- 日
- 関
WordNet
- a class of transferases that catalyze transamination (that transfer an amino group from an amino acid to another compound) (同)aminotransferase, aminopherase
PrepTutorEJDIC
- General Admiral / (またGa)Georgia
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2012/12/18 09:24:42」(JST)
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4-aminobutyrate transaminase |
Identifiers |
EC number |
2.6.1.19 |
CAS number |
9037-67-6 |
Databases |
IntEnz |
IntEnz view |
BRENDA |
BRENDA entry |
ExPASy |
NiceZyme view |
KEGG |
KEGG entry |
MetaCyc |
metabolic pathway |
PRIAM |
profile |
PDB structures |
RCSB PDB PDBe PDBsum |
Gene Ontology |
AmiGO / EGO |
Search |
PMC |
articles |
PubMed |
articles |
NCBI Protein |
search |
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4-aminobutyrate transaminase |
Identifiers |
Symbol |
ABAT |
Entrez |
18 |
HUGO |
23 |
OMIM |
137150 |
RefSeq |
NM_020686 |
UniProt |
P80404 |
Other data |
Locus |
Chr. 16 p13.2 |
In enzymology, 4-aminobutyrate transaminase (EC 2.6.1.19), also called GABA transaminase or 4-aminobutyrate aminotransferase, is an enzyme that catalyzes the chemical reaction:
- 4-aminobutanoate + 2-oxoglutarate succinate semialdehyde + L-glutamate
Thus, the two substrates of this enzyme are 4-aminobutanoate (GABA) and 2-oxoglutarate. The two products are succinate semialdehyde and L-glutamate.
This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is 4-aminobutanoate:2-oxoglutarate aminotransferase. This enzyme participates in 5 metabolic pathways: alanine and aspartate metabolism, glutamate metabolism, beta-alanine metabolism, propanoate metabolism, and butanoate metabolism. It employs one cofactor, pyridoxal phosphate.
Contents
- 1 Structural Studies
- 2 Inhibitors
- 3 References
- 4 External links
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Structural Studies
As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1OHV, 1OHW, 1OHY, 1SF2, 1SFF, 1SZK, 1SZS, 1SZU, and 2EO5.
Inhibitors
- Aminooxyacetic acid
- Gabaculine
- Phenelzine
- Phenylethylidenehydrazine (PEH)
- Rosmarinic acid
- Valproic acid
- Vigabatrin
References
- Scott EM, Jakoby WB (1959). "Soluble gamma-aminobutyric-glutamic transaminase from Pseudomonas fluorescens". J. Biol. Chem. 234 (4): 932–936. PMID 13654294.
- Aurich H (1961). "Ueber die beta-Alanin-alpha-Ketoglutarat-Transaminase aus Neurospora crassa". Hoppe-Seyler's Z. Physiol. Chem. 326: 25–33.
- Schousboe A, Wu JY, Roberts E (1973). "Purification and characterization of the 4-aminobutyrate:2-ketoglutarate transaminase from mouse brain". Biochemistry 12 (15): 2868–73. doi:10.1021/bi00739a015. PMID 4719123.
External links
- 4-Aminobutyrate+Transaminase at the US National Library of Medicine Medical Subject Headings (MeSH)
Metabolism: amino acid metabolism · neurotransmitter enzymes
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monoamine |
histidine→histamine
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anabolism: Histidine decarboxylase
catabolism: Histamine N-methyltransferase · Amine oxidase
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tyrosine→dopamine→epinephrine
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anabolism: Tyrosine hydroxylase · Aromatic L-amino acid decarboxylase · Dopamine beta hydroxylase · Phenylethanolamine N-methyltransferase
catabolism: Catechol-O-methyl transferase · Monoamine oxidase
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glutamate→GABA
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anabolism: Glutamate decarboxylase
catabolism: 4-aminobutyrate transaminase
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tryptophan→serotonin→melatonin
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Tryptophan hydroxylase · Aromatic L-amino acid decarboxylase · Acetylserotonin O-methyltransferase
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arginine→NO |
Nitric oxide synthase (NOS1, NOS2, NOS3)
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choline→Acetylcholine |
anabolism: Choline acetyltransferase
catabolism: Cholinesterase (Acetylcholinesterase, Butyrylcholinesterase)
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mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m
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k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon
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m (A16/C10), i (k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)
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UpToDate Contents
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English Journal
- Contribution of polyamines and other related metabolites to the maintenance of zucchini fruit quality during cold storage.
- Palma F1, Carvajal F2, Jamilena M3, Garrido D2.
