- 日
- 関
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/09/15 15:31:53」(JST)
wiki en
| This article may require copy editing for grammar, style, cohesion, tone, or spelling. You can assist by editing it. (April 2013) |
| Systematic (IUPAC) name | |
|---|---|
| 17α-hydroxy-yohimban-16α- carboxylic acid methyl ester |
|
| Clinical data | |
| Trade names | Actibine, Erex, Testomar, Yocon, Yohimar, Yohimbe |
| Pregnancy cat. | ? |
| Legal status | Prescription Only (S4) (AU) OTC |
| Routes | Oral |
| Identifiers | |
| CAS number | 146-48-5 Y |
| ATC code | G04BE04 QV03AB93 |
| PubChem | CID 8969 |
| IUPHAR ligand | 102 |
| DrugBank | DB01392 |
| ChemSpider | 8622 Y |
| UNII | 2Y49VWD90Q Y |
| ChEBI | CHEBI:10093 Y |
| ChEMBL | CHEMBL15245 Y |
| Chemical data | |
| Formula | C21H26N2O3 |
| Mol. mass | 354.44 g/mol (base) 390.90 g/mol (hydrochloride) |
|
SMILES
|
|
|
InChI
|
|
| Y (what is this?) (verify) |
|
Yohimbine is a mild MAOI with stimulant and aphrodisiac effects. It is sold as prescription medicine in pure form for the treatment of sexual dysfunction. Yohimbine was explored as a remedy for type 2 diabetes in animal and human models carrying polymorphisms of the α2A-adrenergic receptor gene.[1]
Common brand names for Yohimbine are: Erex, Testomar, Yocon, Yohimar, Yohimbe.
Contents
- 1 Synthesis
- 2 Research
- 3 Medical uses
- 3.1 Indications
- 3.1.1 SSRI side-effects
- 3.1.2 Sexual dysfunction
- 3.1.2.1 Dosage
- 3.1.3 Fat loss[unreliable medical source?]
- 3.1.4 Other uses
- 3.2 Adverse effects
- 3.3 Precautions and contraindications
- 3.4 Interactions
- 3.4.1 MAOIs
- 3.4.2 NRIs
- 3.4.3 Stimulants
- 3.1 Indications
- 4 Sports
- 5 Pharmacology
- 5.1 Pharmacologic Profile of Yohimbine
- 6 See also
- 7 References
Synthesis[edit source | edit]
Research[edit source | edit]
Yohimbine primarily acts as an antagonist of α2 receptors.[2] Additionally, it inhibits the function of monoamine oxidase enzymes, although it is not clear if it is a RIMA, MAOA, or MAOB inhibitor.
RIMAS, like moclobemide (an antidepressant), do not require dietary restrictions. Many people have been supplementing with yohimbine on normal diets (containing tyramine and phenylalanine like most cheeses and fish respectively) with no adverse effects. MAOIs are normally contradicted for use with tyrosine rich food[citation needed], but recently numerous[citation needed] companies have taken to combining yohimbine with tyrosine in their fat burners, and energy products.[3] However, tyrosine failed to potentiate the effect of yohimbine except for somewhat augmenting the increase in DHPG.[4]
When yohimbine are used in pharmahuasca it does not have any MAOI effects on tryptamines, e.g. DMT keeps being orally inactive. This suggest that yohimbine is a MAOB inhibitor. A range of cacti contain tyramine, including the Echinopsis pachanoi (syn. Trichocereus pachanoi), known as the San Pedro cactus which also contain the phenylethylamine mescaline.[5] Poly drug use with yohimbine and mescaline cactus are inconclusive.
Overdoses of yohimbine can cause priapism. Normally priapism is treated with pseudoephedrine but in combination with MAOIs like yohimbine it can lead to hypertensive reactions.[6] The first step in management may be blood exchange transfusion.
