Gαqサブユニット、Gαq

WordNet

first in order of importance; "the alpha male in the group of chimpanzees"; "the alpha star in a constellation is the brightest or main star"
the 1st letter of the Greek alphabet
the beginning of a series or sequence; "the Alpha and Omega, the first and the last, the beginning and the end"--Revelations
early testing stage of a software or hardware product; "alpha version"
the 17th letter of the Roman alphabet (同)q
a unit of force equal to the force exerted by gravity; used to indicate the force to which a body is subjected when it is accelerated (同)gee, g-force
the 7th letter of the Roman alphabet (同)g
any high mountain

PrepTutorEJDIC

アルファ(ギリシア語アルファベットの第1字A,α;英語のA,aに相当) / アルファ星(星座の主星)
(チェスの)queen
高山,高峰

UpToDate Contents

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1. α-1アンチトリプシン欠乏の治療 treatment of alpha 1 antitrypsin deficiency
2. 昇圧剤および強心剤の使用 use of vasopressors and inotropes
3. αサラセミアの病態生理 pathophysiology of alpha thalassemia
4. Anesthesia for patients with thyroid disease
5. 下肢末梢動脈疾患の症状を治療するための試験的治療 investigational therapies for treating symptoms of lower extremity peripheral artery disease

English Journal

The somatic GNAQ mutation c.548G>A (p.R183Q) is consistently found in Sturge-Weber syndrome.

Nakashima M1, Miyajima M2, Sugano H2, Iimura Y2, Kato M3, Tsurusaki Y1, Miyake N1, Saitsu H1, Arai H2, Matsumoto N1.
Journal of human genetics.J Hum Genet.2014 Dec;59(12):691-3. doi: 10.1038/jhg.2014.95. Epub 2014 Nov 6.
Sturge-Weber syndrome (SWS) is a neurocutaneous disorder characterized by capillary malformation (port-wine stains), and choroidal and leptomeningeal vascular malformations. Previously, the recurrent somatic mutation c.548G>A (p.R183Q) in the G-α q gene (GNAQ) was identified as causative in SWS
PMID 25374402

Angiotensin II induces DNA damage via AT1 receptor and NADPH oxidase isoform Nox4.

Fazeli G1, Stopper H, Schinzel R, Ni CW, Jo H, Schupp N.
Mutagenesis.Mutagenesis.2012 Nov;27(6):673-81. doi: 10.1093/mutage/ges033. Epub 2012 Jul 27.
Epidemiological studies revealed increased renal cancer incidences and higher cancer mortalities in hypertensive individuals. Activation of the renin-angiotensin-aldosterone system leads to the formation of reactive oxygen species (ROS). In vitro, in renal cells, and ex vivo, in the isolated perfuse
PMID 22844079

A role for intracellular calcium downstream of G-protein signaling in undifferentiated human embryonic stem cell culture.

Ermakov A1, Pells S, Freile P, Ganeva VV, Wildenhain J, Bradley M, Pawson A, Millar R, De Sousa PA.
Stem cell research.Stem Cell Res.2012 Nov;9(3):171-84. doi: 10.1016/j.scr.2012.06.007. Epub 2012 Jul 5.
Multiple signalling pathways maintain human embryonic stem cells (hESC) in an undifferentiated state. Here we sought to define the significance of G protein signal transduction in the preservation of this state distinct from other cellular processes. Continuous treatment with drugs targeting G(αs)-
PMID 22877821

Japanese Journal

G.ALPHA.q-Protein Carboxyl Terminus Imitation Polypeptide GCIP-27 Attenuates Proliferation of Vascular Smooth Muscle Cells and Vascular Remodeling in Spontaneously Hypertensive Rats

Zhang Hai-Gang,Cheng Yi-Qun,Liu Ya [他],Zhou Jian-Zhi,Jia Yi,Wang Xiu-Qin,Li Xiao-Hui
Biological and Pharmaceutical Bulletin 34(10), 1527-1532, 2011
… The carboxyl terminus of Gα-subunit plays a vital role in G-protein-receptor interaction. … The present study was designed to explore the effects of a synthetic Gαq carboxyl terminus imitation peptide, namely GCIP-27, on vascular smooth muscle cells (VSMC) in vitro and vascular remodeling in spontaneous hypertensive rats (SHR). …
NAID 130001086583

Diacylglycerol kinase zeta inhibits G alpha q-induced atrial remodeling in transgenic mice

Hirose M,Takeishi Y,Niizeki T,Shimojo H,Nakada T,Kubota I,Nakayama J,Mende U,Yamada M
HEART RHYTHM 6(1), 78-84, 2009-01
NAID 120001356496

The Rab GTPase-Activating Protein AS160 as a Common Regulator of Insulin- and G.ALPHA.q-Mediated Intracellular GLUT4 Vesicle Distribution

YUASA Tomoyuki,UCHIYAMA Keiji,OGURA Yuko,KIMURA Masafumi,TESHIGAWARA Kiyoshi,HOSAKA Toshio,TANAKA Yoshinori,OBATA Toshiyuki,SANO Hiroyuki,KISHI Kazuhiro,EBINA Yousuke
Endocrine Journal 56(3), 345-359, 2009
… We and others, previously reported that the activation of Gαq protein-coupled receptors (GαqPCRs) also stimulated GLUT4 translocation and glucose uptake in several cell lines. … Here, we report that the activation of GαqPCRs also promoted phosphorylation of AS160 by the 5′-AMP activated protein kinase (AMPK). … This suppression did not affect the ratio of non-induced cell surface GLUT4 to Gαq-induced it. …
NAID 130004443498

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