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the 1st letter of the Roman alphabet (同)a
the blood group whose red cells carry the A antigen (同)type_A, group A

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answer / ampere
antipersonnel / (またA.P.)Associated Press

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/01/17 05:13:41」(JST)

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AP-1/DNA複合体の結晶構造 (PDB 1FOS)。c-Fos（シアン）とc-Jun（緑）から構成されているAP-1ヘテロ二量体とDNA（茶）が複合体を形成している。

AP-1（エーピーワン、activator protein 1、アクチベータータンパク質1）は、c-Fos、c-Jun、ATF、JDPファミリーに属するタンパク質で構成されているヘテロ二量体タンパク質の転写因子である。AP-1はサイトカインや成長因子、ストレス、バクテリアやウイルスの感染など様々な刺激に応答して遺伝子発現を制御している^[1]。同様に、細胞の分化や増殖、アポトーシスなど多くの細胞プロセスを制御している^[2]。

AP-1はTPA DNA応答配列 (TRE; 5'-TGAG/CTCA-3') を含む遺伝子の転写を上昇させる^[1]。AP-1の二量体構造はロイシンジッパーで形成されているが、DNA配列には塩基性アミノ酸領域を介して結合する^[3]。

Regulome

脚注

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^ Sanyal S, Sandstrom DJ, Hoeffer CA, Ramaswami M (April 2002). “AP-1 functions upstream of CREB to control synaptic plasticity in Drosophila”. Nature 416 (6883): 870–4. doi:10.1038/416870a. PMID 11976688.
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^ Heim JM, Singh S, Fülle HJ, Gerzer R (January 1992). “Comparison of a cloned ANF-sensitive guanylate cyclase (GC-A) with particulate guanylate cyclase from adrenal cortex”. Naunyn Schmiedebergs Arch. Pharmacol. 345 (1): 64–70. doi:10.1007/BF00175471. PMID 1347156.
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^ Manicassamy S, Gupta S, Huang Z, Sun Z (June 2006). “Protein kinase C-theta-mediated signals enhance CD4+ T cell survival by up-regulating Bcl-xL”. J. Immunol. 176 (11): 6709–16. PMID 16709830.
^ Wang N, Verna L, Hardy S, Forsayeth J, Zhu Y, Stemerman MB (September 1999). “Adenovirus-mediated overexpression of c-Jun and c-Fos induces intercellular adhesion molecule-1 and monocyte chemoattractant protein-1 in human endothelial cells”. Arterioscler. Thromb. Vasc. Biol. 19 (9): 2078–84. PMID 10479648.
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^ Phelan JP, Millson SH, Parker PJ, Piper PW, Cooke FT (October 2006). “Fab1p and AP-1 are required for trafficking of endogenously ubiquitylated cargoes to the vacuole lumen in S. cerevisiae”. J. Cell. Sci. 119 (Pt 20): 4225–34. doi:10.1242/jcs.03188. PMID 17003107.
^ Nolasco LH, Turner NA, Bernardo A, et al. (December 2005). [http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1895236 “Hemolytic uremic syndrome-associated Shiga toxins promote endothelial-cell secretion and impair ADAMTS13 cleavage of unusually large von Willebrand factor multimers”]. Blood 106 (13): 4199–209. doi:10.1182/blood-2005-05-2111. PMC 1895236. PMID 16131569.
^ Hommura F, Katabami M, Leaner VD, et al. (May 2004). “HMG-I/Y is a c-Jun/activator protein-1 target gene and is necessary for c-Jun-induced anchorage-independent growth in Rat1a cells”. Mol. Cancer Res. 2 (5): 305–14. PMID 15192124.
^ General Introduction
^ Chang CJ, Chao JC (April 2002). “Effect of human milk and epidermal growth factor on growth of human intestinal Caco-2 cells”. J. Pediatr. Gastroenterol. Nutr. 34 (4): 394–401. doi:10.1097/00005176-200204000-00015. PMID 11930096.
^ Weber JR, Skene JH (July 1998). “The activity of a highly promiscuous AP-1 element can be confined to neurons by a tissue-selective repressive element”. J. Neurosci. 18 (14): 5264–74. PMID 9651209.
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^ Cohen MP, Ziyadeh FN, Lautenslager GT, Cohen JA, Shearman CW (May 1999). “Glycated albumin stimulation of PKC-beta activity is linked to increased collagen IV in mesangial cells”. Am. J. Physiol. 276 (5 Pt 2): F684–90. PMID 10330050.
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^ Steiner C, Peters WH, Gallagher EP, Magee P, Rowland I, Pool-Zobel BL (March 2007). “Genistein protects human mammary epithelial cells from benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide and 4-hydroxy-2-nonenal genotoxicity by modulating the glutathione/glutathione S-transferase system”. Carcinogenesis 28 (3): 738–48. doi:10.1093/carcin/bgl180. PMID 17065199.
^ Emerin and inherited disease
^ AccessMedicine - Content
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^ Retinoic Acid Inhibits Serum-stimulated Activator Protein-1 via ...
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^ Erase Your Ugly Scars
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UpToDate Contents