Medical uses[edit source | edit]
Indications[edit source | edit]
SSRI side-effects[edit source | edit]
MAOI and SSRI are normally never mixed as a rule of thumb. However, yohimbine, with its weak MAOI activity, has safely been used to treat sexual side-effects caused by some SSRI antidepressants (see below for more information about sexual dysfunction).[medical citation needed] Also, 14 mg yohimbine increases salivation so yohimbine could have a potential interest in the treatment of dry mouths,[7] another common side-effect caused SSRIs. In fact, doctors believe that heartburn (another common SSRI side-effect) is caused by dry mouth because it reduces the amount of saliva running down the esophagus which is known to neutralize excess acid in the stomach.[8]
Sexual dysfunction[edit source | edit]
Main article: Sexual dysfunction
The NIH states that yohimbine hydrochloride is the standardized form of yohimbine that is available as a prescription medicine in the United States, and has been shown in human studies to be effective in the treatment of male impotence.[9] Yohimbine has been shown to be effective in the treatment of orgasmic dysfunction in men.[10] Yohimbine has also been used to treat hypoactive sexual desire disorder (reduced libido) in women[medical citation needed].
Large doses of yohimbe have caused priapism.[11] However, controlled studies suggest that it is not always an effective treatment for impotence, and evidence of increased sex drive (libido) is anecdotal only.[12]
It cannot be excluded that orally administered yohimbine can have a beneficial effect in some patients with ED. The conflicting results available may be attributed to differences in drug design, patient selection, and definitions of positive response. Generally, however, available results of treatment are not impressive.[13]
Yohimbine blocks the pre- and post-synaptic α2 receptors. Blockade of post-synaptic α2 receptors causes minor corpus cavernosum smooth muscle relaxation. In fact the majority of adrenoceptors in the corpus cavernosum are of the α1 type. Blockade of pre-synaptic α2 receptors facilitates the release of several neurotransmitters, in the central and peripheral nervous system, thus in the corpus cavernosum, such as nitric oxide and norepinephrine. Whether nitric oxide released in the corpus cavernosum is the major vasodilator contributing to the erectile process, norepinephrine is the major vasoconstrictor through stimulation of α1 receptors on the corpus cavernosum smooth muscle. Under physiologic conditions nitric oxide attenuates norepinephrine vasoconstriction. Continuous administration of yohimbine, opposed to on demand administration, might result in less norepinephrine output due to increased turnover, or α1 receptors down regulation via a feedback mechanism, not causing the vasoconstriction due to excessive norepinephrine release which can be seen often with on demand administration. α1 blockers prevent vasoconstriction caused by norepinephrine as well.[14]
Dosage[edit source | edit]
- Anorgasmia or reduced libido: 5.4-16.2 mg a day 1–2 hours before sexual activity.[15] or 5.4 mg three times a day[16]
- Erectile dysfunction: A suggested first line treatment for mild to moderate ED are a combination of 6 mg yohimbine hydrochloride and 6000 mg arginine glutamate (50% arginine, 50% glutamic acid).[17] Other doses of yohimbine alone to treat ED are 15 to 30 mg a day[18] 1–2 hours before sexual activity.[16]
Fat loss[unreliable medical source?][edit source | edit]
According to one study, oral yohimbine supplementation may actuate significant fat loss in athletes, though this study is self-reported and did not monitor caloric intake.[19] Numerous bodybuilding supplement companies sell formulations of yohimbine for transdermal delivery to effect a local reduction of adipose tissue, although the experimental evidence for its efficacy is limited.[20][unreliable source?][21][unreliable source?]
Other uses[edit source | edit]
Yohimbine has also been used as a blood pressure boosting agent in autonomic failure, xerostomia, and as a probe for noradrenergic activity.[unreliable medical source?]
The addition of yohimbine to fluoxetine or venlafaxine has also been found to potentiate the antidepressant action of both of these agents.[22]
Yohimbine has been used to facilitate recall of traumatic memories in the treatment of post traumatic stress disorder (PTSD).[23] Use of yohimbine outside therapeutic settings may not be appropriate for persons suffering from PTSD.[24] In pharmacology, yohimbine is used as a probe for α2-adrenoceptor. In veterinary medicine, yohimbine is used to reverse anesthesia from the drug xylazine in small and large animals.
Adverse effects[edit source | edit]
Depending on dosage yohimbine can both lower and increase systemic blood pressure, known as vasodilation and vasoconstriction respectively; small amounts of yohimbine can increase blood pressure while large amounts can cause dangerously low pressure.[6]
The therapeutic index of yohimbine is quite low; the range between an effective dose and a dangerous dose is very narrow.[25] A typical dose for sexual dysfunction would be 15–30 mg, whereas 100 mg would be considered dangerous. This may also lead to the precipitation of panic disorder type reactions, heart attack and possibly death.
