WordNet

a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
the 5th letter of the Roman alphabet (同)e

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1. 組換え造血成長因子の概要 introduction to recombinant hematopoietic growth factors
2. 透析前および腹膜透析患者における慢性腎疾患の貧血のためのエリスロポエチン erythropoietin for the anemia of chronic kidney disease among predialysis and peritoneal dialysis patients
3. 血液透析患者における慢性腎臓病の貧血治療のためのエリスロポエチン erythropoietin for treatment of the anemia of chronic kidney disease in hemodialysis patients
4. 抗エリスロポエチン抗体による赤芽球癆 pure red cell aplasia due to anti erythropoietin antibodies

Impaired expression of HIF-2α induces compensatory expression of HIF-1α for the recovery from anemia.

Tsuboi I1, Yamashita T, Nagano M, Kimura K, To'a Salazar G, Ohneda O.
Journal of cellular physiology.J Cell Physiol.2015 Jul;230(7):1534-48. doi: 10.1002/jcp.24899.
Erythropoiesis is strongly influenced by the interactions between stromal cells and erythroid progenitors, as well as by a key regulatory factor, erythropoietin (EPO). We previously generated mice with a knockdown mutation of Hif-2α (referred to as kd/kd) and found that these kd/kd mice exhibited n
PMID 25557133

Flipping the molecular switch for innate protection and repair of tissues: Long-lasting effects of a non-erythropoietic small peptide engineered from erythropoietin.

Collino M1, Thiemermann C2, Cerami A3, Brines M3.
Pharmacology & therapeutics.Pharmacol Ther.2015 Jul;151:32-40. doi: 10.1016/j.pharmthera.2015.02.005. Epub 2015 Feb 26.
Many disease processes activate a cellular stress response that initiates a cascade of inflammation and damage. However, this process also triggers a tissue protection and repair system mediated by locally-produced hyposialated erythropoietin (hsEPO). Although recombinant EPO is used widely for trea
PMID 25728128

Chronic overexpression of cerebral Epo improves the ventilatory response to acute hypoxia during the postnatal development.

Caravagna C1, Gasser EM2, Ballot O3, Joseph V4, Soliz J5.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience.Int J Dev Neurosci.2015 Jun 9;44:84-91. doi: 10.1016/j.ijdevneu.2015.06.001. [Epub ahead of print]
Clinicians observed that the treatment of premature human newborns for anemia with erythropoietin (Epo) also improved their respiratory autonomy. This observation is in line with our previous in vitro studies showing that acute and chronic Epo stimulation enhances fictive breathing of brainstem-spin
PMID 26065978

伊禮俊充,種村匡弘,井上雅史,檜山雄一,河野博孝,高野弘嗣,倉岡和矢,谷山清己,吉川幸伸,上池渉
日本消化器外科学会雑誌 47(1), 18-25, 2014
　症例は60歳の男性で，左半身の痺れを主訴に当院受診し，精査で右視床出血，肝S1原発巨大肝細胞癌，赤血球増多症，高エリスロポエチン血症と診断した．視床出血に対する保存的治療後，肝spiegel部切除および腫瘍摘出術を施行した．術後は赤血球増多症，高エリスロポエチン血症の改善を認め，免疫組織学的に肝細胞癌細胞質にエリスロポエチンの産生が証明され，エリスロポエチン産生肝細胞癌に続発した赤血球増多症と診 …
NAID 130004560980

前波輝彦,吉澤亮,大和田滋
日本透析医学会雑誌 46(10), 999-1006, 2013
… erythropoietin receptor activator：CERA）は従来のエポエチンベータ（EPO）に1分子の直鎖メトキシポリエチレングリコール（PEG）を化学的に結合させることによって血中半減期を著しく延長し，持続的な赤血球造血を可能にした新たなESAである．われわれはすでに血液透析（HD）患者に対するCERA隔週投与による28週間までの貧血改善効果について報告している．しかし，EPOからCERAを2週 …
NAID 130003385730

Indoxyl Sulfate Counteracts Endothelial Effects of Erythropoietin Through Suppression of Akt Phosphorylation

Adelibieke Yelixiati,Shimizu Hidehisa,Saito Shinichi,Mironova Roumyana,Niwa Toshimitsu
Circulation Journal 77(5), 1326-1336, 2013
… Background: Erythropoietin (EPO) is used to treat anemia in patients with chronic kidney disease (CKD). … A wide variation in individual response to EPO, however, is often observed, causing EPO resistance. … EPO exhibits not only hematopoietic but also extra-hematopoietic functions such as endothelial effects. …
NAID 130003361617