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1. 常染色体優性多発性嚢胞腎の遺伝学および嚢胞成長のメカニズム genetics of autosomal dominant polycystic kidney disease and mechanisms of cyst growth
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3. 神経線維腫症I型（NF1）：病因、臨床的特徴、および診断 neurofibromatosis type 1 nf1 pathogenesis clinical features and diagnosis
4. クリオピリン関連周期性発熱症候群および関連疾患 cryopyrin associated periodic syndromes and related disorders
5. 複合免疫不全 combined immunodeficiencies

English Journal

Transcriptional regulation of the mouse CD11c promoter by AP-1 complex with JunD and Fra2 in dendritic cells.

Hara M, Yokoyama H, Fukuyama K, Kitamura N, Shimokawa N, Maeda K, Kanada S, Ito T, Usui Y, Ogawa H, Okumura K, Nishiyama M, Nishiyama C.SourceAtopy Research Center, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Molecular immunology.Mol Immunol.2013 Mar;53(3):295-301. doi: 10.1016/j.molimm.2012.08.004. Epub 2012 Sep 16.
CD11c, a member of the β(2) integrin family of adhesion molecule, is expressed on the surface of myeloid lineages and activated lymphoid cells and forms a heterodimeric receptor with CD18. We analyzed the mouse CD11c promoter structure to elucidate the transcriptional regulation in dendritic cells
PMID 22990073

IL-6 promotes ICAM-1 expression and cell motility in human osteosarcoma.

Lin YM, Chang ZL, Liao YY, Chou MC, Tang CH.SourceInstitute of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Orthopedic Surgery, Taichung Veterans General Hospital, Taichung, Taiwan.
Cancer letters.Cancer Lett.2013 Jan 1;328(1):135-43. doi: 10.1016/j.canlet.2012.08.029. Epub 2012 Aug 29.
Osteosarcoma is characterized by a high malignant and metastatic potential. Interleukin-6 (IL-6) is a multifunctional cytokine that is associated with the disease status and outcomes of cancers. However, the effect of IL-6 on migration activity in human osteosarcoma cells is mostly unknown. Here we
PMID 22939995

Japanese Journal

Clioquinol Increases the Expression of VGF, a Neuropeptide Precursor, Through Induction of c-Fos Expression

Katsuyama Masato,Ibi Masakazu,Matsumoto Misaki [他]
Journal of pharmacological sciences 124(4), 427-432, 2014-04
NAID 40020051298

Alimentary Tract : AP-1Bによる蛋白ソーティングは腸管上皮の極性と増殖を制御している

西田淳史,藤山佳秀,HASE KOJI [他]
Review of gastroenterology & clinical gastroenterology and hepatology 8(4), 22-27, 2014-03
NAID 40020006198

Safflower Yellow Inhibits Angiotensin II–Induced Adventitial Fibroblast Proliferation and Migration

Liu Yueqiang,Tian Xuefeng,Cui Mingzhu,Zhao Suzhen
Journal of Pharmacological Sciences, 2014
… and increases in the expression of p-ERK1/2, AP-1, collagen I, and collagen III were observed. … Treatment with SY significantly downregulated cell proliferation, migration, and the expression of p-ERK1/2, AP-1, collagen I, and collagen III. …
NAID 130004690913

Related Pictures

★リンクテーブル★

リンク元	「activator protein-1」「アクチベータータンパク質1」
拡張検索	「転写因子AP-1」「transcription factor AP-1」「AP-1因子」
関連記事	「AP」「A」