P2 receptor

P2受容体、P2レセプター、P2プリン受容体

関

P2 purinergic receptor、P2 purinoceptor、purinergic P2 receptor

WordNet

1. the 16th letter of the Roman alphabet (同)p
2. a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
3. a river in western Thailand; a major tributary of the Chao Phraya (同)Ping River

PrepTutorEJDIC

1. parking
2. phosphorusの化学記号
3. =sense organ / 受信装置

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/10 10:10:40」(JST)

wiki en

[Wiki en表示]

P2 receptor may refer to:

• P2Y receptors
• P2X receptors

P is for purinergic, P2 refers to ATP receptors, as opposed to P1 adenosine adenosine receptors. P2X receptors are ATP activated channels that allows the passage of ions across cell membranes. P2Y receptors are ATP activated G protein-coupled receptors (GPCRs) that initiate an intracellular chain of reactions.

UpToDate Contents

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• 1. インスリン受容体の構造および機能 structure and function of the insulin receptor
• 2. 免疫不全症を引き起こすCD3／T細胞受容体複合体疾患 cd3 t cell receptor complex disorders causing immunodeficiency
• 3. T細胞受容体の遺伝学 t cell receptor genetics
• 4. T細胞受容体シグナル伝達 t cell receptor signaling
• 5. 乳癌予防のための選択的エストロゲン受容体調節因子およびアロマターゼ阻害剤 selective estrogen receptor modulators and aromatase inhibitors for breast cancer prevention

English Journal

• Nucleotide signaling in astrogliosis.

• Franke H1, Illes P2.Author information 1Rudolf-Boehm-Institute of Pharmacology and Toxicology, University of Leipzig, 04107 Leipzig, Germany.2Rudolf-Boehm-Institute of Pharmacology and Toxicology, University of Leipzig, 04107 Leipzig, Germany. Electronic address: Peter.Illes@medizin.uni-leipzig.de.AbstractAcute and chronic damage to the central nervous system (CNS) releases large quantities of ATP. Whereas the ATP concentration in the extracellular space is normally in the micromolar range, under these conditions it increases to millimolar levels. A number of ligand-gated cationic channels termed P2X receptors (7 mammalian subtypes), and G protein-coupled P2Y receptors (8 mammalian subtypes) are located at astrocytes, as confirmed by the measurement of the respective mRNA and protein. Activation of both the P2X7 and P2Y1,2 subtypes identified at astrocytes initiates astrogliosis isolating damaged brain areas from surrounding healthy cells and synthesizing neurotrophins and pleotrophins that participate in neuronal recovery. Astrocytes are considered as cells of high plasticity which may alter their properties in a culture medium. Therefore, recent work concentrates on investigating nucleotide effects at in situ (acute brain slices) and in vivo astrocytes. A wealth of data relates to the involvement of purinergic mechanisms in astrogliosis induced by acute CNS injury such as mechanical trauma and hypoxia/ischemia. The released ATP may act within minutes as an excitotoxic molecule; at a longer time-scale within days it causes neuroinflammation. These effects sum up as necrosis/apoptosis on the one hand and proliferation on the other. Although the role of nucleotides in chronic neurodegenerative illnesses is not quite clear, it appears that they aggravate the consequences of the primary disease. Epilepsy and neuropathic pain are also associated with the release of ATP and a pathologic glia-neuron interaction leading to astrogliosis and cell death. In view of these considerations, P2 receptor antagonists may open new therapeutic vistas in all forms of acute and chronic CNS damage.
• Neuroscience letters.Neurosci Lett.2014 Apr 17;565C:14-22. doi: 10.1016/j.neulet.2013.09.056. Epub 2013 Oct 5.
• Acute and chronic damage to the central nervous system (CNS) releases large quantities of ATP. Whereas the ATP concentration in the extracellular space is normally in the micromolar range, under these conditions it increases to millimolar levels. A number of ligand-gated cationic channels termed P2X
• PMID 24103370

• P2Y1 receptor inhibits GABA transport through a calcium signalling-dependent mechanism in rat cortical astrocytes.

