関: cholecystokinin 4、tetragastrin

WordNet

the 3rd letter of the Roman alphabet (同)c
(music) the keynote of the scale of C major
a general-purpose programing language closely associated with the UNIX operating system

PrepTutorEJDIC

carbonの化学記号

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/01/20 02:19:29」(JST)

wiki en

Cholecystokinin tetrapeptide (CCK-4, Trp-Met-Asp-Phe-NH₂) is a peptide fragment derived from the larger peptide hormone cholecystokinin. Unlike cholecystokin which has a variety of roles in the gastrointestinal system as well as central nervous system effects, CCK-4 acts primarily in the brain as an anxiogenic, although it does retain some GI effects, but not as much as CCK-8 or the full length polypeptide CCK-58.

CCK-4 reliably causes severe anxiety symptoms when administered to humans in a dose of as little as 50μg,^[1] and is commonly used in scientific research to induce panic attacks for the purpose of testing new anxiolytic drugs.^[2]^[3]^[4]^[5] Since it is a peptide, CCK-4 must be administered by injection, and is rapidly broken down once inside the body so has only a short duration of action,^[6] although numerous synthetic analogues with modified properties are known.^[7]^[8]^[9]^[10]^[11]^[12]^[13]^[14]^[15]^[16]^[17]

References

^ Daniela Eser; et al. (2005). "Panic Induction with Cholecystokinin-Tetrapeptide (CCK-4) Increases Plasma Concentrations of the Neuroactive Steroid 3α, 5α Tetrahydrodeoxycorticosterone (3α, 5α-THDOC) in Healthy Volunteers" (PDF). Neuropsychopharmacology. 30 (1): 192–195. doi:10.1038/sj.npp.1300572. PMID 15467707.
^ Bradwejn J. (July 1993). "Neurobiological investigations into the role of cholecystokinin in panic disorder". Journal of Psychiatry and Neuroscience. 18 (4): 178–188. PMC 1188527. PMID 8104032.
^ Schunck T, Erb G, Mathis A, Gilles C, Namer IJ, Hode Y, Demaziere A, Luthringer R, Macher JP (July 2006). "Functional magnetic resonance imaging characterization of CCK-4-induced panic attack and subsequent anticipatory anxiety". NeuroImage. 31 (3): 1197–1208. doi:10.1016/j.neuroimage.2006.01.035. PMID 16600640.
^ Eser D, Schüle C, Baghai T, Floesser A, Krebs-Brown A, Enunwa M, de la Motte S, Engel R, Kucher K, Rupprecht R (July 2007). "Evaluation of the CCK-4 model as a challenge paradigm in a population of healthy volunteers within a proof-of-concept study". Psychopharmacology. 192 (4): 479–487. doi:10.1007/s00213-007-0738-7. PMID 17318504.
^ Eser D, Leicht G, Lutz J, Wenninger S, Kirsch V, Schüle C, Karch S, Baghai T, Pogarell O, Born C, Rupprecht R, Mulert C (December 2007). "Functional neuroanatomy of CCK-4-induced panic attacks in healthy volunteers". Human Brain Mapping. 30 (2): 511–22. doi:10.1002/hbm.20522. PMID 18095276.
^ Koulischer D, Moroder L, Deschodt-Lanckman M (August 1982). "Degradation of cholecystokinin octapeptide, related fragments and analogs by human and rat plasma in vitro". Regulatory Peptides. 4 (3): 127–139. doi:10.1016/0167-0115(82)90080-5. PMID 6291099.
^ Blommaert AG, Dhôtel H, Ducos B, Durieux C, Goudreau N, Bado A, Garbay C, Roques BP (February 1997). "Structure-based design of new constrained cyclic agonists of the cholecystokinin CCK-B receptor". Journal of Medicinal Chemistry. 40 (5): 647–58. doi:10.1021/jm9603072. PMID 9057851.
^ Bellier B, Million ME, DaNascimento S, Meudal H, Kellou S, Maigret B, Garbay C (October 2000). "Replacement of glycine with dicarbonyl and related moieties in analogues of the C-terminal pentapeptide of cholecystokinin: CCK(2) agonists displaying a novel binding mode". Journal of Medicinal Chemistry. 43 (20): 3614–23. doi:10.1021/jm0000416. PMID 11020275.
^ Léna I, Dh tel H, Garbay C, Daugé V (January 2001). "Involvement of D2 dopamine receptors in the opposing effects of two CCK-B agonists in a spatial recognition memory task: role of the anterior nucleus accumbens". Psychopharmacology. 153 (2): 170–9. doi:10.1007/s002130000517. PMID 11205416.
^ Bellier B, Garbay C (2003). "How a single inversion of configuration leads to a reversal of the binding mode: proposal of a novel arrangement of CCK2 ligands in their receptor, and contribution to the development of peptidomimetic or non-peptide CCK2 ligands". European Journal of Medicinal Chemistry. 38 (7-8): 671–86. doi:10.1016/S0223-5234(03)00112-0. PMID 12932898.
^ Bellier B, Crété D, Million ME, Beslot F, Bado A, Garbay C, Daugé V (November 2004). "New CCK2 agonists confirming the heterogeneity of CCK2 receptors: characterisation of BBL454". Naunyn-Schmiedeberg's Archives of Pharmacology. 370 (5): 404–13. doi:10.1007/s00210-004-0969-7. PMID 15480577.
^ Proskuriakova TV, Bespalova ZhD, Pal'keeva ME, Petrichenko OB, Pankratova NV, Shokhonova VA, Anokhina IP (2005). "[Biological activity of cholecystokinin-(30-33) tetrapeptide analogs]". Bioorganicheskaia Khimiia (in Russian). 31 (2): 130–9. PMID 15889786.
^ Anokhina IP, Proskuriakova TV, Bespalova ZhD, Pal'keeva ME, Shokhonova VA, Petrichenko OB (2006). "[Effect of a cholecystokinin tetrapeptide analogue on opioid reception under acute and chronic morphine administration]". Bioorganicheskaia Khimiia (in Russian). 32 (3): 276–83. PMID 16808170.
^ Agnes RS, Lee YS, Davis P, Ma SW, Badghisi H, Porreca F, Lai J, Hruby VJ (May 2006). "Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors". Journal of Medicinal Chemistry. 49 (10): 2868–75. doi:10.1021/jm050921q. PMC 1484468. PMID 16686530.
^ Noble F (2007). "Pharmacology of CCKRs and SAR studies of peptidic analog ligands". Current Topics in Medicinal Chemistry. 7 (12): 1173–9. doi:10.2174/156802607780960447. PMID 17584139.
^ García-López MT, González-Muñiz R, Martín-Martínez M, Herranz R (2007). "Strategies for design of non peptide CCK1R agonist/antagonist ligands". Current Topics in Medicinal Chemistry. 7 (12): 1180–94. doi:10.2174/156802607780960537. PMID 17584140.
^ Kalindjian SB, McDonald IM (2007). "Strategies for the design of non-peptide CCK2 receptor agonist and antagonist ligand". Current Topics in Medicinal Chemistry. 7 (12): 1195–204. doi:10.2174/156802607780960500. PMID 17584141.

