英: prethrombotic state
関: 凝固亢進状態

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1. 血液透析用の人工血管のメンテナンスと閉塞予防の概要overview of hemodialysis arteriovenous graft maintenance and thrombosis prevention [show details]
…considered high risk for AV graft thrombosis (ie, history of thrombosis within three months of surgery of a prior AV access, coagulation abnormality, hypercoagulable state). The management of the high-risk …
2. 脳静脈血栓症：病因、臨床的特徴、診断cerebral venous thrombosis etiology clinical features and diagnosis [show details]
… venous thrombosis is impairment of CSF absorption. Normally, CSF absorption occurs in the arachnoid granulations and glymphatic system, which drain CSF into the venous system. Thrombosis of the… ischemic stroke registry, a risk factor was identified in 98 percent of the children . A prothrombotic state was found in 41 percent. In infants older than four weeks of age and in children, head and neck disorders …
3. 妊娠中の播種性血管内凝固症候群（DIC）：マネージメントおよび予後disseminated intravascular coagulation dic during pregnancy management and prognosis [show details]
… preparation of fully typed and crossmatched RBCs requires at least 20 minutes.… TXA may be appropriate in patients in whom severe bleeding is associated with a hyperfibrinolytic state . rFVIIa and PCCs – There is no proven benefit from use of recombinant activated human factor VII … in pregnant/postpartum women related to DIC. In addition, rFVIIa and PCCs increase the risk for thrombosis. Antithrombin – We do not use antithrombin to treat bleeding in DIC. In two studies, it did not …
4. 敗血症性硬膜静脈洞血栓症septic dural sinus thrombosis [show details]
… hypercoagulable state; The role of anticoagulation in septic lateral sinus thrombosis remains controversial. Although there may be a theoretic benefit, the stimulus precipitating thrombosis in septic cases …
5. 癌に関連する凝固亢進状態：原因およびメカニズムcancer associated hypercoagulable state causes and mechanisms [show details]
… The pathogenesis of thrombosis in malignancy involves an underlying prothrombotic state resulting from cancer-related procoagulant mechanisms, which is further aggravated by clinical risk factors that …

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1．凝固異常と脳卒中 - J-STAGE

血栓形成には血小板機能と血液凝固機能が関与しており，血小板活性化と凝固活性化は易血栓性（血栓準備状態）を招く1）．血液線溶能の低下も血栓形成能を助長する1）．また，血液粘度の上昇（過粘稠症候群）も血栓形成を促進する1）．脳梗塞の原因となる主な血液凝固異常症を表1 に示す2）．また，表2には血液凝固異常症による脳梗塞の特徴を示し，表3には血液凝固異常症のスクリーニング検査を示す． 1）血小板異常症血小板の量的・質的異常は血小板活性化をもたらし，脳梗塞の原因となる1）．真性多血症や原発性血小板増多症のような骨髄増殖性疾患は血小板数の増加と血小板活性化を生じるので脳梗塞の強力な危険因子になる1）．

加齢と血栓傾向 - J-STAGE

一般に加齢にともなって血栓症の頻度は増加すると言われている．その原因としては，血管の老化による硬化性変化や内皮障害の進展と，血液自体が過凝固に傾いていくという両面が考えられる．最近の総説2）にまとめられた「加齢にともなう血液自体の過凝固性」について表1に示す．まず，一次血栓の主体となる血小板の活性化を示す血小板第4因子（platelet factor 4）やトロンボキサンA2，β-トロンボグロブリンなどの血中レベルは高齢者ほど上昇傾向にあり3,4），またフォン・ヴィルブラント因子と血加齢と血栓傾向山本晃士＊ Aging and thrombotic tendency