WordNet
- the 1st letter of the Roman alphabet (同)a
- the blood group whose red cells carry the A antigen (同)type_A, group A
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
PrepTutorEJDIC
- answer / ampere
- =sense organ / 受信装置
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- 1. インスリン受容体の構造および機能 structure and function of the insulin receptor
- 2. インスリン様成長因子 Iの生理学 physiology of insulin like growth factor i
- 3. 糖尿病の治療におけるスルホニル尿素およびメグリチニド sulfonylureas and meglitinides in the treatment of diabetes mellitus
- 4. アンギオテンシン変換酵素阻害剤とアンギオテンシン受容体拮抗剤との相違 differences between angiotensin converting enzyme inhibitors and receptor blockers
- 5. 甲状腺ホルモンの作用 thyroid hormone action
English Journal
- V-ATPase inhibition by archazolid leads to lysosomal dysfunction resulting in impaired cathepsin B activation in vivo.
- Kubisch R1, Fröhlich T, Arnold GJ, Schreiner L, von Schwarzenberg K, Roidl A, Vollmar AM, Wagner E.Author information 1Pharmaceutical Biotechnology Department of Pharmacy, Ludwig Maximilians University, Munich, Germany.AbstractThe myxobacterial agent archazolid inhibits the vacuolar proton pump V-ATPase. V-ATPases are ubiquitously expressed ATP-dependent proton pumps, which are known to regulate the pH in endomembrane systems and thus play a crucial role in endo- and exocytotic processes of the cell. As cancer cells depend on a highly active secretion of proteolytic proteins in order to invade tissue and form metastases, inhibition of V-ATPase is proposed to affect the secretion profile of cancer cells and thus potentially abrogate their metastatic properties. Archazolid is a novel V-ATPase inhibitor. Here, we show that the secretion pattern of archazolid treated cancer cells includes various prometastatic lysosomal proteins like cathepsin A, B, C, D and Z. In particular, archazolid induced the secretion of the proforms of cathepsin B and D. Archazolid treatment abrogates the cathepsin B maturation process leading to reduced intracellular mature cathepsin B protein abundance and finally decreased cathepsin B activity, by inhibiting mannose-6-phoshate receptor-dependent trafficking. Importantly, in vivo reduced cathepsin B protein as well as a decreased proteolytic cathepsin B activity was detected in tumor tissue of archazolid-treated mice. Our results show that inhibition of V-ATPase by archazolid reduces the activity of prometastatic proteases like cathepsin B in vitro and in vivo.
- International journal of cancer. Journal international du cancer.Int J Cancer.2014 May 15;134(10):2478-88. doi: 10.1002/ijc.28562. Epub 2013 Nov 14.
- The myxobacterial agent archazolid inhibits the vacuolar proton pump V-ATPase. V-ATPases are ubiquitously expressed ATP-dependent proton pumps, which are known to regulate the pH in endomembrane systems and thus play a crucial role in endo- and exocytotic processes of the cell. As cancer cells depen
- PMID 24166050
- P2X7 receptors mediate resistance to toxin-induced cell lysis.
- Schoenauer R1, Atanassoff AP1, Wolfmeier H1, Pelegrin P2, Babiychuk EB1, Draeger A3.Author information 1Institute of Anatomy, University of Bern, Bern, Switzerland.2Inflammation and Experimental Surgery Research, University Hospital Virgen de la Arrixaca - FFIS, Murcia, Spain.3Institute of Anatomy, University of Bern, Bern, Switzerland. Electronic address: annette.draeger@ana.unibe.ch.AbstractIn the majority of cells, the integrity of the plasmalemma is recurrently compromised by mechanical or chemical stress. Serum complement or bacterial pore-forming toxins can perforate the plasma membrane provoking uncontrolled Ca(2+) influx, loss of cytoplasmic constituents and cell lysis. Plasmalemmal blebbing has previously been shown to protect cells against bacterial pore-forming toxins. The activation of the P2X7 receptor (P2X7R), an ATP-gated trimeric membrane cation channel, triggers Ca(2+) influx and induces blebbing. We have investigated the role of the P2X7R as a regulator of plasmalemmal protection after toxin-induced membrane perforation caused by bacterial streptolysin O (SLO). Our results show that the expression and activation of the P2X7R furnishes cells with an increased chance of surviving attacks by SLO. This protective effect can be demonstrated not only in human embryonic kidney 293 (HEK) cells transfected with the P2X7R, but also in human mast cells (HMC-1), which express the receptor endogenously. In addition, this effect is abolished by treatment with blebbistatin or A-438079, a selective P2X7R antagonist. Thus blebbing, which is elicited by the ATP-mediated, paracrine activation of the P2X7R, is part of a cellular non-immune defense mechanism. It pre-empts plasmalemmal damage and promotes cellular survival. This mechanism is of considerable importance for cells of the immune system which carry the P2X7R and which are specifically exposed to toxin attacks.
- Biochimica et biophysica acta.Biochim Biophys Acta.2014 May;1843(5):915-22. doi: 10.1016/j.bbamcr.2014.01.024. Epub 2014 Jan 31.