UpToDate Contents

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1. コレシストキニンの生理学 physiology of cholecystokinin
2. 成人における胆嚢機能障害 functional gallbladder disorder in adults
3. 膵外分泌機能検査 pancreatic exocrine function tests
4. ガストリンの生理学 physiology of gastrin
5. アカラシアの病態生理および病因 pathophysiology and etiology of achalasia

English Journal

Reversible Morphological Control of Cholecystokinin Tetrapeptide Amyloid Assemblies as a Function of pH.

Gobeaux F1, Porcher F2, Dattani R3.
The journal of physical chemistry. B.J Phys Chem B.2017 Apr 13;121(14):3059-3069. doi: 10.1021/acs.jpcb.7b02448. Epub 2017 Apr 3.
PMID 28328228

Copeptin - A potential endocrine surrogate marker of CCK-4-induced panic symptoms?

Demiralay C1, Agorastos A2, Yassouridis A3, Jahn H2, Wiedemann K2, Kellner M2.
Psychoneuroendocrinology.Psychoneuroendocrinology.2017 Feb;76:14-18. doi: 10.1016/j.psyneuen.2016.11.006. Epub 2016 Nov 8.
PMID 27871026

Metabotropic glutamate2/3 receptor agonism facilitates autonomic recovery after pharmacological panic challenge in healthy humans.

