WordNet

any of a group of enzymes (occurring especially in plant cells) that catalyze the oxidation of a compound by a peroxide
a leukocyte readily stained with eosin (同)eosinophile

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/05/31 08:14:24」(JST)

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Eosinophil peroxidase is a haloperoxidase enzyme that in humans is encoded by the EPX gene.^[1]^[2] The enzyme is a heterodimeric 71-77 kD peroxidase consisting of a heavier glycosylated chain and a lighter nonglycosylated chain. This enzyme prefers bromide over chloride as a substrate, converting it to toxic hypobromite.

Function

In the presence of H₂O₂ formed by the eosinophil, and either chloride or bromide ions, eosinophil peroxidase provides a potent mechanism by which eosinophils kill multicellular parasites (such as, for example, the nematode worms involved in filariasis); and also certain bacteria (such as tuberculosis bacteria). Eosinophil peroxidase is a haloperoxidase that preferentially uses bromide over chloride for this purpose, generating hypobromite (hypobromous acid).^[3] The enzyme is also capable of oxidizing thiocyanate (SCN-) and uses it as a co-substrate, with optimal concentrations occurring at about normal plasma levels.^[4]

Eosinophil peroxidase is also partly responsible for tissue remodeling.

Role in pathology

The oxidizing compounds produced by eosinophil peroxidase have been implicated in the inflammatory pathology of several disease states, including asthma.^[5]

References

^ Sakamaki K, Tomonaga M, Tsukui K, Nagata S (October 1989). "Molecular cloning and characterization of a chromosomal gene for human eosinophil peroxidase". J. Biol. Chem. 264 (28): 16828–36. PMID 2550461.
^ Ten RM, Pease LR, McKean DJ, Bell MP, Gleich GJ (May 1989). "Molecular cloning of the human eosinophil peroxidase. Evidence for the existence of a peroxidase multigene family". J. Exp. Med. 169 (5): 1757–69. doi:10.1084/jem.169.5.1757. PMC 2189302. PMID 2541222.
^ Mayeno AN, Curran AJ, Roberts RL, Foote CS (April 1989). "Eosinophils preferentially use bromide to generate halogenating agents". J. Biol. Chem. 264 (10): 5660–8. PMID 2538427.
^ Tahboub YR, Galijasevic S, Diamond MP, Abu-Soud HM (2005). "Thiocyanate modulates the catalytic activity of mammalian peroxidases". J. Biol. Chem. 280 (28): 26129–36. doi:10.1074/jbc.M503027200. PMID 15894800.
^ van Dalen CJ, Kettle AJ (August 2001). "Substrates and products of eosinophil peroxidase". Biochem. J. 358 (Pt 1): 233–9. doi:10.1042/0264-6021:3580233. PMC 1222052. PMID 11485572.

External links

Eosinophil peroxidase at the US National Library of Medicine Medical Subject Headings (MeSH)

From JC Segen Dictionary of Modern Medicine database

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1. 原因不明の好酸球増加症患者に対するアプローチ approach to the patient with unexplained eosinophilia
2. 好酸球増加症候群の臨床症状、病態生理、および診断 clinical manifestations pathophysiology and diagnosis of the hypereosinophilic syndromes
3. 喘息の病因 pathogenesis of asthma
4. 好中球二次顆粒欠損症 neutrophil specific granule deficiency
5. HIV関連好酸球性毛包炎 hiv associated eosinophilic folliculitis

English Journal

Indigenous enteric eosinophils control DCs to initiate a primary Th2 immune response in vivo.

Chu DK1, Jimenez-Saiz R1, Verschoor CP1, Walker TD1, Goncharova S1, Llop-Guevara A1, Shen P1, Gordon ME1, Barra NG1, Bassett JD1, Kong J1, Fattouh R2, McCoy KD3, Bowdish DM1, Erjefält JS4, Pabst O5, Humbles AA6, Kolbeck R6, Waserman S1, Jordana M7.
The Journal of experimental medicine.J Exp Med.2014 Jul 28;211(8):1657-72. doi: 10.1084/jem.20131800.
Eosinophils natively inhabit the small intestine, but a functional role for them there has remained elusive. Here, we show that eosinophil-deficient mice were protected from induction of Th2-mediated peanut food allergy and anaphylaxis, and Th2 priming was restored by reconstitution with il4(+/+) or
PMID 25071163

Sex-response differences of immunological and histopathological biomarkers in gill of Prochilodus argenteus from a polluted river in southeast Brazil.

