WordNet

the 1st letter of the Roman alphabet (同)a
the blood group whose red cells carry the A antigen (同)type_A, group A
the 13th letter of the Roman alphabet (同)m
the imperial dynasty of China from 1368 to 1644 (同)Ming dynasty

PrepTutorEJDIC

answer / ampere
Mach number / mark[s] / Monsieur
(中国の)明,明朝(1368‐1644)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/09/26 12:38:56」(JST)

wiki en

Minimally differentiated acute myeloblastic leukemia is a subtype of AML. It is classified as M0 by FAB. It represents 2–3% of all cases of AML.^[1] Although minimally differentiated AML was recognized earlier, criteria for FAB M0 were developed in 1991.^[2] The blasts in these cases cannot be recognized as myeloid based on morphology and cytochemistry, but immunophenotyping demonstrates myeloid antigens.^[3]

Cytochemistry and Molecular Features

In acute myeloblastic leukemia (M0), the blasts are agranular and nonreactive when stained for myeloperoxidase activity, and Auer rods are not seen. The blasts react with antibodies to myeloperoxidase and antibodies to CD13, CD33, and CD34. Human leukocyte antigen (HLA)-DR is positive in most patients. Occasional cases require in situ hybridization to identify the myeloperoxidase gene315 or genomic profiling for early myeloid-associated genes.^[4] Abnormal and unfavorable karyotypes (e.g., loss of the long arm of chromosome 5 (5q-) and 7q-) and higher expression of the multidrug resistance glycoprotein (p170) are frequent.^[5] In general, minimally differentiated acute myeloblastic leukemia has a poor prognosis.^[6]

References

^ Kumar V, Abbas AK, Fausto N, Mitchel RN (2007). Robbins basic Pathology (8th ed.). Saunders.
^ Lee EJ, Pollak A, Leavitt RD, Testa JR, Schiffer CA (November 1987). "Minimally differentiated acute nonlymphocytic leukemia: a distinct entity". Blood 70 (5): 1400–6. PMID 3663939.
^ Greer JP, Foerster J, Lukens JN (2003). Wintrobe's Clinical Hematology (11th ed.). Lippincott Williams & Wilkins.
^ Testa U, Torelli GF, Riccioni R, et al. (June 2002). "Human acute stem cell leukemia with multilineage differentiation potential via cascade activation of growth factor receptors". Blood 99 (12): 4634–7. doi:10.1182/blood.V99.12.4634. PMID 12036900.
^ Lichtman M., et al. (2005). Williams Hematology (7th ed.). McGraw-Hill.
^ Cuneo A, Ferrant A, Michaux JL, et al. (June 1995). "Cytogenetic profile of minimally differentiated (FAB M0) acute myeloid leukemia: correlation with clinicobiologic findings". Blood 85 (12): 3688–94. PMID 7780152.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 急性骨髄性白血病の分類 classification of acute myeloid leukemia
2. 若年成人における急性骨髄性白血病に対する寛解後療法 post remission therapy for acute myeloid leukemia in younger adults
3. 高齢者における急性骨髄性白血病の治療 treatment of acute myeloid leukemia in older adults
4. 若年成人における急性骨髄性白血病に対する導入療法 induction therapy for acute myeloid leukemia in younger adults
5. 急性骨髄性白血病の予後 prognosis of acute myeloid leukemia

English Journal

4q12 translocations with GSX2 expression identify a CD7(+) acute myeloid leukaemia subset.

Di Giacomo D1, La Starza R1, Barba G1, Pierini V1, Baldazzi C2, Storlazzi CT3, Daniele G3, Forghieri F4, Borlenghi E5, Testoni N2, Mecucci C6.
British journal of haematology.Br J Haematol.2015 Oct;171(1):141-5. doi: 10.1111/bjh.13368. Epub 2015 Mar 30.
PMID 25816740

A CD3xCD123 bispecific DART for redirecting host T cells to myelogenous leukemia: preclinical activity and safety in nonhuman primates.

