Pit-1

• 転写因子Pit-1

関

transcription factor Pit-1

WordNet

1. set into opposition or rivalry; "let them match their best athletes against ours"; "pit a chess player against the Russian champion"; "He plays his two children off against each other" (同)oppose, match, play off
2. a concavity in a surface (especially an anatomical depression) (同)fossa
3. remove the pits from; "pit plums and cherries" (同)stone
4. a trap in the form of a concealed hole (同)pitfall
5. a surface excavation for extracting stone or slate; "a British term for `quarry is `stone pit" (同)quarry, stone pit
6. (auto racing) an area at the side of a racetrack where the race cars are serviced and refueled
7. (commodity exchange) the part of the floor of a commodity exchange where trading in a particular commodity is carried on
8. an enclosure in which animals are made to fight
9. a sizeable hole (usually in the ground); "they dug a pit to bury the body" (同)cavity
10. the 16th letter of the Roman alphabet (同)p

PrepTutorEJDIC

1. (自然の,または掘った)『地面の穴』,『くぼみ』 / 《しばしば単数形で》《the pit》立て坑,採掘場 / 落とし穴 / 《単数形で》《the pit》《英》(劇場の)平土間(1階正面後部の安い料金の席全体を指す);平土間の観客;《米》(舞台手前の1段低くなった)オーケストラ席 / (身体や物の表面の自然にできた)くぼみ / 《しばしば複数形で》(傷・天然痘などでできた皮膚の)小さなくぼんだ跡,あばた / (動物を入れておく)囲い;闘鶏場(cockpit),闘犬場 / 《the ~》地獄(hell) / ピット / 自動車修理店などで,車体の下で作業するために床に設けたくぼみ / 《the pits》自動車レースで給油・タイヤ交換などの場所 / …‘に'点々と穴をあける;…‘を'あばたにする / (…と)…‘を'取り組ませる,対坑させる《+『名』+『against』+『名』》
2. (サクランボ・モモなどの)核,種(stone) / 〈果物〉‘から'種を取り除く
3. parking
4. phosphorusの化学記号

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/11/16 17:33:12」(JST)

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[Wiki en表示]

POU1F1
Identifiers
Aliases	POU1F1, CPHD1, GHF-1, PIT1, POU1F1a, Pit-1, POU class 1 homeobox 1
External IDs	OMIM: 173110 MGI: 97588 HomoloGene: 259 GeneCards: POU1F1
Gene ontology Molecular function • sequence-specific DNA binding • DNA binding • transcription corepressor activity • RNA polymerase II activating transcription factor binding • RNA polymerase II transcription factor binding • RNA polymerase II transcription coactivator activity • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • chromatin binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • transcription factor activity, sequence-specific DNA binding • transcription factor binding Cellular component • nucleus • nucleoplasm • cytoplasm • transcription factor complex Biological process • negative regulation of cell proliferation • somatotropin secreting cell development • adenohypophysis development • positive regulation of inositol trisphosphate biosynthetic process • regulation of insulin-like growth factor receptor signaling pathway • pituitary gland development • regulation of transcription, DNA-templated • cell fate specification • B cell differentiation • positive regulation of cell proliferation • positive regulation of transcription, DNA-templated • determination of adult lifespan • positive regulation of transcription from RNA polymerase II promoter • positive regulation of multicellular organism growth • nuclear transport • negative regulation of transcription from RNA polymerase II promoter • somatotropin secreting cell differentiation • transcription, DNA-templated • transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5449	18736
Ensembl	ENSG00000064835	ENSMUSG00000004842
UniProt	P28069	Q00286
RefSeq (mRNA)	NM_001122757 NM_000306	NM_008849
RefSeq (protein)	NP_000297.1 NP_001116229.1	NP_032875.1
Location (UCSC)	Chr 3: 87.26 – 87.28 Mb	Chr 16: 65.52 – 65.54 Mb
PubMed search
Wikidata
View/Edit Human		View/Edit Mouse

POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1), also known as POU1F1, is a transcription factor for growth hormone.

