HTGL

肝性トリグリセリドリパーゼ

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/01/10 18:44:56」(JST)

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Lipase, hepatic
Identifiers
Symbols	LIPC ; HDLCQ12; HL; HTGL; LIPH
External IDs	OMIM: 151670 MGI: 96216 HomoloGene: 199 ChEMBL: 2127 GeneCards: LIPC Gene
EC number	3.1.1.3
Gene ontology Molecular function • phospholipase activity • triglyceride lipase activity • heparin binding • low-density lipoprotein particle binding • apolipoprotein binding Cellular component • extracellular space • high-density lipoprotein particle Biological process • fatty acid biosynthetic process • cholesterol metabolic process • triglyceride catabolic process • very-low-density lipoprotein particle remodeling • intermediate-density lipoprotein particle remodeling • low-density lipoprotein particle remodeling • high-density lipoprotein particle remodeling • chylomicron remnant clearance • phosphatidylcholine catabolic process • cholesterol homeostasis • reverse cholesterol transport • triglyceride homeostasis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3990	15450
Ensembl	ENSG00000166035	ENSMUSG00000032207
UniProt	P11150	P27656
RefSeq (mRNA)	NM_000236	NM_008280
RefSeq (protein)	NP_000227	NP_032306
Location (UCSC)	Chr 15: 58.7 – 58.86 Mb	Chr 9: 70.8 – 70.93 Mb
PubMed search	[1]	[2]

Hepatic lipase, also called hepatic triglyceride lipase (HTGL) or LIPC (for "lipase, hepatic"), is a form of lipase, catalyzing the hydrolysis of fats. It is expressed in the liver and adrenal glands.

One of the principal functions of hepatic lipase is to convert intermediate-density lipoprotein (IDL) to low-density lipoprotein (LDL).

LIPC encodes hepatic triglyceride lipase (HTGL), which is expressed in liver. LIPC has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake.

Clinical significance

Hepatic lipase deficiency is a rare, autosomal recessive disorder that results in elevated high density lipoprotein (HDL) cholesterol due to a mutation in the hepatic lipase gene. Clinical features are not well understood and there are no characteristic xanthomas. There is an association with a delay in atherosclerosis in an animal model.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.

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File:StatinPathway_WP430.png

