WordNet

pertaining to or affecting the liver; "hepatic ducts"; "hepatic cirrhosis"
an enzyme secreted in the digestive tract that catalyzes the breakdown of fats into individual fatty acids that can be absorbed into the bloodstream

PrepTutorEJDIC

肝臓の;肝臓にきく,肝臓のような色の
リパーゼ(脂肪分解酵素)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/10/08 22:16:13」(JST)

wiki en

Hepatic lipase is a form of lipase. It is expressed in the liver and adrenal glands.^[1]

One of the principal functions of hepatic lipase is to convert intermediate-density lipoprotein (IDL) to low-density lipoprotein (LDL).

LIPC encodes hepatic triglyceride lipase (HTGL), which is expressed in liver. LIPC has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake.^[2]

Clinical significance[edit]

Hepatic lipase deficiency is a rare, autosomal recessive disorder that results in elevated high density lipoprotein (HDL) cholesterol due to a mutation in the hepatic lipase gene. Clinical features are not well understood and there are no characteristic xanthomas. There is an association with a delay in atherosclerosis in an animal model.^[3]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

[[File:

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

|{{{bSize}}}px]]

Statin Pathway edit

^ The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430".

References[edit]

^ Dichek HL, Agrawal N, El Andaloussi N, Qian K (2006). "Attenuated corticosterone response to chronic ACTH stimulation in hepatic lipase-deficient mice: evidence for a role for hepatic lipase in adrenal physiology". Am. J. Physiol. Endocrinol. Metab. 290 (5): E908–15. doi:10.1152/ajpendo.00442.2005. PMID 16368783.
^ "Entrez Gene: LIPC lipase, hepatic".
^ Karackattu SL, Trigatti B, Krieger M (2006). "Hepatic lipase deficiency delays atherosclerosis, myocardial infarction, and cardiac dysfunction and extends lifespan in SR-BI/apolipoprotein E double knockout mice". Arterioscler. Thromb. Vasc. Biol. 26 (3): 548–54. doi:10.1161/01.ATV.0000202662.63876.02. PMID 16397139.

External links[edit]

hepatic lipase, human at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. HDLコレステロール：異常値の臨床的側面 hdl cholesterol clinical aspects of abnormal values
2. LDLコレステロール代謝の遺伝性疾患 inherited disorders of ldl cholesterol metabolism
3. リポ蛋白および止血因子に対する運動の影響 effects of exercise on lipoproteins and hemostatic factors
4. リポ蛋白の分類、代謝、およびアテローム性動脈硬化症における役割 lipoprotein classification metabolism and role in atherosclerosis
5. 高トリグリセリド血症患者に対するアプローチ approach to the patient with hypertriglyceridemia

English Journal

ADIPOQ single nucleotide polymorphism: Association with adiponectin and lipoproteins levels restricted to men.

Tureck LV1, Leite N2, Souza RL1, da Silva Timossi L2, Osiecki AC2, Osiecki R2, Alle LF1.
Meta gene.Meta Gene.2015 Jun 17;5:98-104. doi: 10.1016/j.mgene.2015.06.003. eCollection 2015.
Adiponectin is an adipokine inversely correlated with obesity, which has beneficial effect on insulin resistance and lipid metabolism. Considering its potential as a therapeutic target in the metabolic disorder contexts, and in order to add knowledge in the area, our study evaluated the ADIPOQ 276G�
PMID 26137445

Cholestane-3β,5α,6β-triol in lipidosis: High levels in Niemann Pick type C, Cerebrotendinous Xanthomatosis and Lysosomal Acid Lipase deficiency.

Pajares S1, Arias A1, Garcia-Villoria J1, Macias-Vidal J1, Ros E2, de Las Heras J3, Giros M1, Coll MJ1, Ribes A4.
Journal of lipid research.J Lipid Res.2015 Aug 3. pii: jlr.M060343. [Epub ahead of print]
Niemann-Pick type C (NPC) is a progressive neurodegenerative disease characterized by lysosomal/endosomal accumulation of unesterified cholesterol and glycolipids. Recent studies have shown that plasma cholestane-3b,5a,6b-triol (CT) and 7-ketocholesterol (7-KC) could be potential biomarkers for the
PMID 26239048

Plasma Apolipoprotein C-III Levels, Triglycerides, and Coronary Artery Calcification in Type 2 Diabetics.

Qamar A1, Khetarpal SA1, Khera AV1, Qasim A1, Rader DJ2, Reilly MP2.
Arteriosclerosis, thrombosis, and vascular biology.Arterioscler Thromb Vasc Biol.2015 Aug;35(8):1880-8. doi: 10.1161/ATVBAHA.115.305415. Epub 2015 Jun 11.
OBJECTIVE: Triglyceride-rich lipoproteins have emerged as causal risk factors for developing coronary heart disease independent of low-density lipoprotein cholesterol levels. Apolipoprotein C-III (ApoC-III) modulates triglyceride-rich lipoprotein metabolism through inhibition of lipoprotein lipase a
PMID 26069232

Japanese Journal

初代培養ラット肝細胞系におけるプラゾシンによる肝性リパーゼの分泌促進に対するロイコトリエン代謝系の関与

中村徹也,森田哲生
医学と生物学 156(5), 332-337, 2012-05
NAID 40019323978

Related Pictures

Direct and indirect routes of reverse cholesterol transport in humans Intermediate Density Lipoprotein | www.imagenesmy.com Hepatic Overexpression of Endothelial Lipase Lowers High-Density Lipoprotein but 2020 Guidelines of the Polish Society of Laboratory Diagnostics (PSLD Hepatic Lipase, Lipoprotein Metabolism, and Atherogenesis Hepatic Lipase, High Density Lipoproteins, and Hypertriglyceridemia

★リンクテーブル★

リンク元	「肝性トリアシルグリセロールリパーゼ」「肝性リパーゼ」
関連記事	「hepatic」

「肝性トリアシルグリセロールリパーゼ」

Lipase, hepatic
Identifiers
Symbols	LIPC; HDLCQ12; HL; HTGL; LIPH
External IDs	OMIM: 151670 MGI: 96216 HomoloGene: 199 ChEMBL: 2127 GeneCards: LIPC Gene
EC number	3.1.1.3
Gene Ontology
Molecular function	• phospholipase activity; • triglyceride lipase activity; • heparin binding; • low-density lipoprotein particle binding; • apolipoprotein binding; • retinyl-palmitate esterase activity;
Cellular component	• extracellular space; • high-density lipoprotein particle;
Biological process	• fatty acid biosynthetic process; • cholesterol metabolic process; • triglyceride catabolic process; • very-low-density lipoprotein particle remodeling; • intermediate-density lipoprotein particle remodeling; • low-density lipoprotein particle remodeling; • high-density lipoprotein particle remodeling; • chylomicron remnant clearance; • phosphatidylcholine catabolic process; • cholesterol homeostasis; • reverse cholesterol transport; • triglyceride homeostasis;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	This box: view; talk; edit;