Function

PIT1 is a pituitary-specific transcription factor responsible for pituitary development and hormone expression in mammals and is a member of the POU family of transcription factors that regulate mammalian development. The POU family is so named because the first 3 members identified were PIT1 and OCT1 (MIM 164175) of mammals, and Unc-86 of C. elegans (Herr et al., 1988). PIT1 contains 2 protein domains, termed POU-specific and POU-homeo, which are both necessary for high affinity DNA binding on genes encoding growth hormone (GH; MIM 139250) and prolactin (PRL; MIM 176760). PIT1 is also important for regulation of the genes encoding prolactin and thyroid-stimulating hormone beta subunit (TSHB; MIM 188540) by thyrotropin-releasing hormone (TRH; MIM 257120) and cyclic AMP.[supplied by OMIM]

Interactions

Pituitary-specific positive transcription factor 1 has been shown to interact with GATA2 and PITX1.

References

Further reading

• Parks JS, Brown MR (1999). "Transcription factors regulating pituitary development". Growth Horm. IGF Res. 9 Suppl B: 2–8; discussion 8–11. doi:10.1016/S1096-6374(99)80074-4. PMID 10549299. 
• Rodriguez R, Andersen B (2003). "Cellular determination in the anterior pituitary gland: PIT-1 and PROP-1 mutations as causes of human combined pituitary hormone deficiency". Minerva Endocrinol. 28 (2): 123–33. PMID 12717343. 
• Quentien MH, Barlier A, Franc JL, Pellegrini I, Brue T, Enjalbert A (2006). "Pituitary transcription factors: from congenital deficiencies to gene therapy". J. Neuroendocrinol. 18 (9): 633–42. doi:10.1111/j.1365-2826.2006.01461.x. PMID 16879162. 
• Cattini PA, Yang X, Jin Y, Detillieux KA (2006). "Regulation of the human growth hormone gene family: possible role for Pit-1 in early stages of pituitary-specific expression and repression". Neuroendocrinology. 83 (3–4): 145–53. doi:10.1159/000095522. PMID 17047377. 
• Li X, Giachelli CM (2007). "Sodium-dependent phosphate cotransporters and vascular calcification". Curr. Opin. Nephrol. Hypertens. 16 (4): 325–8. doi:10.1097/MNH.0b013e3281c55ef1. PMID 17565274. 
• Tatsumi K, Miyai K, Notomi T, Kaibe K, Amino N, Mizuno Y, Kohno H (1993). "Cretinism with combined hormone deficiency caused by a mutation in the PIT1 gene". Nat. Genet. 1 (1): 56–8. doi:10.1038/ng0492-56. PMID 1302000. 
• Tatsumi K, Notomi T, Amino N, Miyai K (1992). "Nucleotide sequence of the complementary DNA for human Pit-1/GHF-1". Biochim. Biophys. Acta. 1129 (2): 231–4. doi:10.1016/0167-4781(92)90494-k. PMID 1370379. 
• Ohta K, Nobukuni Y, Mitsubuchi H, Fujimoto S, Matsuo N, Inagaki H, Endo F, Matsuda I (1993). "Mutations in the Pit-1 gene in children with combined pituitary hormone deficiency". Biochem. Biophys. Res. Commun. 189 (2): 851–5. doi:10.1016/0006-291X(92)92281-2. PMID 1472057. 