Hallucinations or paralysis may occur with doses greater than 40 mg.[26] Higher doses of oral yohimbine may create numerous side effects, such as rapid heart rate, overstimulation, insomnia and/or sleeplessness. Some effects in rare cases were panic attacks, hallucinations, headaches, dizziness and skin flushing.[25]
More serious adverse effects may include seizures and renal failure. Yohimbine should not be consumed by anyone with liver, kidney, heart disease, or a psychological disorder.[25]
Precautions and contraindications[edit source | edit]
Yohimbe bark is on the FDA list of dangerous supplements.[27] The levels of yohimbine that are present in yohimbe bark extract are variable and often very low.[9] Therefore, although yohimbe bark has been used traditionally to reduce male erectile dysfunction, there is not enough scientific evidence to form a definitive conclusion in this area.
In Africa, yohimbe has traditionally been used as an aphrodisiac.[28] However, it is very important to note that while the terms yohimbine, yohimbine hydrochloride, and yohimbe bark extract are related, they are not interchangeable.[9]
Yohimbine is an alkaloid naturally found in Pausinystalia yohimbe (Yohimbe), Rauwolfia serpentina (Indian Snakeroot), and Alchornea floribunda (Niando), along with several other active alkaloids. Yohimbine has been used as both an over-the-counter dietary supplement in herbal extract
In addition to the main active chemical, yohimbine, Pausinystalia yohimbe contains approximately 55 other alkaloids, of which yohimbine accounts for 1% to 20% of total alkaloids. Among them corynanthine is an α1 receptor blocker. Hence the use of Yohimbe extract in sufficient dosages may provide concomitant α1 and α2 receptors blockade and thus may better enhance erections than yohimbine alone.[14]
Pausinystalia yohimbe is currently threatened with extinction in its native habitat due to international demand.[citation needed] Its conservation is difficult because the bioactivity of the tree has led many Western governments to declare it a proscribed species.
Interactions[edit source | edit]
MAOIs[edit source | edit]
At least 14 days should elapse between discontinuation of MAOI therapy and initiation of treatment with yohimbine.[29]
NRIs[edit source | edit]
Yohimbine in combination with norepinephrine reuptake inhibitor, such as dextromethorphan, tramadol, some antidepressants and central nervous system stimulants used to treat ADHD, can cause a hypertensive crises. This is due to those drugs in combination with an a2 receptor antagonist leads to too much norepinephrine in the brain, which causes blood pressure to spike to dangerous levels.
Yohimbine in combination with modafinil is frequently associated with nausea, dangerous acute rapid heart beat, and acute increased blood pressure. Yohimbine exhibits some degree of MAOI activity while modafinil has been shown to increase levels of various monamines and therefore could result in severe risk of dangerous side effects.
Stimulants[edit source | edit]
Research on cats suggests that yohimbine increases the effects of catecholaminergic stimulants, namely amphetamine and modafinil.[30]
Sports[edit source | edit]
Sport supplements with yohimbine as the main ingredient are sold as purported energy boosters.[citation needed]
Pharmacology[edit source | edit]
Yohimbine has high affinity for the α2-adrenergic receptor, moderate affinity for the α1 receptor, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1F, 5-HT2B, and D2 receptors, and weak affinity for the 5-HT1E, 5-HT2A, 5-HT5A, 5-HT7, and D3 receptors.[31][32] It behaves as an antagonist at α1-adrenergic, α2-adrenergic, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, and D2, and as a partial agonist at 5-HT1A.[31][33][34][35] Its intrinsic activities at the other sites listed are unclear/unknown, but it is probably mostly antagonistic at them.[citation needed] Yohimbine interact with serotonin and dopamine receptors in high concentrations.[36]
