関: CBA mouse、inbred CBA mice

WordNet

the 3rd letter of the Roman alphabet (同)c
(music) the keynote of the scale of C major
a general-purpose programing language closely associated with the UNIX operating system
the syllable naming the third (mediant) note of any major scale in solmization

PrepTutorEJDIC

carbonの化学記号
ミ(全音階の第3音)
citizens band / construction battalion設営大隊
mouseの複数形

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1. 遺伝学およびゲノミクスのためのツール：研究用に育種された遺伝子改変マウス tools for genetics and genomics specially bred and genetically engineered mice
2. レプチンの生理学 physiology of leptin
3. 肥満の病因 pathogenesis of obesity
4. 1型糖尿病の予防 prevention of type 1 diabetes mellitus
5. 1型糖尿病の病因 pathogenesis of type 1 diabetes mellitus

English Journal

In vitro exposure to cigarette smoke induces oxidative stress in follicular cells of F1 hybrid mice.

Siddique S, Sadeu JC, Foster WG, Feng YL, Zhu J.Author information Exposure and Biomonitoring Division, Health Canada, Ottawa, Ontario, Canada.AbstractThis study assessed the influence of cigarette smoke condensate (CSC) and benzo(a)pyrene [B(a)P] on the levels of two oxidative stress biomarkers [8-isoprostane (8-IsoP) and 8-hydroxy-2-deoxy Guanosine (8-OH-dG)], in in-vitro spent media of follicle cells. Follicles (100-130 µm) isolated from ovaries of F1 hybrid (C57Bl/6j × CBA/Ca) mice were cultured for 13 days in media exposed to B(a)P [0 ng ml(-1) (control) to 45 ng ml(-1) ] or CSC [0 µg ml(-1) (control) to 130 µg ml(-1) ]. The concentrations of oxidative stress biomarkers in spent media were quantified by enzyme-linked immune sorbent assays (ELISA). CSC and B(a)P treatment induced a significant, dose-dependent increase in the concentrations of 8-IsoP and 8-OH-dG in the spent media. We conclude that CSC and B(a)P exposure can induce oxidative stress in ovarian follicles, an effect that may contribute to the previously documented decline in follicle development and premature ovarian failure in women who smoke. © Her Majesty the Queen in Right of Canada 2013.
Journal of applied toxicology : JAT.J Appl Toxicol.2014 Feb;34(2):224-6. doi: 10.1002/jat.2884. Epub 2013 May 30.
This study assessed the influence of cigarette smoke condensate (CSC) and benzo(a)pyrene [B(a)P] on the levels of two oxidative stress biomarkers [8-isoprostane (8-IsoP) and 8-hydroxy-2-deoxy Guanosine (8-OH-dG)], in in-vitro spent media of follicle cells. Follicles (100-130 µm) isolated from ova
PMID 23720242

Round window membrane intracochlear drug delivery enhanced by induced advection.

