- モノクローナル抗体
- Ki-67抗原を認識する。
- 細胞の増殖能の指標になるため、免疫組織化学により腫瘍組織の増殖能を調べるために用いられるらしい。
WordNet
- the 13th letter of the Roman alphabet (同)m
PrepTutorEJDIC
- Michigan / Military Intelligence 陸軍情報部
- Mach number / mark[s] / Monsieur
UpToDate Contents
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English Journal
- Clinicopathologic correlation of vitamin D receptor expression with retinoid X receptor and MIB-1 expression in primary and metastatic osteosarcoma.
- Gallagher R, Keighley J, Tancabelic J, Garimella R, Pinson D, Templeton K, Tawfik O.SourceDepartment of Pathology and Laboratory Medicine, Kansas University Medical Center, Kansas City, KS.
- Annals of diagnostic pathology.Ann Diagn Pathol.2012 Oct;16(5):323-9. Epub 2012 Apr 25.
- Vitamin D, in addition to its effects on bone, is important in cell cycle regulation. Vitamin D receptor (VDR) has been identified in breast, prostate, and colon cancers, as well as in canine and human osteosarcoma (OS) cell lines; however, it has not been well investigated in human OS-archived spec
- PMID 22542077
- Estradiol partially recapitulates murine pituitary cell cycle response to pregnancy.
- Toledano Y, Zonis S, Ren SG, Wawrowsky K, Chesnokova V, Melmed S.SourceAcademic Affairs, Cedars-Sinai Medical Center, Room 2015, 8700 Beverly Boulevard, Los Angeles, California 90048. melmed@csmc.edu.
- Endocrinology.Endocrinology.2012 Oct;153(10):5011-22. Epub 2012 Jul 31.
- Because pregnancy and estrogens both induce pituitary lactotroph hyperplasia, we assessed the expression of pituitary cell cycle regulators in two models of murine pituitary hyperplasia. Female mice were assessed during nonpregnancy, pregnancy, day of delivery, and postpartum. We also implanted estr
- PMID 22851678
Japanese Journal
- 口腔扁平上皮癌におけるFAMTならびにFDG集積とMIB-1標識指数に関する検討
- 宮下 剛,宮久保 満之,根岸 明秀,横尾 聡,樋口 徹也,有坂 有紀子,石北 朋宏,対馬 義人
- The Kitakanto medical journal 61(3), 463-464, 2011-08-01
- NAID 120003338758
- Anaplastic Meningioma With Extremely Rapid Recurrence : Case Report
- KAWAHARA Yosuke,NAKADA Mitsutoshi,HAYASHI Yutaka,WATANABE Takuya,TAMASE Akira,HAYASHI Yasuhiko,UCHIYAMA Naoyuki,NITTA Hisashi,HAMADA Jun-ichiro
- Neurologia medico-chirurgica = 神経外科 51(5), 386-388, 2011-05-15
- … Histological examination indicated the presence of anaplastic meningioma with an extremely high MIB-1 labeling index (70%). … The exceptionally high MIB-1 labeling index corresponded with a short tumor doubling time (8.2 days). …
- NAID 10029138044
- Pathological Changes After Autologous Formalin-Fixed Tumor Vaccine Therapy Combined With Temozolomide for Glioblastoma : Three Case Reports
- SAKAMOTO Noriaki,ISHIKAWA Eiichi,YAMAMOTO Tetsuya,SATOMI Kaishi,NAKAI Kei,SATO Masayuki,ENOMOTO Takao,MORISHITA Yukio,TAKANO Shingo,OHNO Tadao,TSUBOI Koji,MATSUMURA Akira
- Neurologia medico-chirurgica = 神経外科 51(4), 319-325, 2011-04-15
- … After a 4-week break from the standard initial treatments, 1 patient with primary GBM and 2 patients with secondary GBM received adjuvant TMZ for 5 days combined with AFTV injection and were subsequently treated with multiple cycles of adjuvant TMZ for 5 days every 28 days (AFTV/TMZ therapy). … CD3+CD8+ lymphocytes were frequently detected in surgical specimens and MIB-1 labeling index in 2 cases decreased after AFTV/TMZ therapy. …
- NAID 10028105397
Related Links
- 「MIB-1」はKi-67抗体のうちのクローン名の一つで、熱処理を加えることによってホルマリン固定標本でも反応する最初の抗体として非常に有名になったため、今日でも「ミブワン」がKi-67の代名詞的に使用されることもある。増殖期細胞の核 ...
- まめ先生ががん(肉腫)の研究・診療を極めるべく研修に励む日々をお届けします ... まめ先生の肉腫を極めるサルドク日記 まめ先生ががん(肉腫)の研究・診療を極めるべく研修に励む日々をお届けします
Related Pictures
★リンクテーブル★
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- medulla 'bone marrow'
- 英
- medulloblastoma
- 同
- 髄芽細胞腫
疫学
- SCN.174
- 男女=1.7:1
- まれに20歳以降
- 2/3は15歳以下、30%が15-35歳 (ATP.488)
好発部位
- SCN.174
病理
- 小型円型異型細胞が密に増殖。クロマチンに富み、核は類円形。細胞質は乏しい。核分裂増は多い
- rosettes様配列(花環状配列, Homer-Wright型ロゼット)
- N-CAM:強陽性 ← 神経細胞由来?
- GFAP±
- MIB-1 LI:約20%
- (他のembryonal tumorと区別するにはさらにマーカーが必要)
- WHO grade IV
CNS tumor: embryonal tumor
進展・転移
- 周囲組織に浸潤傾向が強い
- くも膜下腔に播種しやすい
症状
- 頭痛、嘔吐(噴出性の嘔吐)、体幹運動失調(転びやすい)
- 乳幼児では水頭症で初発することがある。 ← 小脳虫部に原発して第四脳室を閉塞しうることと、乳幼児では前述の症状を訴えにくいことによる
検査
MRI
- T1:低信号
- T2:等信号~高信号
- T1強調画像Gd造影:著明に増強
治療
- SCN.175
- 方針:手術療法で全摘出を目指す。3歳以上には放射線療法と化学療法、3歳未満には化学療法(メトトレキサート)を優先。
- 手術療法
- 放射線療法:喉頭蓋窩、全脳、全脊髄 ← 放射線感受性が高い腫瘍
- 化学療法
予後
- 5年生存率:50%以下 (SCN.175)
- 10年生存率:40-50%
参考
- http://wiki.cns.org/wiki/images/thumb/6/60/MedulloMRI.jpg/250px-MedulloMRI.jpg
- http://frontalcortex.com/?page=oll&topic=24&qid=898
- http://www.cancer.net/patient/Cancer+Types/Medulloblastoma+-+Childhood/ci.Medulloblastoma+-+Childhood.printer
- 4. [charged] Epidemiology, treatment, and prognosis of medulloblastoma - uptodate [1]
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- 関
- MIB-1
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メチオニン methionine