- 同
- SAP
- 同
- SAP
- 同
- SAP
WordNet
- having partial rights and privileges or subordinate status; "an associate member"; "an associate professor"
- a person who joins with others in some activity or endeavor; "he had to consult his associate before continuing"
- a person with subordinate membership in a society, institution, or commercial enterprise; "associates in the law firm bill at a lower rate than do partners"
- any event that usually accompanies or is closely connected with another; "first was the lightning and then its thunderous associate"
- make a logical or causal connection; "I cannot connect these two pieces of evidence in my mind"; "colligate these facts"; "I cannot relate these events at all" (同)tie_in, relate, link, colligate, link up, connect
- throw violently; "He slammed the book on the table" (同)flap down
- winning all or all but one of the tricks in bridge (同)sweep
- a forceful impact that makes a loud noise
- the noise made by the forceful impact of two objects
- close violently; "He slammed the door shut" (同)bang
- strike violently; "slam the ball" (同)bang
- any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
PrepTutorEJDIC
- 〈人〉'を'(…の)『仲間に加える』,(…に)連合させる《+『名』〈人〉+『with』+『名』》 / (…と)…'を'結びつけて考える(起こす)《+『名』+『with』+『名』》 / (…と)『仲間になる』,交際する《+『with』+『名』》 / (…と)合体する,提携する《+『with』+『名』》 / 『仲間』,『同僚』;組合員 / 準会員 / 付属物;連想されるもの / 連合した;仲間の,同僚の / 補助の,準…
- 〈戸・窓など〉‘を'『ピシャリ(バタン)と閉める』 / 《副詞[句]を伴って》…‘を'『ドシン(ドン)ト置く』 / (新聞用語で)…‘を'けなす,攻撃する / 〈戸・窓などが〉ピシャリ(バタン)と閉まる / ドシン(ドン)とぶつかる(動く) / 荒っぽく音を立てて戸を閉めること;ピシャリ(バタン,ドシン)という音
- スラム(ブリッジで全勝(grand slam)または1組を除いて全部勝つこと(little slam))
- 蛋白(たんばく)質
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/09/29 10:40:20」(JST)
[Wiki en表示]
| SH2D1A |
|
| Available structures |
| PDB |
Ortholog search: PDBe RCSB |
| List of PDB id codes |
|
1D1Z, 1D4T, 1D4W, 1KA6, 1KA7, 1M27
|
|
|
| Identifiers |
| Aliases |
SH2D1A, DSHP, EBVS, IMD5, LYP, MTCP1, SAP, SAP/XLP, XLPD, XLPD1, SH2 domain containing 1A |
| External IDs |
MGI: 1328352 HomoloGene: 1762 GeneCards: 4068 |
| Gene ontology |
| Molecular function |
• protein binding
• SH3/SH2 adaptor activity
|
| Cellular component |
• cytoplasm
• cytosol
|
| Biological process |
• cell-cell signaling
• cellular defense response
• innate immune response
• humoral immune response
• positive regulation of natural killer cell mediated cytotoxicity
• adaptive immune response
• immune system process
• regulation of immune response
• positive regulation of signal transduction
|
| Sources:Amigo / QuickGO |
|
| RNA expression pattern |
|
| More reference expression data |
| Orthologs |
| Species |
Human |
Mouse |
| Entrez |
|
|
| Ensembl |
|
|
| UniProt |
|
|
| RefSeq (mRNA) |
|
|
|
NM_011364
NM_001313688
NM_001313689
NM_001313691
|
|
| RefSeq (protein) |
|
|
NP_001108409.1
NP_002342.1
|
|
|
|
NP_001300617.1
NP_001300618.1
NP_001300620.1
NP_035494.1
|
|
| Location (UCSC) |
Chr X: 124.23 – 124.37 Mb |
Chr X: 42.5 – 42.53 Mb |
| PubMed search |
[1] |
[2] |
| Wikidata |
| View/Edit Human |
View/Edit Mouse |
SH2 domain–containing protein 1A is a protein that in humans is encoded by the SH2D1A gene.[3][4][5] It is often called SLAM-associated protein (symbol SAP), where "SLAM" refers to signaling lymphocytic activation molecules. It is a SH2 domain–containing molecule (part of a family of such molecules) that plays a role in SLAM signaling. A putative function is as an adaptor for Fyn and competitor of phosphatases, leading to modulation of SLAM family function. SAP has been implicated in autoimmunity,[6] and a mutation of it is associated with X-linked lymphoproliferative disease.
