P-カドヘリン、Pカドヘリン
- 関
- cadherin、E-cadherin、N-cadherin、uvomorulin
WordNet
- the 16th letter of the Roman alphabet (同)p
- a river in western Thailand; a major tributary of the Chao Phraya (同)Ping River
PrepTutorEJDIC
- parking
- phosphorusの化学記号
- palladiumの化学記号
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/02/13 03:05:40」(JST)
[Wiki en表示]
Cadherin 3, type 1, P-cadherin (placental) |
Available structures |
PDB |
Ortholog search: PDBe, RCSB |
List of PDB id codes |
4OY9
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|
|
Identifiers |
Symbols |
CDH3 ; CDHP; HJMD; PCAD |
External IDs |
OMIM: 114021 MGI: 88356 HomoloGene: 20425 GeneCards: CDH3 Gene |
Gene ontology |
Molecular function |
• molecular_function
• calcium ion binding
|
Cellular component |
• cytoplasm
• plasma membrane
• cell-cell adherens junction
• integral component of membrane
|
Biological process |
• retina homeostasis
• cell adhesion
• homophilic cell adhesion via plasma membrane adhesion molecules
• visual perception
• positive regulation of gene expression
• positive regulation of keratinocyte proliferation
• single organismal cell-cell adhesion
• hair cycle process
• keratinization
• positive regulation of monophenol monooxygenase activity
• negative regulation of transforming growth factor beta2 production
• cell junction assembly
• adherens junction organization
• wound healing
• response to drug
• positive regulation of insulin-like growth factor receptor signaling pathway
• cell-cell junction organization
• positive regulation of melanin biosynthetic process
• negative regulation of catagen
• canonical Wnt signaling pathway
• regulation of hair cycle by canonical Wnt signaling pathway
• positive regulation of melanosome transport
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Sources: Amigo / QuickGO |
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RNA expression pattern |
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More reference expression data |
Orthologs |
Species |
Human |
Mouse |
Entrez |
1001 |
12560 |
Ensembl |
ENSG00000062038 |
ENSMUSG00000061048 |
UniProt |
P22223 |
P10287 |
RefSeq (mRNA) |
NM_001793 |
NM_001037809 |
RefSeq (protein) |
NP_001784 |
NP_001032898 |
Location (UCSC) |
Chr 16:
68.64 – 68.72 Mb |
Chr 8:
106.51 – 106.56 Mb |
PubMed search |
[1] |
[2] |
|
Cadherin-3, also known as P-Cadherin, is a protein that in humans is encoded by the CDH3 gene.[1][2]
Contents
- 1 Function
- 2 Clinical significance
- 3 Interactions
- 4 See also
- 5 References
- 6 Further reading
- 7 External links
Function
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas.
Clinical significance
Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy.[2]
Interactions
CDH3 (gene) has been shown to interact with:
- Beta-catenin,[3][4]
- CDH1,[3]
- Catenin (cadherin-associated protein), alpha 1,[3][4]
- Nephrin[5] and
- Plakoglobin.[3]
See also
References
- ^ Kaupmann K, Becker-Follmann J, Scherer G, Jockusch H, Starzinski-Powitz A (Oct 1992). "The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species". Genomics 14 (2): 488–90. doi:10.1016/S0888-7543(05)80247-2. PMID 1427864.
- ^ a b "Entrez Gene: CDH3 cadherin 3, type 1, P-cadherin (placental)".
- ^ a b c d Klingelhöfer J, Troyanovsky RB, Laur OY, Troyanovsky S (Aug 2000). "Amino-terminal domain of classic cadherins determines the specificity of the adhesive interactions". Journal of Cell Science. 113 ( Pt 16): 2829–36. PMID 10910767.
- ^ a b Schmeiser K, Grand RJ (Apr 1999). "The fate of E- and P-cadherin during the early stages of apoptosis". Cell Death and Differentiation 6 (4): 377–86. doi:10.1038/sj.cdd.4400504. PMID 10381631.
- ^ Lehtonen S, Lehtonen E, Kudlicka K, Holthöfer H, Farquhar MG (Sep 2004). "Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin". The American Journal of Pathology 165 (3): 923–36. doi:10.1016/S0002-9440(10)63354-8. PMC 1618613. PMID 15331416.
