Leptospira interrogans

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1. important pathogens causing Weils disease or canicola fever

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/08/12 04:15:48」(JST)

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Leptospira
Scanning electron micrograph of Leptospira interrogans.
Scientific classification
Kingdom:	Eubacteria
Phylum:	Spirochaetes
Class:	Spirochaetes
Order:	Spirochaetales
Family:	Leptospiraceae
Genus:	Leptospira
Species:	L. interrogans

Leptospira interrogans is a Gram negative, obligate aerobe spirochete, with periplasmic flagella. When viewed through a light microscope, it often resembles a question mark, and this gives the species its name. It is a member of the genus Leptospira. Some important pathogenic serovars from this species are Canicola, Icterohaemorrhagiae and Australis. L. interrogans is difficult to culture, requiring special media and extended incubation periods.

L. interrogans infects wild and domestic animals, including pet dogs. Humans are accidental hosts. It can survive in neutral or slightly alkaline water for 3 months or longer.

L. interrogans is usually transmitted to humans through contact with infected animal urine, either directly or in water. It invades directly through broken skin and can replicate in the liver and kidneys. Risk factors for infection include working in sewers, farming, and recreational water activities. Infection is known as leptospirosis, which can be asymptomatic, a mild non-specific illness, or result in death from liver damage and renal failure (Weil's syndrome).

References

External links

• http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=173
• Leptospira protein abundances

UpToDate Contents

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• 1. レプトスピラ症の疫学、微生物学、臨床症状、および診断 epidemiology microbiology clinical manifestations and diagnosis of leptospirosis
• 2. レプトスピラ症の治療および予防 treatment and prevention of leptospirosis
• 3. 犬からの人畜共通感染症 zoonoses from dogs
• 4. 猫からの人畜共通感染症 zoonoses from cats
• 5. 東南アジアへの旅行によって感染する可能性のある疾患 diseases potentially acquired by travel to southeast asia

English Journal

• Plasmin cleaves fibrinogen and the human complement proteins C3b and C5 in the presence of Leptospira interrogans proteins: A new role of LigA and LigB in invasion and complement immune evasion.

• Castiblanco-Valencia MM1, Fraga TR1, Pagotto AH2, de Toledo Serrano SM2, Abreu PA3, Barbosa AS3, Isaac L4.
• Immunobiology.Immunobiology.2016 May;221(5):679-89. doi: 10.1016/j.imbio.2016.01.001. Epub 2016 Jan 7.
• Plasminogen is a single-chain glycoprotein found in human plasma as the inactive precursor of plasmin. When converted to proteolytically active plasmin, plasmin(ogen) regulates both complement and coagulation cascades, thus representing an important target for pathogenic microorganisms. Leptospira i
• PMID 26822552

• Genomic survey and expression analysis of DNA repair genes in the genus Leptospira.

• Martins-Pinheiro M1,2, Schons-Fonseca L3,4, da Silva JB3, Domingos RH3, Momo LH5, Simões AC6, Ho PL3,4, da Costa RM7.
• Molecular genetics and genomics : MGG.Mol Genet Genomics.2016 Apr;291(2):703-22. doi: 10.1007/s00438-015-1135-2. Epub 2015 Nov 2.
• Leptospirosis is an emerging zoonosis with important economic and public health consequences and is caused by pathogenic leptospires. The genus Leptospira belongs to the order Spirochaetales and comprises saprophytic (L. biflexa), pathogenic (L. interrogans) and host-dependent (L. borgpetersenii) me
• PMID 26527082

• Prevalence of antibodies against Borrelia burgdorferi, Anaplasma phagocytophilum, and Leptospira interrogans serovars in Bernese Mountain Dogs.

• Preyß-Jägeler C1, Müller E, Straubinger RK, Hartmann K.
• Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere.Tierarztl Prax Ausg K Kleintiere Heimtiere.2016 Mar 23;44(2). [Epub ahead of print]
• OBJECTIVE: Bernese Mountain Dogs (BMD) have a higher prevalence of Borrelia burgdorferi sensu lato (Bbsl) antibodies than other breeds, but it is not known whether this is the case for other pathogens. Therefore, the aim of the study was to determine the frequency and level of specific antibodies ag
• PMID 27004451

Japanese Journal

• The usefulness of semi-solid medium in the isolation of highly virulent Leptospira strains from wild rats in an urban area of Fukuoka, Japan

• Microbiology and immunology 59(6), 322-330, 2015-06
• NAID 40020510062

• Evaluation of truncated LipL32 expressed by Escherichia coli and Pichia pastoris for serodiagnosis of Leptospira infection in rodents

• Journal of Veterinary Medical Science advpub(0), 2015
• NAID 130005098992

• Leptospira interrogans serovar Hebdomadisによる豚異常産事例

• 日本獣医師会雑誌 67(12), 908-913, 2014
• NAID 130004888056

Related Links

• Leptospira interrogans - MicrobeWiki

Leptospira interrogans Description and significance Leptospira interrogans is a gram negative obligate aerobe. This bacterium is motile and has a spiral or helical shape like other spirochetes (1). It has an optimum temperature of 30 ...

• Leptospirosis: Practice Essentials, Background, Pathophysiology

Based on this system, the genus Leptospira contains two species: the pathogenic Leptospira interrogans, with at least 218 serovars; and the nonpathogenic, free-living, saprophytic Leptospira biflexa, which has at least 60 ...

Related Pictures

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「レプトスピラ・インターロガンス」

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• Leptospira interrogans、L. interrogans

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レプトスピラ・インテロガンス

「レプトスピラ・インテロガンス」

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Leptospira interrogans

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レプトスピラ・インターロガンス

「L. interrogans」

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• レプトスピラ・インターロガンス

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Leptospira interrogans

「Leptospira interrogans serovar hebdomadis」

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レプトスピラ・ヘブドマディス、秋疫Bレプトスピラ

「Leptospira interrogans serovar canicola」

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レプトスピラ・カニコーラ、イヌ型レプトスピラ

「Leptospira interrogans serovar pomona」

　　[★] レプトスピラ・ポモナ

「interrogans」

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• Leptospira interrogans