Chichili GR1, Huang L1, Li H1, Burke S1, He L1, Tang Q1, Jin L1, Gorlatov S1, Ciccarone V1, Chen F1, Koenig S1, Shannon M1, Alderson R1, Moore PA1, Johnson S1, Bonvini E2.
Science translational medicine.Sci Transl Med.2015 May 27;7(289):289ra82. doi: 10.1126/scitranslmed.aaa5693.
Current therapies for acute myeloid leukemia (AML) are largely ineffective, and AML patients may benefit from targeted immunotherapy approaches. MGD006 is a bispecific CD3xCD123 dual-affinity re-targeting (DART) molecule that binds T lymphocytes and cells expressing CD123, an antigen up-regulated in
PMID 26019218

Malignant pleural effusion in acute myeloid leukemia with hepatitis B virus infection.

Suharti C1, Santosa, Setiawan B.
Acta medica Indonesiana.Acta Med Indones.2015 Apr;47(2):153-6.
Pleural effusions can be the first presentation of a hematologic malignancy. The most common disorders with pleural effusion are Hodgkin and non-Hodgkin lymphoma with a frequency of 20 to 30%, especially if mediastinal involvement. Acute and chronic leukemia are rarely accompanied by pleural involve
PMID 26260558

Japanese Journal

細胞マーカー解析が診断に有用であった骨髄/NK前駆細胞性急性白血病

三浦理加,吉見真弓,菊池裕二,高橋強志
臨床血液 54(6), 579-583, 2013
… この病型はNK細胞系腫瘍としては最も未分化段階に由来し，またAML M0の範疇にも属するとされているが，近年独立した疾患概念として注目されてきている。 …
NAID 130004501822

A tetraploid minimally differentiated acute myeloblastic leukemia with extensive erythrophagocytosis : a case report and literature review

LI Li,LI Jianlan,LI Guoxia,TAN Yanhong,CHEN Xiuhua,REN Fanggang,GUO Haixiu,WANG Hongwei
International journal of hematology 96(6), 801-805, 2012-12-01
NAID 10031144622

血小板ペルオキシダーゼの評価

山崎家春,三谷絹子
細胞 44(3), 149-152, 2012-03
NAID 40019336404

Related Pictures

AML-M0 - 1. Pathology images: Gross pathology, histopathology, histology Histopathology images of AML-M0, Blood by PathPedia.com: Pathology e-Atlas 27. Acute lymphoblastic leukemia/lymphoma - ppt video online download AML-M0 - 2. شبكة الابداع الطبية - leukemias AML M0 FAB: Undifferenzierte akute myeloische Leukämie - Abbildung

★リンクテーブル★

リンク元	「最未分化型急性骨髄性白血病」
関連記事	「AML」「A」「AM」「M0」「M」

「最未分化型急性骨髄性白血病」

Minimally differentiated acute myeloblastic leukemia
	Classification and external resources
	A schematic showing the appearance of acute myeloblastic leukemia, M0 under microscope. Blasts show no Auer rods.
ICD-O:	M9872/3
MeSH	D015470

　　[★]

英: AML, minimally differentiated AML-M0 M0
同: 最小分化型急性骨髄性白血病最小分化型AML
関: 急性骨髄性白血病 AML

「AML」

　　[★]

「A」

　　[★]

「AM」

　　[★]

「M0」

　　[★] 最未分化型急性骨髄性白血病

「M」

　　[★] メチオニン methionine 　　

[1] Kumar V, Abbas AK, Fausto N, Mitchel RN (2007). Robbins basic Pathology (8th ed.). Saunders.

[2] Lee EJ, Pollak A, Leavitt RD, Testa JR, Schiffer CA (November 1987). "Minimally differentiated acute nonlymphocytic leukemia: a distinct entity". Blood 70 (5): 1400–6. PMID 3663939.

[3] Greer JP, Foerster J, Lukens JN (2003). Wintrobe's Clinical Hematology (11th ed.). Lippincott Williams & Wilkins.

[4] Testa U, Torelli GF, Riccioni R, et al. (June 2002). "Human acute stem cell leukemia with multilineage differentiation potential via cascade activation of growth factor receptors". Blood 99 (12): 4634–7. doi:10.1182/blood.V99.12.4634. PMID 12036900.

[5] Lichtman M., et al. (2005). Williams Hematology (7th ed.). McGraw-Hill.

[6] Cuneo A, Ferrant A, Michaux JL, et al. (June 1995). "Cytogenetic profile of minimally differentiated (FAB M0) acute myeloid leukemia: correlation with clinicobiologic findings". Blood 85 (12): 3688–94. PMID 7780152.

匿名

検索

案内

案内

AML-M0