Contents
- 1 Interactions
- 2 References
- 3 Further reading
- 4 External links
Interactions
SH2D1A has been shown to interact with:
- CD84,[7][8][9][10]
- DOK1,[11]
- FYN,[12][13]
- LY9[8][10] and
- SLAMF1.[10][14]
References
- ^ "Human PubMed Reference:".
- ^ "Mouse PubMed Reference:".
- ^ Coffey AJ, Brooksbank RA, Brandau O, Oohashi T, Howell GR, Bye JM, Cahn AP, Durham J, Heath P, Wray P, Pavitt R, Wilkinson J, Leversha M, Huckle E, Shaw-Smith CJ, Dunham A, Rhodes S, Schuster V, Porta G, Yin L, Serafini P, Sylla B, Zollo M, Franco B, Bolino A, Seri M, Lanyi A, Davis JR, Webster D, Harris A, Lenoir G, de St Basile G, Jones A, Behloradsky BH, Achatz H, Murken J, Fassler R, Sumegi J, Romeo G, Vaudin M, Ross MT, Meindl A, Bentley DR (Oct 1998). "Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene". Nature Genetics. 20 (2): 129–35. doi:10.1038/2424. PMID 9771704.
- ^ Sayos J, Wu C, Morra M, Wang N, Zhang X, Allen D, van Schaik S, Notarangelo L, Geha R, Roncarolo MG, Oettgen H, De Vries JE, Aversa G, Terhorst C (Oct 1998). "The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM". Nature. 395 (6701): 462–9. doi:10.1038/26683. PMID 9774102.
- ^ "Entrez Gene: SH2D1A SH2 domain protein 1A, Duncan's disease (lymphoproliferative syndrome)".
- ^ Menard M. et al (2014), 'Signaling lymphocytic activation molecule (SLAM)/SLAM-associated protein pathway regulates human B-cell tolerance', Journal of Allergy and Clinical Immunology, vol. 133, no. 4, pp. 1149-1161
- ^ Tangye SG, Nichols KE, Hare NJ, van de Weerdt BC (Sep 2003). "Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation". Journal of Immunology. 171 (5): 2485–95. doi:10.4049/jimmunol.171.5.2485. PMID 12928397.
- ^ a b Sayós J, Martín M, Chen A, Simarro M, Howie D, Morra M, Engel P, Terhorst C (Jun 2001). "Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP". Blood. 97 (12): 3867–74. doi:10.1182/blood.v97.12.3867. PMID 11389028.
- ^ Tangye SG, van de Weerdt BC, Avery DT, Hodgkin PD (Jun 2002). "CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2". European Journal of Immunology. 32 (6): 1640–9. doi:10.1002/1521-4141(200206)32:6<1640::AID-IMMU1640>3.0.CO;2-S. PMID 12115647.
- ^ a b c Morra M, Simarro-Grande M, Martin M, Chen AS, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck MJ, Sumegi J, Engel P, Li SC, Terhorst C (Sep 2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients". The Journal of Biological Chemistry. 276 (39): 36809–16. doi:10.1074/jbc.M101305200. PMID 11477068.
- ^ Sylla BS, Murphy K, Cahir-McFarland E, Lane WS, Mosialos G, Kieff E (Jun 2000). "The X-linked lymphoproliferative syndrome gene product SH2D1A associates with p62dok (Dok1) and activates NF-kappa B". Proceedings of the National Academy of Sciences of the United States of America. 97 (13): 7470–5. doi:10.1073/pnas.130193097. PMC 16569. PMID 10852966.