• Jacob PF1, Vaz SH, Ribeiro JA, Sebastião AM.Author information 1Institute of Pharmacology and Neurosciences, Faculty of Medicine, University of Lisbon, Lisbon, Portugal; Neurosciences Unit, Institute of Molecular Medicine University of Lisbon, Lisbon, Portugal.AbstractAstrocytes express a variety of purinergic (P2) receptors, involved in astrocytic communication through fast increases in [Ca2+ ]i . Of these, the metabotropic ATP receptors (P2Y) regulate cytoplasmic Ca2+ levels through the PLC-PKC pathway. GABA transporters are a substrate for a number of Ca2+ -related kinases, raising the possibility that calcium signalling in astrocytes impact the control of extracellular levels of the major inhibitory transmitter in the brain. To access this possibility we tested the influence of P2Y receptors upon GABA transport into astrocytes. Mature primary cortical astroglial-enriched cultures expressed functional P2Y receptors, as evaluated through Ca2+ imaging, being P2Y1 the predominant P2Y receptor subtype. ATP (100 μM, for 1 min) caused an inhibition of GABA transport through either GAT-1 or GAT-3 transporters, decreasing the Vmax kinetic constant. ATP-induced inhibition of GATs activity was still evident in the presence of adenosine deaminase, precluding an adenosine-mediated effect. This, was mimicked by a specific agonist for the P2Y1,12,13 receptor (2-MeSADP). The effect of 2-MeSADP on GABA transport was blocked by the P2 (PPADS) and P2Y1 selective (MRS2179) receptor antagonists, as well as by the PLC inhibitor (U73122). 2-MeSADP failed to inhibit GABA transport in astrocytes where intracellular calcium had been chelated (BAPTA-AM) or where calcium stores were depleted (α-cyclopiazonic acid, CPA). In conclusion, P2Y1 receptors in astrocytes inhibit GABA transport through a mechanism dependent of P2Y1 -mediated calcium signalling, suggesting that astrocytic calcium signalling, which occurs as a consequence of neuronal firing, may operate a negative feedback loop to enhance extracellular levels of GABA. GLIA 2014.
• Glia.Glia.2014 Apr 15. doi: 10.1002/glia.22673. [Epub ahead of print]
• Astrocytes express a variety of purinergic (P2) receptors, involved in astrocytic communication through fast increases in [Ca2+ ]i . Of these, the metabotropic ATP receptors (P2Y) regulate cytoplasmic Ca2+ levels through the PLC-PKC pathway. GABA transporters are a substrate for a number of Ca2+ -re
• PMID 24733747

• Molecular insights on the recognition of a Lactococcus lactis cell wall pellicle by phage 1358 receptor binding protein.

• Farenc C1, Spinelli S, Vinogradov E, Tremblay D, Blangy S, Sadovskaya I, Moineau S, Cambillau C.Author information 1Architecture et Fonction des Macromolécules Biologiques, UMR 7257, Aix-Marseille Université, Campus de Luminy, Case 932, 13288 Marseille Cedex 09, France.AbstractThe Gram+ bacterium Lactococcus lactis is used for the production of cheeses and other fermented dairy products. Fortuitous infection of L. lactis cells by virulent lactococcal tailed phages is one of the major risks of fermentation failures in industrial dairy factories. Lactococcal phage 1358 possesses a host range limited to a few L. lactis strains and strong genomic similarities to Listeria phages. We report here the X-ray structures of phage 1358 receptor binding protein (RBP) in complex with monosaccharides. Each monomer of its trimeric RBP is formed of two domains: a "shoulders" domain linking the RBP to the rest of the phage and a jelly-roll fold "head/host recognition" domain. This domain harbors a saccharide binding crevice located in the middle of a monomer. Crystal structures identified two sites at the RBP surface,∼8 Å from each other, one accommodating a GlcNAc monosaccharide, the other a GlcNAc or a Glc1P monosaccharide. GlcNAc and GlcNAc1P are components of the polysaccharide pellicle that we identified at the cell surface of L. lactis SMQ-388, the host of phage 1358. We therefore modelled a Galf sugar bridging the two GlcNAc, suggesting that the trisaccharidic motif GlcNAc-Galf-GlcNAc (or Glc1P) might be common to receptors of genetically distinct lactococcal phages p2, TP901-1 and 1358. Strain specificity might therefore be elicited by steric clashes induced by the remaining components of the pellicle hexasaccharide. Taken together these results provide a first insight in the molecular mechanism of host receptor recognition by lactococcal phages.
• Journal of virology.J Virol.2014 Apr 9. [Epub ahead of print]
• The Gram+ bacterium Lactococcus lactis is used for the production of cheeses and other fermented dairy products. Fortuitous infection of L. lactis cells by virulent lactococcal tailed phages is one of the major risks of fermentation failures in industrial dairy factories. Lactococcal phage 1358 poss
• PMID 24719416