Pharmacologic Profile of Yohimbine[edit source | edit]
| Molecular Target | Binding Affinity (Ki in nM)[37] | Pharmacologic Action[31][33][34][35] | Species | Source |
|---|---|---|---|---|
| SERT | 1,000 | Inhibitor | Human | Frontal Cortex |
| DAT | 1,000 | Inhibitor | Rat | Brain |
| 5-HT1A | 346 | Partial Agonist | Human | Cloned |
| 5-HT1B | 19.9 | Antagonist | Human | Cloned |
| 5-HT1D | 44.3 | Antagonist | Human | Cloned |
| 5-HT1E | 1,264 | Unknown | Human | Cloned |
| 5-HT1F | 91.6 | Unknown | Human | Cloned |
| 5-HT2A | 1,822 | Antagonist | Human | Cloned |
| 5-HT2B | 143.7 | Antagonist | Human | Cloned |
| 5-HT2C | >10,000 | Unknown | Human | Cloned |
| 5-HT3 | >10,000 | Unknown | Rat and Mouse | Cloned, Cortex & NG108-15 |
| 5-HT5A | 1,000 | Unknown | Rat and Mouse | Cloned |
| 5-HT7 | 2,850 | Unknown | Human | Cloned |
| α1A | 1,680 | Antagonist | Human | Cloned |
| α1B | 1,280 | Antagonist | Human | Cloned |
| α1C | 770 | Antagonist | Human | Cloned |
| α1D | 557 | Antagonist | Human | Cloned |
| α2A | 1.05 | Antagonist | Human | Cloned |
| α2B | 1.19 | Antagonist | Human | Cloned |
| α2C | 1.19 | Antagonist | Human | Cloned |
| D1 | >10,000 | Unknown | Human | Cloned |
| D2 | 339 | Unknown | Human | Cloned |
| D3 | 3,235 | Unknown | Human | Cloned |
See also[edit source | edit]
- Ajmalicine
- Corynanthine
- Rauwolscine
- Reserpine
- Deserpidine
- Rescinnamine
References[edit source | edit]
- ^ Rosengren, A. H.; Jokubka, R.; Tojjar, D.; Granhall, C.; Hansson, O.; Li, D.-Q.; Nagaraj, V.; Reinbothe, T. M. et al. (2009). "Overexpression of Alpha2A-Adrenergic Receptors Contributes to Type 2 Diabetes". Science 327 (5962): 217–20. doi:10.1126/science.1176827. PMID 19965390.
|displayauthors=suggested (help) - ^ Verwaerde, P; Tran, MA; Montastruc, JL; Senard, JM; Portolan, G (1997). "Effects of yohimbine, an α2 receptors antagonist, on experimental neurogenic orthostatic hypotension.". Fundamental & clinical pharmacology 11 (6): 567–75. PMID 9444525.
- ^ "Yohimbe Supplements". Livestrong.Com. Retrieved 2013-05-26.
- ^ USA (2013-03-25). "Differential effects of yoh... [Res Commun Chem Pathol Pharmacol. 1988] - PubMed - NCBI". Ncbi.nlm.nih.gov. Retrieved 2013-05-26.
- ^ "Visionary Cactus Guide". Lycaeum.
- ^ a b "Yohimbe: MedlinePlus Supplements". Nlm.nih.gov. Retrieved 2013-05-26.
- ^ USA (2013-03-25). "Yohimbine increases human salivary secretion". Ncbi.nlm.nih.gov. Retrieved 2013-05-26.
- ^ http://www.acidrefluxsymptomsnow.com/Does-zoloft-causes-heartburn.html
- ^ a b c "Yohimbe: MedlinePlus Supplements". nlm.nih.gov. November 19, 2010. Retrieved December 13, 2010.
- ^ Adeniyi AA, Brindley GS, Pryor JP, Ralph DJ (May 2007). "Yohimbine in the treatment of orgasmic dysfunction". Asian Journal of Andrology 9 (3): 403–7. doi:10.1111/J.1745-7262.2007.00276.x. PMID 17486282.
- ^ USA (2013-03-25). "Refractory priapism associated with ingestion ... [J Med Toxicol. 2009] - PubMed - NCBI". Ncbi.nlm.nih.gov. Retrieved 2013-05-26.
- ^ Andersson KE (September 2001). "Pharmacology of penile erection". Pharmacological Reviews 53 (3): 417–50. PMID 11546836.
- ^ Andersson, Karl-Erik; Steers, William D. (1998). "The pharmacological basis of sexual therapeutics". In Morales, Alvaro. Erectile dysfunction: issues in current pharmacotherapy. London: Martin Dunitz. pp. 97–124 [114]. ISBN 978-1-85317-577-0.
- ^ a b Saenz De Tejada, I; Kim, NN; Goldstein, I; Traish, AM (2000). "Regulation of pre-synaptic alpha adrenergic activity in the corpus cavernosum". International Journal of Impotence Research. 12 Suppl 1: S20–25. doi:10.1038/sj.ijir.3900500. PMID 10845761.
- ^ "Pharmacotherapy- Treatment of OCD - OCD Research - Stanford University School of Medicine". Ocd.stanford.edu. 2008-06-20. Retrieved 2013-05-26.
