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Comparative subproteome analysis of three representative Leptospira interrogans vaccine strains reveals cross-reactive antigens and novel virulence determinants.

Zeng LB1, Zhuang XR2, Huang LL2, Zhang YY3, Chen CY2, Dong K2, Zhang Y2, Cui ZL2, Ding XL2, Chang YF4, Guo XK5, Zhu YZ6.
Journal of proteomics.J Proteomics.2014 Sep 6;112C:27-37. doi: 10.1016/j.jprot.2014.08.015. [Epub ahead of print]
Pathogenic Leptospira spp. causes leptospirosis in China and throughout the world. Here, we have sequenced two L. interrogans moderately virulent vaccine strains JDL03 (serovar Canicola) and JDL10 (serovar Hebdomadis) used in China. We selected a subproteomic approach to identify surface-exposed pro
PMID 25201075

Isolation and characterization of two novel plasmids from pathogenic Leptospira interrogans serogroup Canicola Serovar Canicola strain Gui44.

Zhu WN1, Huang LL2, Zeng LB3, Zhuang XR1, Chen CY1, Wang YZ1, Qin JH1, Zhu YZ1, Guo XK1.
PLoS neglected tropical diseases.PLoS Negl Trop Dis.2014 Aug 21;8(8):e3103. doi: 10.1371/journal.pntd.0003103. eCollection 2014.
BACKGROUND: Previous genomic analysis of pathogenic Leptospira has identified two circular chromosomes but no plasmid. This study aims to investigate potential extrachromosomal elements of L.interrogans serovar Canicola strain Gui44.METHODOLOGY: Two novel plasmids, pGui1 and pGui2, were isolated fro
PMID 25144555

Seasonal prevalence of antibodies to Leptospira interrogans in Antillean manatees from a landlocked lake in Tabasco, Mexico.

Aragón-Martínez A1, Olivera-Gómez LD, Jiménez-Domínguez D.
Journal of wildlife diseases.J Wildl Dis.2014 Jul;50(3):505-11. doi: 10.7589/2013-05-102. Epub 2014 Apr 29.
Factors that alter the dynamics of ecologic systems can influence transmission of infectious diseases and may lead to decreases in natural populations. Leptospirosis is a cosmopolitan disease of zoonotic importance that affects most mammals. At the southern Gulf of Mexico, Antillean manatees (Triche
PMID 24779468

Nationwide Survey of Leptospira Antibodies in Dogs in Japan: Results from Microscopic Agglutination Test and Enzyme-Linked Immunosorbent Assay

Effects of Static Magnetic Field on Growth of Leptospire, Leptospira interrogans serovar canicola : Immunoreactivity and Cell Division(MEDICAL BIOTECHNOLOGY)

Effects of Static Magnetic Field on Growth of Leptospire, Leptospira interrogans serovar canicola: Immunoreactivity and Cell Division

人獣共通感染症である。
レプトスピラを腎臓に保有したネズミ・イヌ・家畜の尿に暴露して経皮的、経粘膜的、経口的に感染し、最初はインフルエンザ様の症状を示し、重症化により黄疸(肝障害)、腎障害、出血傾向をきたす疾患である。
四類感染症

熱帯・亜熱帯を中心に全世界的に発生が見られる。
東南アジアや中南米では大雨とそれに続く洪水の後に大規模なレプトスピラ症の発生が見られている。
日本では
秋季レプトスピラ症は田園地帯や山間部に広く分布しており、各地で様々な呼称がある；七日熱(なぬかやみ)・八日熱(福岡県)、秋疫・用水熱・天竜疫(静岡県)、波佐見熱＊(長崎県)、作州熱(岡山県)、アッケ病(大分県)、伊万里熱(佐賀県)。
日本では沖縄での症例が最も多い。