Further reading
- Herrenknecht K, Ozawa M, Eckerskorn C, Lottspeich F, Lenter M, Kemler R (Oct 1991). "The uvomorulin-anchorage protein alpha catenin is a vinculin homologue". Proceedings of the National Academy of Sciences of the United States of America 88 (20): 9156–60. doi:10.1073/pnas.88.20.9156. PMC 52671. PMID 1924379.
- Shimoyama Y, Hirohashi S, Hirano S, Noguchi M, Shimosato Y, Takeichi M, Abe O (Apr 1989). "Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas". Cancer Research 49 (8): 2128–33. PMID 2702654.
- Shimoyama Y, Yoshida T, Terada M, Shimosato Y, Abe O, Hirohashi S (Oct 1989). "Molecular cloning of a human Ca2+-dependent cell-cell adhesion molecule homologous to mouse placental cadherin: its low expression in human placental tissues". The Journal of Cell Biology 109 (4 Pt 1): 1787–94. doi:10.1083/jcb.109.4.1787. PMC 2115800. PMID 2793940.
- Palacios J, Benito N, Pizarro A, Suárez A, Espada J, Cano A, Gamallo C (Mar 1995). "Anomalous expression of P-cadherin in breast carcinoma. Correlation with E-cadherin expression and pathological features". The American Journal of Pathology 146 (3): 605–12. PMC 1869170. PMID 7534041.
- van der Linden PJ, de Goeij AF, Dunselman GA, Erkens HW, Evers JL (Jun 1995). "Expression of cadherins and integrins in human endometrium throughout the menstrual cycle". Fertility and Sterility 63 (6): 1210–6. PMID 7538474.
- Tang A, Eller MS, Hara M, Yaar M, Hirohashi S, Gilchrest BA (Apr 1994). "E-cadherin is the major mediator of human melanocyte adhesion to keratinocytes in vitro". Journal of Cell Science. 107 ( Pt 4) (4): 983–92. PMID 8056851.
- Tassin MT, Beziau A, Gubler MC, Boyer B (Mar 1994). "Spatiotemporal expression of molecules associated with junctional complexes during the in vivo maturation of renal podocytes". The International Journal of Developmental Biology 38 (1): 45–54. PMID 8074995.
- Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Navarro P, Lozano E, Cano A (Aug 1993). "Expression of E- or P-cadherin is not sufficient to modify the morphology and the tumorigenic behavior of murine spindle carcinoma cells. Possible involvement of plakoglobin". Journal of Cell Science. 105 ( Pt 4) (4): 923–34. PMID 8227214.
- Reynolds AB, Daniel JM, Mo YY, Wu J, Zhang Z (Jun 1996). "The novel catenin p120cas binds classical cadherins and induces an unusual morphological phenotype in NIH3T3 fibroblasts". Experimental Cell Research 225 (2): 328–37. doi:10.1006/excr.1996.0183. PMID 8660921.
- Soler AP, Harner GD, Knudsen KA, McBrearty FX, Grujic E, Salazar H, Han AC, Keshgegian AA (Aug 1997). "Expression of P-cadherin identifies prostate-specific-antigen-negative cells in epithelial tissues of male sexual accessory organs and in prostatic carcinomas. Implications for prostate cancer biology". The American Journal of Pathology 151 (2): 471–8. PMC 1858007. PMID 9250159.
- Wakita H, Furukawa F, Baba S, Takigawa M (Nov 1997). "Human squamous-cell-carcinoma cell line (DJM-1) cells synthesize P-cadherin molecules via an elevation of extracellular calcium: calcium regulates P-cadherin-gene expression at the translational level via protein tyrosine phosphorylation". International Journal of Cancer. Journal International Du Cancer 73 (3): 432–9. doi:10.1002/(SICI)1097-0215(19971104)73:3<432::AID-IJC19>3.0.CO;2-E. PMID 9359492.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Kremmidiotis G, Baker E, Crawford J, Eyre HJ, Nahmias J, Callen DF (May 1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity". Genomics 49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID 9615235.
- Jarrard DF, Paul R, van Bokhoven A, Nguyen SH, Bova GS, Wheelock MJ, Johnson KR, Schalken J, Bussemakers M, Isaacs WB (Nov 1997). "P-Cadherin is a basal cell-specific epithelial marker that is not expressed in prostate cancer". Clinical Cancer Research 3 (11): 2121–8. PMID 9815605.
