WordNet

the 2nd letter of the Roman alphabet (同)b
the blood group whose red cells carry the B antigen (同)type_B, group B
the 8th letter of the Roman alphabet (同)h

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鉛筆の硬度 / 《俗》heroin

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/09/07 21:35:30」(JST)

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B*0801-β2MG with bound peptide1m05
major histocompatibility complex (human), class I, B8
Alleles	B*0801
Structure (See HLA-B)		Avail. 3D structures
EBI-HLA	B*0801	1mi5, 1m05 1agf, 1age 1agd, 1agc 1agb,1a9b
Symbol(s)	HLA-B
Locus	chr.6 6p21.31

HLA-B8 (B8) is an HLA-B serotype. The serotype identifies the HLA-B*08 gene products.^[1] (For terminology help see: HLA-serotype tutorial) HLA-B8, previously known as HL-A8 was one of the first identified of the HLA antigens. It coined the "Super B8" haplotype, also called the ancestral European haplotype because of its common occurrence in Europe, particular the isles and Scandinavia. B8 is a component gene-allele of the AH8.1 haplotype in Northern and Western Europeans. Genes between B8 and DR3 on this haplotype are frequently associated with autoimmune disease.

Serotype

B8 serotype recognition of Some HLA B*08 allele-group gene products^[2]
B*08	B8	Sample
allele	%	size (N)
*0801	99	6508
*0804	29	7
Allele links out to IMGT/HLA Databease at EBI

Alleles

**HLA B*0801 frequencies**
		freq
ref.	Population	(%)
^[3]	Ireland South	18.2
^[3]	Australia New South Wales	17.3
^[3]	Ireland Northern	16.2
^[3]	Belgium	12.6
^[3]	Oman	11.0
^[3]	Spain Basque Gipuzkoa Province	9.1
^[3]	Finland	8.9
^[3]	France South East	8.9
^[3]	Scotland Orkney	8.8
^[3]	Morocco Nador Metalsa Class I	8.7
^[3]	India New Delhi	8.3
^[3]	Spain Eastern Andalusia Gipsy	8.1
^[3]	Madeira	7.8
^[3]	Guinea Bissau	7.7
^[3]	Iran Baloch	7.6
^[3]	South African Natal Zulu	7.5
^[3]	Brazil Belo Horizonte	7.4
^[3]	Cape Verde Southeastern Islands	7.3
^[3]	Romanian	7.3
^[3]	Saudi Arabia Guraiat and Hail	7.1
^[3]	South Africa Natal Tamil	7.1
^[3]	Georgia Svaneti Svans	6.9
^[3]	India Andhra Pradesh Golla	6.7
^[3]	Portugal North	6.5
^[3]	Azores Santa Maria and Sao Miguel	6.4
^[3]	Uganda Kampala	6.2
^[3]	Cape Verde Northwestern Islands	5.6
^[3]	Cameroon Yaounde	5.4
^[3]	Italy Bergamo	5.3
^[3]	Czech Republic	5.2
^[3]	Cameroon Pygmy Baka	5.0
^[3]	Senegal Niokholo Mandenka	4.8
^[3]	Kenya Nandi	4.6
^[3]	Spain Catalonia Girona	4.6
^[3]	Tunisia	4.6
^[3]	Bulgaria Gipsy	4.5
^[3]	Tunisia Tunis	4.5
^[3]	Brazil	4.3
^[3]	Portugal Centre	4.0
^[3]	Sudanese	4.0
^[3]	Cameroon Sawa	3.8
^[3]	Jordan Amman	3.8
^[3]	Indig. Australian, Cape York Peninsula	3.5
^[3]	Georgia Tibilisi Kurds	3.4
^[3]	Zambia Lusaka	3.4
^[3]	Kenya	3.1
^[3]	Zimbabwe Harare Shona	3.1
^[3]	Kenya Luo	3.0
^[3]	Mexico Zaptotec Oaxaca	3.0
^[3]	India North Hindus	2.9
^[3]	Mexico Mestizos	2.4
^[3]	Ivory Coast Akan Adiopodoume	2.3
^[3]	Indig. Australian, Groote Eylandt	2.0
^[3]	Portugal South	2.0
^[3]	Georgia Tibilisi Georgians	1.9
^[3]	Azores Central Islands	1.8
^[3]	Bulgaria	1.8
^[3]	Argentina Toba Rosario	1.7
^[3]	Croatia	1.7
^[3]	India North Delhi	1.6
^[3]	China North Han	1.4
^[3]	Cameroon Beti	1.1
^[3]	Cameroon Bakola Pygmy	1.0
^[3]	India West Coast Parsis	1.0
^[3]	Taiwan Siraya	1.0