Borkholder DA1, Zhu X2, Frisina RD3.Author information 1Department of Electrical and Microelectronic Engineering, Rochester Institute of Technology, Rochester 14623, USA; Department of Microsystems Engineering, Rochester Institute of Technology, Rochester 14623, USA; Department of Otolaryngology, University of Rochester Medical School, Rochester 14642, USA; Department of Biomedical Engineering, University of Rochester Medical School, Rochester 14642, USA. Electronic address: david.borkholder@rit.edu.2Department of Otolaryngology, University of Rochester Medical School, Rochester 14642, USA; International Center for Hearing & Speech Research, National Technical Institute for the Deaf, Rochester Institute of Technology, Rochester 14623, USA. Electronic address: xiaoxiazhu@usf.edu.3Department of Otolaryngology, University of Rochester Medical School, Rochester 14642, USA; Department of Biomedical Engineering, University of Rochester Medical School, Rochester 14642, USA; Department of Neurobiology & Anatomy, University of Rochester Medical School, Rochester 14642, USA; International Center for Hearing & Speech Research, National Technical Institute for the Deaf, Rochester Institute of Technology, Rochester 14623, USA. Electronic address: rfrisina@usf.edu.AbstractDelivery of therapeutic compounds to the inner ear via absorption through the round window membrane (RWM) has advantages over direct intracochlear infusions; specifically, minimizing impact upon functional hearing measures. However, previous reports show that significant basal-to-apical concentration gradients occur, with the potential to impact treatment efficacy. Here we present a new approach to inner ear drug delivery with induced advection aiding distribution of compounds throughout the inner ear in the murine cochlea. Polyimide microtubing was placed near the RWM niche through a bullaostomy into the middle ear cavity allowing directed delivery of compounds to the RWM. We hypothesized that a posterior semicircular canalostomy would induce apical flow from the patent cochlear aqueduct to the canalostomy due to influx of cerebral spinal fluid. To test this hypothesis, young adult CBA/CaJ mice were divided into two groups: bullaostomy approach only (BA) and bullaostomy+canalostomy (B+C). Cochlear function was evaluated by distortion product otoacoustic emission (DPOAE) and auditory brainstem response (ABR) thresholds during and after middle ear infusion of salicylate in artificial perilymph (AP), applied near the RWM. The mice recovered for 1week, and were re-tested. The results demonstrate there was no significant impact on auditory function utilizing the RWM surgical procedure with or without the canalostomy, and DPOAE thresholds were elevated reversibly during the salicylate infusion. Comparing the threshold shifts for both methods, the B+C approach had more of a physiological effect than the BA approach, including at lower frequencies representing more apical cochlear locations. Unlike mouse cochleostomies, there was no deleterious auditory functional impact after 1week recovery from surgery. The B+C approach had more drug efficacy at lower frequencies, underscoring potential benefits for more precise control of delivery of inner ear therapeutic compounds.
Journal of controlled release : official journal of the Controlled Release Society.J Control Release.2014 Jan 28;174C:171-176. doi: 10.1016/j.jconrel.2013.11.021. Epub 2013 Dec 1.
Delivery of therapeutic compounds to the inner ear via absorption through the round window membrane (RWM) has advantages over direct intracochlear infusions; specifically, minimizing impact upon functional hearing measures. However, previous reports show that significant basal-to-apical concentratio
PMID 24291333

Blockade of the renin-angiotensin system inhibits growth of colorectal cancer liver metastases in the regenerating liver.

Koh SL, Ager EI, Costa PL, Malcontenti-Wilson C, Muralidharan V, Christophi C.Author information Department of Surgery, Austin Health, The University of Melbourne, Burgundy Street, Heidelberg, VIC, 3084, Australia, shir_lin@hotmail.com.AbstractPartial hepatectomy (PH), the preferred option for selected patients with colorectal cancer liver metastases (CRCLM), is associated with 40-80 % tumor recurrence rates. Renin-angiotensin system (RAS) blockade inhibits tumor growth and has been suggested to improve liver regeneration. We documented the effect of RAS blockade on tumor growth and liver regeneration in a murine model. CRCLM induction followed by 70 % PH was performed on 78 CBA mice. Liver regeneration (days 2, 6) and CRCLM tumor load were measured by liver (and tumor) weights, percentage of CRCLM burden and tumor nodule count (days 16, 21). mRNA expression of the RAS components was characterised. Statistical analysis was performed using 2-independent sample T test or Mann-Whitney test (SPSS). Captopril did not impair liver regeneration. By day 21, Captopril decreased tumor burden (percentage of CRCLM in the liver) (48.7 ± 4.7 % control, 24.4 ± 6.2 Captopril; p = 0.008), tumor volume (1046.2 ± 200.2 mm3, 388.3 ± 150.4; p = 0.02), tumor nodule count per image field (181.1 ± 28.5, 68 ± 17.6; p = 0.005) and tumor angiogenesis (71.8 ± 6.4 vessels/mm2, 43.1 ± 7.6; p = 0.015) compared to controls. Captopril enhanced tumor apoptosis (1 ± 0.2 %, 2.5 ± 0.7; p = 0.028). Liver regeneration and tumor development increased liver ACE levels. Blockade of the RAS effectively retarded CRCLM tumor growth at the late stage of tumor development within the regenerating liver without impeding liver regeneration following PH, via anti-angiogenesis and pro-tumor apoptosis. Captopril may be of therapeutic benefit in patients undergoing PH for CRCLM.
Clinical & experimental metastasis.Clin Exp Metastasis.2014 Jan 18. [Epub ahead of print]
Partial hepatectomy (PH), the preferred option for selected patients with colorectal cancer liver metastases (CRCLM), is associated with 40-80 % tumor recurrence rates. Renin-angiotensin system (RAS) blockade inhibits tumor growth and has been suggested to improve liver regeneration. We documented
PMID 24442969