• Ohta K, Nobukuni Y, Mitsubuchi H, Ohta T, Tohma T, Jinno Y, Endo F, Matsuda I (1993). "Characterization of the gene encoding human pituitary-specific transcription factor, Pit-1". Gene. 122 (2): 387–8. doi:10.1016/0378-1119(92)90234-G. PMID 1487156. 
• Radovick S, Nations M, Du Y, Berg LA, Weintraub BD, Wondisford FE (1992). "A mutation in the POU-homeodomain of Pit-1 responsible for combined pituitary hormone deficiency". Science. 257 (5073): 1115–8. doi:10.1126/science.257.5073.1115. PMID 1509262. 
• Pfäffle RW, DiMattia GE, Parks JS, Brown MR, Wit JM, Jansen M, Van der Nat H, Van den Brande JL, Rosenfeld MG, Ingraham HA (1992). "Mutation of the POU-specific domain of Pit-1 and hypopituitarism without pituitary hypoplasia". Science. 257 (5073): 1118–21. doi:10.1126/science.257.5073.1118. PMID 1509263. 
• Lew AM, Elsholtz HP (1991). "Cloning of the human cDNA for transcription factor Pit-1". Nucleic Acids Res. 19 (22): 6329. doi:10.1093/nar/19.22.6329. PMC 329149. PMID 1956794. 
• He X, Treacy MN, Simmons DM, Ingraham HA, Swanson LW, Rosenfeld MG (1989). "Expression of a large family of POU-domain regulatory genes in mammalian brain development". Nature. 340 (6228): 35–41. doi:10.1038/340035a0. PMID 2739723. 
• Bodner M, Castrillo JL, Theill LE, Deerinck T, Ellisman M, Karin M (1988). "The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein". Cell. 55 (3): 505–18. doi:10.1016/0092-8674(88)90037-2. PMID 2902927. 
• Herr W, Sturm RA, Clerc RG, Corcoran LM, Baltimore D, Sharp PA, Ingraham HA, Rosenfeld MG, Finney M, Ruvkun G (1989). "The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products". Genes Dev. 2 (12A): 1513–6. doi:10.1101/gad.2.12a.1513. PMID 3215510. 
• de Zegher F, Pernasetti F, Vanhole C, Devlieger H, Van den Berghe G, Martial JA (1995). "The prenatal role of thyroid hormone evidenced by fetomaternal Pit-1 deficiency". J. Clin. Endocrinol. Metab. 80 (11): 3127–30. doi:10.1210/jc.80.11.3127. PMID 7593413. 
• Bamberger AM, Bamberger CM, Pu LP, Puy LA, Loh YP, Asa SL (1995). "Expression of pit-1 messenger ribonucleic acid and protein in the human placenta". J. Clin. Endocrinol. Metab. 80 (7): 2021–6. doi:10.1210/jc.80.7.2021. PMID 7608249. 
• Irie Y, Tatsumi K, Ogawa M, Kamijo T, Preeyasombat C, Suprasongsin C, Amino N (1995). "A novel E250X mutation of the PIT1 gene in a patient with combined pituitary hormone deficiency". Endocr. J. 42 (3): 351–4. doi:10.1507/endocrj.42.351. PMID 7670563. 
• Delhase M, Vila V, Hooghe-Peters EL, Castrillo JL (1995). "A novel pituitary transcription factor is produced by alternative splicing of the human GHF-1/PIT-1 gene". Gene. 155 (2): 273–5. doi:10.1016/0378-1119(94)00757-J. PMID 7721104. 
• Okamoto N, Wada Y, Ida S, Koga R, Ozono K, Chiyo H, Hayashi A, Tatsumi K (1995). "Monoallelic expression of normal mRNA in the PIT1 mutation heterozygotes with normal phenotype and biallelic expression in the abnormal phenotype". Hum. Mol. Genet. 3 (9): 1565–8. doi:10.1093/hmg/3.9.1565. PMID 7833912. 

