WordNet

pertaining to or affecting the liver; "hepatic ducts"; "hepatic cirrhosis"
an enzyme secreted in the digestive tract that catalyzes the breakdown of fats into individual fatty acids that can be absorbed into the bloodstream
glyceride occurring naturally in animal and vegetable tissues; it consists of three individual fatty acids bound together in a single large molecule; an important energy source forming much of the fat stored by the body

PrepTutorEJDIC

肝臓の;肝臓にきく,肝臓のような色の
リパーゼ(脂肪分解酵素)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/08 17:16:24」(JST)

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Hepatic lipase, also called hepatic triglyceride lipase (HTGL) or LIPC (for "lipase, hepatic"), is a form of lipase, catalyzing the hydrolysis of fats. It is expressed in the liver and adrenal glands.^[1]

One of the principal functions of hepatic lipase is to convert intermediate-density lipoprotein (IDL) to low-density lipoprotein (LDL).

LIPC encodes hepatic triglyceride lipase (HTGL), which is expressed in liver. LIPC has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake.^[2]

Clinical significance

Hepatic lipase deficiency is a rare, autosomal recessive disorder that results in elevated high density lipoprotein (HDL) cholesterol due to a mutation in the hepatic lipase gene. Clinical features are not well understood and there are no characteristic xanthomas. There is an association with a delay in atherosclerosis in an animal model.^[3]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

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|{{{bSize}}}px|alt=Statin Pathway edit]]

File:StatinPathway_WP430.png

Statin Pathway edit

^ The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430".

References

^ Dichek HL, Agrawal N, El Andaloussi N, Qian K (2006). "Attenuated corticosterone response to chronic ACTH stimulation in hepatic lipase-deficient mice: evidence for a role for hepatic lipase in adrenal physiology". Am. J. Physiol. Endocrinol. Metab. 290 (5): E908–15. doi:10.1152/ajpendo.00442.2005. PMID 16368783.
^ "Entrez Gene: LIPC lipase, hepatic".
^ Karackattu SL, Trigatti B, Krieger M (2006). "Hepatic lipase deficiency delays atherosclerosis, myocardial infarction, and cardiac dysfunction and extends lifespan in SR-BI/apolipoprotein E double knockout mice". Arterioscler. Thromb. Vasc. Biol. 26 (3): 548–54. doi:10.1161/01.ATV.0000202662.63876.02. PMID 16397139.

External links

hepatic lipase, human at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. HDLコレステロール：異常値の臨床的側面 hdl cholesterol clinical aspects of abnormal values
2. LDLコレステロール代謝の遺伝性疾患 inherited disorders of ldl cholesterol metabolism
3. リポ蛋白の分類、代謝、およびアテローム性動脈硬化症における役割 lipoprotein classification metabolism and role in atherosclerosis
4. 高トリグリセリド血症患者に対するアプローチ approach to the patient with hypertriglyceridemia
5. リポ蛋白および止血因子に対する運動の影響 effects of exercise on lipoproteins and hemostatic factors

English Journal

Piperine reverses high fat diet-induced hepatic steatosis and insulin resistance in mice.

Choi S, Choi Y, Choi Y, Kim S, Jang J, Park T.SourceDepartment of Food and Nutrition, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Republic of Korea.
Food chemistry.Food Chem.2013 Dec 15;141(4):3627-35. doi: 10.1016/j.foodchem.2013.06.028. Epub 2013 Jun 17.
This study examined the effect of piperine on hepatic steatosis and insulin resistance induced in mice by feeding a high-fat diet (HFD) for 13weeks and elucidated potential underlying molecular mechanisms. Administration of piperine (50mg/kg body weight) to mice with HFD-induced hepatic steatosis re
PMID 23993530

Effects of cigarette smoking on HDL quantity and function: Implications for atherosclerosis.