- In the majority of cells, the integrity of the plasmalemma is recurrently compromised by mechanical or chemical stress. Serum complement or bacterial pore-forming toxins can perforate the plasma membrane provoking uncontrolled Ca(2+) influx, loss of cytoplasmic constituents and cell lysis. Plasmalem
- PMID 24487066
- Adenosine triphosphate concentrations are higher in the brain of APOE3- compared to APOE4-targeted replacement mice and can be modulated by curcumin.
- Chin D1, Hagl S, Hoehn A, Huebbe P, Pallauf K, Grune T, Frank J, Eckert GP, Rimbach G.Author information 1Institute of Human Nutrition and Food Science, Christian-Albrechts-University Kiel, Hermann-Rodewald-Strasse 6-8, 24118, Kiel, Germany, chin@foodsci.uni-kiel.de.AbstractCurcumin from Curcuma longa may exert putative neuroprotective properties in the brain. Impaired mitochondrial function is implicated in Alzheimer's disease and the presence of the apolipoprotein (APO) E4 genotype, which is a risk factor for late-onset Alzheimer's disease, may aggravate mitochondrial malfunction. Here, we report that in the brain of 16-month-old APOE4-targeted replacement mice, adenosine triphosphate (ATP) concentrations were significantly lower than in APOE3 mice. A 3-month dietary supplementation of 0.2 % curcumin numerically increased ATP concentrations in APOE3 and significantly in APOE4 mice compared to the respective controls. Curcumin significantly induced the transcription of peroxisome proliferator-activated receptor (PPAR) γ and mitochondrial transcription factor A (TFAM) in APOE3, but not in APOE4 mice. Moreover, PPARγ coactivator (PGC)-1α and guanine-adenine repeat binding protein α (GABPa) mRNA was only increased in APOE3 mice. Consistent with these observations, protein expression of mitochondrial respiratory complexes, especially of complex IV, also appeared to be increased in APOE3 mice. In conclusion, we provide evidence that curcumin affects mitochondrial function and gene and protein expression in the murine brain despite its low bioavailability and carriers of the Alzheimer's disease-risk genotype APOE4 may be less responsive to dietary curcumin than APOE3 carriers.
- Genes & nutrition.Genes Nutr.2014 May;9(3):397. doi: 10.1007/s12263-014-0397-3. Epub 2014 Mar 27.
- Curcumin from Curcuma longa may exert putative neuroprotective properties in the brain. Impaired mitochondrial function is implicated in Alzheimer's disease and the presence of the apolipoprotein (APO) E4 genotype, which is a risk factor for late-onset Alzheimer's disease, may aggravate mitochondria
- PMID 24671632
Japanese Journal
- プロレニンと(プロ)レニン受容体の分布と形態 (特集 RAAS研究の進歩 : RAASの新知見) -- (RAAS受容体の基礎研究)
- 谷 祐至,七里 眞義
- 日本臨床 70(9), 1483-1486, 2012-09
- NAID 40019415970
- 脂溶性ビタミン類による遺伝子発現制御の分子機構に関する研究
- 藤木 亮次
- ビタミン 86(3), 142-154, 2012-03-25
- … These actions are exerted by their cognate nuclear receptors (NRs), vitamin A receptor (RAR) and vitamin D receptor (VDR), respectively. … Herein, I report the molecular mechanisms of cell-specific chromatin remodeling in the VDR-mediated transrepression of 25-hydroxyvitamin D_3-1α-hydroxylase [1α(OH)ase] by WSTF, an ATP-dependent chromatin remodeling factor, and RAR-mediated epigenetic regulation through O-linked N-acetylglucosamin signaling during HL60 differentiation. …
- NAID 110009426029
Related Links
- The term purinergic receptor was originally introduced to illustrate specific classes of membrane receptors that mediate relaxation of gut smooth muscle as a response to the release of ATP (P2 receptors) or adenosine (P1 receptors).
- ATP受容体 （ATPじゅようたい、ATP receptor）は、ATP、ADP、UTP、UDPなどの細胞 外ヌクレオチドをリガンドとする細胞膜上受容体であり、大きく、P2X及びP2Yの2つの ファミリーに分類することができる。 「http://ja.wikipedia.org/w/index.php?title=ATP 受容 ...
Related Pictures
★リンクテーブル★
| リンク元 | 「purinergic P2 receptor」「P2 purinoceptor」「ADP receptor」「ATPレセプター」 |
| 関連記事 | 「AT」「ATP」「A」 |
「purinergic P2 receptor」
「P2 purinoceptor」
「ADP receptor」
「ATPレセプター」
- 英
- ATP receptor
- 関
- ATP受容体
「AT」
- 無酸素性作業閾値 anaerobic threshold
- 毛細血管拡張性運動失調症 ataxia telangiectasia
- アンチトロンビン antithrombin
- 加速時間 acceleration time
「ATP」
[★] アデノシン三リン酸 アデノシン3リン酸 adenosine triphosphate adenosine 5'-triphosphate
「A」