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1. バラシクロビル：概要valacyclovir an overview [show details]
…and L-valine . Food does not affect absorption. Valacyclovir, at a dose of 250 mg four times daily, generates essentially the same acyclovir AUC (area under the curve, or exposure over 24 hours) as oral …
2. クリンダマイシン：概要clindamycin an overview [show details]
… clindamycin have also been implicated in causing this disease, which may be attributable to systemic absorption of the drug . Clindamycin should be used with caution among patients with inflammatory bowel disease … concentrations may not exceed the area under the curve to minimum inhibitory concentration target for effective…
3. ポリミキシン：概要polymyxins an overview [show details]
… the exposure to minimum inhibitory concentration (MIC) ratio, area under the concentration-time curve (AUC)/MIC, appears to be the best correlated with bactericidal activity . Although the manufacturer … the pharmacokinetics of intravenous CMS are sparse . CMS has a half-life of 124 minutes, whereas colistin (base) has a half-life of 251 minutes . Colistin has a calculated volume of distribution of…
4. 尿細管性アシドーシスにおける腎結石症nephrolithiasis in renal tubular acidosis [show details]
… Carbonic anhydrase is important for both proximal and distal acidification. Carbonic anhydrase inhibitors,… calcium phosphate release from bone during bone buffering of retained acid, increased intestinal absorption of calcium, and direct reduction in the tubular reabsorption of these ions . The degree of hypercalciuria …
5. 特発性頭蓋内圧亢進症（偽脳腫瘍）：予後および治療idiopathic intracranial hypertension pseudotumor cerebri prognosis and treatment [show details]
…starts with carbonic anhydrase inhibitors. Loop diuretics may be used as an adjunct. Glucocorticoids are not recommended for most patients with IIH. Medical treatment for IIH starts with carbonic anhydrase …