Agorastos A1, Demiralay C, Stiedl O, Muhtz C, Wiedemann K, Kellner M.
International clinical psychopharmacology.Int Clin Psychopharmacol.2016 May;31(3):176-8. doi: 10.1097/YIC.0000000000000117.
PMID 26752621

Japanese Journal

Molecular Forms of Cholecystokinin in Human Bile in Patients with Obstructive Jaunice

The Showa University Journal of Medical Sciences 12(2), 163-173, 2000
NAID 130004190020

CCK-4-induced calcium mobilization in T cells is enhanced in panic disorder

J Neurochem 66, 1610-1616, 1996
NAID 80008878068

Pharmacological Activities of Synthetic Human Cholecystokinin-33 of Which Tyrosine Was Sulfated by Arylsulfotransferase

Chemical & pharmaceutical bulletin 38(5), 1369-1372, 1990-05-25
NAID 110003628552

「コレシストキニン-4」

CCK-4
Clinical data
Routes of; administration	IV
Pharmacokinetic data
Bioavailability	100%
Metabolism	plasma protease enzymes
Biological half-life	13 minutes
Excretion	N/A
Identifiers
	IUPAC name (3S)-3-[(2S)-2-amino-3-phenylpropanamido]-3-{[(1S)-1-{[(1S)-1-carboxy -2-(indol-3-yl)ethyl]carbamoyl}-3-(methylsulfanyl)propyl]carbamoyl}propanoic acid;
CAS Number	1947-37-1
ChemSpider	27470965
Chemical and physical data
Formula	C29H35N5O7S
Molar mass	597.681 g/mol
3D model (Jmol)	Interactive image
	SMILES CSCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N)NC(=O)[C@H](Cc2c[nH]c3c2cccc3)N ;
	InChI InChI=InChI=1S/C29H36N6O6S/c1-42-12-11-22(33-27(39)20(30)14-18-16-32-21-10-6-5-9-19(18)21)28(40)35-24(15-25(36)37)29(41)34-23(26(31)38)13-17-7-3-2-4-8-17/h2-10,16,20,22-24,32H,11-15,30H2,1H3,(H2,31,38)(H,33,39)(H,34,41)(H,35,40)(H,36,37)/t20-,22-,23-,24-/m0/s1 ; Key:RGYLYUZOGHTBRF-BIHRQFPBSA-N ;
(what is this?) (verify)

　　[★]

英: cholecystokinin 4、CCK-4
関: テトラガストリン

「テトラガストリン」

　　[★]

英: tetragastrin、CCK-4
関: コレシストキニン-4

「cholecystokinin 4」

　　[★]

コレシストキニン-4

関: CCK-4、tetragastrin

「C」

　　[★]

炭素 carbon
シトシン cytosine
システイン cysteine
シチジン
セルシウス度摂氏 degrees Celsius degree C
産婦人科領域で「子宮外頚子宮外頚部 exocervix」を表現するための略語

「CC」

　　[★]

「CCK」

　　[★] コレシストキニン cholecystokinin

[1] Daniela Eser; et al. (2005). "Panic Induction with Cholecystokinin-Tetrapeptide (CCK-4) Increases Plasma Concentrations of the Neuroactive Steroid 3α, 5α Tetrahydrodeoxycorticosterone (3α, 5α-THDOC) in Healthy Volunteers" (PDF). Neuropsychopharmacology. 30 (1): 192–195. doi:10.1038/sj.npp.1300572. PMID 15467707.

[2] Bradwejn J. (July 1993). "Neurobiological investigations into the role of cholecystokinin in panic disorder". Journal of Psychiatry and Neuroscience. 18 (4): 178–188. PMC 1188527. PMID 8104032.

[3] Schunck T, Erb G, Mathis A, Gilles C, Namer IJ, Hode Y, Demaziere A, Luthringer R, Macher JP (July 2006). "Functional magnetic resonance imaging characterization of CCK-4-induced panic attack and subsequent anticipatory anxiety". NeuroImage. 31 (3): 1197–1208. doi:10.1016/j.neuroimage.2006.01.035. PMID 16600640.

[4] Eser D, Schüle C, Baghai T, Floesser A, Krebs-Brown A, Enunwa M, de la Motte S, Engel R, Kucher K, Rupprecht R (July 2007). "Evaluation of the CCK-4 model as a challenge paradigm in a population of healthy volunteers within a proof-of-concept study". Psychopharmacology. 192 (4): 479–487. doi:10.1007/s00213-007-0738-7. PMID 17318504.

[5] Eser D, Leicht G, Lutz J, Wenninger S, Kirsch V, Schüle C, Karch S, Baghai T, Pogarell O, Born C, Rupprecht R, Mulert C (December 2007). "Functional neuroanatomy of CCK-4-induced panic attacks in healthy volunteers". Human Brain Mapping. 30 (2): 511–22. doi:10.1002/hbm.20522. PMID 18095276.

