関: cadherin、E-cadherin、P-cadherin、uvomorulin

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the 14th letter of the Roman alphabet (同)n

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nitrogenの化学記号
neodymiumの化学記号

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/24 23:08:10」(JST)

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Cadherin-2 (CDH2), also known as neural cadherin (NCAD) is a protein that in humans is encoded by the CDH2 gene.^[1]^[2] CDH2 has also been designated as CD325 (cluster of differentiation 325).

Function

Cadherin 2 a classical cadherin from the cadherin superfamily. Cadherin 2 is a calcium dependent cell-cell adhesion glycoprotein comprising five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product.^[3]

N-cadherins interact with catenins to play an important role in learning and memory (For full article see Cadherin-catenin complex in learning and memory).

Role in cancer metastasis

N-Cadherin is commonly found in cancer cells and provides a mechanism for transendothelial migration. When a cancer cell adheres to the endothelial cells of a blood vessel it up-regulates the src kinase pathway, which phosphorylates beta-catenins attached to both N-cadherin (this protein) and E-cadherins. This causes the intercellular connection between two adjacent endothelial cells to fail and allows the cancer cell to slip through.^[4]

Interactions

CDH2 has been shown to interact with:

Beta-catenin,^[5]^[6]
CDH11,^[5]
type IIb RPTPs including PTPmu (CTNND1,^[5]^[6]
CTNNA1,^[5]^[6]
LRRC7,^[7]
PTPRM)^[8]^[9]
PTPrho (PTPRT),^[10] and
Plakoglobin.^[5]^[11]

References

^ Walsh FS, Barton CH, Putt W, Moore SE, Kelsell D, Spurr N et al. (September 1990). "N-cadherin gene maps to human chromosome 18 and is not linked to the E-cadherin gene". J. Neurochem. 55 (3): 805–12. doi:10.1111/j.1471-4159.1990.tb04563.x. PMID 2384753.
^ Reid RA, Hemperly JJ (October 1990). "Human N-cadherin: nucleotide and deduced amino acid sequence". Nucleic Acids Res. 18 (19): 5896–5896. doi:10.1093/nar/18.19.5896. PMC 332345. PMID 2216790.
^ "Entrez Gene: CDH2 cadherin 2, type 1, N-cadherin (neuronal)".
^ Ramis-Conde I, Chaplain MA, Anderson AR, Drasdo D (2009). "Multi-scale modelling of cancer cell intravasation: the role of cadherins in metastasis". Phys Biol 6 (1): 016008. doi:10.1088/1478-3975/6/1/016008. PMID 19321920.
^ ^a ^b ^c ^d ^e Straub BK, Boda J, Kuhn C, Schnoelzer M, Korf U, Kempf T et al. (Dec 2003). "A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells". J. Cell. Sci. 116 (Pt 24): 4985–95. doi:10.1242/jcs.00815. PMID 14625392.
^ ^a ^b ^c Wahl JK, Kim YJ, Cullen JM, Johnson KR, Wheelock MJ (May 2003). "N-cadherin-catenin complexes form prior to cleavage of the proregion and transport to the plasma membrane". J. Biol. Chem. 278 (19): 17269–76. doi:10.1074/jbc.M211452200. PMID 12604612.
^ Izawa I, Nishizawa M, Ohtakara K, Inagaki M (Feb 2002). "Densin-180 interacts with delta-catenin/neural plakophilin-related armadillo repeat protein at synapses". J. Biol. Chem. 277 (7): 5345–50. doi:10.1074/jbc.M110052200. PMID 11729199.
^ Brady-Kalnay SM, Rimm DL, Tonks NK. "Receptor protein tyrosine phosphatase PTPmu associates with cadherins and catenins in vivo". J. Cell Biol. 130 (4): 977–86. doi:10.1083/jcb.130.4.977. PMC 2199947. PMID 7642713.
^ Brady-Kalnay SM, Mourton T, Nixon JP, Pietz GE, Kinch M, Chen H et al. "Dynamic interaction of PTPmu with multiple cadherins in vivo". J. Cell Biol. 141 (1): 287–96. doi:10.1083/jcb.141.1.287. PMC 2132733. PMID 9531566.
^ Besco JA, Hooft van Huijsduijnen R, Frostholm A, Rotter A. "Intracellular substrates of brain-enriched receptor protein tyrosine phosphatase rho (RPTPrho/PTPRT)". Brain Res. 1116 (1): 50–7. doi:10.1016/j.brainres.2006.07.122. PMID 16973135.
^ Sacco PA, McGranahan TM, Wheelock MJ, Johnson KR (Aug 1995). "Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin". J. Biol. Chem. 270 (34): 20201–6. doi:10.1074/jbc.270.34.20201. PMID 7650039.

External links

CDH2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
CDH2 human gene location in the UCSC Genome Browser.
CDH2 human gene details in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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English Journal

Characterization and neural differentiation of mouse embryonic and induced pluripotent stem cells on cadherin-based substrata.

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Biomaterials.Biomaterials.2012 Jul;33(20):5094-106. Epub 2012 Apr 19.
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Rap1GAP regulates renal cell carcinoma invasion.

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Japanese Journal

特異的シナプス形成の分子メカニズム

米倉真一
信州大学農学部紀要 48(1-2), 1-7, 2012-03-27
… 本総説では，特異的シナプス形成の分子メカニズムに関する最新の知見について述べると共に，特に，著者が明らかにした特異的シナプス形成におけるＮカドヘリンの機能について紹介する。 … Especially, I introduce our studies about N-cadherin functionss in the neuronal connectivity. …
NAID 120003988813

PP-770 Participation of N-cadherin in Bladder Cancer

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NAID 110008613143

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★リンクテーブル★

リンク元	「N-カドヘリン」「E-cadherin」「P-cadherin」「uvomorulin」「Nカドヘリン」
関連記事	「n」「N」「Nd」

「N-カドヘリン」

Cadherin 2, type 1, N-cadherin (neuronal)
	; PDB rendering based on 1ncg.
Identifiers
Symbols	CDH2 ; CD325; CDHN; CDw325; NCAD
External IDs	OMIM: 114020 MGI: 88355 HomoloGene: 20424 ChEMBL: 1697669 GeneCards: CDH2 Gene
Gene ontology
Molecular function	• calcium ion binding; • protein binding; • beta-catenin binding; • protein phosphatase binding; • alpha-catenin binding; • gamma-catenin binding;
Cellular component	• plasma membrane; • cell-cell junction; • cell-cell adherens junction; • fascia adherens; • intercalated disc; • integral component of membrane; • apical plasma membrane; • catenin complex; • lamellipodium; • synapse; • extracellular vesicular exosome;
Biological process	• cell adhesion; • homophilic cell adhesion; • heterophilic cell-cell adhesion; • calcium-dependent cell-cell adhesion; • cell migration; • cell junction assembly; • adherens junction organization; • muscle cell differentiation; • positive regulation of MAPK cascade; • cell-cell junction organization; • blood vessel morphogenesis; • striated muscle cell differentiation; • positive regulation of muscle cell differentiation; • negative regulation of canonical Wnt signaling pathway;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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