Japanese Journal

• Close association of B2 bradykinin receptors with P2Y₂ ATP receptors

• Yashima Sayo,Shimazaki Ayaka,Mitoma Junya [他]
• The journal of biochemistry 158(2), 155-163, 2015-08
• NAID 40020554118

• Contributions of purinergic P2X₃ receptors within the midbrain periaqueductal gray to diabetes-induced neuropathic pain

• Guo Jianfei,Fu Xudong,Cui Xia [他]
• The journal of physiological sciences 65(1), 99-104, 2015-01
• NAID 40020323606

• Platelets: Small in Size But Essential in the Regulation of Vascular Homeostasis　– Translation From Basic Science to Clinical Medicine –

• Goto Shinya,Hasebe Terumitsu,Takagi Shu
• Circulation Journal advpub(0), 2015
• … Thrombin produces fibrin around the activated platelets and further activates the platelets through thrombin receptor stimulation. … Of the various platelet-stimulating receptors and activation signals, cyclo-oxygenase-1, P2Y12adenosine 5'-diphosphate receptor, and thrombin receptor (protease activated receptor)-1 blockers are used clinically as antiplatelet agents. …
• NAID 130005093171

Related Links

• P2 Receptor | P2 Signaling - Selleckchem.com - Inhibitor ...

Antagonists and agonists targeting P2 receptor are available at Selleck. Check P2 reviews and assay information. ... Cat.No. Product Name Information Product Use Citation Customer Product Validation

• P2 receptor-mediated signaling in mast cell biology

P2 receptor-mediated signaling in mast cell biology P2 receptor-mediated signaling in mast cell biology Your browsing activity is empty. Activity recording is turned off. Turn recording back on Links Nucleotide PubMed Taxonomy ...

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★リンクテーブル★

リンク元	「P2受容体」「P2プリン受容体」「P2 purinoceptor」「P2 purinergic receptor」「P2レセプター」
拡張検索	「purinergic P2 receptor」
関連記事	「P」

「P2受容体」

　　[★]

英

P2 receptor

関

プリン受容体

種類

• P2X₁～P2X₇：イオンチャネル連結型受容体：シナプス伝達：P2X₃(痛み)、P2X₄(神経痛)
• P2Y₁,P2Y₂,P2Y₄,P2Y₆,P2Y₁₁～P2Y₁₂：イオンチャネル連結型受容体：シナプス伝達の修飾：チクロピジンはP2Y₁₂(痛み)を遮断して血小板凝集抑制

「P2プリン受容体」

　　[★]

英

P2 purinoceptor、P2 purinergic receptor、purinergic P2 receptor、P2 receptor

関

P2受容体、P2レセプター、ATP受容体、プリンP2受容体、P2プリンレセプター、ADP受容体

「P2 purinoceptor」

　　[★]

• P2プリン受容体

関

ADP receptor、ATP receptor、P2 purinergic receptor、P2 receptor、purinergic P2 receptor

「P2 purinergic receptor」

　　[★]

• P2プリン受容体、P2プリンレセプター

関

P2 purinoceptor、P2 receptor、purinergic P2 receptor

「P2レセプター」

　　[★]

英

P2 receptor

関

P2受容体、P2プリン受容体

「purinergic P2 receptor」

　　[★]

• プリンP2受容体、P2プリン受容体

関

ADP receptor、ATP receptor、P2 purinergic receptor、P2 purinoceptor、P2 receptor

「P」

　　[★]

• プロリン proline
• P波 P wave
• リン phosphorus