WordNet

a gastrointestinal hormone that stimulates the secretion of pancreatic enzymes and the contraction and emptying of the gall bladder; its release is stimulated by the presence of fatty acids and amino acids in the small intestine

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Kolik LG, Konstantinopolsky MA, Ryibina IV, Povarnina PY, Gudasheva TA, Seredenin SB.SourceV. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia. lgkolik@mail.ru.
Bulletin of experimental biology and medicine.Bull Exp Biol Med.2013 Jun;155(2):200-3.
The anxiolytic effects of GB-115, a retroanalogue of cholecystokinin-4, administered orally to outbred and inbred animals with different level of emotionality, were studied in the open field test and elevated plus-maze test. The anxiolytic effect of talanax was observed in outbred mice (0.1-0.5 mg/k
PMID 24130989

Benzodiazepines counteract rostral anterior cingulate cortex activation induced by cholecystokinin-tetrapeptide in humans.

Leicht G, Mulert C, Eser D, Sämann PG, Ertl M, Laenger A, Karch S, Pogarell O, Meindl T, Czisch M, Rupprecht R.SourcePsychiatry Neuroimaging Branch, University Medical Center Hamburg-Eppendorf, Department of Psychiatry and Psychotherapy, Psychiatry Neuroimiaging Branch, Hamburg, Germany. g.leicht@uke.de
Biological psychiatry.Biol Psychiatry.2013 Feb 15;73(4):337-44. doi: 10.1016/j.biopsych.2012.09.004. Epub 2012 Oct 8.
BACKGROUND: Benzodiazepines modulate γ-aminobutyric acid type A (GABA(A)) receptors throughout the brain. However, it is not fully understood which brain regions within anxiety-related brain circuits are really responsible for their anxiolytic effects and how these regions interact.METHODS: We inve
PMID 23059050

Behavioral and cortical EEG evaluations confirm the roles of both CCKA and CCKB receptors in mouse CCK-induced anxiety.

Li H, Ohta H, Izumi H, Matsuda Y, Seki M, Toda T, Akiyama M, Matsushima Y, Goto Y, Kaga M, Inagaki M.SourceDepartment of Developmental Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawa Higashi, Kodaira, Tokyo 187-8553, Japan.
Behavioural brain research.Behav Brain Res.2013 Jan 15;237:325-32. doi: 10.1016/j.bbr.2012.09.051. Epub 2012 Oct 5.
This study investigated the roles of cholecystokinin (CCK)(A) and CCK(B) receptors on CCK-4-induced anxiety-like behaviors in mice through behavioral and neural evaluations. Anxiety-like behaviors in mice were induced by an intracerebroventricular (i.c.v.) administration of CCK-4, which can bind to
PMID 23043971