GMP還元酵素、GMPレダクターゼ
WordNet
- an enzyme that catalyses the biochemical reduction of some specified substance
- the 7th letter of the Roman alphabet (同)g
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/09/12 01:47:51」(JST)
[Wiki en表示]
| guanosine monophosphate reductase |
|
| Identifiers |
| Symbol |
GMPR |
| Entrez |
2766 |
| HUGO |
4376 |
| OMIM |
139265 |
| RefSeq |
NM_006877 |
| UniProt |
P36959 |
| Other data |
| EC number |
1.7.1.7 |
| Locus |
Chr. 6 p23 |
| guanosine monophosphate reductase 2 |
| Identifiers |
| Symbol |
GMPR2 |
| Entrez |
51292 |
| HUGO |
4377 |
| OMIM |
610781 |
| RefSeq |
NM_016576 |
| UniProt |
Q9P2T1 |
| Other data |
| Locus |
Chr. 14 q11.2 |
GMP reductase EC 1.7.1.7 (Guanosine 5'-monophosphate oxidoreductase ) is an enzyme that catalyses the irreversible and NADPH-dependent reductive deamination of GMP into IMP.[1]
NADPH + guanosine 5-phosphate = NADP+ + inosine 5-phosphate + NH3
It converts nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and maintains intracellular balance of A and G nucleotides.
In melanocytic cells, GMP reductase gene expression may be regulated by MITF.[2]
See also
References
- ^ Andrews SC, Guest JR (Oct 1988). "Nucleotide sequence of the gene encoding the GMP reductase of Escherichia coli K12". The Biochemical Journal. 255 (1): 35–43. doi:10.1042/bj2550035. PMC 1135187. PMID 2904262.
- ^ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (Dec 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
External links
- GMP reductase at the US National Library of Medicine Medical Subject Headings (MeSH)
|
|
|
| Purine metabolism |
| Anabolism |
| R5P→IMP: |
- Ribose-phosphate diphosphokinase
- Amidophosphoribosyltransferase
- Phosphoribosylglycinamide formyltransferase
- AIR synthetase (FGAM cyclase)
- Phosphoribosylaminoimidazole carboxylase
- Phosphoribosylaminoimidazolesuccinocarboxamide synthase
- IMP synthase
|
|
| IMP→AMP: |
- Adenylosuccinate synthase
- Adenylosuccinate lyase
- reverse
|
|
| IMP→GMP: |
- IMP dehydrogenase
- GMP synthase
- reverse
|
|
|
| Nucleotide salvage |
- Hypoxanthine-guanine phosphoribosyltransferase
- Adenine phosphoribosyltransferase
|
|
| Catabolism |
- Adenosine deaminase
- Purine nucleoside phosphorylase
- Guanine deaminase
- Xanthine oxidase
- Urate oxidase
|
|
|
| Pyrimidine metabolism |
| Anabolism |
- CAD
- Carbamoyl phosphate synthase II
- Aspartate carbamoyltransferase
- Dihydroorotase
|
|
- Dihydroorotate dehydrogenase
- Orotidine 5'-phosphate decarboxylase/Uridine monophosphate synthetase
|
|
|
|
|
|
| Catabolism |
- Dihydropyrimidine dehydrogenase
- Dihydropyrimidinase/DPYS
- Beta-ureidopropionase/UPB1
|
|
|
| Deoxyribonucleotides |
- Ribonucleotide reductase
- Nucleoside-diphosphate kinase
- DCMP deaminase
- Thymidylate synthase
- Dihydrofolate reductase
|
|
Oxidoreductases: nitrogenous donor (EC 1.7)
|
|
| 1.7.1 |
|
|
| 1.7.2 |
- Nitrite reductase (NO-forming)
|
|
| 1.7.3 |
|
|
| 1.7.7 |
- Ferredoxin—nitrite reductase
|
|
| 1.7.99 |
|
This article incorporates text from the public domain Pfam and InterPro IPR001093
UpToDate Contents
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English Journal
- Association of a multi-synthetase complex with translating ribosomes in the archaeon Thermococcus kodakarensis.
- Raina M, Elgamal S, Santangelo TJ, Ibba M.SourceOhio State Biochemistry Program, Ohio State University, Columbus, OH 43210, USA.
- FEBS letters.FEBS Lett.2012 Jul 30;586(16):2232-8. Epub 2012 Jun 7.
- In archaea and eukaryotes aminoacyl-tRNA synthetases (aaRSs) associate in multi-synthetase complexes (MSCs), however the role of such MSCs in translation is unknown. MSC function was investigated in vivo in the archaeon Thermococcus kodakarensis, wherein six aaRSs were affinity co-purified together
- PMID 22683511
- Cerebral Blood Flow Regulation by Nitric Oxide in Alzheimer's Disease.
- Toda N, Okamura T.SourceToyama Institute for Cardiovascular Pharmacology Research, Osaka, Japan Department of Pharmacology, Shiga University of Medical Science, Shiga, Japan.
- Journal of Alzheimer's disease : JAD.J Alzheimers Dis.2012 Jul 17. [Epub ahead of print]
- Cerebral hypoperfusion due to impaired bioavailability of nitric oxide (NO) synthesized by endothelial nitric oxide synthase and neuronal nitric oxide synthase leads to cognitive decline and neurodegeneration in Alzheimer's disease (AD). Risk factors for endothelial dysfunction, such as inadequate l
- PMID 22810094
Japanese Journal
- gsk Disruption Leads to Guanosine Accumulation in Escherichia coli
- Matsui Hiroshi,Shimaoka Megumi,Takenaka Yasuhiro [他],KAWASAKI Hisashi,KURAHASHI Osamu
- Bioscience, biotechnology, and biochemistry 65(5), 1230-1235, 2001-05-23
- … The further addition of guaC (guanosine 5'-monophosphate (GMP) reductase gene) disruption did not lead to an increased guanosine accumulation, but brought about the decrease of inosine accumulation. …
- NAID 110002680423
- 2-Amino-4-hydroxy-6-formyldihydropteridineの代謝
- 鈴木 讓
- ビタミン 48(2), 41-61, 1974-02-25
- … 2-Amino-4-hydroxy-6-carboxydihydropteridine (V), but not 2-amino-4-hydroxy-6-carboxypteridine (VI), inhibits enzymatic synthesis of (II) from GMP by specific attacking an enzyme reaction catalyzed by 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine (VII) pyrophosphokinase. … The enzymatic conversion of (VIII) to (VII) is catalyzed by a specific reductase dependent on NADPH, and the conversion of (IX) to (VIII) requires FAD and NADH as the cofactors. …
- NAID 110002845874
Related Links
- GMP re·duc·tase (rē-dŭk'tās), Abbreviation for guanylic acid reductase. ... Disclaimer All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only.
- Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G ... « Hide 10 20 30 40 50 MPRIEFEPKL ...
★リンクテーブル★
[★]
- 英
- GMP reductase
- 関
- GMPレダクターゼ
[★]
- 英
- GMP reductase
- 関
- GMP還元酵素
[★]
[★]
- (酵素)還元酵素、レダクターゼ、リダクターゼ
- 関
- dehydrogenase、oxidase、oxidoreductase、reducing enzyme
[★]