Statin Pathway edit

References

Further reading

• Santamarina-Fojo S, Haudenschild C, Amar M (1998). "The role of hepatic lipase in lipoprotein metabolism and atherosclerosis.". Curr. Opin. Lipidol. 9 (3): 211–9. doi:10.1097/00041433-199806000-00005. PMID 9645503. 
• Jansen H, Verhoeven AJ, Sijbrands EJ (2003). "Hepatic lipase: a pro- or anti-atherogenic protein?". J. Lipid Res. 43 (9): 1352–62. doi:10.1194/jlr.R200008-JLR200. PMID 12235167. 
• Zambon A, Deeb SS, Pauletto P, et al. (2003). "Hepatic lipase: a marker for cardiovascular disease risk and response to therapy.". Curr. Opin. Lipidol. 14 (2): 179–89. doi:10.1097/01.mol.0000064055.08840.77. PMID 12642787. 
• Hegele RA, Tu L, Connelly PW (1993). "Human hepatic lipase mutations and polymorphisms.". Hum. Mutat. 1 (4): 320–4. doi:10.1002/humu.1380010410. PMID 1301939. 
• Hegele RA, Vezina C, Moorjani S, et al. (1991). "A hepatic lipase gene mutation associated with heritable lipolytic deficiency.". J. Clin. Endocrinol. Metab. 72 (3): 730–2. doi:10.1210/jcem-72-3-730. PMID 1671786. 
• Hegele RA, Little JA, Connelly PW (1991). "Compound heterozygosity for mutant hepatic lipase in familial hepatic lipase deficiency.". Biochem. Biophys. Res. Commun. 179 (1): 78–84. doi:10.1016/0006-291X(91)91336-B. PMID 1883393. 
• Ameis D, Stahnke G, Kobayashi J, et al. (1990). "Isolation and characterization of the human hepatic lipase gene.". J. Biol. Chem. 265 (12): 6552–5. PMID 2324091. 
• Datta S, Luo CC, Li WH, et al. (1988). "Human hepatic lipase. Cloned cDNA sequence, restriction fragment length polymorphisms, chromosomal localization, and evolutionary relationships with lipoprotein lipase and pancreatic lipase.". J. Biol. Chem. 263 (3): 1107–10. PMID 2447084. 
• Cai SJ, Wong DM, Chen SH, Chan L (1990). "Structure of the human hepatic triglyceride lipase gene.". Biochemistry 28 (23): 8966–71. doi:10.1021/bi00449a002. PMID 2605236. 
• Stahnke G, Sprengel R, Augustin J, Will H (1988). "Human hepatic triglyceride lipase: cDNA cloning, amino acid sequence and expression in a cultured cell line.". Differentiation 35 (1): 45–52. doi:10.1111/j.1432-0436.1987.tb00150.x. PMID 2828141. 
• Martin GA, Busch SJ, Meredith GD, et al. (1988). "Isolation and cDNA sequence of human postheparin plasma hepatic triglyceride lipase.". J. Biol. Chem. 263 (22): 10907–14. PMID 2839510. 
• Sparkes RS, Zollman S, Klisak I, et al. (1988). "Human genes involved in lipolysis of plasma lipoproteins: mapping of loci for lipoprotein lipase to 8p22 and hepatic lipase to 15q21.". Genomics 1 (2): 138–44. doi:10.1016/0888-7543(87)90005-X. PMID 3692485. 
• Kounnas MZ, Chappell DA, Wong H, et al. (1995). "The cellular internalization and degradation of hepatic lipase is mediated by low density lipoprotein receptor-related protein and requires cell surface proteoglycans.". J. Biol. Chem. 270 (16): 9307–12. doi:10.1074/jbc.270.16.9543. PMID 7721852. 
• Mori A, Takagi A, Ikeda Y, et al. (1996). "An AvaII polymorphism in exon 5 of the human hepatic triglyceride lipase gene.". Mol. Cell. Probes 10 (4): 309–11. doi:10.1006/mcpr.1996.0040. PMID 8865179. 
• Takagi A, Ikeda Y, Mori A, et al. (1996). "Identification of a BstNI polymorphism in exon 9 of the human hepatic triglyceride lipase gene.". Mol. Cell. Probes 10 (4): 313–4. doi:10.1006/mcpr.1996.0041. PMID 8865180. 
• Choi SY, Goldberg IJ, Curtiss LK, Cooper AD (1998). "Interaction between ApoB and hepatic lipase mediates the uptake of ApoB-containing lipoproteins.". J. Biol. Chem. 273 (32): 20456–62. doi:10.1074/jbc.273.32.20456. PMID 9685400. 
• Cargill M, Altshuler D, Ireland J, et al. (1999). "Characterization of single-nucleotide polymorphisms in coding regions of human genes.". Nat. Genet. 22 (3): 231–8. doi:10.1038/10290. PMID 10391209. 
• Tiebel O, Gehrisch S, Pietzsch J, et al. (2000). "18 bp insertion/duplication with internal missense mutation in human hepatic lipase gene exon 3. Mutations in brief no. 181. Online.". Hum. Mutat. 12 (3): 216. PMID 10660332. 
• Yamakawa-Kobayashi K, Somekawa Y, Fujimura M, et al. (2002). "Relation of the -514C/T polymorphism in the hepatic lipase gene to serum HDL and LDL cholesterol levels in postmenopausal women under hormone replacement therapy.". Atherosclerosis 162 (1): 17–21. doi:10.1016/S0021-9150(01)00675-X. PMID 11947893. 

External links

• hepatic lipase, human at the US National Library of Medicine Medical Subject Headings (MeSH)

English Journal

• Postprandial triglyceridemia after single dose of alcohol in healthy young men.

• Mudráková E, Poledne R, Kovář J.SourceInstitute for Clinical and Experimental Medicine, Prague, Vídeňská 1958/9, 140 21 Prague 4, Czech Republic.
• Nutrition, metabolism, and cardiovascular diseases : NMCD.Nutr Metab Cardiovasc Dis.2011 Sep 13. [Epub ahead of print]
• BACKGROUND AND AIMS: Moderate alcohol consumption provides protection against cardiovascular disease primarily due to increase of HDL-cholesterol. However, it also has some adverse effects on metabolism of triglycerides (TG). Therefore, we addressed the question how a single dose of alcohol affects
• PMID 21917433

• Lipoprotein lipase and hepatic triglyceride lipase reduce the infectivity of hepatitis C virus (HCV) through their catalytic activities on HCV-associated lipoproteins.