- ^ Li C, Iosef C, Jia CY, Han VK, Li SS (Feb 2003). "Dual functional roles for the X-linked lymphoproliferative syndrome gene product SAP/SH2D1A in signaling through the signaling lymphocyte activation molecule (SLAM) family of immune receptors". The Journal of Biological Chemistry. 278 (6): 3852–9. doi:10.1074/jbc.M206649200. PMID 12458214.
- ^ Chan B, Lanyi A, Song HK, Griesbach J, Simarro-Grande M, Poy F, Howie D, Sumegi J, Terhorst C, Eck MJ (Feb 2003). "SAP couples Fyn to SLAM immune receptors". Nature Cell Biology. 5 (2): 155–60. doi:10.1038/ncb920. PMID 12545174.
- ^ Howie D, Simarro M, Sayos J, Guirado M, Sancho J, Terhorst C (Feb 2002). "Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation". Blood. 99 (3): 957–65. doi:10.1182/blood.v99.3.957. PMID 11806999.
Further reading
- Sumegi J, Seemayer TA, Huang D, Davis JR, Morra M, Gross TG, Yin L, Romco G, Klein E, Terhorst C, Lanyi A (Jun 2002). "A spectrum of mutations in SH2D1A that causes X-linked lymphoproliferative disease and other Epstein-Barr virus-associated illnesses". Leukemia & Lymphoma. 43 (6): 1189–201. doi:10.1080/10428190290026240. PMID 12152986.
- Engel P, Eck MJ, Terhorst C (Oct 2003). "The SAP and SLAM families in immune responses and X-linked lymphoproliferative disease". Nature Reviews. Immunology. 3 (10): 813–21. doi:10.1038/nri1202. PMID 14523387.
- Stern MH, Soulier J, Rosenzwajg M, Nakahara K, Canki-Klain N, Aurias A, Sigaux F, Kirsch IR (Sep 1993). "MTCP-1: a novel gene on the human chromosome Xq28 translocated to the T cell receptor alpha/delta locus in mature T cell proliferations". Oncogene. 8 (9): 2475–83. PMID 8361760.
- Skare J, Wu BL, Madan S, Pulijaal V, Purtilo D, Haber D, Nelson D, Sylla B, Grierson H, Nitowsky H (Apr 1993). "Characterization of three overlapping deletions causing X-linked lymphoproliferative disease". Genomics. 16 (1): 254–5. doi:10.1006/geno.1993.1169. PMID 8387453.
- Nichols KE, Harkin DP, Levitz S, Krainer M, Kolquist KA, Genovese C, Bernard A, Ferguson M, Zuo L, Snyder E, Buckler AJ, Wise C, Ashley J, Lovett M, Valentine MB, Look AT, Gerald W, Housman DE, Haber DA (Nov 1998). "Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome". Proceedings of the National Academy of Sciences of the United States of America. 95 (23): 13765–70. doi:10.1073/pnas.95.23.13765. PMC 24894. PMID 9811875.
- Poy F, Yaffe MB, Sayos J, Saxena K, Morra M, Sumegi J, Cantley LC, Terhorst C, Eck MJ (Oct 1999). "Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition". Molecular Cell. 4 (4): 555–61. doi:10.1016/S1097-2765(00)80206-3. PMID 10549287.
- Li SC, Gish G, Yang D, Coffey AJ, Forman-Kay JD, Ernberg I, Kay LE, Pawson T (Dec 1999). "Novel mode of ligand binding by the SH2 domain of the human XLP disease gene product SAP/SH2D1A". Current Biology. 9 (23): 1355–62. doi:10.1016/S0960-9822(00)80080-9. PMID 10607564.
- Sylla BS, Murphy K, Cahir-McFarland E, Lane WS, Mosialos G, Kieff E (Jun 2000). "The X-linked lymphoproliferative syndrome gene product SH2D1A associates with p62dok (Dok1) and activates NF-kappa B". Proceedings of the National Academy of Sciences of the United States of America. 97 (13): 7470–5. doi:10.1073/pnas.130193097. PMC 16569. PMID 10852966.
