- 関
- GABA transaminase、gamma-aminobutyrate transaminase
WordNet
- a class of transferases that catalyze transamination (that transfer an amino group from an amino acid to another compound) (同)aminotransferase, aminopherase
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/02/08 11:25:49」(JST)
[Wiki en表示]
| 4-aminobutyrate transaminase |
| Identifiers |
| EC number |
2.6.1.19 |
| CAS number |
9037-67-6 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Gene Ontology |
AmiGO / EGO |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
|
| 4-aminobutyrate transaminase |
| Identifiers |
| Symbol |
ABAT |
| Entrez |
18 |
| HUGO |
23 |
| OMIM |
137150 |
| RefSeq |
NM_020686 |
| UniProt |
P80404 |
| Other data |
| Locus |
Chr. 16 p13.2 |
In enzymology, 4-aminobutyrate transaminase (EC 2.6.1.19), also called GABA transaminase or 4-aminobutyrate aminotransferase, is an enzyme that catalyzes the chemical reaction:
- 4-aminobutanoate + 2-oxoglutarate succinate semialdehyde + L-glutamate
Thus, the two substrates of this enzyme are 4-aminobutanoate (GABA) and 2-oxoglutarate. The two products are succinate semialdehyde and L-glutamate.
This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is 4-aminobutanoate:2-oxoglutarate aminotransferase. This enzyme participates in 5 metabolic pathways: alanine and aspartate metabolism, glutamate metabolism, beta-alanine metabolism, propanoate metabolism, and butanoate metabolism. It employs one cofactor, pyridoxal phosphate.
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Contents
- 1 Structural Studies
- 2 Inhibitors
- 3 References
- 4 External links
|
Structural Studies
As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1OHV, 1OHW, 1OHY, 1SF2, 1SFF, 1SZK, 1SZS, 1SZU, and 2EO5.
Inhibitors
- Aminooxyacetic acid
- Gabaculine
- Phenelzine
- Phenylethylidenehydrazine (PEH)
- Rosmarinic acid
- Valproic acid
- Vigabatrin
References
- Scott EM, Jakoby WB (1959). "Soluble gamma-aminobutyric-glutamic transaminase from Pseudomonas fluorescens". J. Biol. Chem. 234 (4): 932–936. PMID 13654294.
- Aurich H (1961). "Ueber die beta-Alanin-alpha-Ketoglutarat-Transaminase aus Neurospora crassa". Hoppe-Seyler's Z. Physiol. Chem. 326: 25–33.
- Schousboe A, Wu JY, Roberts E (1973). "Purification and characterization of the 4-aminobutyrate:2-ketoglutarate transaminase from mouse brain". Biochemistry 12 (15): 2868–73. doi:10.1021/bi00739a015. PMID 4719123.
External links
- 4-Aminobutyrate+Transaminase at the US National Library of Medicine Medical Subject Headings (MeSH)
|
Metabolism: amino acid metabolism · neurotransmitter enzymes
|
|
| monoamine |
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histidine→histamine
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anabolism: Histidine decarboxylase
catabolism: Histamine N-methyltransferase · Amine oxidase
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tyrosine→dopamine→epinephrine
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anabolism: Tyrosine hydroxylase · Aromatic L-amino acid decarboxylase · Dopamine beta hydroxylase · Phenylethanolamine N-methyltransferase
catabolism: Catechol-O-methyl transferase · Monoamine oxidase
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|
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glutamate→GABA
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anabolism: Glutamate decarboxylase
catabolism: 4-aminobutyrate transaminase
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tryptophan→serotonin→melatonin
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Tryptophan hydroxylase · Aromatic L-amino acid decarboxylase · Acetylserotonin O-methyltransferase
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| arginine→NO |
Nitric oxide synthase (NOS1, NOS2, NOS3)
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| choline→Acetylcholine |
anabolism: Choline acetyltransferase
catabolism: Cholinesterase (Acetylcholinesterase, Butyrylcholinesterase)
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mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m
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k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon
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m (A16/C10), i (k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)
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UpToDate Contents
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English Journal
- Contribution of polyamines and other related metabolites to the maintenance of zucchini fruit quality during cold storage.