- ^ a b Neuropsychiatry - Google Books. Books.google.se. Retrieved 2013-05-26.
- ^ Lebret, T.; Hervéa, J. M.; Gornyb, P.; Worcelc, M.; Botto, H. (2002). "Efficacy and Safety of a Novel Combination of L-Arginine Glutamate and Yohimbine Hydrochloride: A New Oral Therapy for Erectile Dysfunction". European Urology 41 (6): 608–613. doi:10.1016/S0302-2838(02)00175-6. PMID 12074777.
- ^ "Dietary Supplement Information Bureau –". Naturalproductsinfo.org. Retrieved 2013-05-26.
- ^ Ostojic SM (2006). "Yohimbine: the effects on body composition and exercise performance in soccer players". Research in Sports Medicine 14 (4): 289–99. doi:10.1080/15438620600987106. PMID 17214405.
- ^ December 1, 1998 (1998-12-01). "Fat Loss, alpha2-Adrenoceptors and Yohimbine, Part 2". Mesomorphosis.com. Retrieved 2013-05-26.
- ^ Yohimbe Info and Products at Bodybuilding.com
- ^ Dhir, A; Kulkarni, SK (2007). "Effect of addition of yohimbine (α2 receptors antagonist) to the antidepressant activity of fluoxetine or venlafaxine in the mouse forced swim test". Pharmacology 80 (4): 239–43. doi:10.1159/000104877. PMID 17622775.
- ^ van der Kolk, Bessel A. (1995). "The Treatment of Post Traumatic Stress Disorder". In Hobfoll, Stevan E.; De Vries, Marten W. Extreme stress and communities: impact and intervention. Boston: Kluwer Academic Publishers. pp. 421–44. ISBN 978-0-7923-3468-2.
- ^ Morgan CA, Grillon C, Southwick SM et al. (February 1995). "Yohimbine facilitated acoustic startle in combat veterans with post-traumatic stress disorder". Psychopharmacology 117 (4): 466–71. doi:10.1007/BF02246220. PMID 7604149.
- ^ a b c Prescription for Nutritional Healing, fourth edition Phyllis A. Balch, CNC
- ^ "Yohimbine Dangers". Livestrong.Com. Retrieved 2013-05-26.
- ^ "Yohimbe Bark Supplements for ED: Side Effects, Safety, Dangers, and More". Webmd.com. 2012-08-06. Retrieved 2013-05-26.
- ^ Yohimbe. National Center for Complementary and Alternative Medicine.
- ^ HealthCare.com. "Interactions with Yohimbine". Healthcare.com. Retrieved 2013-05-26.
- ^ Lin, J. S.; Roussel, B.; Akaoka, H.; Fort, P.; Debilly, G.; Jouvet, M. (1992). "Role of catecholamines in the modafinil and amphetamine induced wakefulness, a comparative pharmacological study in the cat". Brain research 591 (2): 319–326. doi:10.1016/0006-8993(92)91713-O. PMID 1359924. edit
- ^ a b c Millan MJ, Newman-Tancredi A, Audinot V et al. (February 2000). "Agonist and antagonist actions of yohimbine as compared to fluparoxan at alpha(2)-adrenergic receptors (AR)s, serotonin (5-HT)(1A), 5-HT(1B), 5-HT(1D) and dopamine D(2) and D(3) receptors. Significance for the modulation of frontocortical monoaminergic transmission and depressive states". Synapse 35 (2): 79–95. doi:10.1002/(SICI)1098-2396(200002)35:2<79::AID-SYN1>3.0.CO;2-X. PMID 10611634.
- ^ "PDSP Ki Database".
- ^ a b Arthur JM, Casañas SJ, Raymond JR (June 1993). "Partial agonist properties of rauwolscine and yohimbine for the inhibition of adenylyl cyclase by recombinant human 5-HT1A receptors". Biochemical Pharmacology 45 (11): 2337–41. doi:10.1016/0006-2952(93)90208-E. PMID 8517875.
- ^ a b Kaumann AJ (June 1983). "Yohimbine and rauwolscine inhibit 5-hydroxytryptamine-induced contraction of large coronary arteries of calf through blockade of 5 HT2 receptors". Naunyn-Schmiedeberg's Archives of Pharmacology 323 (2): 149–54. doi:10.1007/BF00634263. PMID 6136920.