- Benoit L, Wang X, Pabst HF, Dutz J, Tan R (Oct 2000). "Defective NK cell activation in X-linked lymphoproliferative disease". Journal of Immunology. 165 (7): 3549–53. doi:10.4049/jimmunol.165.7.3549. PMID 11034354.
- Nagy N, Cerboni C, Mattsson K, Maeda A, Gogolák P, Sümegi J, Lányi A, Székely L, Carbone E, Klein G, Klein E (Nov 2000). "SH2D1A and SLAM protein expression in human lymphocytes and derived cell lines". International Journal of Cancer. Journal International Du Cancer. 88 (3): 439–47. doi:10.1002/1097-0215(20001101)88:3<439::AID-IJC17>3.0.CO;2-#. PMID 11054674.
- Shlapatska LM, Mikhalap SV, Berdova AG, Zelensky OM, Yun TJ, Nichols KE, Clark EA, Sidorenko SP (May 2001). "CD150 association with either the SH2-containing inositol phosphatase or the SH2-containing protein tyrosine phosphatase is regulated by the adaptor protein SH2D1A". Journal of Immunology. 166 (9): 5480–7. doi:10.4049/jimmunol.166.9.5480. PMID 11313386.
- Sayós J, Martín M, Chen A, Simarro M, Howie D, Morra M, Engel P, Terhorst C (Jun 2001). "Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP". Blood. 97 (12): 3867–74. doi:10.1182/blood.V97.12.3867. PMID 11389028.
- Morra M, Simarro-Grande M, Martin M, Chen AS, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck MJ, Sumegi J, Engel P, Li SC, Terhorst C (Sep 2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients". The Journal of Biological Chemistry. 276 (39): 36809–16. doi:10.1074/jbc.M101305200. PMID 11477068.
- Latour S, Gish G, Helgason CD, Humphries RK, Pawson T, Veillette A (Aug 2001). "Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product". Nature Immunology. 2 (8): 681–90. doi:10.1038/90615. PMID 11477403.
- Bottino C, Falco M, Parolini S, Marcenaro E, Augugliaro R, Sivori S, Landi E, Biassoni R, Notarangelo LD, Moretta L, Moretta A (Aug 2001). "NTB-A [correction of GNTB-A], a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked lymphoproliferative disease". The Journal of Experimental Medicine. 194 (3): 235–46. doi:10.1084/jem.194.3.235. PMC 2193462. PMID 11489943.
- Liu A, Klein G, Bandobashi K, Klein E, Nagy N (Mar 2002). "SH2D1A expression reflects activation of T and NK cells in cord blood lymphocytes infected with EBV and treated with the immunomodulator PSK". Immunology Letters. 80 (3): 181–8. doi:10.1016/S0165-2478(01)00330-3. PMID 11803050.
- Howie D, Simarro M, Sayos J, Guirado M, Sancho J, Terhorst C (Feb 2002). "Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation". Blood. 99 (3): 957–65. doi:10.1182/blood.V99.3.957. PMID 11806999.
- Aoukaty A, Tan R (Apr 2002). "Association of the X-linked lymphoproliferative disease gene product SAP/SH2D1A with 2B4, a natural killer cell-activating molecule, is dependent on phosphoinositide 3-kinase". The Journal of Biological Chemistry. 277 (15): 13331–7. doi:10.1074/jbc.M112029200. PMID 11815622.