References

^ Marsh SG, Albert ED, Bodmer WF et al. (2005). "Nomenclature for factors of the HLA system, 2004". Tissue Antigens 65 (4): 301–69. doi:10.1111/j.1399-0039.2005.00379.x. PMID 15787720.
^ derived from IMGT/HLA
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m ⁿ ^o ^p ^q ^r ^s ^t ^u ^v ^w ^x ^y ^z ^aa ^ab ^ac ^ad ^ae ^af ^ag ^ah ^ai ^aj ^ak ^al ^am ^an ^ao ^ap ^aq ^ar ^as ^at ^au ^av ^aw ^ax ^ay ^az ^ba ^bb ^bc ^bd ^be ^bf ^bg ^bh ^bi ^bj ^bk ^bl ^bm Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.

UpToDate Contents

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English Journal

Human leukocyte antigen type and posttransplant lymphoproliferative disorder.

Lustberg ME1, Pelletier RP, Porcu P, Martin SI, Quinion CD, Geyer SM, Caligiuri MA, Baiocchi RA.
Transplantation.Transplantation.2015 Jun;99(6):1220-5. doi: 10.1097/TP.0000000000000487.
BACKGROUND: Posttransplant lymphoproliferative disorder (PTLD) is an infrequent but serious complication of solid organ transplantation. Early detection and initiation of therapy may improve outcomes. The purpose of this study was to identify human leukocyte antigen (HLA) type as risk and prognostic
PMID 25427163

Association Between HLA Haplotypes and Increased Serum Levels of IgG4 in Patients With Primary Sclerosing Cholangitis.

Berntsen NL1, Klingenberg O2, Juran BD3, Benito de Valle M4, Lindkvist B4, Lazaridis KN4, Boberg KM5, Karlsen TH6, Hov JR7.
Gastroenterology.Gastroenterology.2015 May;148(5):924-927.e2. doi: 10.1053/j.gastro.2015.01.041. Epub 2015 Feb 2.
Increased serum levels of IgG4 have been reported in 9%-15% of patients with primary sclerosing cholangitis (PSC); it is not clear whether this increase contributes to pathogenesis. We performed genetic analyses of the HLA complex in patients with PSC from Norway, Sweden, and from the United States.
PMID 25655558

Japanese Journal

The human UTY gene encodes a novel HLA-B8-restricted H-Y antigen

WARREN EH
J Immunol 164, 2807-2814, 2000
NAID 80011598170

Related Pictures

★リンクテーブル★

リンク元	「ヒト白血球抗原」「疱疹状皮膚炎」
拡張検索	「HLA-B8 antigen」
関連記事	「B」「HL」「H」「HLA」

「ヒト白血球抗原」

　　[★]

英: human leucocyte antigen, HLA
同: ヒト白血球型抗原、HLA抗原 HLA antigen、ヒト組織適合性白血球抗原 human histocompatibility leukocyteantigen; 主要組織適合抗原 MHC　←　免疫との関連はこちらを参照
関: 骨髄バンク、HLA抗原

疾患との関連

出典不明

強直性脊椎炎	B27
関節リウマチ	DR4
重症筋無力症	DR9,DQ3
尋常性天疱瘡	A26,DR4
バセドウ病	DR5
I型糖尿病(インスリン依存性糖尿病)	B54,DR4,DR9,DR53,DQ4
グレーブス病	DR5
ベーチェット病	B51
原田病	DR4,DR53
潰瘍性大腸炎	B52,DR2
クローン病	DR4,DQ3
高安病	B52,DR2,DQ1
バージャー病	B52,DR2,DQ1
ナルコレプシー	DR2

first aid step1 2006 p.191

HLA-B27	psoriasis, ankylosing spondylitis, inflammatory bowel disease, Reiter's syndrome.
HLA-B8	Graves' disease, celiac sprue.
HLA-DR2	multiple sclerosis, hay fever, SLE, Goodpasture's syndrome.
HLA-DR3	diabetes mellitus type 1.
HLA-DR4	rheumatoid arthritis, diabetes mellitus type 1.
HLA-DR5	pernicious anemia → B12 deficiency, Hashimoto's thyroiditis.
HLA-DR7	steroid-responsive nephrotic syndrome.