- Schmeiser K, Grand RJ (Apr 1999). "The fate of E- and P-cadherin during the early stages of apoptosis". Cell Death and Differentiation 6 (4): 377–86. doi:10.1038/sj.cdd.4400504. PMID 10381631.
- Rufas O, Fisch B, Ziv S, Shalgi R (Feb 2000). "Expression of cadherin adhesion molecules on human gametes". Molecular Human Reproduction 6 (2): 163–9. doi:10.1093/molehr/6.2.163. PMID 10655458.
- Klingelhöfer J, Troyanovsky RB, Laur OY, Troyanovsky S (Aug 2000). "Amino-terminal domain of classic cadherins determines the specificity of the adhesive interactions". Journal of Cell Science. 113 ( Pt 16) (16): 2829–36. PMID 10910767.
- Han AC, Edelson MI, Peralta Soler A, Knudsen KA, Lifschitz-Mercer B, Czernobilsky B, Rosenblum NG, Salazar H (Nov 2000). "Cadherin expression in glandular tumors of the cervix". Cancer 89 (10): 2053–8. doi:10.1002/1097-0142(20001115)89:10<2053::AID-CNCR4>3.0.CO;2-C. PMID 11066045.
- Bauer K, Gosau M, Reinders J, Oefner P, Reichert TE, Bauer R (Nov 2013). "Presenilin 1/γ-secretase modulates P-cadherin processing and influences cell adhesion in oral squamous cell carcinoma cell lines". Carcinogenesis 34 (11): 2622–8. doi:10.1093/carcin/bgt211. PMID 23740836.
External links
- CDH3 human gene location in the UCSC Genome Browser.
- CDH3 human gene details in the UCSC Genome Browser.
Membrane proteins: cell adhesion molecules
|
|
Calcium-independent |
IgSF CAM |
- N-CAM (Myelin protein zero)
- ICAM (1, 5)
- VCAM-1
- PE-CAM
- L1-CAM
- Nectin (PVRL1, PVRL2, PVRL3)
|
|
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Calcium-dependent |
Cadherins |
Classical |
|
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Desmosomal |
- Desmoglein (DSG1, DSG2, DSG3, DSG4)
- Desmocollin (DSC1, DSC2, DSC3)
|
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Protocadherin |
|
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Unconventional/ungrouped |
- T-cadherin
- CDH4
- CDH5
- CDH6
- CDH8
- CDH11
- CDH12
- CDH15
- CDH16
- CDH17
- CDH9
- CDH10
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|
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Selectins |
- E-selectin
- L-selectin
- P-selectin
|
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Integrins |
- LFA-1 (CD11a+CD18)
- Integrin alphaXbeta2 (CD11c+CD18)
- Macrophage-1 antigen (CD11b+CD18)
- VLA-4 (CD49d+CD29)
- Glycoprotein IIb/IIIa (ITGA2B+ITGB3)
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|
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Other |
- Lymphocyte homing receptor: CD44
- L-selectin
- integrin (VLA-4, LFA-1)
- Carcinoembryonic antigen
- CD22
- CD24
- CD44
- CD146
- CD164
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UpToDate Contents
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English Journal
- Sulindac modulates secreted protein expression from LIM1215 colon carcinoma cells prior to apoptosis.
- Greening DW, Ji H, Kapp EA, Simpson RJ.SourceLa Trobe Institute for Molecular Science (LIMS), La Trobe University, Bundoora, Victoria, Australia.
- Biochimica et biophysica acta.Biochim Biophys Acta.2013 Nov;1834(11):2293-307. doi: 10.1016/j.bbapap.2013.07.007. Epub 2013 Jul 27.
- Colorectal cancer (CRC) is a major cause of mortality in Western populations. Growing evidence from human and rodent studies indicate that nonsteroidal anti-inflammatory drugs (NSAIDs) cause regression of existing colon tumors and act as effective chemopreventive agents in sporadic colon tumor forma
- PMID 23899461
- Mining the O-mannose glycoproteome reveals cadherins as major O-mannosylated glycoproteins.