- Plant physiology and biochemistry : PPB / Société française de physiologie végétale.Plant Physiol Biochem.2014 Sep;82:161-71. doi: 10.1016/j.plaphy.2014.06.001. Epub 2014 Jun 13.
- In order to investigate the contribution of polyamines and related amino acids in the maintenance of zucchini fruit quality during cold storage, two varieties of Cucurbita pepo with different degrees of chilling tolerance were used, Natura (more tolerant) and Sinatra (moresensitive). After harvest,
- PMID 24960300
- Population Dose-Response Analysis of Daily Seizure Count Following Vigabatrin Therapy in Adult and Pediatric Patients with Refractory Complex Partial Seizures.
- Nielsen JC1, Hutmacher MM, Wesche DL, Tolbert D, Patel M, Kowalski KG.
- Journal of clinical pharmacology.J Clin Pharmacol.2014 Aug 12. doi: 10.1002/jcph.378. [Epub ahead of print]
- Vigabatrin is an irreversible inhibitor of γ-aminobutyric acid transaminase (GABA-T) and is used as an adjunctive therapy for adult patients with refractory complex partial seizures (rCPS). The purpose of this investigation was to describe the relationship between vigabatrin dosage and daily seizur
- PMID 25117853
- Elevation of rat brain tyrosine levels by phenelzine is mediated by its active metabolite β-phenylethylidenehydrazine.
- Matveychuk D1, Nunes E2, Ullah N3, Aldawsari FS4, Velázquez-Martínez CA5, Baker GB6.
- Progress in neuro-psychopharmacology & biological psychiatry.Prog Neuropsychopharmacol Biol Psychiatry.2014 Aug 4;53:67-73. doi: 10.1016/j.pnpbp.2014.02.011. Epub 2014 Mar 6.
- Phenelzine, a non-selective irreversible inhibitor of monoamine oxidase (MAO), has been used in the treatment of depression and anxiety disorders for several decades. It is a unique inhibitor of MAO as it is also a substrate for MAO, with one of the metabolites being β-phenylethylidenehydrazine (PE
- PMID 24607770
Japanese Journal
- Rat Submandibular Gland Perfusion Method for Clarifying Inhibitory Regulation of GABAA Receptor
- Okubo Migiwa,Kawaguchi Mitsuru
- Journal of Pharmacological Sciences 122(1), 42-50, 2013
- … GABA is an inhibitory transmitter found in rat salivary gland. … However, the inhibitory potential of GABA on salivary secretion is unclear. …
- NAID 130003362695
- γ-アミノ酪酸(GABA)の投与が繰り返しストレス下のラットの肝臓および脳のGABA代謝に及ぼす影響
- Purification and Characterization of a Novel (S)-Enantioselective Transaminase from Pseudomonas fluorescens KNK08-18 for the Synthesis of Optically Active Amines
- ITO Noriyuki,KAWANO Shigeru,HASEGAWA Junzo [他],YASOHARA Yoshihiko
- Bioscience, biotechnology, and biochemistry 75(11), 2093-2098, 2011-11-23
- … KNK08-18, showing (<I>S</I>)-selective transaminase activity, was isolated from soil by an enrichment culture method using (<I>S</I>)-7-methoxy-2-aminotetraline as the main nitrogen source. … A transaminase was purified from the strain to homogeneity in seven steps. …
- NAID 10030396348
Related Links
- Clinical Synopsis TEXT A number sign (#) is used with this entry because GABA-transaminase deficiency is caused by mutation in the ABAT gene (137150). Clinical Features Jaeken et al. (1984) reported 2 sibs, born of ...
- gaba transaminase, mgenex corp. develops novel reagents, including antibodies, gene and protein expression systems, and arrays of various cells and tissues for use in studies of functional genomics. ... Gaba Transaminase ...
Related Pictures
★リンクテーブル★
[★]
- 関
- GABA transaminase、gamma-aminobutyrate transaminase
[★]
- 英
- GABA transaminase
- 関
- GABAアミノ基転移酵素、4-アミノブチル酸トランスアミナーゼ
[★]
- 英
- GABA transaminase
- 関
- GABAトランスアミナーゼ
[★]
- butyl
- 英
- γ-aminobutyric acid, γ-aminobutyrate, gamma aminobutyric acid
- 同
- γ-アミノ酪酸、4-アミノ酪酸、γ-アミノ酪酸、γアミノ酪酸、ガンマアミノブチル酸
- 関
- GABA受容体。ブチル
構造
生合成
[★]
[★]
[★]
トランスアミナーゼ