[6] Koulischer D, Moroder L, Deschodt-Lanckman M (August 1982). "Degradation of cholecystokinin octapeptide, related fragments and analogs by human and rat plasma in vitro". Regulatory Peptides. 4 (3): 127–139. doi:10.1016/0167-0115(82)90080-5. PMID 6291099.

[pmid9057851-7] Blommaert AG, Dhôtel H, Ducos B, Durieux C, Goudreau N, Bado A, Garbay C, Roques BP (February 1997). "Structure-based design of new constrained cyclic agonists of the cholecystokinin CCK-B receptor". Journal of Medicinal Chemistry. 40 (5): 647–58. doi:10.1021/jm9603072. PMID 9057851.

[pmid11020275-8] Bellier B, Million ME, DaNascimento S, Meudal H, Kellou S, Maigret B, Garbay C (October 2000). "Replacement of glycine with dicarbonyl and related moieties in analogues of the C-terminal pentapeptide of cholecystokinin: CCK(2) agonists displaying a novel binding mode". Journal of Medicinal Chemistry. 43 (20): 3614–23. doi:10.1021/jm0000416. PMID 11020275.

[pmid11205416-9] Léna I, Dh tel H, Garbay C, Daugé V (January 2001). "Involvement of D2 dopamine receptors in the opposing effects of two CCK-B agonists in a spatial recognition memory task: role of the anterior nucleus accumbens". Psychopharmacology. 153 (2): 170–9. doi:10.1007/s002130000517. PMID 11205416.

[pmid12932898-10] Bellier B, Garbay C (2003). "How a single inversion of configuration leads to a reversal of the binding mode: proposal of a novel arrangement of CCK2 ligands in their receptor, and contribution to the development of peptidomimetic or non-peptide CCK2 ligands". European Journal of Medicinal Chemistry. 38 (7-8): 671–86. doi:10.1016/S0223-5234(03)00112-0. PMID 12932898.

[pmid15480577-11] Bellier B, Crété D, Million ME, Beslot F, Bado A, Garbay C, Daugé V (November 2004). "New CCK2 agonists confirming the heterogeneity of CCK2 receptors: characterisation of BBL454". Naunyn-Schmiedeberg's Archives of Pharmacology. 370 (5): 404–13. doi:10.1007/s00210-004-0969-7. PMID 15480577.

[pmid15889786-12] Proskuriakova TV, Bespalova ZhD, Pal'keeva ME, Petrichenko OB, Pankratova NV, Shokhonova VA, Anokhina IP (2005). "[Biological activity of cholecystokinin-(30-33) tetrapeptide analogs]". Bioorganicheskaia Khimiia (in Russian). 31 (2): 130–9. PMID 15889786.

[pmid16808170-13] Anokhina IP, Proskuriakova TV, Bespalova ZhD, Pal'keeva ME, Shokhonova VA, Petrichenko OB (2006). "[Effect of a cholecystokinin tetrapeptide analogue on opioid reception under acute and chronic morphine administration]". Bioorganicheskaia Khimiia (in Russian). 32 (3): 276–83. PMID 16808170.

[pmid16686530-14] Agnes RS, Lee YS, Davis P, Ma SW, Badghisi H, Porreca F, Lai J, Hruby VJ (May 2006). "Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors". Journal of Medicinal Chemistry. 49 (10): 2868–75. doi:10.1021/jm050921q. PMC 1484468. PMID 16686530.

[pmid17584139-15] Noble F (2007). "Pharmacology of CCKRs and SAR studies of peptidic analog ligands". Current Topics in Medicinal Chemistry. 7 (12): 1173–9. doi:10.2174/156802607780960447. PMID 17584139.

[pmid17584140-16] García-López MT, González-Muñiz R, Martín-Martínez M, Herranz R (2007). "Strategies for design of non peptide CCK1R agonist/antagonist ligands". Current Topics in Medicinal Chemistry. 7 (12): 1180–94. doi:10.2174/156802607780960537. PMID 17584140.

[pmid17584141-17] Kalindjian SB, McDonald IM (2007). "Strategies for the design of non-peptide CCK2 receptor agonist and antagonist ligand". Current Topics in Medicinal Chemistry. 7 (12): 1195–204. doi:10.2174/156802607780960500. PMID 17584141.

リンク元	「コレシストキニン-4」「テトラガストリン」「cholecystokinin 4」
関連記事	「C」「CC」「CCK」

匿名

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案内

案内

CCK-4