External links

• PIT1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Transcription Factor Pit-1 at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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English Journal

• Struvite for composting of agricultural wastes with termite mound: Utilizing the unutilized.

• Karak T1, Sonar I2, Nath JR2, Paul RK3, Das S4, Boruah RK2, Dutta AK2, Das K5.
• Bioresource technology.Bioresour Technol.2015 Jul;187:49-59. doi: 10.1016/j.biortech.2015.03.070. Epub 2015 Mar 24.
• Although, compost is the store house of different plant nutrients, there is a concern for low amount of major nutrients especially nitrogen content in prepared compost. The present study deals with preparation of compost by using agricultural wastes with struvite (MgNH4PO4·6H2O) along with termite
• PMID 25836374

• Long-lived Snell dwarf mice display increased proteostatic mechanisms that are not dependent on decreased mTORC1 activity.

• Drake JC1, Bruns DR, Peelor FF 3rd, Biela LM, Miller RA, Miller BF, Hamilton KL.
• Aging cell.Aging Cell.2015 Jun;14(3):474-82. doi: 10.1111/acel.12329. Epub 2015 Feb 26.
• Maintaining proteostasis is thought to be a key factor in slowed aging. In several growth-restricted models of long-life, we have shown evidence of increased proteostatic mechanisms, suggesting that proteostasis may be a shared characteristic of slowed aging. The Snell dwarf mouse is generated throu
• PMID 25720574

• Pit-1 inhibits BRCA1 and sensitizes human breast tumors to cisplatin and vitamin D treatment.

• Seoane S1,2, Arias E2,3, Sigueiro R4, Sendon-Lago J1,2, Martinez-Ordoñez A1,2, Castelao E5, Eiró N6, Garcia-Caballero T7, Macia M3, Lopez-Lopez R8, Maestro M4, Vizoso F6, Mouriño A4, Perez-Fernandez R1,2.
• Oncotarget.Oncotarget.2015 May 8. [Epub ahead of print]
• The POU class 1 homeobox 1 (POU1F1, also known as Pit-1), pertaining to the Pit-Oct-Unc (POU) family of transcription factors, has been related to tumor growth and metastasis in breast. However, its role in response to breast cancer therapy is unknown.We found that Pit-1 down-regulated DNA-damage an
• PMID 25992773

Japanese Journal

• 新たな自己抗体病の発見「抗PIT-1抗体症候群」 : 転写因子に対する自己免疫によって引き起こされた新規疾患概念 (第57回近畿支部総会 シンポジウム : 自己免疫疾患への多角的検査アプローチ)

• 高橋 裕,坂東 弘教,井口 元三
• 臨床病理 : 日本臨床検査医学会誌 63(4), 491-497, 2015-04
• NAID 40020474874

• サハリン新石器時代前期スラブナヤ５遺跡の発掘調査報告

• 福田 正宏,グリシェンコ V.,ワシレフスキー A.,大貫 静夫,熊木 俊朗,國木田 大,森先 一貴,佐藤 宏之,モジャエフ A.,パシェンツェフ P.,ペレグドフ A.,役重 みゆき,夏木 大吾,髙鹿 哲大
• 東京大学考古学研究室研究紀要 29, 121-146, 2015-03-29
• … 出土土器は、2006・2008 年調査第1、第2 発掘区古段階の一群と共通する。 … The eastern part of the Slavnaya-5 site, South Sakhalin Island, Russia, was excavated in 2013 (Excavation #3) (Fig. 1). … However, in the lower part of Layer II, Large Pit 1 and Pits 1 and 2 were discovered along the southern zone of the excavation. … 1). …
• NAID 120005595974

• Mineral Composition of Phosphate-Induced Calcification in a Rat Aortic Tissue Culture Model

• Sonou Tomohiro,Ohya Masaki,Yashiro Mitsuru,Masumoto Asuka,Nakashima Yuri,Ito Teppei,Mima Toru,Negi Shigeo,Kimura-Suda Hiromi,Shigematsu Takashi
• Journal of Atherosclerosis and Thrombosis advpub(0), 2015
• … The concentration of the phosphate transporter Pit-1 in the aortic tissue exposed to HiP was higher than that in the control incubated sections. … Exposure to high Pi concentration augments aortic calcification via an increase in Pit-1, which mainly contains calcium phosphate. …
• NAID 130005083661

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拡張検索	「転写因子Pit-1」「transcription factor Pit-1」
関連記事	「pit」「P」「Pi」

「転写因子Pit-1」

　　[★]

英

transcription factor Pit-1、Pit-1

「transcription factor Pit-1」

　　[★]

転写因子Pit-1

関

Pit-1

「pit」

　　[★]

• n.

• 穴、くぼみ。落とし穴。不慮の危険

　 　 　 　 　 　 　 　 　 　 　

「P」

　　[★]

• プロリン proline
• P波 P wave
• リン phosphorus

　 　 　

「Pi」

　　[★] オルトリン酸

関

orthophosphate、orthophosphoric acid