External links
- GeneReviews/NCBI/NIH/UW entry on Lymphoproliferative Disease, X-Linked
|
PDB gallery
|
|
|
|
|
1d1z: CRYSTAL STRUCTURE OF THE XLP PROTEIN SAP
|
|
|
|
1d4t: CRYSTAL STRUCTURE OF THE XLP PROTEIN SAP IN COMPLEX WITH A SLAM PEPTIDE
|
|
|
|
1d4w: CRYSTAL STRUCTURE OF THE XLP PROTEIN SAP IN COMPLEX WITH SLAM PHOSPHOPEPTIDE
|
|
|
|
1ka6: SAP/SH2D1A bound to peptide n-pY
|
|
|
|
1ka7: SAP/SH2D1A bound to peptide n-Y-c
|
|
|
|
1m27: Crystal structure of SAP/FynSH3/SLAM ternary complex
|
|
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Inhibition of NKp30- and 2B4-mediated NK cell activation by evolutionary different human and bovine CEACAM1 receptors.
- Merkt W1, Urlaub D, Meinke S, Kammerer R, Watzl C.
- European journal of immunology.Eur J Immunol.2015 Mar 30. doi: 10.1002/eji.201445151. [Epub ahead of print]
- Carcinoembryonicantigen-related cell adhesion molecule 1 (CEACAM1) is a receptor involved in the regulation of NK-cell function. In most species, the CEACAM1 cytoplasmic tail possesses a membrane-proximal ITIM paired with a membrane-distal immunoreceptor tyrosine-based switch motif (ITSM) signaling
- PMID 25824372
- Negative Regulation of Humoral Immunity Due to Interplay between the SLAMF1, SLAMF5, and SLAMF6 Receptors.
- Wang N1, Halibozek PJ1, Yigit B1, Zhao H1, O'Keeffe MS1, Sage P2, Sharpe A2, Terhorst C1.
- Frontiers in immunology.Front Immunol.2015 Apr 14;6:158. doi: 10.3389/fimmu.2015.00158. eCollection 2015.
- Whereas the SLAMF-associated protein (SAP) is involved in differentiation of T follicular helper (Tfh) cells and antibody responses, the precise requirements of SLAMF receptors in humoral immune responses are incompletely understood. By analyzing mice with targeted disruptions of the Slamf1, Slamf5,
- PMID 25926831
- Severe XLP Phenotype Caused by a Novel Intronic Mutation in the SH2D1A Gene.
- Tóth B1, Soltész B, Gyimesi E, Csorba G, Veres A, Lányi A, Kovács G, Maródi L, Erdős M.
- Journal of clinical immunology.J Clin Immunol.2014 Dec 10. [Epub ahead of print]
- We describe here a novel c.137 + 5G > A intronic mutation in the SH2D1A gene of the signaling lymphocyte activation molecule (SLAM)-associated protein (SAP) in association with Epstein-Barr virus (EBV)-induced fatal infectious mononucleosis (FIM) in an 8-year-old male patient and his 3-year-o
- PMID 25491288
Japanese Journal
- 自己免疫疾患におけるSLAMファミリー受容体の関与 (特集 自己免疫疾患の発症関与要因)
- W8-1 EBウイルス誘発ビラン性関節炎のヒト免疫化マウスモデル
Related Pictures
★リンクテーブル★
[★]
- 結合する、連合させる。連想によって結びつける。(人を)仲間/友達などとしての関係に置く。(化)会合させる
- 仲間/友人などとして交際する(with)。一つにまとめる、連合する
- 仕事仲間、提携者、同僚。友人、朋友。準会員。従業員、社員
- 密接な蒸す偽付きのある物、付随する物、つきもの。準国家
- 連想によって心に浮かぶ言葉/思い、連想物
- 仲間の、同僚の。製紙機械員に次ぐ資格の
- 付随する、連想される
- 関
- accompany、association、associative、attach、bearing、bind、binding、bond、bonding、coassemble、colleague、combine、conjoin、conjugate、conjugation、conjunction、connect、connection、correlate、correlation、couple、dock、engage、engagement、federation、implication、join、joint、ligate、link、linkage、peer、pertinent、reference、relate、relation、relationship、relative、relevance、relevant、symphysial、union
[★]
- 関
- concomitant、erratic、erratically
- associate
[★]
- 関
- related protein
[★]
- 同
- signaling lymphocyte activation molecule
[★]