- ^ a b Baxter GS, Murphy OE, Blackburn TP (May 1994). "Further characterization of 5-hydroxytryptamine receptors (putative 5-HT2B) in rat stomach fundus longitudinal muscle". British Journal of Pharmacology 112 (1): 323–31. doi:10.1111/j.1476-5381.1994.tb13072.x. PMC 1910288. PMID 8032658.
- ^ "Yohimbine (PIM 567)". Inchem.org. Retrieved 2013-05-26.
- ^ National Institute of Mental Health. "PDSP Ki Database". University of North Carolina. Retrieved 5 July 2013.
|
||||||||||||||||||||||||||||||||||||
|
||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
- 1. 男性性機能不全の治療 treatment of male sexual dysfunction
- 2. 起立性低血圧および食後低血圧の治療 treatment of orthostatic and postprandial hypotension
- 3. 心血管疾患患者における性的活動 sexual activity in patients with cardiovascular disease
- 4. 選択的セロトニン再取り込み阻害剤（SSRI）に起因する性機能不全：マネージメント sexual dysfunction caused by selective serotonin reuptake inhibitors ssris management
- 5. レイノー現象の病因 pathogenesis of the raynaud phenomenon
English Journal
- Alpha(1) receptor antagonist in the median raphe nucleus evoked hyperphagia in free-feeding rats.
- Mansur SS, Terenzi MG, Neto JM, Faria MS, Paschoalini MA.SourceDepartment of Physiological Sciences, Centre of Biological Sciences - CCB, Federal University of Santa Catarina (UFSC), 88040-970, Florianopolis, SC, Brazil.
- Appetite.Appetite.2011 Oct;57(2):498-503. Epub 2011 Jul 2.
- Serotonergic neurons in the median raphe nucleus (MnR) are stimulated by α(1)-adrenergic agonists and inhibited by α(2)-agonists. This study investigated the effect of the blockade of the MnR α(1)-adrenergic receptors of free feeding rats as an attempt to elucidate the functional role of these re
- PMID 21745511
- The role of adrenergic and cholinergic receptors on the antinociception of sildenafil in the spinal cord of rats.
- Park CH, Lee HG, Lee SH, Chung CW, Yoon MH.SourceDepartment of Anesthesiology and Pain Medicine, Kwangju Christian Hospital, Gwangju, Republic of Korea.
- Neuroscience letters.Neurosci Lett.2011 Sep 15;502(2):99-102. Epub 2011 Jul 29.
- The role played by spinal adrenergic and cholinergic receptors in the antinociceptive effects of intrathecal sildenafil in formalin-induced nociception was examined. Intrathecal catheters were inserted into the subarachnoid space of male Sprague-Dawley rats, and nociception was assessed using the fo
- PMID 21820036
Japanese Journal
- ヨヒンビン投与卵巣摘出ラットにおけるホットフラッシュ様症状に対するエストロゲン及び桂枝茯苓丸の作用
- 森元 康夫,青塚 保志,柴田 裕次郎
- 薬学雑誌 131(8), 1241-1250, 2011
- NAID 40018943024
- Tonic Inhibition of Allergic Itch Signaling by the Descending Noradrenergic System in Mice
- Gotoh Yoshikazu,Omori Yu,Andoh Tsugunobu,Kuraishi Yasushi
- Journal of Pharmacological Sciences 115(3), 417-420, 2011
- … The biting was inhibited by intrathecal clonidine and reversed by yohimbine, an α2-adrenoceptor antagonist. …
- NAID 130000663405
Related Links
- HOME 製品のご案内 販売元のご案内 製品モニターのご案内 お問合せ・ご相談窓口 お問合せ ヨヒンビン製剤「ガラナポーン」 ヨヒンビンの起源 ヨヒンビン製剤の歴史 ヨヒンビンの副作用・ 注意事項について （海外情報）
- Yohimbine is a fat burning compound. Although effective, it may cause anxiety, it adversely interacts with many pharmaceuticals, and the labeled dose of supplements that contain it often does not match the actual dose.
Related Pictures
★リンクテーブル★
| リンク元 | 「α受容体遮断薬」 |
| 関連記事 | 「yohimbin」 |
「α受容体遮断薬」
- 英
- α adrenergic receptor blocker α-adrenergic blocking agent, α-adrenoceptor blocking agent
- 同
- αアドレナリン受容体遮断薬、α遮断薬 α-blocker, α-blockade