Procópio MS1, Ribeiro HJ1, Pereira LA2, Oliveira Lopes GA3, Castro AC1, Rizzo E1, Sato Y4, Russo RC3, Corrêa JD Jr5.
Fish & shellfish immunology.Fish Shellfish Immunol.2014 Jul;39(1):108-17. doi: 10.1016/j.fsi.2014.04.010. Epub 2014 May 2.
The fish gill is in direct and standing contact with the immediate external environment and, therefore, is highly vulnerable to aquatic pollutants. In this study, Prochilodus argenteus were caught at two different points in São Francisco river. The first point is located near Três Marias dam, whil
PMID 24795082

Eosinophil Granule Proteins: Form and Function.

Acharya KR1, Ackerman SJ2.
The Journal of biological chemistry.J Biol Chem.2014 Jun 20;289(25):17406-17415. Epub 2014 May 6.
Experimental and clinical data strongly support a role for the eosinophil in the pathogenesis of asthma, allergic and parasitic diseases, and hypereosinophilic syndromes, in addition to more recently identified immunomodulatory roles in shaping innate host defense, adaptive immunity, tissue repair/r
PMID 24802755

Japanese Journal

マイクロウェーブ固定で観察した鼻アレルギー鼻粘膜中の好酸球

廣瀬壮
Dokkyo journal of medical sciences 37(2), 97-101, 2010-07-25
好酸球顆粒内蛋白は組織障害性物質であることが知られている.しかし,これらの蛋白がどのように細胞外へ放出されるかの報告は非常に少ない.今回,我々はタンニンを含んだ固定液を用いてマイクロウェーブ照射(MWI)を試みた.タンニンは蛋白の固定力が強く,蛋白を高電子物質として可視化する.好酸球顆粒内蛋白がどのように顆粒外に出てくるかを検討した.MWIを施して, そしてこの結果が既に報告されているDAB 法に …
NAID 110007616516

Chromatographic methods for the analyses of 2-halofatty aldehydes and chlorohydrin molecular species of lysophosphatidylcholine

ALBERT Carolyn J.,ANBUKUMAR Dhanalakshmi S.,MESSNER Maria C.,FORD David A.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 877(26), 2768-2777, 2009-09-15
NAID 10028023497

Efficient assay for total antioxidant capacity in human plasma using a 96-well microplte

Kambayashi Yasuhiro,Ogino Keiki,Takemoto Kei,Imagama Takashi,Takigawa Tomoko,Kimura Shingo,Hibino Yuri,Hitomi Yoshiaki,Nakamura Hiroyuki
Journal of Clinical Biochemistry and Nutrition 44(1), 95-103, 2009-01
… (Di)bromotyrosine is formed by the specific reaction of eosinophil peroxidase and can be used as an eosinophil activation marker. … In the present study, an antibody for (di)bromotyrosine in proteins was prepared to investigate the pathogenesis of eosinophil-related diseases such as allergic responses. …
NAID 120001170065

「EPO」

Eosinophil peroxidase
Identifiers
Symbols	EPX ; EPO; EPP; EPX-PEN
External IDs	OMIM: 131399 MGI: 107569 HomoloGene: 20144 ChEMBL: 2438 GeneCards: EPX Gene
EC number	1.11.1.7
Gene ontology
Molecular function	• peroxidase activity; • heme binding; • metal ion binding;
Biological process	• defense response to nematode; • negative regulation of interleukin-10 production; • negative regulation of interleukin-5 production; • positive regulation of interleukin-4 production; • hydrogen peroxide catabolic process; • eosinophil migration;
	Sources: Amigo / QuickGO
Orthologs
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