• Shimizu Y, Hishiki T, Sugiyama K, Ogawa K, Funami K, Kato A, Ohsaki Y, Fujimoto T, Takaku H, Shimotohno K.SourceResearch Institute, Chiba Institute of Technology, 2-17-1 Tsudanuma, Narashino, Chiba 275-0016, Japan. yuko.shimizu@it-chiba.ac.jp
• Virology.Virology.2010 Nov 10;407(1):152-9. Epub 2010 Sep 6.
• The effect of lipolysis by lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL) on hepatitis C virus (HCV) infection was evaluated. First, medium from HuH7.5 cells bearing HCV genome replication was treated with LPL. LPL treatment led to reduced HCV infectivity, shifted HCV to higher dens
• PMID 20822787

• Association of angiopoietin-like protein 3 with hepatic triglyceride lipase and lipoprotein lipase activities in human plasma.

• Nakajima K, Kobayashi J, Mabuchi H, Nakano T, Tokita Y, Nagamine T, Imamura S, Ai M, Otokozawa S, Schaefer EF.SourceDepartment of Lipidology and Division of Cardiology, Kanazawa University Graduate School of Medical Science, Kanazawa City, Ishikawa, Japan. nakajimak05@ybb.ne.jp
• Annals of clinical biochemistry.Ann Clin Biochem.2010 Sep;47(Pt 5):423-31. Epub 2010 Jul 1.
• BACKGROUND: The relationship between plasma angiopoietin-like protein 3 (ANGPTL3), and lipoprotein lipase (LPL) activity and hepatic triglyceride lipase (HTGL) activity has not been investigated in the metabolism of remnant lipoproteins (RLPs) and high-density lipoprotein (HDL) in human plasma.METHO
• PMID 20595410

Japanese Journal

• Effects of a Purified Saponin Mixture from Alfalfa on Plasma Lipid Metabolism in Hyperlipidemic Mice

• Yu Cong-Hong,Xie Guo,He Rong-Rong,Zhai Yu-Jia,Li Yi-Fang,Tsoi Bun,Kurihara Hiroshi,Yang De-Po
• JOURNAL OF HEALTH SCIENCE 57(5), 401-405, 2011
• … Further study demonstrated that PSM not only enhanced the activities of lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL) in liver, but also increased their mRNA levels in hyperlipidemic mice. …
• NAID 130001151380

• Association of angiopoietin-like protein 3 with hepatic triglyceride lipase and lipoprotein lipase activities in human plasma

• Nakajima Katsuyuki,Kobayashi Junji,Mabuchi Hiroshi,Nakano T.,Tokita Yoshiharu,Nagamine T.,Imamura S.,Ai Masumi,Otokozawa Seiko,Schaefer E. F.
• Annals of Clinical Biochemistry 47(5), 423-431, 2010-09
• … Background: The relationship between plasma angiopoietin-like protein 3 (ANGPTL3), and lipoprotein lipase (LPL) activity and hepatic triglyceride lipase (HTGL) activity has not been investigated in the metabolism of remnant lipoproteins (RLPs) and high-density lipoprotein (HDL) in human plasma. … Methods: ANGPTL3, LPL activity, HTGL activity, RLP-C and RLP-TG and small, dense LDL-cholesterol (sd LDL-C) were measured in 20 overweight and obese subjects in the fasting and postprandial states. …
• NAID 120002519245

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表1 主要なアポ蛋白の機能 アポ蛋白 産生臓器 存在するリポ蛋白 機能 アポA-I 小腸、肝 HDL←カイロミクロン LCATの活性化、HDL受容体との結合 アポA-II 肝 HDL LCATの活性阻害、HTGLの活性阻害

Related Pictures

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★リンクテーブル★

リンク元	「肝性トリグリセリドリパーゼ」「肝性トリアシルグリセロールリパーゼ」
関連記事	「HT」

「肝性トリグリセリドリパーゼ」

　　[★]

英

hepatic triglyceride lipase, HTGL

• 肝臓で発現するリパーゼ
• 高脂血症薬のフィブラート系薬がRRARαに作用してHTGLを活性化する

「肝性トリアシルグリセロールリパーゼ」

　　[★]

英

hepatic triacylglycerol lipase, HTGL

同

肝性リパーゼ hepatic lipase

「HT」

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• 高血圧症 高血圧 hypertension
• 心移植 heart transplantation