cappallo-Obermann H, Feig C, Schulze W, Spiess AN.SourceDepartment of Andrology, University Hospital Hamburg-Eppendorf, Martinistr. 52, Hamburg 20246, Germany.
• Human reproduction (Oxford, England).Hum Reprod.2013 Mar;28(3):590-8. doi: 10.1093/humrep/des433. Epub 2013 Jan 9.
• STUDY QUESTION: What are the reference values for delineating altered somatic cell gene expression from transcript enrichment/dilution in gene expression studies of human spermatogenesis SUMMARY ANSWER: We have designed a crosstable and rule-of-thumb values for different stages of spermatogenic impa
• PMID 23303554

• Pericentric inversion of chromosom 12 [Inv (12) (p12q12)] associated with idiopathic azoospermia in one infertile Tunisian man.

• Ghorbel M, Baklouti-Gargouri S, Elghazel H, Zribi N, Abdallah FB, Cherif M, Fakhfakh F, Saad A, Ammar-Keskes L.SourceLaboratory of Human Molecular Genetics, Faculty of Medicine, Sfax, Tunisia. Electronic address: myriamgh29@gmail.com.
• Biochemical and biophysical research communications.Biochem Biophys Res Commun.2013 Feb 8. pii: S0006-291X(13)00211-8. doi: 10.1016/j.bbrc.2013.01.110. [Epub ahead of print]
• Chromosome aberrations are found in 2-7% of couples with fertility problems and pericentric inversions are structural chromosomal abnormalities, potentially associated with infertility or multiple miscarriages. In this study, we report the first case of pericentric inversion of chromosome 12 associa
• PMID 23399567

Japanese Journal

• 特発性男性不妊症患者 (特に Sertoli cell only syndrome) ゲノムDNAを用いた競合的ゲノムハイブリダイゼーションよるゲノム欠失の検討(第93回日本泌尿器科学会総会)

• Choi Jin,山本 健朗,松井 太,福島 正人,前田 雄司,高 栄哲,並木 幹夫,吉田 淳
• 日本泌尿器科學會雜誌 96(2), 183, 2005-03-05
• NAID 110004038742

• Sertoli cell only syndromeにおける精細管内セルトリ細胞数の年次的変化について

• 山崎 隆文,藤澤 正人,土橋 正樹,堅田 明浩,神崎 正徳,岡田 弘,荒川 創一,守殿 貞夫
• 日本泌尿器科學會雜誌 91(3), 373, 2000-03-20
• NAID 110003071106

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★リンクテーブル★

リンク元	「セルトリ細胞遺残症候群」
関連記事	「only」「on」「cell」「syndrome」

「セルトリ細胞遺残症候群」

　　[★]

英

Sertoli cell-only syndrome

「only」

　　[★]

• adj.

• 唯一の

• adv.

• 単に、わずかに

関

a fraction of、few、insignificant、little、marginally、merely、modest、modestly、scant、simply、singular、slight、slightly、sole、solely、subtle、subtly、unique、uniquely

　 　 　 　 　 　

「on」

　　[★]

• adj.
• prep.

• adv.

　 　 　 　 　

「cell」

　　[★] 細胞 　 　 　 　 　 　 　

「syndrome」

　　[★]

• n.

• 症候群