He BM, Zhao SP, Peng ZY.SourceDepartment of Geriatric Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, P.R., China.
Journal of cellular biochemistry.J Cell Biochem.2013 Nov;114(11):2431-6. doi: 10.1002/jcb.24581.
Cigarette smoking has been identified as an independent and preventable risk factor for atherosclerosis and cardiovascular disease. Population studies have shown that plasma high density lipoprotein (HDL) cholesterol levels are inversely related to the risk of developing cardiovascular disease. Ciga
PMID 23852759

Insulin, IGF-I, and muscle MAPK pathway responses after sustained exercise and their contribution to growth and lipid metabolism regulation in gilthead sea bream.

Sánchez-Gurmaches J, Cruz-Garcia L, Ibarz A, Fernández-Borrás J, Blasco J, Gutiérrez J, Navarro I.SourceDepartament de Fisiologia i Immunologia, Facultat de Biologia, Universitat de Barcelona, Av. Diagonal 643, E-08028 Barcelona, Catalunya, Spain. Electronic address: juansangu@gmail.com.
Domestic animal endocrinology.Domest Anim Endocrinol.2013 Oct;45(3):145-53. doi: 10.1016/j.domaniend.2013.08.001. Epub 2013 Aug 30.
Herein, we studied whether sustained exercise positively affects growth of gilthead sea bream by alterations in a) plasma concentrations of insulin and IGF-I, b) signaling pathways in muscle, or c) regulation of lipid metabolism. Specifically, we evaluated the effects of moderated swimming (1.5 body
PMID 24011532

Japanese Journal

Effects of a Purified Saponin Mixture from Alfalfa on Plasma Lipid Metabolism in Hyperlipidemic Mice

Yu Cong-Hong,Xie Guo,He Rong-Rong,Zhai Yu-Jia,Li Yi-Fang,Tsoi Bun,Kurihara Hiroshi,Yang De-Po
JOURNAL OF HEALTH SCIENCE 57(5), 401-405, 2011
… Further study demonstrated that PSM not only enhanced the activities of lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL) in liver, but also increased their mRNA levels in hyperlipidemic mice. …
NAID 130001151380

Association of angiopoietin-like protein 3 with hepatic triglyceride lipase and lipoprotein lipase activities in human plasma

Nakajima Katsuyuki,Kobayashi Junji,Mabuchi Hiroshi,Nakano T.,Tokita Yoshiharu,Nagamine T.,Imamura S.,Ai Masumi,Otokozawa Seiko,Schaefer E. F.
Annals of Clinical Biochemistry 47(5), 423-431, 2010-09
… Background: The relationship between plasma angiopoietin-like protein 3 (ANGPTL3), and lipoprotein lipase (LPL) activity and hepatic triglyceride lipase (HTGL) activity has not been investigated in the metabolism of remnant lipoproteins (RLPs) and high-density lipoprotein (HDL) in human plasma. …
NAID 120002519245

Related Pictures

★リンクテーブル★

リンク元	「肝性トリグリセリドリパーゼ」
関連記事	「hepatic」「triglycerides」「triglyceride」「triglyceride lipase」

「肝性トリグリセリドリパーゼ」

Lipase, hepatic
Identifiers
Symbols	LIPC ; HDLCQ12; HL; HTGL; LIPH
External IDs	OMIM: 151670 MGI: 96216 HomoloGene: 199 ChEMBL: 2127 GeneCards: LIPC Gene
EC number	3.1.1.3
Gene ontology
Molecular function	• phospholipase activity; • triglyceride lipase activity; • heparin binding; • low-density lipoprotein particle binding; • apolipoprotein binding;
Cellular component	• extracellular space; • high-density lipoprotein particle;
Biological process	• fatty acid biosynthetic process; • cholesterol metabolic process; • triglyceride catabolic process; • very-low-density lipoprotein particle remodeling; • intermediate-density lipoprotein particle remodeling; • low-density lipoprotein particle remodeling; • high-density lipoprotein particle remodeling; • chylomicron remnant clearance; • phosphatidylcholine catabolic process; • cholesterol homeostasis; • reverse cholesterol transport; • triglyceride homeostasis;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	v; t; e;