- Vester-Christensen MB, Halim A, Joshi HJ, Steentoft C, Bennett EP, Levery SB, Vakhrushev SY, Clausen H.SourceCopenhagen Center for Glycomics and Department of Cellular and Molecular Medicine and School of Dentistry, Faculty of Health Sciences, University of Copenhagen, DK-2200 Copenhagen N, Denmark.
- Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2013 Oct 7. [Epub ahead of print]
- The metazoan O-mannose (O-Man) glycoproteome is largely unknown. It has been shown that up to 30% of brain O-glycans are of the O-Man type, but essentially only alpha-dystroglycan (α-DG) of the dystrophin-glycoprotein complex is well characterized as an O-Man glycoprotein. Defects in O-Man glycosyl
- PMID 24101494
- N-cadherin Expression in Feline Mammary Tumors Is Associated With a Reduced E-cadherin Expression and the Presence of Regional Metastasis.
- Buendia AJ, Peñafiel-Verdu C, Navarro JA, Vilafranca M, Sanchez J.SourceFacultad de Veterinaria, Universidad de Murcia, Murcia, Spain.
- Veterinary pathology.Vet Pathol.2013 Oct 3. [Epub ahead of print]
- The cadherin family of adhesion molecules regulates cell-cell interactions. N-cadherin is expressed by neural and fibroblast cells but not by normal epithelial cells. In human medicine, the role of N-cadherin in breast cancer remains controversial, but some studies have described the switch from E-c
- PMID 24091815
Japanese Journal
- Expression of Podoplanin and Classical Cadherins in Salivary Gland Epithelial Cells of Klotho-Deficient Mice
- Amano Ikuko,Imaizumi Yuri,Kaji Chiaki,Kojima Hiroshi,Sawa Yoshihiko
- ACTA HISTOCHEMICA ET CYTOCHEMICA 44(6), 267-276, 2011
- … Although aging resulted in growth suppression of myoepithelial cells because of the sparse distribution of the cells in kl/kl mouse salivary glands, the expression of podoplanin and E-cadherin was shown in aging myoepithelial cells. … It is thought that podoplanin participates in the actin-E-cadherin networks which are maintained in aging myoepithelial cells. …
- NAID 130001258484
- Kinetics of p120-catenin in a human gingival cancer cell line treated with ZD1839
- Tamura Isao,Wato Masahiro,Kamada Aiko,Goda Seiji,Yoshikawa Yoshihiro,Domae Eisuke,Tanaka Akio,Ikeo Takashi
- Journal of Osaka Dental University 44(2), 169-175, 2010-10-00
- … p120-catenin (p120) is a very critical element in the cadherin/catenin cell-cell adhesion complex. … We previously reported that phosphorylated β-catenin disrupts the regulation of E- and P-cadherin stability and adherens junction formation in cancer tissues. …
- NAID 110007811667
- High-grade neuroendocrine carcinoma of the lung : Comparative clinicopathological study of large cell neuroendocrine carcinoma and small cell lung carcinoma
- SUN Lihua,SAKURAI Shinji,SANO Takaaki,HIRONAKA Mitsugu,KAWASHIMA Osamu,NAKAJIMA Takashi
- Pathology international 59(8), 522-529, 2009-08-01
- NAID 10027381029
Related Links
- P-Cadherin - Antigen Background P-cadherin, like E-cadherin, is a Ca2+-dependent cell adhesion molecule and has a fundamental role in... ... Antigen Background P-cadherin, like E-cadherin, is a Ca 2+-dependent cell adhesion ...
- 米国CST社の日本法人CSTジャパン株式会社【公式サイト】P-Cadherin Antibodyページ。高品質の研究用試薬、米国本社の開発研究者による技術的サポートをご提供しております。
Related Pictures
★リンクテーブル★
[★]
- 英
- P-cadherin
- 関
- ウボモルリン、カドヘリン、E-カドヘリン、N-カドヘリン、Pカドヘリン
[★]
E-カドヘリン、Eカドヘリン
- 関
- cadherin、N-cadherin、P-cadherin、uvomorulin
[★]
ウボモルリン
- 関
- cadherin、E-cadherin、N-cadherin、P-cadherin
[★]
N-カドヘリン
- 関
- cadherin、E-cadherin、P-cadherin、uvomorulin
[★]
- 英
- P-cadherin
- 関
- P-カドヘリン
[★]
[★]
- 10の-12乗
- 関
- pico
[★]
パラジウム palladium