- Palma F1, Carvajal F2, Jamilena M3, Garrido D2.
- Plant physiology and biochemistry : PPB / Société française de physiologie végétale.Plant Physiol Biochem.2014 Sep;82:161-71. doi: 10.1016/j.plaphy.2014.06.001. Epub 2014 Jun 13.
- In order to investigate the contribution of polyamines and related amino acids in the maintenance of zucchini fruit quality during cold storage, two varieties of Cucurbita pepo with different degrees of chilling tolerance were used, Natura (more tolerant) and Sinatra (moresensitive). After harvest,
- PMID 24960300
- Stereoelectronic explanations for the mechanistic details of transimination and HF elimination reactions.
- Gökcan H1, Konuklar FA2.
- Journal of molecular graphics & modelling.J Mol Graph Model.2014 Jun;51:173-83. doi: 10.1016/j.jmgm.2014.05.006. Epub 2014 Jun 2.
- The β-fluoroamines are commonly used as substrate analogs to determine the mechanistic details of enzymatic reactions. Presence of fluorine atom gives rise to the alterations in the electronic profile and the pKa of molecules which results in mechanistic deviations. The fluorine-substituted mechani
- PMID 24929816
- Revealing pharmacodynamics of medicinal plants using in silico approach: a case study with wet lab validation.
- Singh D1, Gawande DY1, Singh T1, Poroikov V2, Goel RK3.
- Computers in biology and medicine.Comput Biol Med.2014 Apr;47:1-6. doi: 10.1016/j.compbiomed.2014.01.003. Epub 2014 Jan 16.
- BACKGROUND: Exploration of therapeutic mechanism is an integral part of medicinal plant based drug discovery for better understanding of pharmacological behavior of these agents. But, its study using conventional hit and trial wet laboratory experiments proves to be very tedious, time consuming and
- PMID 24503467
Japanese Journal
- 4-Aminobutyrate aminotransferase (GABA-transaminase) deficiency
- A single transaminase for 1,4-diaminobutane and 4-aminobutyrate in a Pseudomonas species.
Related Links
- Neurotransmitter Enzymes Neuromethods Volume 5, 1986, pp 389-420 4-Aminobutyrate Transaminase Godfrey Tunnicliff … show all 1 hide * Final gross prices may vary according to local VAT. Get Access Abstract γ ...
- 4-Aminobutyrate Transaminase information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues. ... Introduction: 4-Aminobutyrate Transaminase Description of 4-Aminobutyrate ...
★リンクテーブル★
[★]
- 英
- gamma-aminobutyrate transaminase、4-aminobutyrate transaminase
- 関
- 4-アミノブチル酸トランスアミナーゼ、4-アミノ酪酸トランスアミナーゼ、γ-アミノ酪酸トランスアミナーゼ
[★]
- 英
- gamma-aminobutyrate transaminase、4-aminobutyrate transaminase
- 関
- 4-アミノブチル酸トランスアミナーゼ、4-アミノ酪酸トランスアミナーゼ、γアミノ酪酸トランスアミナーゼ
[★]
- 英
- 4-aminobutyrate transaminase
- 関
- GABAトランスアミナーゼ、4-アミノ酪酸トランスアミナーゼ、γ-アミノ酪酸トランスアミナーゼ、γアミノ酪酸トランスアミナーゼ
[★]
- 英
- 4-aminobutyrate transaminase
- 関
- 4-アミノブチル酸トランスアミナーゼ、γ-アミノ酪酸トランスアミナーゼ、γアミノ酪酸トランスアミナーゼ
[★]
- 関
- 4-aminobutyrate transaminase
[★]
アミノ酪酸、アミノ酪酸塩
- 関
- aminobutyric acid
[★]
トランスアミナーゼ